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Protein

26S proteasome non-ATPase regulatory subunit 6

Gene

Psmd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-MMU-4608870. Asymmetric localization of PCP proteins.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641258. Degradation of DVL.
R-MMU-5358346. Hedgehog ligand biogenesis.
R-MMU-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5610780. Degradation of GLI1 by the proteasome.
R-MMU-5610785. GLI3 is processed to GLI3R by the proteasome.
R-MMU-5632684. Hedgehog 'on' state.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676590. NIK-->noncanonical NF-kB signaling.
R-MMU-5687128. MAPK6/MAPK4 signaling.
R-MMU-68827. CDT1 association with the CDC6:ORC:origin complex.
R-MMU-68949. Orc1 removal from chromatin.
R-MMU-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-MMU-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-MMU-69481. G2/M Checkpoints.
R-MMU-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
26S proteasome regulatory subunit RPN7
26S proteasome regulatory subunit S10
p42A
Gene namesi
Name:Psmd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1913663. Psmd6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 38938826S proteasome non-ATPase regulatory subunit 6PRO_0000173839Add
BLAST

Proteomic databases

EPDiQ99JI4.
MaxQBiQ99JI4.
PaxDbiQ99JI4.
PeptideAtlasiQ99JI4.
PRIDEiQ99JI4.

PTM databases

iPTMnetiQ99JI4.
PhosphoSiteiQ99JI4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021737.
GenevisibleiQ99JI4. MM.

Interactioni

Subunit structurei

Component of the PA700 complex.1 Publication

Protein-protein interaction databases

BioGridi211457. 35 interactions.
IntActiQ99JI4. 39 interactions.
MINTiMINT-4611978.
STRINGi10090.ENSMUSP00000022256.

Structurei

3D structure databases

ProteinModelPortaliQ99JI4.
SMRiQ99JI4. Positions 30-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 358168PCIAdd
BLAST

Sequence similaritiesi

Belongs to the proteasome subunit S10 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiKOG0687. Eukaryota.
COG5187. LUCA.
GeneTreeiENSGT00510000046608.
HOGENOMiHOG000214998.
HOVERGENiHBG023924.
InParanoidiQ99JI4.
KOiK03037.
OMAiVCMIALK.
OrthoDBiEOG091G03SE.
PhylomeDBiQ99JI4.
TreeFamiTF313819.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR019585. Rpn7/CSN1.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
PF10602. RPN7. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVREE LMAAVRENNM
60 70 80 90 100
APYYEALCKS LDWQMDVDLL SKMKKANEEE LKRLDEELED AEKNLGESEI
110 120 130 140 150
RDAMMAKAEY LCQIGDKEGA LTAFRKTYDK TVALGHRLDI VFYLLRIGLF
160 170 180 190 200
YMDNDLITRN TEKAKSLIEE GGDWDRRNRL KVYQGLYCVA IRDFKQAAEL
210 220 230 240 250
FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV IKGAEILEVL
260 270 280 290 300
HSLPAVRQYL FSLYECRYSV FFQSLAIVEQ EMKKDWLFAP HYRYYVREMR
310 320 330 340 350
IHAYSQLLES YRSLTLGYMA EAFGVGVDFI DQELSRFIAA GRLHCKIDKV
360 370 380
NEIVETNRPD SKNWQYQETI KKGDLLLNRV QKLSRVINM
Length:389
Mass (Da):45,536
Last modified:June 1, 2001 - v1
Checksum:iDC8C54144D2884B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 233QLR → DCV in BAB26823 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ252147 mRNA. Translation: CAC34579.1.
AK010287 mRNA. Translation: BAB26823.1.
BC006869 mRNA. Translation: AAH06869.1.
CCDSiCCDS26824.1.
RefSeqiNP_079826.2. NM_025550.2.
UniGeneiMm.27591.

Genome annotation databases

EnsembliENSMUST00000022256; ENSMUSP00000022256; ENSMUSG00000021737.
GeneIDi66413.
KEGGimmu:66413.
UCSCiuc007sgj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ252147 mRNA. Translation: CAC34579.1.
AK010287 mRNA. Translation: BAB26823.1.
BC006869 mRNA. Translation: AAH06869.1.
CCDSiCCDS26824.1.
RefSeqiNP_079826.2. NM_025550.2.
UniGeneiMm.27591.

3D structure databases

ProteinModelPortaliQ99JI4.
SMRiQ99JI4. Positions 30-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211457. 35 interactions.
IntActiQ99JI4. 39 interactions.
MINTiMINT-4611978.
STRINGi10090.ENSMUSP00000022256.

PTM databases

iPTMnetiQ99JI4.
PhosphoSiteiQ99JI4.

Proteomic databases

EPDiQ99JI4.
MaxQBiQ99JI4.
PaxDbiQ99JI4.
PeptideAtlasiQ99JI4.
PRIDEiQ99JI4.

Protocols and materials databases

DNASUi66413.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022256; ENSMUSP00000022256; ENSMUSG00000021737.
GeneIDi66413.
KEGGimmu:66413.
UCSCiuc007sgj.1. mouse.

Organism-specific databases

CTDi9861.
MGIiMGI:1913663. Psmd6.

Phylogenomic databases

eggNOGiKOG0687. Eukaryota.
COG5187. LUCA.
GeneTreeiENSGT00510000046608.
HOGENOMiHOG000214998.
HOVERGENiHBG023924.
InParanoidiQ99JI4.
KOiK03037.
OMAiVCMIALK.
OrthoDBiEOG091G03SE.
PhylomeDBiQ99JI4.
TreeFamiTF313819.

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-MMU-4608870. Asymmetric localization of PCP proteins.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641258. Degradation of DVL.
R-MMU-5358346. Hedgehog ligand biogenesis.
R-MMU-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5610780. Degradation of GLI1 by the proteasome.
R-MMU-5610785. GLI3 is processed to GLI3R by the proteasome.
R-MMU-5632684. Hedgehog 'on' state.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676590. NIK-->noncanonical NF-kB signaling.
R-MMU-5687128. MAPK6/MAPK4 signaling.
R-MMU-68827. CDT1 association with the CDC6:ORC:origin complex.
R-MMU-68949. Orc1 removal from chromatin.
R-MMU-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-MMU-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-MMU-69481. G2/M Checkpoints.
R-MMU-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiPsmd6. mouse.
PROiQ99JI4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021737.
GenevisibleiQ99JI4. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR019585. Rpn7/CSN1.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
PF10602. RPN7. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPSMD6_MOUSE
AccessioniPrimary (citable) accession number: Q99JI4
Secondary accession number(s): Q9CWZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.