Q99JG2 (ETBR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin B receptor-like protein 2
Short name=ETBR-LP-2

Alternative name(s):
G-protein coupled receptor 37-like 1

Gene names

Name:	Gpr37l1
Synonyms:	Etbrlp2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan receptor By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Tissue specificity	Highly expressed in brain. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAA32062.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 481	457	Endothelin B receptor-like protein 2		PRO_0000012797
Regions
	Topological domain	25 – 134	110	Extracellular Potential
	Transmembrane	135 – 155	21	Helical; Name=1; Potential
	Topological domain	156 – 167	12	Cytoplasmic Potential
	Transmembrane	168 – 188	21	Helical; Name=2; Potential
	Topological domain	189 – 205	17	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=3; Potential
	Topological domain	227 – 251	25	Cytoplasmic Potential
	Transmembrane	252 – 272	21	Helical; Name=4; Potential
	Topological domain	273 – 310	38	Extracellular Potential
	Transmembrane	311 – 331	21	Helical; Name=5; Potential
	Topological domain	332 – 360	29	Cytoplasmic Potential
	Transmembrane	361 – 381	21	Helical; Name=6; Potential
	Topological domain	382 – 398	17	Extracellular Potential
	Transmembrane	399 – 419	21	Helical; Name=7; Potential
	Topological domain	420 – 481	62	Cytoplasmic Potential
	Compositional bias	418 – 439	22	Cys-rich
Amino acid modifications
	Modified residue	471	1	Phosphoserine Ref.4
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Disulfide bond	203 ↔ 286		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99JG2 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: D7CF26B83B7F6E8C	FASTA	481	52,729
	10 20 30 40 50 60 MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD EGPKEVQHYV 70 80 90 100 110 120 PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ ELRVNLTGTP SQRLQIQNPL 130 140 150 160 170 180 YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL 190 200 210 220 230 240 FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR 250 260 270 280 290 300 PIERCQSILA KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS 310 320 330 340 350 360 LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH EQCESQLNST 370 380 390 400 410 420 VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC 430 440 450 460 470 480 RPLGQAFLDC CCCCCCEECG GASDSSATVS ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic analysis of GPR37 and related orphan G-protein coupled receptor genes highly expressed in the mammalian brain." Marazziti D., Golini E., Magrelli A., Matteoni R., Tocchini-Valentini G.P. Curr. Genomics 2:253-260(2001) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Liver.
[2]	"Cloning of a cDNA encoding a novel G-protein coupled receptor uniquely expressed in the adult brain." Matsuo N., Kawamoto S., Matsubara K., Okubo K. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-481. Strain: C57BL/6. Tissue: Hippocampus.
[3]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-454.
[4]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-471, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ306537 Genomic DNA. Translation: CAC34842.1. AJ306538 Genomic DNA. Translation: CAC34843.1. AB016602 mRNA. Translation: BAA32062.1. Different initiation. AY255561 mRNA. Translation: AAO85073.1.
IPI	IPI00468685.
RefSeq	NP_602320.2. NM_134438.3.
UniGene	Mm.272290.
3D structure databases
ProteinModelPortal	Q99JG2.
SMR	Q99JG2. Positions 127-328.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q99JG2.
Proteomic databases
PaxDb	Q99JG2.
PRIDE	Q99JG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
GeneID	171469.
KEGG	mmu:171469.
UCSC	uc007csv.2. mouse.
Organism-specific databases
CTD	9283.
MGI	MGI:1928503. Gpr37l1.
Phylogenomic databases
eggNOG	NOG291459.
GeneTree	ENSGT00690000101856.
HOGENOM	HOG000252922.
HOVERGEN	HBG051808.
InParanoid	Q99JG2.
KO	K04244.
OMA	VWHSYYL.
OrthoDB	EOG4CNQS6.
Gene expression databases
ArrayExpress	Q99JG2.
Bgee	Q99JG2.
CleanEx	MM_GPR37L1.
Genevestigator	Q99JG2.
GermOnline	ENSMUSG00000026424. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003909. GPR37_orph. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01421. GPR37ORPHANR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	371005.
SOURCE	Search...

Entry information

Entry name

ETBR2_MOUSE

Accession

Primary (citable) accession number: Q99JG2
Secondary accession number(s): O88313, Q80UB9, Q99JG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program