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Protein
Submitted name:

Glycine receptor alpha 3

Gene

Glra3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glycine receptor alpha 3Imported
Gene namesi
Name:Glra3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621229. Glra3.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei271 – 293HelicalSequence analysisAdd BLAST23
Transmembranei334 – 357HelicalSequence analysisAdd BLAST24
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevisibleiQ99JC9. RN.

Structurei

3D structure databases

ProteinModelPortaliQ99JC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 269Neur_chan_LBDInterPro annotationAdd BLAST208
Domaini276 – 368Neur_chan_membInterPro annotationAdd BLAST93

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG051707.
KOiK05195.
PhylomeDBiQ99JC9.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99JC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWIRLFSGS GISFRIMAHV RHFRTLLSGF YFWEAALLLS LVATKETNSA
60 70 80 90 100
RSRSAPMSPS DFLDKLMGRT SGYDARIRPN FKGPPVNVTC NIFINSFGSI
110 120 130 140 150
AETTMDYRVN IFLRQKWNDP RLAYSEYPDD SLDLDPSMLD SIWKPDLFFA
160 170 180 190 200
NEKGANFHEV TTDNKLLRIF KNGNVLYSIR LTLTLSCPMD LKNFPMDVQT
210 220 230 240 250
CIMQLESFGY TMNDLIFEWQ DEAPVQVAEG LTLPQFLLKE EKDLRYCTKH
260 270 280 290 300
YNTGKFTCIE VRFHLERQMG YYLIQMYIPS LLIVILSWVS FWINMDAAPA
310 320 330 340 350
RVALGITTVL TMTTQSSGSR ASLPKVSYVK AIDIWMAVCL LFVFSALLEY
360 370 380 390 400
AAVNFVSRQH KELLRFRRKR KNKTEAFALE KFYRFSDTDD EVRESRFSFT
410 420 430 440 450
AYGMGPCLQA KDGVVPKGPN HAVQVMPKSA DEMRKVFIDR AKKIDTISRA
460 470 480
CFPLAFLIFN IFYWVIYKIL RHEDIHHQQD
Length:480
Mass (Da):55,555
Last modified:June 1, 2001 - v1
Checksum:i322478D9A3052299
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310838 mRNA. Translation: CAC35982.1.
RefSeqiNP_446176.3. NM_053724.3.
UniGeneiRn.10038.

Genome annotation databases

GeneIDi114516.
KEGGirno:114516.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ99JC9_RAT
AccessioniPrimary (citable) accession number: Q99JC9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)