ID   CALCA_MOUSE             Reviewed;         128 AA.
AC   Q99JA0;
DT   21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Calcitonin gene-related peptide 1;
DE   AltName: Full=Alpha-type CGRP;
DE   AltName: Full=Calcitonin gene-related peptide I;
DE            Short=CGRP-I;
DE   Flags: Precursor;
GN   Name=Calca; Synonyms=Calc;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sarasa M., Catalan J., Aramayona J., Sorribas V.;
RT   "Mouse CGRP precursor is highly homologous to that of the rat.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/Sv;
RX   PubMed=11761712; DOI=10.3109/10425170109047567;
RA   Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.;
RT   "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha
RT   and beta genes.";
RL   DNA Seq. 12:131-135(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=18544925; DOI=10.1159/000124380;
RA   Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
RA   Nishibori M., Hamano K., Minamino N., Yasue H.;
RT   "Genomic organization, expression and evolution of porcine CRSP1, 2, and
RT   3.";
RL   Cytogenet. Genome Res. 121:41-49(2008).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role. It also elevates platelet cAMP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Calcitonin-gene related peptide I;
CC         IsoId=Q99JA0-1; Sequence=Displayed;
CC       Name=Calcitonin;
CC         IsoId=P70160-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Detected in nerve cells of cerebrum, hippocampus
CC       and pons/midbrain in newborns, and only in nerve cells of pons/midbrain
CC       in adult. {ECO:0000269|PubMed:18544925}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AF330212; AAK06841.1; -; mRNA.
DR   EMBL; AF325522; AAK18181.1; -; Genomic_DNA.
DR   EMBL; AF325521; AAK18181.1; JOINED; Genomic_DNA.
DR   EMBL; BC028771; AAH28771.1; -; mRNA.
DR   CCDS; CCDS21762.1; -. [Q99JA0-1]
DR   RefSeq; NP_001029126.1; NM_001033954.3. [Q99JA0-1]
DR   RefSeq; NP_001276373.1; NM_001289444.1. [Q99JA0-1]
DR   RefSeq; XP_011239962.1; XM_011241660.2. [Q99JA0-1]
DR   AlphaFoldDB; Q99JA0; -.
DR   DIP; DIP-60043N; -.
DR   IntAct; Q99JA0; 2.
DR   ProteomicsDB; 281760; -. [Q99JA0-1]
DR   Antibodypedia; 3493; 1992 antibodies from 46 providers.
DR   DNASU; 12310; -.
DR   Ensembl; ENSMUST00000032906.11; ENSMUSP00000032906.5; ENSMUSG00000030669.14. [Q99JA0-1]
DR   GeneID; 12310; -.
DR   KEGG; mmu:12310; -.
DR   UCSC; uc009jif.2; mouse. [Q99JA0-1]
DR   AGR; MGI:2151253; -.
DR   CTD; 796; -.
DR   MGI; MGI:2151253; Calca.
DR   VEuPathDB; HostDB:ENSMUSG00000030669; -.
DR   GeneTree; ENSGT00940000162876; -.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   OMA; RMERGIM; -.
DR   OrthoDB; 4002581at2759; -.
DR   BioGRID-ORCS; 12310; 0 hits in 79 CRISPR screens.
DR   ChiTaRS; Calca; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000030669; Expressed in facial nucleus and 100 other cell types or tissues.
DR   ExpressionAtlas; Q99JA0; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:MGI.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005576; C:extracellular region; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; ISO:MGI.
DR   GO; GO:0043005; C:neuron projection; IDA:MGI.
DR   GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISO:MGI.
DR   GO; GO:0043195; C:terminal bouton; IDA:MGI.
DR   GO; GO:0031716; F:calcitonin receptor binding; IDA:MGI.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; IDA:MGI.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:MGI.
DR   GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; IMP:MGI.
DR   GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:MGI.
DR   GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI.
DR   GO; GO:0007631; P:feeding behavior; IDA:MGI.
DR   GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; IGI:MGI.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
DR   GO; GO:0030279; P:negative regulation of ossification; IMP:MGI.
DR   GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:MGI.
DR   GO; GO:0001976; P:nervous system process involved in regulation of systemic arterial blood pressure; ISA:MGI.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR   GO; GO:0001503; P:ossification; IMP:MGI.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IMP:MGI.
DR   GO; GO:0048265; P:response to pain; IMP:MGI.
DR   GO; GO:0006939; P:smooth muscle contraction; IDA:MGI.
DR   GO; GO:0048240; P:sperm capacitation; ISA:MGI.
DR   GO; GO:0042311; P:vasodilation; ISO:MGI.
DR   Gene3D; 6.10.250.2190; -; 1.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505:SF3; CALCITONIN GENE-RELATED PEPTIDE 2; 1.
DR   PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
DR   Genevisible; Q99JA0; MM.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..80
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004059"
FT   PEPTIDE         83..119
FT                   /note="Calcitonin gene-related peptide 1"
FT                   /id="PRO_0000004060"
FT   PROPEP          125..128
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004061"
FT   MOD_RES         119
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..89
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  14065 MW;  83BB0E36C8B4239E CRC64;
     MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK
     ARELEQEEEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAFG
     RRRRDLQA
//