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Protein

Prosaposin receptor GPR37L1

Gene

Gpr37l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled peptide receptor activity Source: MGI
  2. peptide binding Source: MGI

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  2. negative regulation of astrocyte differentiation Source: MGI
  3. negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
  4. negative regulation of neuron differentiation Source: MGI
  5. negative regulation of smoothened signaling pathway Source: MGI
  6. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
  7. positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:Gpr37l1
Synonyms:Etbrlp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1928503. Gpr37l1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 134110ExtracellularSequence AnalysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini332 – 36029CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei361 – 38121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini382 – 39817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini420 – 48162CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 481457Prosaposin receptor GPR37L1PRO_0000012797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ99JG2.
PaxDbiQ99JG2.
PRIDEiQ99JG2.

PTM databases

PhosphoSiteiQ99JG2.

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

BgeeiQ99JG2.
CleanExiMM_GPR37L1.
ExpressionAtlasiQ99JG2. baseline and differential.
GenevestigatoriQ99JG2.

Structurei

3D structure databases

ProteinModelPortaliQ99JG2.
SMRiQ99JG2. Positions 123-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 43922Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ99JG2.
KOiK04244.
OMAiSCRAVPF.
OrthoDBiEOG7CVPXV.
PhylomeDBiQ99JG2.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD
60 70 80 90 100
EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ
110 120 130 140 150
ELRVNLTGTP SQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS
460 470 480
ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,729
Last modified:June 7, 2005 - v2
Checksum:iD7CF26B83B7F6E8C
GO

Sequence cautioni

The sequence BAA32062.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306537 Genomic DNA. Translation: CAC34842.1.
AJ306538 Genomic DNA. Translation: CAC34843.1.
AB016602 mRNA. Translation: BAA32062.1. Different initiation.
AY255561 mRNA. Translation: AAO85073.1.
CCDSiCCDS48371.1.
RefSeqiNP_602320.2. NM_134438.3.
UniGeneiMm.272290.

Genome annotation databases

EnsembliENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
GeneIDi171469.
KEGGimmu:171469.
UCSCiuc007csv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306537 Genomic DNA. Translation: CAC34842.1.
AJ306538 Genomic DNA. Translation: CAC34843.1.
AB016602 mRNA. Translation: BAA32062.1. Different initiation.
AY255561 mRNA. Translation: AAO85073.1.
CCDSiCCDS48371.1.
RefSeqiNP_602320.2. NM_134438.3.
UniGeneiMm.272290.

3D structure databases

ProteinModelPortaliQ99JG2.
SMRiQ99JG2. Positions 123-435.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ99JG2.

Proteomic databases

MaxQBiQ99JG2.
PaxDbiQ99JG2.
PRIDEiQ99JG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027682; ENSMUSP00000027682; ENSMUSG00000026424.
GeneIDi171469.
KEGGimmu:171469.
UCSCiuc007csv.2. mouse.

Organism-specific databases

CTDi9283.
MGIiMGI:1928503. Gpr37l1.

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ99JG2.
KOiK04244.
OMAiSCRAVPF.
OrthoDBiEOG7CVPXV.
PhylomeDBiQ99JG2.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi371005.
PROiQ99JG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99JG2.
CleanExiMM_GPR37L1.
ExpressionAtlasiQ99JG2. baseline and differential.
GenevestigatoriQ99JG2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic analysis of GPR37 and related orphan G-protein coupled receptor genes highly expressed in the mammalian brain."
    Marazziti D., Golini E., Magrelli A., Matteoni R., Tocchini-Valentini G.P.
    Curr. Genomics 2:253-260(2001)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Liver.
  2. "Cloning of a cDNA encoding a novel G-protein coupled receptor uniquely expressed in the adult brain."
    Matsuo N., Kawamoto S., Matsubara K., Okubo K.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-481.
    Strain: C57BL/6.
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-454.

Entry informationi

Entry nameiETBR2_MOUSE
AccessioniPrimary (citable) accession number: Q99JG2
Secondary accession number(s): O88313, Q80UB9, Q99JG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: February 4, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.