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Protein
Submitted name:

TAP-binding protein

Gene

Tapbp

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: RGD

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1236974. ER-Phagosome pathway.
R-RNO-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
TAP-binding proteinImported
Submitted name:
Tap-binding protein (Tapasin)Imported
Submitted name:
TapasinImported
Gene namesi
Name:TapbpImported
Synonyms:AA926063Imported, B3galt4Imported, Cdk2ap1-ps1Imported, Col11a2Imported, DaxxImported, Hsd17b8Imported, Kifc1Imported, LOC224733l-1Imported, LOC224733l-2Imported, Phf1Imported, Rps25-ps1Imported, RT1-A1Imported, RT1-A2Imported, RT1-A3Imported, RT1-DOaImported, RT1-HbImported, RT1-Ke4Imported, RxrbImported, Sacm2l-ps1Imported, Sacm2l-ps2Imported, Sec61-psImported, Syngap1Imported, tapasinImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3819. Tapbp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei418 – 441HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501084760622 – 464Sequence analysisAdd BLAST443

Expressioni

Gene expression databases

BgeeiENSRNOG00000029500.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tap1P363702EBI-11304538,EBI-11303917

GO - Molecular functioni

  • unfolded protein binding Source: RGD

Protein-protein interaction databases

IntActiQ99JC6. 2 interactors.
STRINGi10116.ENSRNOP00000045630.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 401Ig-likeInterPro annotationAdd BLAST108

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410II43. Eukaryota.
ENOG4111QPK. LUCA.
GeneTreeiENSGT00530000063758.
HOGENOMiHOG000231214.
HOVERGENiHBG005156.
KOiK08058.
OMAiHGARYAC.
OrthoDBiEOG091G0ATU.
TreeFamiTF334274.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR008056. Tapasin.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PRINTSiPR01669. TAPASIN.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99JC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLPLLVVV ALGLATVVVS AGPQTIECWF VEDAGGGGLS KKPATLLLRH
60 70 80 90 100
GPRGPPPRPD LDPKLYFKVD DPAGMLLAAF RRYPAGAHAP HCEMSSYIPF
110 120 130 140 150
PASAKWARGL SPQQNCSRAL DGDWLMVSVS GTVFSLSSLL RPLPEPQREP
160 170 180 190 200
VFITMATVVL TVLTRHPAPR IHLGKDAVLD LRFAYAPPAL EDAPSVASGP
210 220 230 240 250
PPFGLEWRRQ HRGKGHLLLA AIPGLLEKMP PAREKAVAFA AWDDDNDPWG
260 270 280 290 300
PWTGNGTLWL PAVSPSQEGV YLATVHLPYL QGQVSLELTV HKPPRVSLTP
310 320 330 340 350
APIVWAAPGE APPELLCLVS HFYPEEGLEV EWELRGGPEG SSRKAEGKTW
360 370 380 390 400
VSTVRHHSDG SVSQSGHLQL PPVTDKQHGV RYACRVRHPS LPSSGRSAEV
410 420 430 440 450
TLEVAGFSGP SIEDGIGLFL SAFLLLGLFK ALGWMAAYLT IPKILKEKAS
460
ATSLTVPKDE KKSE
Length:464
Mass (Da):50,045
Last modified:June 1, 2001 - v1
Checksum:iEC39C228265BC6B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128962 Genomic DNA. No translation available.
BC062007 mRNA. Translation: AAH62007.1.
KC222917 mRNA. Translation: AGV39014.1.
KC222918 mRNA. Translation: AGV39015.1.
KC222919 mRNA. Translation: AGV39016.1.
KC222920 mRNA. Translation: AGV39017.1.
AJ400732 mRNA. Translation: CAC34730.1.
BX883042 Genomic DNA. Translation: CAE83920.1.
RefSeqiNP_149089.1. NM_033098.2.
UniGeneiRn.51023.

Genome annotation databases

EnsembliENSRNOT00000044975; ENSRNOP00000045630; ENSRNOG00000029500.
GeneIDi25217.
KEGGirno:25217.
UCSCiRGD:3819. rat.

Similar proteinsi

Entry informationi

Entry nameiQ99JC6_RAT
AccessioniPrimary (citable) accession number: Q99JC6
Secondary accession number(s): F1MAR8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported