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Q99JA0

- CALCA_MOUSE

UniProt

Q99JA0 - CALCA_MOUSE

Protein

Calcitonin gene-related peptide 1

Gene

Calca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP By similarity.By similarity

    GO - Molecular functioni

    1. calcitonin receptor binding Source: MGI
    2. receptor binding Source: MGI

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    3. cellular calcium ion homeostasis Source: MGI
    4. detection of temperature stimulus involved in sensory perception of pain Source: MGI
    5. feeding behavior Source: MGI
    6. inflammatory response Source: MGI
    7. negative regulation of blood pressure Source: MGI
    8. negative regulation of neurological system process Source: MGI
    9. negative regulation of ossification Source: MGI
    10. negative regulation of smooth muscle contraction Source: MGI
    11. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
    12. neuropeptide signaling pathway Source: MGI
    13. positive regulation of ossification Source: MGI
    14. regulation of heart rate Source: MGI
    15. response to heat Source: MGI
    16. response to pain Source: MGI
    17. sperm capacitation Source: MGI
    18. vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin gene-related peptide 1
    Alternative name(s):
    Alpha-type CGRP
    Calcitonin gene-related peptide I
    Short name:
    CGRP-I
    Gene namesi
    Name:Calca
    Synonyms:Calc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2151253. Calca.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. cytoplasm Source: MGI
    3. extracellular region Source: MGI
    4. extracellular space Source: MGI
    5. intracellular Source: MGI
    6. neuronal cell body Source: MGI
    7. neuron projection Source: MGI
    8. terminal bouton Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 8055By similarityPRO_0000004059Add
    BLAST
    Peptidei83 – 11937Calcitonin gene-related peptide 1PRO_0000004060Add
    BLAST
    Propeptidei125 – 1284By similarityPRO_0000004061

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi84 ↔ 89By similarity
    Modified residuei119 – 1191Phenylalanine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ99JA0.

    Expressioni

    Tissue specificityi

    Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult.1 Publication

    Gene expression databases

    ArrayExpressiQ99JA0.
    BgeeiQ99JA0.
    CleanExiMM_CALCA.
    GenevestigatoriQ99JA0.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60043N.
    STRINGi10090.ENSMUSP00000032907.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99JA0.
    SMRiQ99JA0. Positions 83-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcitonin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40787.
    GeneTreeiENSGT00390000010511.
    HOGENOMiHOG000038203.
    HOVERGENiHBG031362.
    OrthoDBiEOG7PCJK5.

    Family and domain databases

    InterProiIPR018360. Calcitonin_CS.
    IPR015476. Calcitonin_gene-rel_peptide.
    IPR001693. Calcitonin_peptide-like.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view]
    PANTHERiPTHR10505. PTHR10505. 1 hit.
    PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view]
    PRINTSiPR00817. CALCITONINB.
    SMARTiSM00113. CALCITONIN. 1 hit.
    [Graphical view]
    PROSITEiPS00258. CALCITONIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA    50
    ALVQDYMQMK ARELEQEEEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR 100
    SGGVVKDNFV PTNVGSEAFG RRRRDLQA 128
    Length:128
    Mass (Da):14,065
    Last modified:June 1, 2001 - v1
    Checksum:i83BB0E36C8B4239E
    GO
    Isoform Calcitonin (identifier: P70160-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P70160.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:136
    Mass (Da):15,141
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF330212 mRNA. Translation: AAK06841.1.
    AF325522, AF325521 Genomic DNA. Translation: AAK18181.1.
    BC028771 mRNA. Translation: AAH28771.1.
    CCDSiCCDS21762.1. [Q99JA0-1]
    RefSeqiNP_001029126.1. NM_001033954.3. [Q99JA0-1]
    NP_001276373.1. NM_001289444.1. [Q99JA0-1]
    UniGeneiMm.4361.

    Genome annotation databases

    EnsembliENSMUST00000032906; ENSMUSP00000032906; ENSMUSG00000030669. [Q99JA0-1]
    GeneIDi12310.
    KEGGimmu:12310.
    UCSCiuc009jif.2. mouse. [Q99JA0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF330212 mRNA. Translation: AAK06841.1 .
    AF325522 , AF325521 Genomic DNA. Translation: AAK18181.1 .
    BC028771 mRNA. Translation: AAH28771.1 .
    CCDSi CCDS21762.1. [Q99JA0-1 ]
    RefSeqi NP_001029126.1. NM_001033954.3. [Q99JA0-1 ]
    NP_001276373.1. NM_001289444.1. [Q99JA0-1 ]
    UniGenei Mm.4361.

    3D structure databases

    ProteinModelPortali Q99JA0.
    SMRi Q99JA0. Positions 83-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60043N.
    STRINGi 10090.ENSMUSP00000032907.

    Proteomic databases

    PRIDEi Q99JA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032906 ; ENSMUSP00000032906 ; ENSMUSG00000030669 . [Q99JA0-1 ]
    GeneIDi 12310.
    KEGGi mmu:12310.
    UCSCi uc009jif.2. mouse. [Q99JA0-1 ]

    Organism-specific databases

    CTDi 796.
    MGIi MGI:2151253. Calca.

    Phylogenomic databases

    eggNOGi NOG40787.
    GeneTreei ENSGT00390000010511.
    HOGENOMi HOG000038203.
    HOVERGENi HBG031362.
    OrthoDBi EOG7PCJK5.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.

    Miscellaneous databases

    ChiTaRSi CALCA. mouse.
    NextBioi 280856.
    PROi Q99JA0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99JA0.
    Bgeei Q99JA0.
    CleanExi MM_CALCA.
    Genevestigatori Q99JA0.

    Family and domain databases

    InterProi IPR018360. Calcitonin_CS.
    IPR015476. Calcitonin_gene-rel_peptide.
    IPR001693. Calcitonin_peptide-like.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view ]
    PANTHERi PTHR10505. PTHR10505. 1 hit.
    Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view ]
    PRINTSi PR00817. CALCITONINB.
    SMARTi SM00113. CALCITONIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00258. CALCITONIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse CGRP precursor is highly homologous to that of the rat."
      Sarasa M., Catalan J., Aramayona J., Sorribas V.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes."
      Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.
      DNA Seq. 12:131-135(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCALCA_MOUSE
    AccessioniPrimary (citable) accession number: Q99JA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3