Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99JB0

- KLF7_MOUSE

UniProt

Q99JB0 - KLF7_MOUSE

Protein

Krueppel-like factor 7

Gene

Klf7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional activator. Binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri218 – 24225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. axonogenesis Source: MGI
    3. dendrite morphogenesis Source: MGI
    4. positive regulation of transcription, DNA-templated Source: MGI
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 7
    Gene namesi
    Name:Klf7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1935151. Klf7.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Krueppel-like factor 7PRO_0000047175Add
    BLAST

    Proteomic databases

    PRIDEiQ99JB0.

    Expressioni

    Tissue specificityi

    Expressed primarily in the nervous system.

    Gene expression databases

    ArrayExpressiQ99JB0.
    BgeeiQ99JB0.
    CleanExiMM_KLF7.
    GenevestigatoriQ99JB0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99JB0.
    SMRiQ99JB0. Positions 218-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi214 – 2196Nuclear localization signalSequence Analysis

    Domaini

    The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri218 – 24225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117252.
    HOGENOMiHOG000231192.
    HOVERGENiHBG000836.
    InParanoidiQ99JB0.
    KOiK09207.
    OMAiDLDCFLR.
    PhylomeDBiQ99JB0.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99JB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI    50
    SETFGEDLDC FLHASPPPCI EESFRRLDPL LLPVEATICE KSSAVDILLS 100
    RDKLLSETCL SLQPTSSSLD SYTAVNQAQL NAVTSLTPPS SPELSRHLVK 150
    TSQTLSAVDG TVTLKLVAKK ASLSSVKVGG VAAAAAVTPA GAVKSGQSDS 200
    EQGGGGADTC PENKKRVHRC QFNGCRKVYT KSSHLKAHQR THTGEKPYKC 250
    SWEGCEWRFA RSDELTRHYR KHTGAKPFKC NHCDRCFSRS DHLALHMKRH 300
    I 301
    Length:301
    Mass (Da):33,337
    Last modified:June 1, 2001 - v1
    Checksum:i3AEB7135A9F6E6E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751S → P in AAK08964. (PubMed:11336497)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338369 mRNA. Translation: AAK31139.1.
    AF327568 mRNA. Translation: AAK08964.1.
    BC004700 mRNA. Translation: AAH04700.1.
    BC019604 mRNA. Translation: AAH19604.1.
    BC040794 mRNA. Translation: AAH40794.1.
    CCDSiCCDS15003.1.
    RefSeqiNP_291041.2. NM_033563.2.
    XP_006496417.1. XM_006496354.1.
    UniGeneiMm.29466.
    Mm.458200.

    Genome annotation databases

    EnsembliENSMUST00000055001; ENSMUSP00000054674; ENSMUSG00000025959.
    GeneIDi93691.
    KEGGimmu:93691.
    UCSCiuc007bgo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338369 mRNA. Translation: AAK31139.1 .
    AF327568 mRNA. Translation: AAK08964.1 .
    BC004700 mRNA. Translation: AAH04700.1 .
    BC019604 mRNA. Translation: AAH19604.1 .
    BC040794 mRNA. Translation: AAH40794.1 .
    CCDSi CCDS15003.1.
    RefSeqi NP_291041.2. NM_033563.2.
    XP_006496417.1. XM_006496354.1.
    UniGenei Mm.29466.
    Mm.458200.

    3D structure databases

    ProteinModelPortali Q99JB0.
    SMRi Q99JB0. Positions 218-300.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q99JB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055001 ; ENSMUSP00000054674 ; ENSMUSG00000025959 .
    GeneIDi 93691.
    KEGGi mmu:93691.
    UCSCi uc007bgo.2. mouse.

    Organism-specific databases

    CTDi 8609.
    MGIi MGI:1935151. Klf7.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117252.
    HOGENOMi HOG000231192.
    HOVERGENi HBG000836.
    InParanoidi Q99JB0.
    KOi K09207.
    OMAi DLDCFLR.
    PhylomeDBi Q99JB0.
    TreeFami TF350556.

    Miscellaneous databases

    NextBioi 351437.
    PROi Q99JB0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99JB0.
    Bgeei Q99JB0.
    CleanExi MM_KLF7.
    Genevestigatori Q99JB0.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "mKlf7, a potential transcriptional regulator of TrkA nerve growth factor receptor expression in sensory and sympathetic neurons."
      Lei L., Ma L., Nef S., Thai T., Parada L.F.
      Development 128:1147-1158(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. "Developmental expression of mouse Kruppel-like transcription factor KLF7 suggests a potential role in neurogenesis."
      Laub F.B., Aldabe R., Friedrich V. Jr., Ohnishi S., Yoshida T., Ramirez F.
      Dev. Biol. 233:305-318(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster / NIH.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiKLF7_MOUSE
    AccessioniPrimary (citable) accession number: Q99JB0
    Secondary accession number(s): Q99P62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3