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Q99JG2

- ETBR2_MOUSE

UniProt

Q99JG2 - ETBR2_MOUSE

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Protein
Prosaposin receptor GPR37L1
Gene
Gpr37l1, Etbrlp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. protein binding Source: MGI

GO - Biological processi

  1. negative regulation of astrocyte differentiation Source: MGI
  2. negative regulation of neuron differentiation Source: MGI
  3. negative regulation of smoothened signaling pathway Source: MGI
  4. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:Gpr37l1
Synonyms:Etbrlp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1928503. Gpr37l1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 134110Extracellular Reviewed prediction
Add
BLAST
Transmembranei135 – 15521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini156 – 16712Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini189 – 20517Extracellular Reviewed prediction
Add
BLAST
Transmembranei206 – 22621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini227 – 25125Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini273 – 31038Extracellular Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini332 – 36029Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei361 – 38121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini382 – 39817Extracellular Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini420 – 48162Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 481457Prosaposin receptor GPR37L1
PRO_0000012797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi203 ↔ 286 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ99JG2.
PaxDbiQ99JG2.
PRIDEiQ99JG2.

PTM databases

PhosphoSiteiQ99JG2.

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

ArrayExpressiQ99JG2.
BgeeiQ99JG2.
CleanExiMM_GPR37L1.
GenevestigatoriQ99JG2.

Structurei

3D structure databases

ProteinModelPortaliQ99JG2.
SMRiQ99JG2. Positions 123-435.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 43922Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00690000101856.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ99JG2.
KOiK04244.
OMAiVWHSYYL.
OrthoDBiEOG7CVPXV.
PhylomeDBiQ99JG2.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JG2-1 [UniParc]FASTAAdd to Basket

« Hide

MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD    50
EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ 100
ELRVNLTGTP SQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS 150
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD 200
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA 250
KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS 300
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH 350
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI 400
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS 450
ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C 481
Length:481
Mass (Da):52,729
Last modified:June 7, 2005 - v2
Checksum:iD7CF26B83B7F6E8C
GO

Sequence cautioni

The sequence BAA32062.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ306537 Genomic DNA. Translation: CAC34842.1.
AJ306538 Genomic DNA. Translation: CAC34843.1.
AB016602 mRNA. Translation: BAA32062.1. Different initiation.
AY255561 mRNA. Translation: AAO85073.1.
CCDSiCCDS48371.1.
RefSeqiNP_602320.2. NM_134438.3.
UniGeneiMm.272290.

Genome annotation databases

EnsembliENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
GeneIDi171469.
KEGGimmu:171469.
UCSCiuc007csv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ306537 Genomic DNA. Translation: CAC34842.1 .
AJ306538 Genomic DNA. Translation: CAC34843.1 .
AB016602 mRNA. Translation: BAA32062.1 . Different initiation.
AY255561 mRNA. Translation: AAO85073.1 .
CCDSi CCDS48371.1.
RefSeqi NP_602320.2. NM_134438.3.
UniGenei Mm.272290.

3D structure databases

ProteinModelPortali Q99JG2.
SMRi Q99JG2. Positions 123-435.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q99JG2.

Proteomic databases

MaxQBi Q99JG2.
PaxDbi Q99JG2.
PRIDEi Q99JG2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027682 ; ENSMUSP00000027682 ; ENSMUSG00000026424 .
GeneIDi 171469.
KEGGi mmu:171469.
UCSCi uc007csv.2. mouse.

Organism-specific databases

CTDi 9283.
MGIi MGI:1928503. Gpr37l1.

Phylogenomic databases

eggNOGi NOG291459.
GeneTreei ENSGT00690000101856.
HOGENOMi HOG000252922.
HOVERGENi HBG051808.
InParanoidi Q99JG2.
KOi K04244.
OMAi VWHSYYL.
OrthoDBi EOG7CVPXV.
PhylomeDBi Q99JG2.
TreeFami TF331292.

Miscellaneous databases

NextBioi 371005.
PROi Q99JG2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99JG2.
Bgeei Q99JG2.
CleanExi MM_GPR37L1.
Genevestigatori Q99JG2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic analysis of GPR37 and related orphan G-protein coupled receptor genes highly expressed in the mammalian brain."
    Marazziti D., Golini E., Magrelli A., Matteoni R., Tocchini-Valentini G.P.
    Curr. Genomics 2:253-260(2001)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Liver.
  2. "Cloning of a cDNA encoding a novel G-protein coupled receptor uniquely expressed in the adult brain."
    Matsuo N., Kawamoto S., Matsubara K., Okubo K.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-481.
    Strain: C57BL/6.
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-454.

Entry informationi

Entry nameiETBR2_MOUSE
AccessioniPrimary (citable) accession number: Q99JG2
Secondary accession number(s): O88313, Q80UB9, Q99JG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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