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Protein
Submitted name:

N-acetylneuraminic acid synthase (Sialic acid synthase)

Gene

Nans

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • N-acylneuraminate-9-phosphate synthase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-4085001. Sialic acid metabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
N-acetylneuraminic acid synthase (Sialic acid synthase)Imported
Submitted name:
Protein NansImported
Gene namesi
Name:NansImported
ORF Names:mCG_4426Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2149820. Nans.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • extracellular exosome Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000028334.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030018.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 353AFP-likeInterPro annotationAdd BLAST60

Phylogenomic databases

eggNOGiENOG410IHMI. Eukaryota.
COG2089. LUCA.
GeneTreeiENSGT00390000011081.
HOGENOMiHOG000284783.
HOVERGENiHBG000665.
KOiK05304.
OMAiAYPSKIE.
OrthoDBiEOG091G0D9G.
TreeFamiTF324826.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR006013. Antifreeze_III.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamiPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SMARTiSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99J77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLELELCPG RWVGGKHPCF IIAEIGQNHQ GDIDVAKRMI RTAKECGADC
60 70 80 90 100
AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYKELQS
110 120 130 140 150
YAQEIGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG
160 170 180 190 200
RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDANLRVI
210 220 230 240 250
SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH
260 270 280 290 300
SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK
310 320 330 340 350
IPAGTTLTLD MLTVKVGEPK GYPPEDIFNL AGKKVLVTIE EDDTVMEESV

ESHSKKIKA
Length:359
Mass (Da):40,024
Last modified:June 1, 2001 - v1
Checksum:i4C66CB883558A373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683884 Genomic DNA. No translation available.
BC003307 mRNA. Translation: AAH03307.1.
BC057977 mRNA. Translation: AAH57977.1.
AK076290 mRNA. Translation: BAC36290.1.
AK156254 mRNA. Translation: BAE33642.1.
CH466565 Genomic DNA. Translation: EDL02367.1.
RefSeqiNP_444409.1. NM_053179.3.
UniGeneiMm.249349.

Genome annotation databases

EnsembliENSMUST00000030018; ENSMUSP00000030018; ENSMUSG00000028334.
GeneIDi94181.
KEGGimmu:94181.
UCSCiuc008stv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683884 Genomic DNA. No translation available.
BC003307 mRNA. Translation: AAH03307.1.
BC057977 mRNA. Translation: AAH57977.1.
AK076290 mRNA. Translation: BAC36290.1.
AK156254 mRNA. Translation: BAE33642.1.
CH466565 Genomic DNA. Translation: EDL02367.1.
RefSeqiNP_444409.1. NM_053179.3.
UniGeneiMm.249349.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030018.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030018; ENSMUSP00000030018; ENSMUSG00000028334.
GeneIDi94181.
KEGGimmu:94181.
UCSCiuc008stv.1. mouse.

Organism-specific databases

CTDi54187.
MGIiMGI:2149820. Nans.

Phylogenomic databases

eggNOGiENOG410IHMI. Eukaryota.
COG2089. LUCA.
GeneTreeiENSGT00390000011081.
HOGENOMiHOG000284783.
HOVERGENiHBG000665.
KOiK05304.
OMAiAYPSKIE.
OrthoDBiEOG091G0D9G.
TreeFamiTF324826.

Enzyme and pathway databases

ReactomeiR-MMU-4085001. Sialic acid metabolism.

Miscellaneous databases

ChiTaRSiNans. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028334.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR006013. Antifreeze_III.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamiPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SMARTiSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ99J77_MOUSE
AccessioniPrimary (citable) accession number: Q99J77
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 5, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.