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Protein

Prosaposin receptor GPR37L1

Gene

Gpr37l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of astrocyte differentiation Source: MGI
  • negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of smoothened signaling pathway Source: MGI
  • positive regulation of cerebellar granule cell precursor proliferation Source: MGI
  • positive regulation of MAPK cascade Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:Gpr37l1
Synonyms:Etbrlp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1928503 Gpr37l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 134ExtracellularSequence analysisAdd BLAST110
Transmembranei135 – 155Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini156 – 167CytoplasmicSequence analysisAdd BLAST12
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 205ExtracellularSequence analysisAdd BLAST17
Transmembranei206 – 226Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini227 – 251CytoplasmicSequence analysisAdd BLAST25
Transmembranei252 – 272Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini273 – 310ExtracellularSequence analysisAdd BLAST38
Transmembranei311 – 331Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini332 – 360CytoplasmicSequence analysisAdd BLAST29
Transmembranei361 – 381Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini382 – 398ExtracellularSequence analysisAdd BLAST17
Transmembranei399 – 419Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini420 – 481CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001279725 – 481Prosaposin receptor GPR37L1Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation
Modified residuei471PhosphoserineCombined sources1
Modified residuei479PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99JG2
PaxDbiQ99JG2
PeptideAtlasiQ99JG2
PRIDEiQ99JG2

PTM databases

iPTMnetiQ99JG2
PhosphoSitePlusiQ99JG2
SwissPalmiQ99JG2

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000026424
CleanExiMM_GPR37L1
GenevisibleiQ99JG2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027682

Structurei

3D structure databases

ProteinModelPortaliQ99JG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi418 – 439Cys-richAdd BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000252922
HOVERGENiHBG051808
InParanoidiQ99JG2
KOiK04244
OMAiTEMSSSI
OrthoDBiEOG091G053G
PhylomeDBiQ99JG2
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003909 GPR37_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01421 GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD
60 70 80 90 100
EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ
110 120 130 140 150
ELRVNLTGTP SQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS
460 470 480
ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,729
Last modified:June 7, 2005 - v2
Checksum:iD7CF26B83B7F6E8C
GO

Sequence cautioni

The sequence BAA32062 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306537 Genomic DNA Translation: CAC34842.1
AJ306538 Genomic DNA Translation: CAC34843.1
AB016602 mRNA Translation: BAA32062.1 Different initiation.
AY255561 mRNA Translation: AAO85073.1
CCDSiCCDS48371.1
RefSeqiNP_602320.2, NM_134438.3
UniGeneiMm.272290

Genome annotation databases

EnsembliENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424
GeneIDi171469
KEGGimmu:171469
UCSCiuc007csv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiETBR2_MOUSE
AccessioniPrimary (citable) accession number: Q99JG2
Secondary accession number(s): O88313, Q80UB9, Q99JG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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