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Protein

Tetraspanin-1

Gene

Tspan1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-1
Short name:
Tspan-1
Gene namesi
Name:Tspan1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914055. Tspan1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Tetraspanin-1PRO_0000382891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99J59.
PRIDEiQ99J59.

Expressioni

Gene expression databases

BgeeiQ99J59.
ExpressionAtlasiQ99J59. baseline and differential.
GenevisibleiQ99J59. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030465.

Structurei

3D structure databases

ProteinModelPortaliQ99J59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
InParanoidiQ99J59.
KOiK17348.
OMAiFTQVWNT.
OrthoDBiEOG7CK38F.
PhylomeDBiQ99J59.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99J59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCFKFIKVM MFLFNLLIFL CGAALLAVGI WVSVDGTSFL KVFGSLSSSA
60 70 80 90 100
MQFVNVGYFL IAAGAVLFIL GFLGCYGAHS ENKCVLMMFF SILLIIFIAE
110 120 130 140 150
IAGAVVALVY TTLAEQFLTL LVVPAIEKDY GYQTDFTQVW NTTMEELHCC
160 170 180 190 200
GFNNYTDFNA SRFVKENKVF PPPCCANPGN HTVEPCTEEK AKSMKVQGCF
210 220 230 240
KEILHRIRAN AVTVGGVAVG VAALELAAMV VSMYLYCNLK
Length:240
Mass (Da):26,356
Last modified:June 1, 2001 - v1
Checksum:iAD4C448A32BC2999
GO

Sequence cautioni

The sequence CAO78026.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAO78128.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078869 mRNA. Translation: BAC37431.1.
CH466552 Genomic DNA. Translation: EDL30614.1.
AL670603, AL611947 Genomic DNA. Translation: CAM19375.1.
AL611947, AL670603 Genomic DNA. Translation: CAM20669.1.
AL670603, AL611947 Genomic DNA. Translation: CAO78026.1. Sequence problems.
AL611947, AL670603 Genomic DNA. Translation: CAO78128.1. Sequence problems.
BC003448 mRNA. Translation: AAH03448.1.
CCDSiCCDS18508.1.
RefSeqiNP_598442.1. NM_133681.4.
XP_006503353.1. XM_006503290.2.
UniGeneiMm.45994.

Genome annotation databases

EnsembliENSMUST00000030465; ENSMUSP00000030465; ENSMUSG00000028699.
GeneIDi66805.
KEGGimmu:66805.
UCSCiuc008ugk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078869 mRNA. Translation: BAC37431.1.
CH466552 Genomic DNA. Translation: EDL30614.1.
AL670603, AL611947 Genomic DNA. Translation: CAM19375.1.
AL611947, AL670603 Genomic DNA. Translation: CAM20669.1.
AL670603, AL611947 Genomic DNA. Translation: CAO78026.1. Sequence problems.
AL611947, AL670603 Genomic DNA. Translation: CAO78128.1. Sequence problems.
BC003448 mRNA. Translation: AAH03448.1.
CCDSiCCDS18508.1.
RefSeqiNP_598442.1. NM_133681.4.
XP_006503353.1. XM_006503290.2.
UniGeneiMm.45994.

3D structure databases

ProteinModelPortaliQ99J59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030465.

Proteomic databases

PaxDbiQ99J59.
PRIDEiQ99J59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030465; ENSMUSP00000030465; ENSMUSG00000028699.
GeneIDi66805.
KEGGimmu:66805.
UCSCiuc008ugk.1. mouse.

Organism-specific databases

CTDi10103.
MGIiMGI:1914055. Tspan1.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
InParanoidiQ99J59.
KOiK17348.
OMAiFTQVWNT.
OrthoDBiEOG7CK38F.
PhylomeDBiQ99J59.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiTspan1. mouse.
PROiQ99J59.
SOURCEiSearch...

Gene expression databases

BgeeiQ99J59.
ExpressionAtlasiQ99J59. baseline and differential.
GenevisibleiQ99J59. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTSN1_MOUSE
AccessioniPrimary (citable) accession number: Q99J59
Secondary accession number(s): A6PW93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.