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Q99JG2 (ETBR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name=ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene names
Name:Gpr37l1
Synonyms:Etbrlp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Tissue specificity

Highly expressed in brain. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAA32062.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 481457Prosaposin receptor GPR37L1
PRO_0000012797

Regions

Topological domain25 – 134110Extracellular Potential
Transmembrane135 – 15521Helical; Name=1; Potential
Topological domain156 – 16712Cytoplasmic Potential
Transmembrane168 – 18821Helical; Name=2; Potential
Topological domain189 – 20517Extracellular Potential
Transmembrane206 – 22621Helical; Name=3; Potential
Topological domain227 – 25125Cytoplasmic Potential
Transmembrane252 – 27221Helical; Name=4; Potential
Topological domain273 – 31038Extracellular Potential
Transmembrane311 – 33121Helical; Name=5; Potential
Topological domain332 – 36029Cytoplasmic Potential
Transmembrane361 – 38121Helical; Name=6; Potential
Topological domain382 – 39817Extracellular Potential
Transmembrane399 – 41921Helical; Name=7; Potential
Topological domain420 – 48162Cytoplasmic Potential
Compositional bias418 – 43922Cys-rich

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Disulfide bond203 ↔ 286 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99JG2 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: D7CF26B83B7F6E8C

FASTA48152,729
        10         20         30         40         50         60 
MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD EGPKEVQHYV 

        70         80         90        100        110        120 
PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ ELRVNLTGTP SQRLQIQNPL 

       130        140        150        160        170        180 
YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL 

       190        200        210        220        230        240 
FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR 

       250        260        270        280        290        300 
PIERCQSILA KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS 

       310        320        330        340        350        360 
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH EQCESQLNST 

       370        380        390        400        410        420 
VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC 

       430        440        450        460        470        480 
RPLGQAFLDC CCCCCCEECG GASDSSATVS ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP 


C 

« Hide

References

« Hide 'large scale' references
[1]"Genomic analysis of GPR37 and related orphan G-protein coupled receptor genes highly expressed in the mammalian brain."
Marazziti D., Golini E., Magrelli A., Matteoni R., Tocchini-Valentini G.P.
Curr. Genomics 2:253-260(2001)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Liver.
[2]"Cloning of a cDNA encoding a novel G-protein coupled receptor uniquely expressed in the adult brain."
Matsuo N., Kawamoto S., Matsubara K., Okubo K.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-481.
Strain: C57BL/6.
Tissue: Hippocampus.
[3]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-454.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ306537 Genomic DNA. Translation: CAC34842.1.
AJ306538 Genomic DNA. Translation: CAC34843.1.
AB016602 mRNA. Translation: BAA32062.1. Different initiation.
AY255561 mRNA. Translation: AAO85073.1.
RefSeqNP_602320.2. NM_134438.3.
UniGeneMm.272290.

3D structure databases

ProteinModelPortalQ99JG2.
SMRQ99JG2. Positions 135-328.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ99JG2.

Proteomic databases

PaxDbQ99JG2.
PRIDEQ99JG2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
GeneID171469.
KEGGmmu:171469.
UCSCuc007csv.2. mouse.

Organism-specific databases

CTD9283.
MGIMGI:1928503. Gpr37l1.

Phylogenomic databases

eggNOGNOG291459.
GeneTreeENSGT00690000101856.
HOGENOMHOG000252922.
HOVERGENHBG051808.
InParanoidQ99JG2.
KOK04244.
OMAVWHSYYL.
OrthoDBEOG7CVPXV.
PhylomeDBQ99JG2.
TreeFamTF331292.

Gene expression databases

ArrayExpressQ99JG2.
BgeeQ99JG2.
CleanExMM_GPR37L1.
GenevestigatorQ99JG2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio371005.
PROQ99JG2.
SOURCESearch...

Entry information

Entry nameETBR2_MOUSE
AccessionPrimary (citable) accession number: Q99JG2
Secondary accession number(s): O88313, Q80UB9, Q99JG1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries