Reviewed-Annotation score: <p>Annotation score: 5 out of 5</p>
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.</p><p><a href='../manual/annotation_score' target='_top'>More...</a></p>Annotation score: 5 out of 5-Experimental evidence at protein leveli
<p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.</p><p><a href='../manual/protein_existence' target='_top'>More...</a></p> Select a section on the left to see content.
<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CONJUGATION TO ATG12, MUTAGENESIS OF LYS-130.
Cited for: CONJUGATION TO ATG12 BY ATG10, FUNCTION.
"The autophagy gene ATG5 plays an essential role in B lymphocyte development."Miller B.C.,
Zhao Z.,
Stephenson L.M.,
Cadwell K.,
Pua H.H.,
Lee H.K.,
Mizushima N.N.,
Iwasaki A.,
He Y.W.,
Swat W.,
Virgin H.W.Autophagy 4:309-314(2008) [
PubMed] [
Europe PMC] [
Abstract]
Cited for: FUNCTION.
Cited for: SUBCELLULAR LOCATION, FUNCTION.
May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity).
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
- aggrephagy
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- antigen processing and presentation of endogenous antigen
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- apoptotic process
- autophagosome assembly
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- autophagy
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- blood vessel remodeling
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- cellular homeostasis
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- cellular response to nitrogen starvation
- cellular response to nitrosative stress
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- cellular response to starvation
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- heart contraction
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- innate immune response
- macroautophagy
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- negative regulation of apoptotic process
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- negative regulation of cell death
- negative regulation of histone H4-K16 acetylation
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- negative regulation of phagocytosis
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- negative regulation of protein ubiquitination
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- negative regulation of reactive oxygen species metabolic process
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- negative regulation of type I interferon production
- negative stranded viral RNA replication
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- negative thymic T cell selection
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- nucleophagy
- otolith development
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- positive regulation of mitophagy
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- positive regulation of mucus secretion
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- post-translational protein modification
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- protein lipidation involved in autophagosome assembly
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- regulation of cilium assembly
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- regulation of cytokine secretion involved in immune response
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- regulation of reactive oxygen species metabolic process
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- regulation of release of sequestered calcium ion into cytosol
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- response to drug
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- response to fungus
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- vasodilation
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- ventricular cardiac muscle cell development
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Biological processi
Apoptosis, Autophagy, Immunity, Innate immunityEnzyme and pathway databases
|
Reactome - a knowledgebase of biological pathways and processes<br/><a href='/database/88'>More..</a>Reactomei | R-MMU-1632852. Macroautophagy.
R-MMU-5205685. Pink/Parkin Mediated Mitophagy.
R-MMU-936440. Negative regulators of RIG-I/MDA5 signaling.
|
<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>Provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.</p><p><a href='../manual/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Autophagy protein 5Alternative name(s): |
| <p>Indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.</p><p><a href='../manual/gene_name' target='_top'>More...</a></p>Gene namesi | |
| <p>Provides information on the name(s) of the organism that is the source of the protein sequence.</p><p><a href='../manual/organism-name' target='_top'>More...</a></p>Organismi | Mus musculus (Mouse) |
| <p>Shows the unique identifier assigned by the <span class="caps">NCBI</span> to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.</p><p><a href='../manual/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 10090 [NCBI] |
| <p>Contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.</p><p><a href='../manual/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
| <p>Is present for entries that are part of a <a href="/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.</p><p><a href='../manual/proteomes_manual' target='_top'>More...</a></p>Proteomesi | - UP000000589
<p>A UniProt <a href="/manual/proteomes_manual">proteome</a> can consist of several components. <br />The component name refers to the genomic component encoding a set of proteins. <br />These range from a single component such as Viral genomes to several components as in the case of eukaryotic chromosomes. They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun (WGS) master records.</p><p><a href='../manual/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10
|
Organism-specific databases
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Mouse genome database (MGD) from Mouse Genome Informatics (MGI)<br/><a href='/database/60'>More..</a>MGIi | MGI:1277186. Atg5.
|
<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
- Cytoplasm
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
Cited for: SUBCELLULAR LOCATION, FUNCTION.
- Preautophagosomal structure membrane
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
Cited for: SUBCELLULAR LOCATION, FUNCTION.
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
Cited for: SUBCELLULAR LOCATION, FUNCTION.
Note: The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti
- Atg12-Atg5-Atg16 complex
- autophagosome
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- axoneme
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- cytoplasm
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- cytosol
- ER-mitochondrion membrane contact site
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- membrane
Inferred from sequence orthologyi
- pre-autophagosomal structure membrane
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Cytoplasm, Membrane<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
Mutagenesis
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|
| <p>Describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.</p><p><a href='../manual/mutagen' target='_top'>More...</a></p>Mutagenesisi | 130 – 130 | 1 | K → R: Loss of conjugation.
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CONJUGATION TO ATG12, MUTAGENESIS OF LYS-130.
|   | | |
<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|
| <p>Describes the extent of a polypeptide chain in the mature protein following processing.</p><p><a href='../manual/chain' target='_top'>More...</a></p>Chaini | 1 – 275 | 275 | Autophagy protein 5 | | PRO_0000218995 | Add
BLAST |
Amino acid modifications
<p>Describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.</p><p><a href='../manual/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi
Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
Acetylated by EP300.
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
|
Encyclopedia of Proteome Dynamics<br/><a href='/database/205'>More..</a>EPDi | Q99J83.
|
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MaxQB - The MaxQuant DataBase<br/><a href='/database/186'>More..</a>MaxQBi | Q99J83.
|
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PaxDb, a database of protein abundance averages across all three domains of life<br/><a href='/database/173'>More..</a>PaxDbi | Q99J83.
|
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PeptideAtlas<br/><a href='/database/71'>More..</a>PeptideAtlasi | Q99J83.
|
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PRoteomics IDEntifications database<br/><a href='/database/130'>More..</a>PRIDEi | Q99J83.
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PTM databases
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iPTMnet integrated resource for PTMs in systems biology context<br/><a href='/database/200'>More..</a>iPTMneti | Q99J83.
|
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Comprehensive resource for the study of human and mouse PTMs<br/><a href='/database/123'>More..</a>PhosphoSitei | Q99J83.
|
<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni
<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br />Examples: <a href="/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="/uniprot/O14734#expression"><span class="caps">O14734</span></a></p><p><a href='../manual/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Ubiquitous.
Gene expression databases
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Bgee dataBase for Gene Expression Evolution<br/><a href='/database/133'>More..</a>Bgeei | ENSMUSG00000038160.
|
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CleanEx database of gene expression profiles<br/><a href='/database/8'>More..</a>CleanExi | MM_ATG5.
|
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Genevisible search portal to normalized and curated expression data from Genevestigator<br/><a href='/database/194'>More..</a>Genevisiblei | Q99J83. MM.
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<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni
<p>Provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="/help/function_section">‘Function’</a> section).</p><p><a href='../manual/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Forms a conjugate with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16L. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5-ATG12 conjugate (By similarity). ATG12-ATG5 also interacts with MAVS, MGA, and RARRES3 (By similarity). Interacts with ATG3, ATG7 and ATG10. Interacts with FADD (By similarity).
<p>Provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.</p><p><a href='../manual/binary_interactions' target='_top'>More...</a></p>Binary interactionsi
Protein-protein interaction databases
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The Biological General Repository for Interaction Datasets (BioGrid)<br/><a href='/database/184'>More..</a>BioGridi | 198146. 7 interactions.
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Database of interacting proteins<br/><a href='/database/16'>More..</a>DIPi | DIP-46420N.
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Protein interaction database and analysis system<br/><a href='/database/51'>More..</a>IntActi | Q99J83. 10 interactions.
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Molecular INTeraction database<br/><a href='/database/158'>More..</a>MINTi | MINT-4088049.
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STRING: functional protein association networks<br/><a href='/database/141'>More..</a>STRINGi | 10090.ENSMUSP00000044769.
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<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei
3D structure databases
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Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase<br/><a href='/database/159'>More..</a>ProteinModelPortali | Q99J83.
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SWISS-MODEL Repository - a database of annotated 3D protein structure models<br/><a href='/database/98'>More..</a>SMRi | Q99J83. Positions 2-274.
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Database of comparative protein structure models<br/><a href='/database/63'>More..</a>ModBasei | Search...
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MobiDB: a database of protein disorder and mobility annotations<br/><a href='/database/183'>More..</a>MobiDBi | Search...
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<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Phylogenomic databases
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evolutionary genealogy of genes: Non-supervised Orthologous Groups<br/><a href='/database/152'>More..</a>eggNOGi | KOG2976. Eukaryota.
ENOG410XQ71. LUCA.
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Ensembl GeneTree<br/><a href='/database/162'>More..</a>GeneTreei | ENSGT00390000004766.
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The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms<br/><a href='/database/44'>More..</a>HOGENOMi | HOG000007893.
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The HOVERGEN Database of Homologous Vertebrate Genes<br/><a href='/database/45'>More..</a>HOVERGENi | HBG018731.
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InParanoid: Eukaryotic Ortholog Groups<br/><a href='/database/146'>More..</a>InParanoidi | Q99J83.
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KEGG Orthology (KO)<br/><a href='/database/164'>More..</a>KOi | K08339.
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Identification of Orthologs from Complete Genome Data<br/><a href='/database/137'>More..</a>OMAi | ETPIQWL.
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Database of Orthologous Groups<br/><a href='/database/143'>More..</a>OrthoDBi | EOG091G0JU7.
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Database for complete collections of gene phylogenies<br/><a href='/database/144'>More..</a>PhylomeDBi | Q99J83.
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TreeFam database of animal gene trees<br/><a href='/database/185'>More..</a>TreeFami | TF314415.
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Family and domain databases
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Integrated resource of protein families, domains and functional sites<br/><a href='/database/52'>More..</a>InterProi | IPR007239. Atg5.
[Graphical view] |
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The PANTHER Classification System<br/><a href='/database/69'>More..</a>PANTHERi | PTHR13040. PTHR13040. 1 hit.
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Pfam protein domain database<br/><a href='/database/73'>More..</a>Pfami | PF04106. APG5. 1 hit.
[Graphical view] |
<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei
<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
Sequence databases
Genome annotation databases
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Ensembl eukaryotic genome annotation project<br/><a href='/database/23'>More..</a>Ensembli | ENSMUST00000039286; ENSMUSP00000044769; ENSMUSG00000038160.
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Database of genes from NCBI RefSeq genomes<br/><a href='/database/118'>More..</a>GeneIDi | 11793.
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KEGG: Kyoto Encyclopedia of Genes and Genomes<br/><a href='/database/53'>More..</a>KEGGi | mmu:11793.
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UCSC genome browser<br/><a href='/database/139'>More..</a>UCSCi | uc007ezt.1. mouse.
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<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
3D structure databases
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Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase<br/><a href='/database/159'>More..</a>ProteinModelPortali | Q99J83.
|
|
SWISS-MODEL Repository - a database of annotated 3D protein structure models<br/><a href='/database/98'>More..</a>SMRi | Q99J83. Positions 2-274.
|
|
Database of comparative protein structure models<br/><a href='/database/63'>More..</a>ModBasei | Search...
|
|
MobiDB: a database of protein disorder and mobility annotations<br/><a href='/database/183'>More..</a>MobiDBi | Search...
|
Protein-protein interaction databases
|
The Biological General Repository for Interaction Datasets (BioGrid)<br/><a href='/database/184'>More..</a>BioGridi | 198146. 7 interactions.
|
|
Database of interacting proteins<br/><a href='/database/16'>More..</a>DIPi | DIP-46420N.
|
|
Protein interaction database and analysis system<br/><a href='/database/51'>More..</a>IntActi | Q99J83. 10 interactions.
|
|
Molecular INTeraction database<br/><a href='/database/158'>More..</a>MINTi | MINT-4088049.
|
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STRING: functional protein association networks<br/><a href='/database/141'>More..</a>STRINGi | 10090.ENSMUSP00000044769.
|
PTM databases
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iPTMnet integrated resource for PTMs in systems biology context<br/><a href='/database/200'>More..</a>iPTMneti | Q99J83.
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Comprehensive resource for the study of human and mouse PTMs<br/><a href='/database/123'>More..</a>PhosphoSitei | Q99J83.
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Proteomic databases
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Encyclopedia of Proteome Dynamics<br/><a href='/database/205'>More..</a>EPDi | Q99J83.
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MaxQB - The MaxQuant DataBase<br/><a href='/database/186'>More..</a>MaxQBi | Q99J83.
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PaxDb, a database of protein abundance averages across all three domains of life<br/><a href='/database/173'>More..</a>PaxDbi | Q99J83.
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PeptideAtlas<br/><a href='/database/71'>More..</a>PeptideAtlasi | Q99J83.
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PRoteomics IDEntifications database<br/><a href='/database/130'>More..</a>PRIDEi | Q99J83.
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Protocols and materials databases
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The DNASU plasmid repository<br/><a href='/database/167'>More..</a>DNASUi | 11793.
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Structural Biology Knowledgebase | Search...
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Genome annotation databases
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Ensembl eukaryotic genome annotation project<br/><a href='/database/23'>More..</a>Ensembli | ENSMUST00000039286; ENSMUSP00000044769; ENSMUSG00000038160.
|
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Database of genes from NCBI RefSeq genomes<br/><a href='/database/118'>More..</a>GeneIDi | 11793.
|
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KEGG: Kyoto Encyclopedia of Genes and Genomes<br/><a href='/database/53'>More..</a>KEGGi | mmu:11793.
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UCSC genome browser<br/><a href='/database/139'>More..</a>UCSCi | uc007ezt.1. mouse.
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Organism-specific databases
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Comparative Toxicogenomics Database<br/><a href='/database/140'>More..</a>CTDi | 9474.
|
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Mouse genome database (MGD) from Mouse Genome Informatics (MGI)<br/><a href='/database/60'>More..</a>MGIi | MGI:1277186. Atg5.
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Phylogenomic databases
|
evolutionary genealogy of genes: Non-supervised Orthologous Groups<br/><a href='/database/152'>More..</a>eggNOGi | KOG2976. Eukaryota.
ENOG410XQ71. LUCA.
|
|
Ensembl GeneTree<br/><a href='/database/162'>More..</a>GeneTreei | ENSGT00390000004766.
|
|
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms<br/><a href='/database/44'>More..</a>HOGENOMi | HOG000007893.
|
|
The HOVERGEN Database of Homologous Vertebrate Genes<br/><a href='/database/45'>More..</a>HOVERGENi | HBG018731.
|
|
InParanoid: Eukaryotic Ortholog Groups<br/><a href='/database/146'>More..</a>InParanoidi | Q99J83.
|
|
KEGG Orthology (KO)<br/><a href='/database/164'>More..</a>KOi | K08339.
|
|
Identification of Orthologs from Complete Genome Data<br/><a href='/database/137'>More..</a>OMAi | ETPIQWL.
|
|
Database of Orthologous Groups<br/><a href='/database/143'>More..</a>OrthoDBi | EOG091G0JU7.
|
|
Database for complete collections of gene phylogenies<br/><a href='/database/144'>More..</a>PhylomeDBi | Q99J83.
|
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TreeFam database of animal gene trees<br/><a href='/database/185'>More..</a>TreeFami | TF314415.
|
Enzyme and pathway databases
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Reactome - a knowledgebase of biological pathways and processes<br/><a href='/database/88'>More..</a>Reactomei | R-MMU-1632852. Macroautophagy.
R-MMU-5205685. Pink/Parkin Mediated Mitophagy.
R-MMU-936440. Negative regulators of RIG-I/MDA5 signaling.
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Miscellaneous databases
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Protein Ontology<br/><a href='/database/181'>More..</a>PROi | Q99J83.
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The Stanford Online Universal Resource for Clones and ESTs<br/><a href='/database/99'>More..</a>SOURCEi | Search...
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Gene expression databases
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Bgee dataBase for Gene Expression Evolution<br/><a href='/database/133'>More..</a>Bgeei | ENSMUSG00000038160.
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CleanEx database of gene expression profiles<br/><a href='/database/8'>More..</a>CleanExi | MM_ATG5.
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Genevisible search portal to normalized and curated expression data from Genevestigator<br/><a href='/database/194'>More..</a>Genevisiblei | Q99J83. MM.
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Family and domain databases
|
Integrated resource of protein families, domains and functional sites<br/><a href='/database/52'>More..</a>InterProi | IPR007239. Atg5.
[Graphical view] |
|
The PANTHER Classification System<br/><a href='/database/69'>More..</a>PANTHERi | PTHR13040. PTHR13040. 1 hit.
|
|
Pfam protein domain database<br/><a href='/database/73'>More..</a>Pfami | PF04106. APG5. 1 hit.
[Graphical view] |
|
ProtoNet; Automatic hierarchical classification of proteins<br/><a href='/database/85'>More..</a>ProtoNeti | Search...
|
<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi
| <p>Provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.</p><p><a href='../manual/entry_name' target='_top'>More...</a></p>Entry namei | ATG5_MOUSE |
| <p>Provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.</p><p><a href='../manual/accession_numbers' target='_top'>More...</a></p>Accessioni | Q99J83Primary (citable) accession number: Q99J83 |
| <p>Shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="help/canonical_and_isoforms">canonical sequence</a> are also displayed.</p><p><a href='../manual/entry_history' target='_top'>More...</a></p>Entry historyi | | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 | | Last sequence update: | June 1, 2001 | | Last modified: | September 7, 2016 | | This is version 123 of the entry and version 1 of the sequence. [Complete history] |
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| <p>Indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).</p><p><a href='../manual/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
| Annotation program | Chordata Protein Annotation Program |
<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
- SIMILARITY comments
Index of protein domains and families
<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
