Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Protein Tapbp

Gene

Tapbp

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: RGD

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein TapbpImported
Submitted name:
TAP binding proteinImported
Submitted name:
Tap-binding protein (Tapasin)Imported
Submitted name:
TapasinImported
Gene namesi
Name:TapbpImported
Synonyms:AA926063Imported, B3galt4Imported, Cdk2ap1-ps1Imported, Col11a2Imported, DaxxImported, Hsd17b8Imported, Kifc1Imported, LOC224733l-1Imported, LOC224733l-2Imported, Phf1Imported, Rps25-ps1Imported, RT1-A1Imported, RT1-A2Imported, RT1-A3Imported, RT1-DOaImported, RT1-HbImported, RT1-Ke4Imported, RxrbImported, Sacm2l-ps1Imported, Sacm2l-ps2Imported, Sec61-psImported, Syngap1Imported, tapasinImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3819. Tapbp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei418 – 44124HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • MHC class I peptide loading complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 464443Sequence analysisPRO_5007928629Add
BLAST

PTM databases

PhosphoSiteiQ99JC6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029500.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tap1P363702EBI-11304538,EBI-11303917

GO - Molecular functioni

  • unfolded protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045630.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 401108Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410II43. Eukaryota.
ENOG4111QPK. LUCA.
GeneTreeiENSGT00530000063758.
HOGENOMiHOG000231214.
HOVERGENiHBG005156.
KOiK08058.
OMAiYLATVHL.
OrthoDBiEOG091G0ATU.
TreeFamiTF334274.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR008056. Tapasin.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
PRINTSiPR01669. TAPASIN.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLPLLVVV ALGLATVVVS AGPQTIECWF VEDAGGGGLS KKPATLLLRH
60 70 80 90 100
GPRGPPPRPD LDPKLYFKVD DPAGMLLAAF RRYPAGAHAP HCEMSSYIPF
110 120 130 140 150
PASAKWARGL SPQQNCSRAL DGDWLMVSVS GTVFSLSSLL RPLPEPQREP
160 170 180 190 200
VFITMATVVL TVLTRHPAPR IHLGKDAVLD LRFAYAPPAL EDAPSVASGP
210 220 230 240 250
PPFGLEWRRQ HRGKGHLLLA AIPGLLEKMP PAREKAVAFA AWDDDNDPWG
260 270 280 290 300
PWTGNGTLWL PAVSPSQEGV YLATVHLPYL QGQVSLELTV HKPPRVSLTP
310 320 330 340 350
APIVWAAPGE APPELLCLVS HFYPEEGLEV EWELRGGPEG SSRKAEGKTW
360 370 380 390 400
VSTVRHHSDG SVSQSGHLQL PPVTDKQHGV RYACRVRHPS LPSSGRSAEV
410 420 430 440 450
TLEVAGFSGP SIEDGIGLFL SAFLLLGLFK ALGWMAAYLT IPKILKEKAS
460
ATSLTVPKDE KKSE
Length:464
Mass (Da):50,045
Last modified:June 1, 2001 - v1
Checksum:iEC39C228265BC6B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128962 Genomic DNA. No translation available.
BC062007 mRNA. Translation: AAH62007.1.
KC222917 mRNA. Translation: AGV39014.1.
KC222918 mRNA. Translation: AGV39015.1.
KC222919 mRNA. Translation: AGV39016.1.
KC222920 mRNA. Translation: AGV39017.1.
AJ400732 mRNA. Translation: CAC34730.1.
BX883042 Genomic DNA. Translation: CAE83920.1.
RefSeqiNP_149089.1. NM_033098.2.
UniGeneiRn.51023.

Genome annotation databases

EnsembliENSRNOT00000044975; ENSRNOP00000045630; ENSRNOG00000029500.
GeneIDi25217.
KEGGirno:25217.
UCSCiRGD:3819. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128962 Genomic DNA. No translation available.
BC062007 mRNA. Translation: AAH62007.1.
KC222917 mRNA. Translation: AGV39014.1.
KC222918 mRNA. Translation: AGV39015.1.
KC222919 mRNA. Translation: AGV39016.1.
KC222920 mRNA. Translation: AGV39017.1.
AJ400732 mRNA. Translation: CAC34730.1.
BX883042 Genomic DNA. Translation: CAE83920.1.
RefSeqiNP_149089.1. NM_033098.2.
UniGeneiRn.51023.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045630.

PTM databases

PhosphoSiteiQ99JC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044975; ENSRNOP00000045630; ENSRNOG00000029500.
GeneIDi25217.
KEGGirno:25217.
UCSCiRGD:3819. rat.

Organism-specific databases

CTDi6892.
RGDi3819. Tapbp.

Phylogenomic databases

eggNOGiENOG410II43. Eukaryota.
ENOG4111QPK. LUCA.
GeneTreeiENSGT00530000063758.
HOGENOMiHOG000231214.
HOVERGENiHBG005156.
KOiK08058.
OMAiYLATVHL.
OrthoDBiEOG091G0ATU.
TreeFamiTF334274.

Enzyme and pathway databases

ReactomeiR-RNO-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

PROiQ99JC6.

Gene expression databases

BgeeiENSRNOG00000029500.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR008056. Tapasin.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
PRINTSiPR01669. TAPASIN.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ99JC6_RAT
AccessioniPrimary (citable) accession number: Q99JC6
Secondary accession number(s): F1MAR8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.