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Q99JG2

- ETBR2_MOUSE

UniProt

Q99JG2 - ETBR2_MOUSE

Protein

Prosaposin receptor GPR37L1

Gene

Gpr37l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. negative regulation of astrocyte differentiation Source: MGI
    2. negative regulation of neuron differentiation Source: MGI
    3. negative regulation of smoothened signaling pathway Source: MGI
    4. positive regulation of cerebellar granule cell precursor proliferation Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosaposin receptor GPR37L1
    Alternative name(s):
    Endothelin B receptor-like protein 2
    Short name:
    ETBR-LP-2
    G-protein coupled receptor 37-like 1
    Gene namesi
    Name:Gpr37l1
    Synonyms:Etbrlp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1928503. Gpr37l1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 481457Prosaposin receptor GPR37L1PRO_0000012797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ99JG2.
    PaxDbiQ99JG2.
    PRIDEiQ99JG2.

    PTM databases

    PhosphoSiteiQ99JG2.

    Expressioni

    Tissue specificityi

    Highly expressed in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ99JG2.
    BgeeiQ99JG2.
    CleanExiMM_GPR37L1.
    GenevestigatoriQ99JG2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99JG2.
    SMRiQ99JG2. Positions 123-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 134110ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 36029CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini382 – 39817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini420 – 48162CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi418 – 43922Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291459.
    GeneTreeiENSGT00690000101856.
    HOGENOMiHOG000252922.
    HOVERGENiHBG051808.
    InParanoidiQ99JG2.
    KOiK04244.
    OMAiVWHSYYL.
    OrthoDBiEOG7CVPXV.
    PhylomeDBiQ99JG2.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99JG2-1 [UniParc]FASTAAdd to Basket

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    MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD    50
    EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ 100
    ELRVNLTGTP SQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS 150
    VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD 200
    VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA 250
    KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS 300
    LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH 350
    EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI 400
    NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS 450
    ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C 481
    Length:481
    Mass (Da):52,729
    Last modified:June 7, 2005 - v2
    Checksum:iD7CF26B83B7F6E8C
    GO

    Sequence cautioni

    The sequence BAA32062.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306537 Genomic DNA. Translation: CAC34842.1.
    AJ306538 Genomic DNA. Translation: CAC34843.1.
    AB016602 mRNA. Translation: BAA32062.1. Different initiation.
    AY255561 mRNA. Translation: AAO85073.1.
    CCDSiCCDS48371.1.
    RefSeqiNP_602320.2. NM_134438.3.
    UniGeneiMm.272290.

    Genome annotation databases

    EnsembliENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
    GeneIDi171469.
    KEGGimmu:171469.
    UCSCiuc007csv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306537 Genomic DNA. Translation: CAC34842.1 .
    AJ306538 Genomic DNA. Translation: CAC34843.1 .
    AB016602 mRNA. Translation: BAA32062.1 . Different initiation.
    AY255561 mRNA. Translation: AAO85073.1 .
    CCDSi CCDS48371.1.
    RefSeqi NP_602320.2. NM_134438.3.
    UniGenei Mm.272290.

    3D structure databases

    ProteinModelPortali Q99JG2.
    SMRi Q99JG2. Positions 123-435.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99JG2.

    Proteomic databases

    MaxQBi Q99JG2.
    PaxDbi Q99JG2.
    PRIDEi Q99JG2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027682 ; ENSMUSP00000027682 ; ENSMUSG00000026424 .
    GeneIDi 171469.
    KEGGi mmu:171469.
    UCSCi uc007csv.2. mouse.

    Organism-specific databases

    CTDi 9283.
    MGIi MGI:1928503. Gpr37l1.

    Phylogenomic databases

    eggNOGi NOG291459.
    GeneTreei ENSGT00690000101856.
    HOGENOMi HOG000252922.
    HOVERGENi HBG051808.
    InParanoidi Q99JG2.
    KOi K04244.
    OMAi VWHSYYL.
    OrthoDBi EOG7CVPXV.
    PhylomeDBi Q99JG2.
    TreeFami TF331292.

    Miscellaneous databases

    NextBioi 371005.
    PROi Q99JG2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99JG2.
    Bgeei Q99JG2.
    CleanExi MM_GPR37L1.
    Genevestigatori Q99JG2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of GPR37 and related orphan G-protein coupled receptor genes highly expressed in the mammalian brain."
      Marazziti D., Golini E., Magrelli A., Matteoni R., Tocchini-Valentini G.P.
      Curr. Genomics 2:253-260(2001)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Liver.
    2. "Cloning of a cDNA encoding a novel G-protein coupled receptor uniquely expressed in the adult brain."
      Matsuo N., Kawamoto S., Matsubara K., Okubo K.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-481.
      Strain: C57BL/6.
      Tissue: Hippocampus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-454.

    Entry informationi

    Entry nameiETBR2_MOUSE
    AccessioniPrimary (citable) accession number: Q99JG2
    Secondary accession number(s): O88313, Q80UB9, Q99JG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3