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Protein

Annexin A13

Gene

Anxa13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A13
Alternative name(s):
Annexin XIII
Annexin-13
Gene namesi
Name:Anxa13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917037. Anxa13.

Subcellular locationi

  • Cell membrane By similarity

  • Note: Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 317316Annexin A13PRO_0000067515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ99JG3.
PRIDEiQ99JG3.

PTM databases

PhosphoSiteiQ99JG3.

Expressioni

Gene expression databases

CleanExiMM_ANXA13.

Interactioni

Protein-protein interaction databases

IntActiQ99JG3. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ99JG3.
SMRiQ99JG3. Positions 15-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 8461Annexin 1Add
BLAST
Repeati96 – 15661Annexin 2Add
BLAST
Repeati180 – 24061Annexin 3Add
BLAST
Repeati255 – 31561Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

HOVERGENiHBG061815.
InParanoidiQ99JG3.
KOiK17099.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009166. AnnexinXIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01811. ANNEXINXIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNRHAKERS HHHGFDADRD AKKLYKACKG MGTDEAAIIE VLSSRTSEER
60 70 80 90 100
QQIKQKYKEK YGKDLEEVLN SELSGNFKKT ALALLDRPNE YAARQLQKAM
110 120 130 140 150
KGVGTDEAML IEILCTRSNK EIVAIKEAYQ RLFGRSLESD VKEDTSGNLR
160 170 180 190 200
KILVSLLQAS RDEEDTVDKE LAGQDAKDLY DAGEGRWGTD ELAFNEVLAK
210 220 230 240 250
RSYKQLRATF QAYQILIGKD MEETIEEETS GDLKKAYLTI VRCAQDLEGY
260 270 280 290 300
FADLLYKAMK GMGTDEETLI RIIVTRAEVD LQGIKAKFQE KYQKSLSDMV
310
HSDTSGDFRK LLVALLH
Length:317
Mass (Da):35,922
Last modified:January 23, 2007 - v3
Checksum:i5B43B7564BBAC54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306451 mRNA. Translation: CAC34623.1.
BC013521 mRNA. Translation: AAH13521.1.
RefSeqiNP_081487.1. NM_027211.2.
UniGeneiMm.237985.

Genome annotation databases

GeneIDi69787.
KEGGimmu:69787.
UCSCiuc007vtm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306451 mRNA. Translation: CAC34623.1.
BC013521 mRNA. Translation: AAH13521.1.
RefSeqiNP_081487.1. NM_027211.2.
UniGeneiMm.237985.

3D structure databases

ProteinModelPortaliQ99JG3.
SMRiQ99JG3. Positions 15-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99JG3. 4 interactions.

PTM databases

PhosphoSiteiQ99JG3.

Proteomic databases

MaxQBiQ99JG3.
PRIDEiQ99JG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69787.
KEGGimmu:69787.
UCSCiuc007vtm.1. mouse.

Organism-specific databases

CTDi312.
MGIiMGI:1917037. Anxa13.

Phylogenomic databases

HOVERGENiHBG061815.
InParanoidiQ99JG3.
KOiK17099.

Miscellaneous databases

NextBioi330342.
PROiQ99JG3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ANXA13.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009166. AnnexinXIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01811. ANNEXINXIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins."
    Iglesias J.M., Morgan R.O., Jenkins N.A., Copeland N.G., Gilbert D.J., Fernandez M.-P.
    Mol. Biol. Evol. 19:608-618(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiANX13_MOUSE
AccessioniPrimary (citable) accession number: Q99JG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.