Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99J47

- DRS7B_MOUSE

UniProt

Q99J47 - DRS7B_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei192 – 1921SubstrateSequence Analysis
Active sitei205 – 2051Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 8025NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Gene namesi
Name:Dhrs7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2384931. Dhrs7b.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Dehydrogenase/reductase SDR family member 7BPRO_0000312106Add
BLAST

Proteomic databases

MaxQBiQ99J47.
PaxDbiQ99J47.
PRIDEiQ99J47.

PTM databases

PhosphoSiteiQ99J47.

Expressioni

Gene expression databases

BgeeiQ99J47.
CleanExiMM_DHRS7B.
ExpressionAtlasiQ99J47. baseline and differential.
GenevestigatoriQ99J47.

Interactioni

Protein-protein interaction databases

BioGridi229794. 1 interaction.
IntActiQ99J47. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99J47.
SMRiQ99J47. Positions 50-301.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini39 – 323285LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118798.
HOVERGENiHBG107825.
InParanoidiQ99J47.
KOiK11166.
OMAiQGKFAIP.
OrthoDBiEOG7W6WM5.
PhylomeDBiQ99J47.
TreeFamiTF313474.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99J47-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPSFRKGM LKERVMDLAS QTTILPLLFG CLGIFSLFRL LQRIRSKAYL
60 70 80 90 100
RNAVVVVTGA TSGLGRECAK VFHAAGAKLV LCGRNVKALE ELSRELAGSS
110 120 130 140 150
QGQTHQPFVV TFDLADPGTI AAAAAEILQC FGYVDVLINN AGISYRGTIS
160 170 180 190 200
DTIVDVDRKV MEINYFGPVA LTKALLPSMV ERKQGHIVAI SSIQGKISIP
210 220 230 240 250
FRSAYSASKH ATQAFFDCLR AEMEEANIKV TVISPGYIHT NLSVNAVTAD
260 270 280 290 300
GSRYGALDKN TAQGRSAAEV AQDVFDAVGK KKKDVLLTDF VPSMAVYIRT
310 320
LAPGLFFRIM ASRARKERKS KSS
Length:323
Mass (Da):34,987
Last modified:June 1, 2001 - v1
Checksum:i6C75A07F9BC9B398
GO
Isoform 2 (identifier: Q99J47-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:314
Mass (Da):33,982
Checksum:i1E04957327E4F1C6
GO

Sequence cautioni

The sequence CAI35261.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99Missing in isoform 2. 1 PublicationVSP_029698

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052209 mRNA. Translation: BAC34887.1.
AK139084 mRNA. Translation: BAE23884.1.
AK144057 mRNA. Translation: BAE25674.1.
AL596215 Genomic DNA. Translation: CAI35261.1. Different initiation.
BC003479 mRNA. Translation: AAH03479.1.
CCDSiCCDS24800.1. [Q99J47-1]
RefSeqiNP_001165583.1. NM_001172112.1. [Q99J47-2]
NP_663403.1. NM_145428.2. [Q99J47-1]
UniGeneiMm.21475.

Genome annotation databases

EnsembliENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569. [Q99J47-1]
GeneIDi216820.
KEGGimmu:216820.
UCSCiuc007jgq.2. mouse. [Q99J47-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052209 mRNA. Translation: BAC34887.1 .
AK139084 mRNA. Translation: BAE23884.1 .
AK144057 mRNA. Translation: BAE25674.1 .
AL596215 Genomic DNA. Translation: CAI35261.1 . Different initiation.
BC003479 mRNA. Translation: AAH03479.1 .
CCDSi CCDS24800.1. [Q99J47-1 ]
RefSeqi NP_001165583.1. NM_001172112.1. [Q99J47-2 ]
NP_663403.1. NM_145428.2. [Q99J47-1 ]
UniGenei Mm.21475.

3D structure databases

ProteinModelPortali Q99J47.
SMRi Q99J47. Positions 50-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229794. 1 interaction.
IntActi Q99J47. 1 interaction.

PTM databases

PhosphoSitei Q99J47.

Proteomic databases

MaxQBi Q99J47.
PaxDbi Q99J47.
PRIDEi Q99J47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042281 ; ENSMUSP00000044924 ; ENSMUSG00000042569 . [Q99J47-1 ]
GeneIDi 216820.
KEGGi mmu:216820.
UCSCi uc007jgq.2. mouse. [Q99J47-1 ]

Organism-specific databases

CTDi 25979.
MGIi MGI:2384931. Dhrs7b.

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00760000118798.
HOVERGENi HBG107825.
InParanoidi Q99J47.
KOi K11166.
OMAi QGKFAIP.
OrthoDBi EOG7W6WM5.
PhylomeDBi Q99J47.
TreeFami TF313474.

Miscellaneous databases

NextBioi 375350.
PROi Q99J47.
SOURCEi Search...

Gene expression databases

Bgeei Q99J47.
CleanExi MM_DHRS7B.
ExpressionAtlasi Q99J47. baseline and differential.
Genevestigatori Q99J47.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Embryonic heart and Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiDRS7B_MOUSE
AccessioniPrimary (citable) accession number: Q99J47
Secondary accession number(s): Q3UNS3, Q5NCT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3