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Q99JA0 (CALCA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcitonin gene-related peptide 1
Alternative name(s):
Alpha-type CGRP
Calcitonin gene-related peptide I
Short name=CGRP-I
Gene names
Name:Calca
Synonyms:Calc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP By similarity.

Subcellular location

Secreted.

Tissue specificity

Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. Ref.4

Sequence similarities

Belongs to the calcitonin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of adenylate cyclase activity

Inferred from direct assay PubMed 8582325. Source: MGI

adenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from genetic interaction PubMed 8582325. Source: MGI

cellular calcium ion homeostasis

Inferred from genetic interaction PubMed 12488435. Source: MGI

detection of temperature stimulus involved in sensory perception of pain

Inferred from mutant phenotype PubMed 16118273. Source: MGI

feeding behavior

Inferred from direct assay PubMed 8735980. Source: MGI

inflammatory response

Inferred from direct assay PubMed 7698182. Source: MGI

negative regulation of blood pressure

Inferred from mutant phenotype PubMed 10642343PubMed 11717154PubMed 15583078. Source: MGI

negative regulation of neurological system process

Inferred from mutant phenotype PubMed 11717154. Source: MGI

negative regulation of ossification

Inferred from mutant phenotype PubMed 12488435PubMed 15537449. Source: MGI

negative regulation of smooth muscle contraction

Inferred from direct assay PubMed 9322931. Source: MGI

neurological system process involved in regulation of systemic arterial blood pressure

Inferred from sequence alignment PubMed 10642343. Source: MGI

neuropeptide signaling pathway

Inferred from direct assay PubMed 7698182. Source: MGI

positive regulation of ossification

Inferred from mutant phenotype PubMed 15537449. Source: MGI

regulation of heart rate

Inferred from mutant phenotype PubMed 11717154. Source: MGI

response to heat

Inferred from mutant phenotype PubMed 11166483PubMed 16118273. Source: MGI

response to pain

Inferred from mutant phenotype PubMed 10208559PubMed 11276224. Source: MGI

sperm capacitation

Inferred from sequence alignment PubMed 12704735. Source: MGI

vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure

Inferred from mutant phenotype PubMed 11717154. Source: MGI

   Cellular_componentaxon

Inferred from direct assay PubMed 1317267PubMed 21606356PubMed 7521790PubMed 8261138PubMed 8582325. Source: MGI

cytoplasm

Inferred from direct assay PubMed 11551509PubMed 14765981PubMed 9271704. Source: MGI

extracellular region

Inferred from direct assay PubMed 8735980. Source: MGI

extracellular space

Inferred from direct assay PubMed 14765981. Source: MGI

intracellular

Inferred from direct assay PubMed 12888222PubMed 7955356. Source: MGI

neuron projection

Inferred from direct assay PubMed 11466438. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 9838101. Source: MGI

terminal bouton

Inferred from direct assay PubMed 10208559PubMed 10532808PubMed 8453761PubMed 9853118. Source: MGI

   Molecular_functioncalcitonin receptor binding

Inferred from direct assay PubMed 9322931. Source: MGI

receptor binding

Inferred from direct assay PubMed 7698182PubMed 8278635. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Calcitonin (identifier: P70160-1)

The sequence of this isoform can be found in the external entry P70160.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 8055 By similarity
PRO_0000004059
Peptide83 – 11937Calcitonin gene-related peptide 1
PRO_0000004060
Propeptide125 – 1284 By similarity
PRO_0000004061

Amino acid modifications

Modified residue1191Phenylalanine amide By similarity
Disulfide bond84 ↔ 89 By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform Calcitonin-gene related peptide I [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 83BB0E36C8B4239E

FASTA12814,065
        10         20         30         40         50         60 
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK 

        70         80         90        100        110        120 
ARELEQEEEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAFG 


RRRRDLQA 

« Hide

Isoform Calcitonin [UniParc].

See P70160.

References

« Hide 'large scale' references
[1]"Mouse CGRP precursor is highly homologous to that of the rat."
Sarasa M., Catalan J., Aramayona J., Sorribas V.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes."
Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.
DNA Seq. 12:131-135(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[4]"Genomic organization, expression and evolution of porcine CRSP1, 2, and 3."
Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T., Nishibori M., Hamano K., Minamino N., Yasue H.
Cytogenet. Genome Res. 121:41-49(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF330212 mRNA. Translation: AAK06841.1.
AF325522, AF325521 Genomic DNA. Translation: AAK18181.1.
BC028771 mRNA. Translation: AAH28771.1.
RefSeqNP_001029126.1. NM_001033954.3.
UniGeneMm.4361.

3D structure databases

ProteinModelPortalQ99JA0.
SMRQ99JA0. Positions 83-119.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60043N.
STRING10090.ENSMUSP00000032907.

Proteomic databases

PRIDEQ99JA0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032906; ENSMUSP00000032906; ENSMUSG00000030669. [Q99JA0-1]
GeneID12310.
KEGGmmu:12310.
UCSCuc009jif.2. mouse. [Q99JA0-1]

Organism-specific databases

CTD796.
MGIMGI:2151253. Calca.

Phylogenomic databases

eggNOGNOG40787.
GeneTreeENSGT00390000010511.
HOGENOMHOG000038203.
HOVERGENHBG031362.
OMAEQETQGS.
OrthoDBEOG7PCJK5.

Gene expression databases

ArrayExpressQ99JA0.
BgeeQ99JA0.
CleanExMM_CALCA.
GenevestigatorQ99JA0.

Family and domain databases

InterProIPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERPTHR10505. PTHR10505. 1 hit.
PTHR10505:SF2. PTHR10505:SF2. 1 hit.
PfamPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSPR00817. CALCITONINB.
SMARTSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCALCA. mouse.
NextBio280856.
PROQ99JA0.
SOURCESearch...

Entry information

Entry nameCALCA_MOUSE
AccessionPrimary (citable) accession number: Q99JA0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot