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Q99JA4

- CLTR1_MOUSE

UniProt

Q99JA4 - CLTR1_MOUSE

Protein

Cysteinyl leukotriene receptor 1

Gene

Cysltr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

    GO - Molecular functioni

    1. leukotriene receptor activity Source: MGI

    GO - Biological processi

    1. calcium ion transport Source: MGI
    2. cell surface receptor signaling pathway Source: MGI
    3. chemotaxis Source: MGI
    4. inflammatory response Source: Ensembl
    5. positive regulation of angiogenesis Source: Ensembl
    6. positive regulation of vasoconstriction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Short name:
    CysLTR1
    Alternative name(s):
    Cysteinyl leukotriene D4 receptor
    Short name:
    LTD4 receptor
    Gene namesi
    Name:Cysltr1
    Synonyms:Cyslt1, Cyslt1r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1926218. Cysltr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Cysteinyl leukotriene receptor 1PRO_0000069300Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ99JA4.
    PRIDEiQ99JA4.

    PTM databases

    PhosphoSiteiQ99JA4.

    Expressioni

    Tissue specificityi

    Widely expressed, with higher expression in the lung and skin, intermediate levels in the heart, kidney and stomach and lower levels in several other tissues. Isoform 1 is the most abundant form in all tested tissues.

    Gene expression databases

    BgeeiQ99JA4.
    CleanExiMM_CYSLTR1.
    GenevestigatoriQ99JA4.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48916N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99JA4.
    SMRiQ99JA4. Positions 40-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 728CytoplasmicSequence Analysis
    Topological domaini94 – 12128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 15614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 24516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 29125ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini313 – 35240CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    GeneTreeiENSGT00750000117402.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.
    InParanoidiQ99JA4.
    KOiK04322.
    OMAiPQDNQAK.
    OrthoDBiEOG7992R9.
    PhylomeDBiQ99JA4.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99JA4-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYLQGTKQTF LENMNGTENL TTSLINNTCH DTIDEFRNQV YSTMYSVISV    50
    VGFFGNSFVL YVLIKTYHEK SAFQVYMINL AIADLLCVCT LPLRVVYYVH 100
    KGKWLFGDFL CRLTTYALYV NLYCSIFFMT AMSFFRCVAI VFPVQNINLV 150
    TQKKARFVCI GIWIFVILTS SPFLMYKSYQ DEKNNTKCFE PPQNNQAKKY 200
    VLILHYVSLF FGFIIPFVTI IVCYTMIILT LLKNTMKKNM PSRRKAIGMI 250
    IVVTAAFLVS FMPYHIQRTI HLHLLHSETR PCDSVLRMQK SVVITLSLAA 300
    SNCCFDPLLY FFSGGNFRRR LSTFRKHSLS SMTYVPKKKA SLPEKGEEIC 350
    NE 352
    Length:352
    Mass (Da):40,715
    Last modified:June 1, 2001 - v1
    Checksum:i5BDC94B3F1CD0CAB
    GO
    Isoform 2 (identifier: Q99JA4-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: Missing.

    Show »
    Length:339
    Mass (Da):39,160
    Checksum:i27BF72C0F3F0F00F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761Y → D in AAF73047. (PubMed:11342226)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313Missing in isoform 2. 1 PublicationVSP_001921Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329272 Genomic DNA. Translation: AAK16715.1.
    AF329272 Genomic DNA. Translation: AAK16716.1.
    AF205830 mRNA. Translation: AAK15433.1.
    AF263370 mRNA. Translation: AAF73047.1.
    AB044087 mRNA. Translation: BAA96809.1.
    AK033476 mRNA. Translation: BAC28308.1.
    AL732460 Genomic DNA. Translation: CAM13712.1.
    BC027102 mRNA. Translation: AAH27102.1.
    CCDSiCCDS41098.1. [Q99JA4-1]
    RefSeqiNP_001268788.1. NM_001281859.1. [Q99JA4-1]
    NP_001268791.1. NM_001281862.1. [Q99JA4-2]
    NP_067451.2. NM_021476.5. [Q99JA4-1]
    XP_006528275.1. XM_006528212.1. [Q99JA4-2]
    UniGeneiMm.287166.

    Genome annotation databases

    EnsembliENSMUST00000064892; ENSMUSP00000063520; ENSMUSG00000052821. [Q99JA4-1]
    ENSMUST00000113480; ENSMUSP00000109108; ENSMUSG00000052821. [Q99JA4-1]
    GeneIDi58861.
    KEGGimmu:58861.
    UCSCiuc009ubt.1. mouse. [Q99JA4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329272 Genomic DNA. Translation: AAK16715.1 .
    AF329272 Genomic DNA. Translation: AAK16716.1 .
    AF205830 mRNA. Translation: AAK15433.1 .
    AF263370 mRNA. Translation: AAF73047.1 .
    AB044087 mRNA. Translation: BAA96809.1 .
    AK033476 mRNA. Translation: BAC28308.1 .
    AL732460 Genomic DNA. Translation: CAM13712.1 .
    BC027102 mRNA. Translation: AAH27102.1 .
    CCDSi CCDS41098.1. [Q99JA4-1 ]
    RefSeqi NP_001268788.1. NM_001281859.1. [Q99JA4-1 ]
    NP_001268791.1. NM_001281862.1. [Q99JA4-2 ]
    NP_067451.2. NM_021476.5. [Q99JA4-1 ]
    XP_006528275.1. XM_006528212.1. [Q99JA4-2 ]
    UniGenei Mm.287166.

    3D structure databases

    ProteinModelPortali Q99JA4.
    SMRi Q99JA4. Positions 40-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48916N.

    Chemistry

    GuidetoPHARMACOLOGYi 269.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99JA4.

    Proteomic databases

    PaxDbi Q99JA4.
    PRIDEi Q99JA4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064892 ; ENSMUSP00000063520 ; ENSMUSG00000052821 . [Q99JA4-1 ]
    ENSMUST00000113480 ; ENSMUSP00000109108 ; ENSMUSG00000052821 . [Q99JA4-1 ]
    GeneIDi 58861.
    KEGGi mmu:58861.
    UCSCi uc009ubt.1. mouse. [Q99JA4-1 ]

    Organism-specific databases

    CTDi 10800.
    MGIi MGI:1926218. Cysltr1.

    Phylogenomic databases

    eggNOGi NOG119185.
    GeneTreei ENSGT00750000117402.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.
    InParanoidi Q99JA4.
    KOi K04322.
    OMAi PQDNQAK.
    OrthoDBi EOG7992R9.
    PhylomeDBi Q99JA4.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 314416.
    PROi Q99JA4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99JA4.
    CleanExi MM_CYSLTR1.
    Genevestigatori Q99JA4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing."
      Maekawa A., Kanaoka Y., Lam B.K., Austen K.F.
      Proc. Natl. Acad. Sci. U.S.A. 98:2256-2261(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
      Strain: 129/Sv.
    2. "Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT1) receptors."
      Martin V., Sawyer N., Stocco R., Unett D., Lerner M.R., Abramovitz M., Funk C.D.
      Biochem. Pharmacol. 62:1193-1200(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Trachea.
    3. "Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes."
      Mollerup J., Jorgensen S.T., Hougaard C., Hoffmann E.K.
      Biochim. Biophys. Acta 1517:455-459(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Blood.
    4. Ogasawara H., Izumi T., Shimizu T.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: T-cell.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Colon.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCLTR1_MOUSE
    AccessioniPrimary (citable) accession number: Q99JA4
    Secondary accession number(s): Q544P1, Q9JJ71, Q9JK47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    MK-571, a selective antagonist, was shown to inhibit eosinophilia, bronchial hyperreactivity and microvascular leakage. Zafirlukast (Accolate) and pranlukast (Onon) were also shown to be selective antagonists.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3