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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

Slc25a21

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:Slc25a21
Synonyms:Odc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621444. Slc25a21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei69 – 8820Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Mitochondrial 2-oxodicarboxylate carrierPRO_0000090647Add
BLAST

Proteomic databases

PaxDbiQ99JD3.
PRIDEiQ99JD3.

PTM databases

iPTMnetiQ99JD3.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevisibleiQ99JD3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037607.

Structurei

3D structure databases

ProteinModelPortaliQ99JD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 9990Solcar 1Add
BLAST
Repeati106 – 19590Solcar 2Add
BLAST
Repeati204 – 29390Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0754. Eukaryota.
ENOG410XRZG. LUCA.
HOGENOMiHOG000168307.
HOVERGENiHBG105598.
InParanoidiQ99JD3.
KOiK15110.
OMAiCINIPFD.
OrthoDBiEOG74N5H8.
PhylomeDBiQ99JD3.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASNVSLLH ETCRQVAAGG CAGLVEICLM HPLDVVKTRF QVQRSVTDPQ
60 70 80 90 100
SYKSLRDSFQ VIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL
110 120 130 140 150
GYMSLSPGLT FPIAGLGSGL TEAVVVNPFE VVKVGLQVNR NMFTEQPSTF
160 170 180 190 200
AYARQIIKKE GWGFQGLNKG FTATLGRHGI FNMTYFGFYY NVKDNIPSSK
210 220 230 240 250
DPTLEFLRKF GIGFVSGTVG SVFNIPFDVA KSRIQGPQPV PGEIKYRGCF
260 270 280 290
KTMETVYREE GILALYKGLL PKVMRLGPGG GVMLLVYEYT YAWLQENW
Length:298
Mass (Da):33,279
Last modified:June 1, 2001 - v1
Checksum:iAD8CEE88165D18CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ289714 mRNA. Translation: CAC27796.1.
BC089099 mRNA. Translation: AAH89099.1.
RefSeqiNP_598298.1. NM_133614.2.
XP_006240176.1. XM_006240114.2.
UniGeneiRn.205044.

Genome annotation databases

GeneIDi171151.
KEGGirno:171151.
UCSCiRGD:621444. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ289714 mRNA. Translation: CAC27796.1.
BC089099 mRNA. Translation: AAH89099.1.
RefSeqiNP_598298.1. NM_133614.2.
XP_006240176.1. XM_006240114.2.
UniGeneiRn.205044.

3D structure databases

ProteinModelPortaliQ99JD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037607.

PTM databases

iPTMnetiQ99JD3.

Proteomic databases

PaxDbiQ99JD3.
PRIDEiQ99JD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171151.
KEGGirno:171151.
UCSCiRGD:621444. rat.

Organism-specific databases

CTDi89874.
RGDi621444. Slc25a21.

Phylogenomic databases

eggNOGiKOG0754. Eukaryota.
ENOG410XRZG. LUCA.
HOGENOMiHOG000168307.
HOVERGENiHBG105598.
InParanoidiQ99JD3.
KOiK15110.
OMAiCINIPFD.
OrthoDBiEOG74N5H8.
PhylomeDBiQ99JD3.

Miscellaneous databases

PROiQ99JD3.

Gene expression databases

GenevisibleiQ99JD3. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location."
    Fiermonte G., Dolce V., Palmieri L., Ventura M., Runswick M.J., Palmieri F., Walker J.E.
    J. Biol. Chem. 276:8225-8230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiODC_RAT
AccessioniPrimary (citable) accession number: Q99JD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.