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Q99JA4

- CLTR1_MOUSE

UniProt

Q99JA4 - CLTR1_MOUSE

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Protein
Cysteinyl leukotriene receptor 1
Gene
Cysltr1, Cyslt1, Cyslt1r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

GO - Molecular functioni

  1. leukotriene receptor activity Source: MGI

GO - Biological processi

  1. calcium ion transport Source: MGI
  2. cell surface receptor signaling pathway Source: MGI
  3. chemotaxis Source: MGI
  4. inflammatory response Source: Ensembl
  5. positive regulation of angiogenesis Source: Ensembl
  6. positive regulation of vasoconstriction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name:
LTD4 receptor
Gene namesi
Name:Cysltr1
Synonyms:Cyslt1, Cyslt1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1926218. Cysltr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Extracellular Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini65 – 728Cytoplasmic Reviewed prediction
Transmembranei73 – 9321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini94 – 12128Extracellular Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini143 – 15614Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini178 – 20831Extracellular Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini230 – 24516Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei246 – 26621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini267 – 29125Extracellular Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini313 – 35240Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Cysteinyl leukotriene receptor 1
PRO_0000069300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 188 By similarity
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99JA4.
PRIDEiQ99JA4.

PTM databases

PhosphoSiteiQ99JA4.

Expressioni

Tissue specificityi

Widely expressed, with higher expression in the lung and skin, intermediate levels in the heart, kidney and stomach and lower levels in several other tissues. Isoform 1 is the most abundant form in all tested tissues.

Gene expression databases

BgeeiQ99JA4.
CleanExiMM_CYSLTR1.
GenevestigatoriQ99JA4.

Interactioni

Protein-protein interaction databases

DIPiDIP-48916N.

Structurei

3D structure databases

ProteinModelPortaliQ99JA4.
SMRiQ99JA4. Positions 40-331.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00750000117402.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ99JA4.
KOiK04322.
OMAiPQDNQAK.
OrthoDBiEOG7992R9.
PhylomeDBiQ99JA4.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99JA4-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYLQGTKQTF LENMNGTENL TTSLINNTCH DTIDEFRNQV YSTMYSVISV    50
VGFFGNSFVL YVLIKTYHEK SAFQVYMINL AIADLLCVCT LPLRVVYYVH 100
KGKWLFGDFL CRLTTYALYV NLYCSIFFMT AMSFFRCVAI VFPVQNINLV 150
TQKKARFVCI GIWIFVILTS SPFLMYKSYQ DEKNNTKCFE PPQNNQAKKY 200
VLILHYVSLF FGFIIPFVTI IVCYTMIILT LLKNTMKKNM PSRRKAIGMI 250
IVVTAAFLVS FMPYHIQRTI HLHLLHSETR PCDSVLRMQK SVVITLSLAA 300
SNCCFDPLLY FFSGGNFRRR LSTFRKHSLS SMTYVPKKKA SLPEKGEEIC 350
NE 352
Length:352
Mass (Da):40,715
Last modified:June 1, 2001 - v1
Checksum:i5BDC94B3F1CD0CAB
GO
Isoform 2 (identifier: Q99JA4-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:339
Mass (Da):39,160
Checksum:i27BF72C0F3F0F00F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313Missing in isoform 2.
VSP_001921Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761Y → D in AAF73047. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF329272 Genomic DNA. Translation: AAK16715.1.
AF329272 Genomic DNA. Translation: AAK16716.1.
AF205830 mRNA. Translation: AAK15433.1.
AF263370 mRNA. Translation: AAF73047.1.
AB044087 mRNA. Translation: BAA96809.1.
AK033476 mRNA. Translation: BAC28308.1.
AL732460 Genomic DNA. Translation: CAM13712.1.
BC027102 mRNA. Translation: AAH27102.1.
CCDSiCCDS41098.1. [Q99JA4-1]
RefSeqiNP_001268788.1. NM_001281859.1. [Q99JA4-1]
NP_001268791.1. NM_001281862.1. [Q99JA4-2]
NP_067451.2. NM_021476.5. [Q99JA4-1]
XP_006528275.1. XM_006528212.1. [Q99JA4-2]
UniGeneiMm.287166.

Genome annotation databases

EnsembliENSMUST00000064892; ENSMUSP00000063520; ENSMUSG00000052821. [Q99JA4-1]
ENSMUST00000113480; ENSMUSP00000109108; ENSMUSG00000052821. [Q99JA4-1]
GeneIDi58861.
KEGGimmu:58861.
UCSCiuc009ubt.1. mouse. [Q99JA4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF329272 Genomic DNA. Translation: AAK16715.1 .
AF329272 Genomic DNA. Translation: AAK16716.1 .
AF205830 mRNA. Translation: AAK15433.1 .
AF263370 mRNA. Translation: AAF73047.1 .
AB044087 mRNA. Translation: BAA96809.1 .
AK033476 mRNA. Translation: BAC28308.1 .
AL732460 Genomic DNA. Translation: CAM13712.1 .
BC027102 mRNA. Translation: AAH27102.1 .
CCDSi CCDS41098.1. [Q99JA4-1 ]
RefSeqi NP_001268788.1. NM_001281859.1. [Q99JA4-1 ]
NP_001268791.1. NM_001281862.1. [Q99JA4-2 ]
NP_067451.2. NM_021476.5. [Q99JA4-1 ]
XP_006528275.1. XM_006528212.1. [Q99JA4-2 ]
UniGenei Mm.287166.

3D structure databases

ProteinModelPortali Q99JA4.
SMRi Q99JA4. Positions 40-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48916N.

Chemistry

GuidetoPHARMACOLOGYi 269.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q99JA4.

Proteomic databases

PaxDbi Q99JA4.
PRIDEi Q99JA4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064892 ; ENSMUSP00000063520 ; ENSMUSG00000052821 . [Q99JA4-1 ]
ENSMUST00000113480 ; ENSMUSP00000109108 ; ENSMUSG00000052821 . [Q99JA4-1 ]
GeneIDi 58861.
KEGGi mmu:58861.
UCSCi uc009ubt.1. mouse. [Q99JA4-1 ]

Organism-specific databases

CTDi 10800.
MGIi MGI:1926218. Cysltr1.

Phylogenomic databases

eggNOGi NOG119185.
GeneTreei ENSGT00750000117402.
HOGENOMi HOG000236328.
HOVERGENi HBG099611.
InParanoidi Q99JA4.
KOi K04322.
OMAi PQDNQAK.
OrthoDBi EOG7992R9.
PhylomeDBi Q99JA4.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 314416.
PROi Q99JA4.
SOURCEi Search...

Gene expression databases

Bgeei Q99JA4.
CleanExi MM_CYSLTR1.
Genevestigatori Q99JA4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing."
    Maekawa A., Kanaoka Y., Lam B.K., Austen K.F.
    Proc. Natl. Acad. Sci. U.S.A. 98:2256-2261(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
    Strain: 129/Sv.
  2. "Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT1) receptors."
    Martin V., Sawyer N., Stocco R., Unett D., Lerner M.R., Abramovitz M., Funk C.D.
    Biochem. Pharmacol. 62:1193-1200(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Trachea.
  3. "Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes."
    Mollerup J., Jorgensen S.T., Hougaard C., Hoffmann E.K.
    Biochim. Biophys. Acta 1517:455-459(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Blood.
  4. Ogasawara H., Izumi T., Shimizu T.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: T-cell.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Colon.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCLTR1_MOUSE
AccessioniPrimary (citable) accession number: Q99JA4
Secondary accession number(s): Q544P1, Q9JJ71, Q9JK47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

MK-571, a selective antagonist, was shown to inhibit eosinophilia, bronchial hyperreactivity and microvascular leakage. Zafirlukast (Accolate) and pranlukast (Onon) were also shown to be selective antagonists.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi