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Q99JB0 (KLF7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 7
Gene names
Name:Klf7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator. Binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed primarily in the nervous system.

Domain

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Krueppel-like factor 7
PRO_0000047175

Regions

Zinc finger218 – 24225C2H2-type 1
Zinc finger248 – 27225C2H2-type 2
Zinc finger278 – 30023C2H2-type 3
Motif214 – 2196Nuclear localization signal Potential

Experimental info

Sequence conflict1751S → P in AAK08964. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q99JB0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3AEB7135A9F6E6E7

FASTA30133,337
        10         20         30         40         50         60 
MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI SETFGEDLDC 

        70         80         90        100        110        120 
FLHASPPPCI EESFRRLDPL LLPVEATICE KSSAVDILLS RDKLLSETCL SLQPTSSSLD 

       130        140        150        160        170        180 
SYTAVNQAQL NAVTSLTPPS SPELSRHLVK TSQTLSAVDG TVTLKLVAKK ASLSSVKVGG 

       190        200        210        220        230        240 
VAAAAAVTPA GAVKSGQSDS EQGGGGADTC PENKKRVHRC QFNGCRKVYT KSSHLKAHQR 

       250        260        270        280        290        300 
THTGEKPYKC SWEGCEWRFA RSDELTRHYR KHTGAKPFKC NHCDRCFSRS DHLALHMKRH 


I 

« Hide

References

« Hide 'large scale' references
[1]"mKlf7, a potential transcriptional regulator of TrkA nerve growth factor receptor expression in sensory and sympathetic neurons."
Lei L., Ma L., Nef S., Thai T., Parada L.F.
Development 128:1147-1158(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"Developmental expression of mouse Kruppel-like transcription factor KLF7 suggests a potential role in neurogenesis."
Laub F.B., Aldabe R., Friedrich V. Jr., Ohnishi S., Yoshida T., Ramirez F.
Dev. Biol. 233:305-318(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster / NIH.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF338369 mRNA. Translation: AAK31139.1.
AF327568 mRNA. Translation: AAK08964.1.
BC004700 mRNA. Translation: AAH04700.1.
BC019604 mRNA. Translation: AAH19604.1.
BC040794 mRNA. Translation: AAH40794.1.
CCDSCCDS15003.1.
RefSeqNP_291041.2. NM_033563.2.
XP_006496417.1. XM_006496354.1.
UniGeneMm.29466.
Mm.458200.

3D structure databases

ProteinModelPortalQ99JB0.
SMRQ99JB0. Positions 218-300.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ99JB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055001; ENSMUSP00000054674; ENSMUSG00000025959.
GeneID93691.
KEGGmmu:93691.
UCSCuc007bgo.2. mouse.

Organism-specific databases

CTD8609.
MGIMGI:1935151. Klf7.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117252.
HOGENOMHOG000231192.
HOVERGENHBG000836.
InParanoidQ99JB0.
KOK09207.
OMADLDCFLR.
PhylomeDBQ99JB0.
TreeFamTF350556.

Gene expression databases

ArrayExpressQ99JB0.
BgeeQ99JB0.
CleanExMM_KLF7.
GenevestigatorQ99JB0.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio351437.
PROQ99JB0.
SOURCESearch...

Entry information

Entry nameKLF7_MOUSE
AccessionPrimary (citable) accession number: Q99JB0
Secondary accession number(s): Q99P62
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot