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Q99JA0

- CALCA_MOUSE

UniProt

Q99JA0 - CALCA_MOUSE

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Protein

Calcitonin gene-related peptide 1

Gene

Calca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).By similarity

GO - Molecular functioni

  1. calcitonin receptor binding Source: MGI
  2. receptor binding Source: MGI

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  3. cellular calcium ion homeostasis Source: MGI
  4. detection of temperature stimulus involved in sensory perception of pain Source: MGI
  5. feeding behavior Source: MGI
  6. inflammatory response Source: MGI
  7. negative regulation of blood pressure Source: MGI
  8. negative regulation of neurological system process Source: MGI
  9. negative regulation of ossification Source: MGI
  10. negative regulation of smooth muscle contraction Source: MGI
  11. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  12. neuropeptide signaling pathway Source: MGI
  13. positive regulation of ossification Source: MGI
  14. regulation of heart rate Source: MGI
  15. response to heat Source: MGI
  16. response to pain Source: MGI
  17. sperm capacitation Source: MGI
  18. vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_198563. Amyloids.
REACT_242871. G alpha (s) signalling events.
REACT_255862. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 1
Alternative name(s):
Alpha-type CGRP
Calcitonin gene-related peptide I
Short name:
CGRP-I
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2151253. Calca.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular region Source: MGI
  4. extracellular space Source: MGI
  5. intracellular Source: MGI
  6. neuronal cell body Source: MGI
  7. neuron projection Source: MGI
  8. terminal bouton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 8055By similarityPRO_0000004059Add
BLAST
Peptidei83 – 11937Calcitonin gene-related peptide 1PRO_0000004060Add
BLAST
Propeptidei125 – 1284By similarityPRO_0000004061

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi84 ↔ 89By similarity
Modified residuei119 – 1191Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ99JA0.

Expressioni

Tissue specificityi

Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult.1 Publication

Gene expression databases

BgeeiQ99JA0.
CleanExiMM_CALCA.
ExpressionAtlasiQ99JA0. baseline and differential.
GenevestigatoriQ99JA0.

Interactioni

Protein-protein interaction databases

DIPiDIP-60043N.
STRINGi10090.ENSMUSP00000032907.

Structurei

3D structure databases

ProteinModelPortaliQ99JA0.
SMRiQ99JA0. Positions 83-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40787.
GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
OrthoDBiEOG7PCJK5.

Family and domain databases

InterProiIPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA
60 70 80 90 100
ALVQDYMQMK ARELEQEEEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR
110 120
SGGVVKDNFV PTNVGSEAFG RRRRDLQA
Length:128
Mass (Da):14,065
Last modified:June 1, 2001 - v1
Checksum:i83BB0E36C8B4239E
GO
Isoform Calcitonin (identifier: P70160-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P70160.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:136
Mass (Da):15,141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330212 mRNA. Translation: AAK06841.1.
AF325522, AF325521 Genomic DNA. Translation: AAK18181.1.
BC028771 mRNA. Translation: AAH28771.1.
CCDSiCCDS21762.1. [Q99JA0-1]
RefSeqiNP_001029126.1. NM_001033954.3. [Q99JA0-1]
NP_001276373.1. NM_001289444.1. [Q99JA0-1]
UniGeneiMm.4361.

Genome annotation databases

EnsembliENSMUST00000032906; ENSMUSP00000032906; ENSMUSG00000030669. [Q99JA0-1]
GeneIDi12310.
KEGGimmu:12310.
UCSCiuc009jif.2. mouse. [Q99JA0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330212 mRNA. Translation: AAK06841.1 .
AF325522 , AF325521 Genomic DNA. Translation: AAK18181.1 .
BC028771 mRNA. Translation: AAH28771.1 .
CCDSi CCDS21762.1. [Q99JA0-1 ]
RefSeqi NP_001029126.1. NM_001033954.3. [Q99JA0-1 ]
NP_001276373.1. NM_001289444.1. [Q99JA0-1 ]
UniGenei Mm.4361.

3D structure databases

ProteinModelPortali Q99JA0.
SMRi Q99JA0. Positions 83-119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60043N.
STRINGi 10090.ENSMUSP00000032907.

Proteomic databases

PRIDEi Q99JA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032906 ; ENSMUSP00000032906 ; ENSMUSG00000030669 . [Q99JA0-1 ]
GeneIDi 12310.
KEGGi mmu:12310.
UCSCi uc009jif.2. mouse. [Q99JA0-1 ]

Organism-specific databases

CTDi 796.
MGIi MGI:2151253. Calca.

Phylogenomic databases

eggNOGi NOG40787.
GeneTreei ENSGT00390000010511.
HOGENOMi HOG000038203.
HOVERGENi HBG031362.
OrthoDBi EOG7PCJK5.

Enzyme and pathway databases

Reactomei REACT_198563. Amyloids.
REACT_242871. G alpha (s) signalling events.
REACT_255862. Calcitonin-like ligand receptors.

Miscellaneous databases

NextBioi 280856.
PROi Q99JA0.
SOURCEi Search...

Gene expression databases

Bgeei Q99JA0.
CleanExi MM_CALCA.
ExpressionAtlasi Q99JA0. baseline and differential.
Genevestigatori Q99JA0.

Family and domain databases

InterProi IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view ]
PANTHERi PTHR10505. PTHR10505. 1 hit.
Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view ]
PRINTSi PR00817. CALCITONINB.
SMARTi SM00113. CALCITONIN. 1 hit.
[Graphical view ]
PROSITEi PS00258. CALCITONIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse CGRP precursor is highly homologous to that of the rat."
    Sarasa M., Catalan J., Aramayona J., Sorribas V.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes."
    Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.
    DNA Seq. 12:131-135(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCALCA_MOUSE
AccessioniPrimary (citable) accession number: Q99JA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3