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Protein

Interferon-induced transmembrane protein 2

Gene

Ifitm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 2
Alternative name(s):
Dispanin subfamily A member 2c
Short name:
DSPA2c
Fragilis protein 3
Gene namesi
Name:Ifitm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1933382. Ifitm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence analysisAdd
BLAST
Intramembranei57 – 7721HelicalBy similarityAdd
BLAST
Topological domaini78 – 11033CytoplasmicSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Topological domaini132 – 14413ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Interferon-induced transmembrane protein 2PRO_0000398566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Lipidationi70 – 701S-palmitoyl cysteineBy similarity
Lipidationi71 – 711S-palmitoyl cysteineBy similarity
Lipidationi104 – 1041S-palmitoyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDiQ99J93.
MaxQBiQ99J93.
PaxDbiQ99J93.
PRIDEiQ99J93.

PTM databases

iPTMnetiQ99J93.
PhosphoSiteiQ99J93.
SwissPalmiQ99J93.

Expressioni

Tissue specificityi

Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells.1 Publication

Developmental stagei

From E5.5 to E7.5 expressed within the epiblast. At E8.5 expressed throughout the entire embryo. Expressed in the gonadal germ cells at E11.5/12.5.1 Publication

Gene expression databases

BgeeiQ99J93.
GenevisibleiQ99J93. MM.

Interactioni

Subunit structurei

Interacts with CD81.1 Publication

Protein-protein interaction databases

BioGridi219823. 1 interaction.
STRINGi10090.ENSMUSP00000071470.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ99J93.
KOiK06566.
OMAiMVIICII.
OrthoDBiEOG7288T5.
PhylomeDBiQ99J93.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99J93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHNSQAFLS TNAGLPPSYE TIKEEYGVTE LGEPSNSAVV RTTVINMPRE
60 70 80 90 100
VSVPDHVVWS LFNTLFFNAC CLGFVAYAYS VKSRDRKMVG DVVGAQAYAS
110 120 130 140
TAKCLNISSL IFSILMVIIC IIIFSTTSVV VFQSFAQRTP HSGF
Length:144
Mass (Da):15,743
Last modified:June 1, 2001 - v1
Checksum:i99C7CDBA25CAF1A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082486 mRNA. Translation: AAM03318.1.
AK141392 mRNA. Translation: BAE24670.1.
AK167865 mRNA. Translation: BAE39882.1.
CH466531 Genomic DNA. Translation: EDL17975.1.
BC002102 mRNA. Translation: AAH02102.1.
BC002160 mRNA. Translation: AAH02160.1.
BC084679 mRNA. Translation: AAH84679.1.
CCDSiCCDS21994.1.
RefSeqiNP_109619.1. NM_030694.1.
UniGeneiMm.379266.

Genome annotation databases

EnsembliENSMUST00000081649; ENSMUSP00000071470; ENSMUSG00000060591.
GeneIDi80876.
KEGGimmu:80876.
UCSCiuc009kiz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082486 mRNA. Translation: AAM03318.1.
AK141392 mRNA. Translation: BAE24670.1.
AK167865 mRNA. Translation: BAE39882.1.
CH466531 Genomic DNA. Translation: EDL17975.1.
BC002102 mRNA. Translation: AAH02102.1.
BC002160 mRNA. Translation: AAH02160.1.
BC084679 mRNA. Translation: AAH84679.1.
CCDSiCCDS21994.1.
RefSeqiNP_109619.1. NM_030694.1.
UniGeneiMm.379266.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219823. 1 interaction.
STRINGi10090.ENSMUSP00000071470.

PTM databases

iPTMnetiQ99J93.
PhosphoSiteiQ99J93.
SwissPalmiQ99J93.

Proteomic databases

EPDiQ99J93.
MaxQBiQ99J93.
PaxDbiQ99J93.
PRIDEiQ99J93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081649; ENSMUSP00000071470; ENSMUSG00000060591.
GeneIDi80876.
KEGGimmu:80876.
UCSCiuc009kiz.1. mouse.

Organism-specific databases

CTDi10581.
MGIiMGI:1933382. Ifitm2.

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ99J93.
KOiK06566.
OMAiMVIICII.
OrthoDBiEOG7288T5.
PhylomeDBiQ99J93.
TreeFamiTF334894.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiIfitm2. mouse.
NextBioi350171.
PROiQ99J93.
SOURCEiSearch...

Gene expression databases

BgeeiQ99J93.
GenevisibleiQ99J93. MM.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice."
    Lange U.C., Saitou M., Western P.S., Barton S.C., Surani M.A.
    BMC Dev. Biol. 3:1-1(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ and C57BL/6J.
    Tissue: Embryo.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Mammary tumor.
  5. "Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes."
    Smith R.A., Young J., Weis J.J., Weis J.H.
    Genes Immun. 7:113-121(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD81.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver, Lung, Spleen and Testis.
  7. "The small interferon-induced transmembrane genes and proteins."
    Siegrist F., Ebeling M., Certa U.
    J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. Cited for: FUNCTION.
  9. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
    Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
    PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiIFM2_MOUSE
AccessioniPrimary (citable) accession number: Q99J93
Secondary accession number(s): Q3TIG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.