Q99JC6 (Q99JC6_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Tapbp Ensembl ENSRNOP00000045630

Submitted name:
TAP binding protein EMBL AAH62007.1
Submitted name:
Tap-binding protein (Tapasin) EMBL CAE83920.1
Submitted name:
Tapasin EMBL CAC34730.1

Gene names

Name:

Tapbp EMBL CAE83920.1 Ensembl ENSRNOP00000045630 RGD 3819

Synonyms:

AA926063 RGD 1303072, B3galt4 RGD 620328, Cdk2ap1-ps1 RGD 1591984, Col11a2 RGD 1593281, Daxx RGD 621227, Hsd17b8 RGD 1303158, Kifc1 RGD 1359118, LOC224733l-1 RGD 1594401, LOC224733l-2 RGD 1594400, Phf1 RGD 1303205, Rps25-ps1 RGD 1591986, RT1-A1 RGD 1595924, RT1-A2 RGD 1595923, RT1-A3 RGD 1359610, RT1-DOa RGD 3477, RT1-Hb RGD 1595866, RT1-Ke4 RGD 1593280, Rxrb RGD 3611, Sacm2l-ps1 RGD 1594399, Sacm2l-ps2 RGD 1594398, Sec61-ps RGD 1591985, Syngap1 RGD 621090, tapasin EMBL CAC34730.1

Organism

Rattus norvegicus (Rat) [Reference proteome] EMBL CAC34730.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MHC class I protein complex assembly Inferred from expression pattern PubMed 12407112. Source: RGD antigen processing and presentation of endogenous peptide antigen via MHC class I Inferred from electronic annotation. Source: InterPro antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Inferred from electronic annotation. Source: Compara defense response Inferred from electronic annotation. Source: Compara peptide antigen stabilization Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: Compara MHC class I peptide loading complex Inferred from direct assay Ref.1. Source: RGD TAP complex Inferred from electronic annotation. Source: Compara
Molecular_function	unfolded protein binding Non-traceable author statement PubMed 12407112. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q99JC6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: EC39C228265BC6B0	FASTA	464	50,045
	10 20 30 40 50 60 MKLLPLLVVV ALGLATVVVS AGPQTIECWF VEDAGGGGLS KKPATLLLRH GPRGPPPRPD 70 80 90 100 110 120 LDPKLYFKVD DPAGMLLAAF RRYPAGAHAP HCEMSSYIPF PASAKWARGL SPQQNCSRAL 130 140 150 160 170 180 DGDWLMVSVS GTVFSLSSLL RPLPEPQREP VFITMATVVL TVLTRHPAPR IHLGKDAVLD 190 200 210 220 230 240 LRFAYAPPAL EDAPSVASGP PPFGLEWRRQ HRGKGHLLLA AIPGLLEKMP PAREKAVAFA 250 260 270 280 290 300 AWDDDNDPWG PWTGNGTLWL PAVSPSQEGV YLATVHLPYL QGQVSLELTV HKPPRVSLTP 310 320 330 340 350 360 APIVWAAPGE APPELLCLVS HFYPEEGLEV EWELRGGPEG SSRKAEGKTW VSTVRHHSDG 370 380 390 400 410 420 SVSQSGHLQL PPVTDKQHGV RYACRVRHPS LPSSGRSAEV TLEVAGFSGP SIEDGIGLFL 430 440 450 460 SAFLLLGLFK ALGWMAAYLT IPKILKEKAS ATSLTVPKDE KKSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rat tapasin: cDNA cloning and identification as a component of the class I MHC assembly complex." Deverson E.V., Powis S.J., Morrice N.A., Herberg J.A., Trowsdale J., Butcher G.W. Genes Immun. 2:48-51(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: DA EMBL CAC34730.1.
[2]	Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., Sudbrak R., Reinhardt R. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Brown Norway EMBL CAE83920.1.
[3]	"The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Brown Norway EMBL CAE83920.1.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate EMBL AAH62007.1.
[5]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000045630.
[6]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000045630.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06099905 Genomic DNA. No translation available. BC062007 mRNA. Translation: AAH62007.1. AJ400732 mRNA. Translation: CAC34730.1. BX883042 Genomic DNA. Translation: CAE83920.1.
IPI	IPI00911233.
RefSeq	NP_149089.1. NM_033098.2.
UniGene	Rn.51023.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000045630.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000044975; ENSRNOP00000045630; ENSRNOG00000029500.
GeneID	25217.
KEGG	rno:25217.
UCSC	RGD:3819. rat.
Organism-specific databases
CTD	6892.
RGD	3819. Tapbp.
Phylogenomic databases
eggNOG	NOG41000.
GeneTree	ENSGT00530000063758.
HOGENOM	HOG000231214.
HOVERGEN	HBG005156.
KO	K08058.
OrthoDB	EOG469QV7.
Gene expression databases
Genevestigator	Q99JC6.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR008056. Tapasin. [Graphical view]
PANTHER	PTHR23411. PTHR23411. 1 hit.
Pfam	PF07654. C1-set. 1 hit. [Graphical view]
PRINTS	PR01669. TAPASIN.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35583301.

Entry information

Entry name

Q99JC6_RAT

Accession

Primary (citable) accession number: Q99JC6
Secondary accession number(s): F1MAR8

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)