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Protein

ER lumen protein-retaining receptor 1

Gene

Kdelr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 1
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 1
Short name:
KDEL receptor 1
Gene namesi
Name:Kdelr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915387. Kdelr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 212CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941541 – 212ER lumen protein-retaining receptor 1Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei209Phosphoserine; by PKABy similarity1

Post-translational modificationi

Phosphorylation by PKA at Ser-209 is required for ER retention function.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99JH8.
PaxDbiQ99JH8.
PeptideAtlasiQ99JH8.
PRIDEiQ99JH8.
TopDownProteomicsiQ99JH8.

PTM databases

PhosphoSitePlusiQ99JH8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002778.
GenevisibleiQ99JH8. MM.

Interactioni

Subunit structurei

Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002855.

Structurei

3D structure databases

ProteinModelPortaliQ99JH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiQ99JH8.
KOiK10949.
OMAiAPFELLW.
OrthoDBiEOG091G0Q1H.
PhylomeDBiQ99JH8.
TreeFamiTF314792.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD
60 70 80 90 100
LFTNYISLYN TCMKVVYIAC SFTTVWMIYS KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PTAILAFLVN HDFTPLEILW TFSIYLESVA ILPQLFMVSK TGEAETITSH
160 170 180 190 200
YLFALGVYRT LYLFNWIWRY HFEGFFDLIA IVAGLVQTVL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,560
Last modified:June 1, 2001 - v1
Checksum:i261285F09CFD4051
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027435 mRNA. Translation: AAK11732.1.
AJ278132 mRNA. Translation: CAC34584.1.
BC011370 mRNA. Translation: AAH11370.1.
CCDSiCCDS21268.1.
RefSeqiNP_598711.1. NM_133950.2.
UniGeneiMm.298433.

Genome annotation databases

EnsembliENSMUST00000002855; ENSMUSP00000002855; ENSMUSG00000002778.
GeneIDi68137.
KEGGimmu:68137.
UCSCiuc009gxn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027435 mRNA. Translation: AAK11732.1.
AJ278132 mRNA. Translation: CAC34584.1.
BC011370 mRNA. Translation: AAH11370.1.
CCDSiCCDS21268.1.
RefSeqiNP_598711.1. NM_133950.2.
UniGeneiMm.298433.

3D structure databases

ProteinModelPortaliQ99JH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002855.

PTM databases

PhosphoSitePlusiQ99JH8.

Proteomic databases

MaxQBiQ99JH8.
PaxDbiQ99JH8.
PeptideAtlasiQ99JH8.
PRIDEiQ99JH8.
TopDownProteomicsiQ99JH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002855; ENSMUSP00000002855; ENSMUSG00000002778.
GeneIDi68137.
KEGGimmu:68137.
UCSCiuc009gxn.1. mouse.

Organism-specific databases

CTDi10945.
MGIiMGI:1915387. Kdelr1.

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiQ99JH8.
KOiK10949.
OMAiAPFELLW.
OrthoDBiEOG091G0Q1H.
PhylomeDBiQ99JH8.
TreeFamiTF314792.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiKdelr1. mouse.
PROiQ99JH8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002778.
GenevisibleiQ99JH8. MM.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERD21_MOUSE
AccessioniPrimary (citable) accession number: Q99JH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.