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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

Slc25a21

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:Slc25a21
Synonyms:Odc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621444 Slc25a21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 88Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei276 – 296Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906471 – 298Mitochondrial 2-oxodicarboxylate carrierAdd BLAST298

Proteomic databases

PaxDbiQ99JD3
PRIDEiQ99JD3

PTM databases

iPTMnetiQ99JD3
PhosphoSitePlusiQ99JD3

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevisibleiQ99JD3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037607

Structurei

3D structure databases

ProteinModelPortaliQ99JD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 99Solcar 1Add BLAST90
Repeati106 – 195Solcar 2Add BLAST90
Repeati204 – 293Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0754 Eukaryota
ENOG410XRZG LUCA
HOGENOMiHOG000168307
HOVERGENiHBG105598
InParanoidiQ99JD3
KOiK15110
OrthoDBiEOG091G0DEF
PhylomeDBiQ99JD3

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q99JD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASNVSLLH ETCRQVAAGG CAGLVEICLM HPLDVVKTRF QVQRSVTDPQ
60 70 80 90 100
SYKSLRDSFQ VIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL
110 120 130 140 150
GYMSLSPGLT FPIAGLGSGL TEAVVVNPFE VVKVGLQVNR NMFTEQPSTF
160 170 180 190 200
AYARQIIKKE GWGFQGLNKG FTATLGRHGI FNMTYFGFYY NVKDNIPSSK
210 220 230 240 250
DPTLEFLRKF GIGFVSGTVG SVFNIPFDVA KSRIQGPQPV PGEIKYRGCF
260 270 280 290
KTMETVYREE GILALYKGLL PKVMRLGPGG GVMLLVYEYT YAWLQENW
Length:298
Mass (Da):33,279
Last modified:June 1, 2001 - v1
Checksum:iAD8CEE88165D18CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ289714 mRNA Translation: CAC27796.1
BC089099 mRNA Translation: AAH89099.1
RefSeqiNP_598298.1, NM_133614.2
XP_006240176.1, XM_006240114.3
UniGeneiRn.205044

Genome annotation databases

GeneIDi171151
KEGGirno:171151
UCSCiRGD:621444 rat

Entry informationi

Entry nameiODC_RAT
AccessioniPrimary (citable) accession number: Q99JD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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