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Protein

Prosaposin receptor GPR37L1

Gene

Gpr37l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of astrocyte differentiation Source: MGI
  • negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of smoothened signaling pathway Source: MGI
  • positive regulation of cerebellar granule cell precursor proliferation Source: MGI
  • positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:Gpr37l1
Synonyms:Etbrlp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1928503. Gpr37l1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 134ExtracellularSequence analysisAdd BLAST110
Transmembranei135 – 155Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini156 – 167CytoplasmicSequence analysisAdd BLAST12
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 205ExtracellularSequence analysisAdd BLAST17
Transmembranei206 – 226Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini227 – 251CytoplasmicSequence analysisAdd BLAST25
Transmembranei252 – 272Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini273 – 310ExtracellularSequence analysisAdd BLAST38
Transmembranei311 – 331Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini332 – 360CytoplasmicSequence analysisAdd BLAST29
Transmembranei361 – 381Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini382 – 398ExtracellularSequence analysisAdd BLAST17
Transmembranei399 – 419Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini420 – 481CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001279725 – 481Prosaposin receptor GPR37L1Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation
Modified residuei471PhosphoserineCombined sources1
Modified residuei479PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99JG2.
PaxDbiQ99JG2.
PeptideAtlasiQ99JG2.
PRIDEiQ99JG2.

PTM databases

iPTMnetiQ99JG2.
PhosphoSitePlusiQ99JG2.

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000026424.
CleanExiMM_GPR37L1.
GenevisibleiQ99JG2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027682.

Structurei

3D structure databases

ProteinModelPortaliQ99JG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi418 – 439Cys-richAdd BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ99JG2.
KOiK04244.
OMAiTVVYALC.
OrthoDBiEOG091G053G.
PhylomeDBiQ99JG2.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD
60 70 80 90 100
EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ
110 120 130 140 150
ELRVNLTGTP SQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS
460 470 480
ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,729
Last modified:June 7, 2005 - v2
Checksum:iD7CF26B83B7F6E8C
GO

Sequence cautioni

The sequence BAA32062 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306537 Genomic DNA. Translation: CAC34842.1.
AJ306538 Genomic DNA. Translation: CAC34843.1.
AB016602 mRNA. Translation: BAA32062.1. Different initiation.
AY255561 mRNA. Translation: AAO85073.1.
CCDSiCCDS48371.1.
RefSeqiNP_602320.2. NM_134438.3.
UniGeneiMm.272290.

Genome annotation databases

EnsembliENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
GeneIDi171469.
KEGGimmu:171469.
UCSCiuc007csv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306537 Genomic DNA. Translation: CAC34842.1.
AJ306538 Genomic DNA. Translation: CAC34843.1.
AB016602 mRNA. Translation: BAA32062.1. Different initiation.
AY255561 mRNA. Translation: AAO85073.1.
CCDSiCCDS48371.1.
RefSeqiNP_602320.2. NM_134438.3.
UniGeneiMm.272290.

3D structure databases

ProteinModelPortaliQ99JG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027682.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99JG2.
PhosphoSitePlusiQ99JG2.

Proteomic databases

MaxQBiQ99JG2.
PaxDbiQ99JG2.
PeptideAtlasiQ99JG2.
PRIDEiQ99JG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
GeneIDi171469.
KEGGimmu:171469.
UCSCiuc007csv.2. mouse.

Organism-specific databases

CTDi9283.
MGIiMGI:1928503. Gpr37l1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ99JG2.
KOiK04244.
OMAiTVVYALC.
OrthoDBiEOG091G053G.
PhylomeDBiQ99JG2.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Miscellaneous databases

PROiQ99JG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026424.
CleanExiMM_GPR37L1.
GenevisibleiQ99JG2. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETBR2_MOUSE
AccessioniPrimary (citable) accession number: Q99JG2
Secondary accession number(s): O88313, Q80UB9, Q99JG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.