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Protein

Sialic acid synthase

Gene

Nans

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Produces N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) from N-acetylmannosamine 6-phosphate. Has no detectable activity towards N-acetylmannosamine or mannose 6-phosphate.1 Publication

Catalytic activityi

Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate.1 Publication

GO - Molecular functioni

  • N-acylneuraminate-9-phosphate synthase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14514.
BRENDAi2.5.1.57. 3474.
ReactomeiR-MMU-4085001. Sialic acid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid synthase1 Publication
Alternative name(s):
N-acetylneuraminate-9-phosphate synthase1 Publication (EC:2.5.1.571 Publication)
N-acetylneuraminic acid phosphate synthase1 Publication
Gene namesi
Name:NansImported
Synonyms:SasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2149820. Nans.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • extracellular exosome Source: MGI

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004386812 – 359Sialic acid synthaseBy similarityAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9JJH0.
PeptideAtlasiQ9JJH0.

Expressioni

Tissue specificityi

Ubiquitious.1 Publication

Gene expression databases

BgeeiENSMUSG00000028334.

Interactioni

Protein-protein interaction databases

IntActiQ9JJH0. 1 interactor.
MINTiMINT-4130021.
STRINGi10090.ENSMUSP00000030018.

Structurei

3D structure databases

SMRiQ99J77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 353AFP-likePROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Contains 1 AFP-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHMI. Eukaryota.
COG2089. LUCA.
GeneTreeiENSGT00390000011081.
HOGENOMiHOG000284783.
HOVERGENiHBG000665.
KOiK05304.
OMAiAYPSKIE.
OrthoDBiEOG091G0D9G.
PhylomeDBiQ99J77.
TreeFamiTF324826.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR006013. Antifreeze_III.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamiPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SMARTiSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99J77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLELELCPG RWVGGKHPCF IIAEIGQNHQ GDIDVAKRMI RTAKECGADC
60 70 80 90 100
AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYKELQS
110 120 130 140 150
YAQEIGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG
160 170 180 190 200
RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDANLRVI
210 220 230 240 250
SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH
260 270 280 290 300
SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK
310 320 330 340 350
IPAGTTLTLD MLTVKVGEPK GYPPEDIFNL AGKKVLVTIE EDDTVMEESV

ESHSKKIKA
Length:359
Mass (Da):40,024
Last modified:June 1, 2001 - v1
Checksum:i4C66CB883558A373
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311M → T in BAA98131 (PubMed:10873658).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041263 mRNA. Translation: BAA98131.1.
AK076290 mRNA. Translation: BAC36290.1.
AK156254 mRNA. Translation: BAE33642.1.
AL683884 Genomic DNA. No translation available.
CH466565 Genomic DNA. Translation: EDL02367.1.
BC003307 mRNA. Translation: AAH03307.1.
BC057977 mRNA. Translation: AAH57977.1.
PIRiJC7321.
RefSeqiNP_444409.1. NM_053179.3.
UniGeneiMm.249349.

Genome annotation databases

EnsembliENSMUST00000030018; ENSMUSP00000030018; ENSMUSG00000028334.
GeneIDi94181.
KEGGimmu:94181.
UCSCiuc008stv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041263 mRNA. Translation: BAA98131.1.
AK076290 mRNA. Translation: BAC36290.1.
AK156254 mRNA. Translation: BAE33642.1.
AL683884 Genomic DNA. No translation available.
CH466565 Genomic DNA. Translation: EDL02367.1.
BC003307 mRNA. Translation: AAH03307.1.
BC057977 mRNA. Translation: AAH57977.1.
PIRiJC7321.
RefSeqiNP_444409.1. NM_053179.3.
UniGeneiMm.249349.

3D structure databases

SMRiQ99J77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JJH0. 1 interactor.
MINTiMINT-4130021.
STRINGi10090.ENSMUSP00000030018.

Proteomic databases

PaxDbiQ9JJH0.
PeptideAtlasiQ9JJH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030018; ENSMUSP00000030018; ENSMUSG00000028334.
GeneIDi94181.
KEGGimmu:94181.
UCSCiuc008stv.1. mouse.

Organism-specific databases

CTDi54187.
MGIiMGI:2149820. Nans.

Phylogenomic databases

eggNOGiENOG410IHMI. Eukaryota.
COG2089. LUCA.
GeneTreeiENSGT00390000011081.
HOGENOMiHOG000284783.
HOVERGENiHBG000665.
KOiK05304.
OMAiAYPSKIE.
OrthoDBiEOG091G0D9G.
PhylomeDBiQ99J77.
TreeFamiTF324826.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14514.
BRENDAi2.5.1.57. 3474.
ReactomeiR-MMU-4085001. Sialic acid metabolism.

Miscellaneous databases

ChiTaRSiNans. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028334.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR006013. Antifreeze_III.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamiPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SMARTiSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIAS_MOUSE
AccessioniPrimary (citable) accession number: Q99J77
Secondary accession number(s): Q9JJH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
Last sequence update: June 1, 2001
Last modified: January 18, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.