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Q99J47

- DRS7B_MOUSE

UniProt

Q99J47 - DRS7B_MOUSE

Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Putative oxidoreductase.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei192 – 1921SubstrateSequence Analysis
    Active sitei205 – 2051Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 8025NAD or NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
    Gene namesi
    Name:Dhrs7b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2384931. Dhrs7b.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Dehydrogenase/reductase SDR family member 7BPRO_0000312106Add
    BLAST

    Proteomic databases

    MaxQBiQ99J47.
    PaxDbiQ99J47.
    PRIDEiQ99J47.

    PTM databases

    PhosphoSiteiQ99J47.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99J47.
    BgeeiQ99J47.
    CleanExiMM_DHRS7B.
    GenevestigatoriQ99J47.

    Interactioni

    Protein-protein interaction databases

    BioGridi229794. 1 interaction.
    IntActiQ99J47. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99J47.
    SMRiQ99J47. Positions 50-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 323285LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    GeneTreeiENSGT00740000115336.
    HOVERGENiHBG107825.
    InParanoidiQ99J47.
    KOiK11166.
    OMAiQGKFAIP.
    OrthoDBiEOG7W6WM5.
    PhylomeDBiQ99J47.
    TreeFamiTF313474.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99J47-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MISPSFRKGM LKERVMDLAS QTTILPLLFG CLGIFSLFRL LQRIRSKAYL    50
    RNAVVVVTGA TSGLGRECAK VFHAAGAKLV LCGRNVKALE ELSRELAGSS 100
    QGQTHQPFVV TFDLADPGTI AAAAAEILQC FGYVDVLINN AGISYRGTIS 150
    DTIVDVDRKV MEINYFGPVA LTKALLPSMV ERKQGHIVAI SSIQGKISIP 200
    FRSAYSASKH ATQAFFDCLR AEMEEANIKV TVISPGYIHT NLSVNAVTAD 250
    GSRYGALDKN TAQGRSAAEV AQDVFDAVGK KKKDVLLTDF VPSMAVYIRT 300
    LAPGLFFRIM ASRARKERKS KSS 323
    Length:323
    Mass (Da):34,987
    Last modified:June 1, 2001 - v1
    Checksum:i6C75A07F9BC9B398
    GO
    Isoform 2 (identifier: Q99J47-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:314
    Mass (Da):33,982
    Checksum:i1E04957327E4F1C6
    GO

    Sequence cautioni

    The sequence CAI35261.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99Missing in isoform 2. 1 PublicationVSP_029698

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052209 mRNA. Translation: BAC34887.1.
    AK139084 mRNA. Translation: BAE23884.1.
    AK144057 mRNA. Translation: BAE25674.1.
    AL596215 Genomic DNA. Translation: CAI35261.1. Different initiation.
    BC003479 mRNA. Translation: AAH03479.1.
    CCDSiCCDS24800.1. [Q99J47-1]
    RefSeqiNP_001165583.1. NM_001172112.1. [Q99J47-2]
    NP_663403.1. NM_145428.2. [Q99J47-1]
    UniGeneiMm.21475.

    Genome annotation databases

    EnsembliENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569. [Q99J47-1]
    GeneIDi216820.
    KEGGimmu:216820.
    UCSCiuc007jgq.2. mouse. [Q99J47-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052209 mRNA. Translation: BAC34887.1 .
    AK139084 mRNA. Translation: BAE23884.1 .
    AK144057 mRNA. Translation: BAE25674.1 .
    AL596215 Genomic DNA. Translation: CAI35261.1 . Different initiation.
    BC003479 mRNA. Translation: AAH03479.1 .
    CCDSi CCDS24800.1. [Q99J47-1 ]
    RefSeqi NP_001165583.1. NM_001172112.1. [Q99J47-2 ]
    NP_663403.1. NM_145428.2. [Q99J47-1 ]
    UniGenei Mm.21475.

    3D structure databases

    ProteinModelPortali Q99J47.
    SMRi Q99J47. Positions 50-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229794. 1 interaction.
    IntActi Q99J47. 1 interaction.

    PTM databases

    PhosphoSitei Q99J47.

    Proteomic databases

    MaxQBi Q99J47.
    PaxDbi Q99J47.
    PRIDEi Q99J47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042281 ; ENSMUSP00000044924 ; ENSMUSG00000042569 . [Q99J47-1 ]
    GeneIDi 216820.
    KEGGi mmu:216820.
    UCSCi uc007jgq.2. mouse. [Q99J47-1 ]

    Organism-specific databases

    CTDi 25979.
    MGIi MGI:2384931. Dhrs7b.

    Phylogenomic databases

    eggNOGi COG1028.
    GeneTreei ENSGT00740000115336.
    HOVERGENi HBG107825.
    InParanoidi Q99J47.
    KOi K11166.
    OMAi QGKFAIP.
    OrthoDBi EOG7W6WM5.
    PhylomeDBi Q99J47.
    TreeFami TF313474.

    Miscellaneous databases

    NextBioi 375350.
    PROi Q99J47.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99J47.
    Bgeei Q99J47.
    CleanExi MM_DHRS7B.
    Genevestigatori Q99J47.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Cerebellum, Embryonic heart and Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N-3.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiDRS7B_MOUSE
    AccessioniPrimary (citable) accession number: Q99J47
    Secondary accession number(s): Q3UNS3, Q5NCT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3