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Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

Fut9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides (By similarity).By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: Ensembl
  • fucosyltransferase activity Source: RGD

GO - Biological processi

  • nervous system development Source: RGD
  • protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name:
Fuc-TIX
Short name:
FucT-IX
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi619955. Fut9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini33 – 359327LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 9PRO_0000221121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99JB3.
PRIDEiQ99JB3.

Expressioni

Gene expression databases

GenevisibleiQ99JB3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011393.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ99JB3.
KOiK03663.
OMAiLMYFKPS.
OrthoDBiEOG7Z69C9.
PhylomeDBiQ99JB3.
TreeFamiTF316348.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTSKGILR PFLIVCIILG CFVACLLIYI KPTNSWVFSP MESASSVLKM
60 70 80 90 100
KNFFSRKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY
110 120 130 140 150
NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH
160 170 180 190 200
LFNLTLTYRR DSDIQVPYGF LTVSTSPFVF EVPSKEKLVC WVVSNWNPEH
210 220 230 240 250
ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK
260 270 280 290 300
DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DFNSPSELAK
310 320 330 340 350
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV

GNLEKWFWN
Length:359
Mass (Da):42,037
Last modified:June 1, 2001 - v1
Checksum:i369B4A7BD0C6CC80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049819 mRNA. Translation: BAB40953.1.
AF345993 mRNA. Translation: AAK16591.1.
RefSeqiNP_445917.1. NM_053465.1.
XP_008761820.1. XM_008763598.1.
UniGeneiRn.212206.

Genome annotation databases

EnsembliENSRNOT00000011393; ENSRNOP00000011393; ENSRNOG00000008475.
GeneIDi84597.
KEGGirno:84597.
UCSCiRGD:619955. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049819 mRNA. Translation: BAB40953.1.
AF345993 mRNA. Translation: AAK16591.1.
RefSeqiNP_445917.1. NM_053465.1.
XP_008761820.1. XM_008763598.1.
UniGeneiRn.212206.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011393.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Proteomic databases

PaxDbiQ99JB3.
PRIDEiQ99JB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011393; ENSRNOP00000011393; ENSRNOG00000008475.
GeneIDi84597.
KEGGirno:84597.
UCSCiRGD:619955. rat.

Organism-specific databases

CTDi10690.
RGDi619955. Fut9.

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ99JB3.
KOiK03663.
OMAiLMYFKPS.
OrthoDBiEOG7Z69C9.
PhylomeDBiQ99JB3.
TreeFamiTF316348.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

NextBioi617223.
PROiQ99JB3.

Gene expression databases

GenevisibleiQ99JB3. RN.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha 1,3-fucosyltransferase IX expression."
    Shimoda Y., Tajima Y., Osanai T., Katsume A., Kohara M., Kudo T., Narimatsu H., Takashima N., Ishii Y., Nakamura S., Osumi N., Sanai Y.
    J. Biol. Chem. 277:2033-2039(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of rat alpha1,3-fucosyltransferase IX (Fuc-TIX) and comparison of the expression of Fuc-TIV and Fuc-TIX genes during rat postnatal cerebellum development."
    Baboval T., Henion T., Kinnally E., Smith F.I.
    J. Neurosci. Res. 62:206-215(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFUT9_RAT
AccessioniPrimary (citable) accession number: Q99JB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.