Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Krueppel-like factor 7

Gene

Klf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. axonogenesis Source: MGI
  3. dendrite morphogenesis Source: MGI
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 7
Gene namesi
Name:Klf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1935151. Klf7.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Krueppel-like factor 7PRO_0000047175Add
BLAST

Proteomic databases

PRIDEiQ99JB0.

Expressioni

Tissue specificityi

Expressed primarily in the nervous system.

Gene expression databases

BgeeiQ99JB0.
CleanExiMM_KLF7.
ExpressionAtlasiQ99JB0. baseline and differential.
GenevestigatoriQ99JB0.

Structurei

3D structure databases

ProteinModelPortaliQ99JB0.
SMRiQ99JB0. Positions 218-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi214 – 2196Nuclear localization signalSequence Analysis

Domaini

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000231192.
HOVERGENiHBG000836.
InParanoidiQ99JB0.
KOiK09207.
OMAiDLDCFLR.
PhylomeDBiQ99JB0.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI
60 70 80 90 100
SETFGEDLDC FLHASPPPCI EESFRRLDPL LLPVEATICE KSSAVDILLS
110 120 130 140 150
RDKLLSETCL SLQPTSSSLD SYTAVNQAQL NAVTSLTPPS SPELSRHLVK
160 170 180 190 200
TSQTLSAVDG TVTLKLVAKK ASLSSVKVGG VAAAAAVTPA GAVKSGQSDS
210 220 230 240 250
EQGGGGADTC PENKKRVHRC QFNGCRKVYT KSSHLKAHQR THTGEKPYKC
260 270 280 290 300
SWEGCEWRFA RSDELTRHYR KHTGAKPFKC NHCDRCFSRS DHLALHMKRH

I
Length:301
Mass (Da):33,337
Last modified:June 1, 2001 - v1
Checksum:i3AEB7135A9F6E6E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751S → P in AAK08964 (PubMed:11336497).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338369 mRNA. Translation: AAK31139.1.
AF327568 mRNA. Translation: AAK08964.1.
BC004700 mRNA. Translation: AAH04700.1.
BC019604 mRNA. Translation: AAH19604.1.
BC040794 mRNA. Translation: AAH40794.1.
CCDSiCCDS15003.1.
RefSeqiNP_291041.2. NM_033563.2.
XP_006496417.1. XM_006496354.2.
UniGeneiMm.29466.
Mm.458200.

Genome annotation databases

EnsembliENSMUST00000114086; ENSMUSP00000109720; ENSMUSG00000025959.
GeneIDi93691.
KEGGimmu:93691.
UCSCiuc007bgo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338369 mRNA. Translation: AAK31139.1.
AF327568 mRNA. Translation: AAK08964.1.
BC004700 mRNA. Translation: AAH04700.1.
BC019604 mRNA. Translation: AAH19604.1.
BC040794 mRNA. Translation: AAH40794.1.
CCDSiCCDS15003.1.
RefSeqiNP_291041.2. NM_033563.2.
XP_006496417.1. XM_006496354.2.
UniGeneiMm.29466.
Mm.458200.

3D structure databases

ProteinModelPortaliQ99JB0.
SMRiQ99JB0. Positions 218-300.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ99JB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114086; ENSMUSP00000109720; ENSMUSG00000025959.
GeneIDi93691.
KEGGimmu:93691.
UCSCiuc007bgo.2. mouse.

Organism-specific databases

CTDi8609.
MGIiMGI:1935151. Klf7.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000231192.
HOVERGENiHBG000836.
InParanoidiQ99JB0.
KOiK09207.
OMAiDLDCFLR.
PhylomeDBiQ99JB0.
TreeFamiTF350556.

Miscellaneous databases

NextBioi351437.
PROiQ99JB0.
SOURCEiSearch...

Gene expression databases

BgeeiQ99JB0.
CleanExiMM_KLF7.
ExpressionAtlasiQ99JB0. baseline and differential.
GenevestigatoriQ99JB0.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "mKlf7, a potential transcriptional regulator of TrkA nerve growth factor receptor expression in sensory and sympathetic neurons."
    Lei L., Ma L., Nef S., Thai T., Parada L.F.
    Development 128:1147-1158(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "Developmental expression of mouse Kruppel-like transcription factor KLF7 suggests a potential role in neurogenesis."
    Laub F.B., Aldabe R., Friedrich V. Jr., Ohnishi S., Yoshida T., Ramirez F.
    Dev. Biol. 233:305-318(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiKLF7_MOUSE
AccessioniPrimary (citable) accession number: Q99JB0
Secondary accession number(s): Q99P62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.