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Protein

Cysteinyl leukotriene receptor 1

Gene

Cysltr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

GO - Molecular functioni

GO - Biological processi

  • calcium ion transport Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • chemotaxis Source: MGI
  • circulatory system process Source: GO_Central
  • inflammatory response to antigenic stimulus Source: MGI
  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391906. Leukotriene receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name:
LTD4 receptor
Gene namesi
Name:Cysltr1
Synonyms:Cyslt1, Cyslt1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1926218. Cysltr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 72CytoplasmicSequence analysis8
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 121ExtracellularSequence analysisAdd BLAST28
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini143 – 156CytoplasmicSequence analysisAdd BLAST14
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 208ExtracellularSequence analysisAdd BLAST31
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 245CytoplasmicSequence analysisAdd BLAST16
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 291ExtracellularSequence analysisAdd BLAST25
Transmembranei292 – 312Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini313 – 352CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693001 – 352Cysteinyl leukotriene receptor 1Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99JA4.
PRIDEiQ99JA4.

PTM databases

iPTMnetiQ99JA4.
PhosphoSitePlusiQ99JA4.

Expressioni

Tissue specificityi

Widely expressed, with higher expression in the lung and skin, intermediate levels in the heart, kidney and stomach and lower levels in several other tissues. Isoform 1 is the most abundant form in all tested tissues.

Gene expression databases

BgeeiENSMUSG00000052821.
CleanExiMM_CYSLTR1.
GenevisibleiQ99JA4. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-48916N.
STRINGi10090.ENSMUSP00000063520.

Structurei

3D structure databases

ProteinModelPortaliQ99JA4.
SMRiQ99JA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK2. Eukaryota.
ENOG410XRU6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ99JA4.
KOiK04322.
OMAiPQDNQAK.
OrthoDBiEOG091G0FE0.
PhylomeDBiQ99JA4.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99JA4-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYLQGTKQTF LENMNGTENL TTSLINNTCH DTIDEFRNQV YSTMYSVISV
60 70 80 90 100
VGFFGNSFVL YVLIKTYHEK SAFQVYMINL AIADLLCVCT LPLRVVYYVH
110 120 130 140 150
KGKWLFGDFL CRLTTYALYV NLYCSIFFMT AMSFFRCVAI VFPVQNINLV
160 170 180 190 200
TQKKARFVCI GIWIFVILTS SPFLMYKSYQ DEKNNTKCFE PPQNNQAKKY
210 220 230 240 250
VLILHYVSLF FGFIIPFVTI IVCYTMIILT LLKNTMKKNM PSRRKAIGMI
260 270 280 290 300
IVVTAAFLVS FMPYHIQRTI HLHLLHSETR PCDSVLRMQK SVVITLSLAA
310 320 330 340 350
SNCCFDPLLY FFSGGNFRRR LSTFRKHSLS SMTYVPKKKA SLPEKGEEIC

NE
Length:352
Mass (Da):40,715
Last modified:June 1, 2001 - v1
Checksum:i5BDC94B3F1CD0CAB
GO
Isoform 2 (identifier: Q99JA4-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:339
Mass (Da):39,160
Checksum:i27BF72C0F3F0F00F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176Y → D in AAF73047 (PubMed:11342226).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0019211 – 13Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329272 Genomic DNA. Translation: AAK16715.1.
AF329272 Genomic DNA. Translation: AAK16716.1.
AF205830 mRNA. Translation: AAK15433.1.
AF263370 mRNA. Translation: AAF73047.1.
AB044087 mRNA. Translation: BAA96809.1.
AK033476 mRNA. Translation: BAC28308.1.
AL732460 Genomic DNA. Translation: CAM13712.1.
BC027102 mRNA. Translation: AAH27102.1.
CCDSiCCDS41098.1. [Q99JA4-1]
RefSeqiNP_001268788.1. NM_001281859.1. [Q99JA4-1]
NP_001268791.1. NM_001281862.1. [Q99JA4-2]
NP_067451.2. NM_021476.5. [Q99JA4-1]
UniGeneiMm.287166.

Genome annotation databases

EnsembliENSMUST00000064892; ENSMUSP00000063520; ENSMUSG00000052821. [Q99JA4-1]
ENSMUST00000113480; ENSMUSP00000109108; ENSMUSG00000052821. [Q99JA4-1]
GeneIDi58861.
KEGGimmu:58861.
UCSCiuc009ubt.2. mouse. [Q99JA4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329272 Genomic DNA. Translation: AAK16715.1.
AF329272 Genomic DNA. Translation: AAK16716.1.
AF205830 mRNA. Translation: AAK15433.1.
AF263370 mRNA. Translation: AAF73047.1.
AB044087 mRNA. Translation: BAA96809.1.
AK033476 mRNA. Translation: BAC28308.1.
AL732460 Genomic DNA. Translation: CAM13712.1.
BC027102 mRNA. Translation: AAH27102.1.
CCDSiCCDS41098.1. [Q99JA4-1]
RefSeqiNP_001268788.1. NM_001281859.1. [Q99JA4-1]
NP_001268791.1. NM_001281862.1. [Q99JA4-2]
NP_067451.2. NM_021476.5. [Q99JA4-1]
UniGeneiMm.287166.

3D structure databases

ProteinModelPortaliQ99JA4.
SMRiQ99JA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48916N.
STRINGi10090.ENSMUSP00000063520.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99JA4.
PhosphoSitePlusiQ99JA4.

Proteomic databases

PaxDbiQ99JA4.
PRIDEiQ99JA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064892; ENSMUSP00000063520; ENSMUSG00000052821. [Q99JA4-1]
ENSMUST00000113480; ENSMUSP00000109108; ENSMUSG00000052821. [Q99JA4-1]
GeneIDi58861.
KEGGimmu:58861.
UCSCiuc009ubt.2. mouse. [Q99JA4-1]

Organism-specific databases

CTDi10800.
MGIiMGI:1926218. Cysltr1.

Phylogenomic databases

eggNOGiENOG410IKK2. Eukaryota.
ENOG410XRU6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ99JA4.
KOiK04322.
OMAiPQDNQAK.
OrthoDBiEOG091G0FE0.
PhylomeDBiQ99JA4.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-MMU-391906. Leukotriene receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ99JA4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052821.
CleanExiMM_CYSLTR1.
GenevisibleiQ99JA4. MM.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLTR1_MOUSE
AccessioniPrimary (citable) accession number: Q99JA4
Secondary accession number(s): Q544P1, Q9JJ71, Q9JK47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

MK-571, a selective antagonist, was shown to inhibit eosinophilia, bronchial hyperreactivity and microvascular leakage. Zafirlukast (Accolate) and pranlukast (Onon) were also shown to be selective antagonists.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.