Q99J39 (DCMC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malonyl-CoA decarboxylase, mitochondrial
Short name=MCD
EC=4.1.1.9

Gene names

Name:

Mlycd

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced By similarity.
Catalytic activity	Malonyl-CoA = acetyl-CoA + CO2.
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1.
Subcellular location	Mitochondrion. Cytoplasm. Peroxisome.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm Mitochondrion Peroxisome
Coding sequence diversity	Alternative initiation
Domain	Transit peptide
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acetyl-CoA biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW fatty acid oxidation Inferred from electronic annotation. Source: Compara malonyl-CoA catabolic process Inferred from electronic annotation. Source: Compara positive regulation of fatty acid oxidation Inferred from electronic annotation. Source: Compara regulation of fatty acid beta-oxidation Inferred from electronic annotation. Source: Compara regulation of glucose metabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara mitochondrion Inferred from direct assay PubMed 14651853PubMed 18614015. Source: MGI peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	malonyl-CoA decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform Mitochondrial (identifier: Q99J39-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Cytoplasmic+peroxisomal (identifier: Q99J39-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 492		Malonyl-CoA decarboxylase, mitochondrial		PRO_0000021090
Regions
	Motif	490 – 492	3	Microbody targeting signal Potential
Natural variations
	Alternative sequence	1 – 38	38	Missing in isoform Cytoplasmic+peroxisomal.		VSP_018817

Sequences

	Sequence		Length	Mass (Da)
	Isoform Mitochondrial [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CEBDA62714A21DC1	FASTA	492	54,736
	10 20 30 40 50 60 MRGLGPGLRA RRLLPLRSPP RPPGPRGRRL CGGLAASAMD ELLRRAVPPT PAYELREKTP 70 80 90 100 110 120 APAEGQCADF VSFYGGLAEA SQRAELLGRL AQGFGVDHGQ VAEQSAGVLQ LRQQAREAAV 130 140 150 160 170 180 LLQAEDRLRY ALVPRYRGLF HHISKLDGGV RFLVQLRADL LEAQALKLVE GPHVREMNGV 190 200 210 220 230 240 LKSMLSEWFS SGFLNLERVT WHSPCEVLQK ISECEAVHPV KNWMDMKRRV GPYRRCYFFS 250 260 270 280 290 300 HCSTPGEPLV VLHVALTGDI SNNIQGIVKE CPPTETEERN RIAAAIFYSI SLTQQGLQGV 310 320 330 340 350 360 ELGTFLIKRV VKELQKEFPQ LGAFSSLSPI PGFTKWLLGL LNVQGKEHGR NELFTDSECQ 370 380 390 400 410 420 EISAVTGNPV HESLKGFLSS GEWVKSEKLT QALQGPLMRL CAWYLYGEKH RGYALNPVAN 430 440 450 460 470 480 FHLQNGAVMW RINWMADSSL KGLTSSCGLM VNYRYYLEET GPNSISYLGS KNIKASEQIL 490 SLVAQFQNNS KL
	Isoform Cytoplasmic+peroxisomal [UniParc]. Checksum: 233693B9C1BF74CA	FASTA	454	50,766
	10 20 30 40 50 60 MDELLRRAVP PTPAYELREK TPAPAEGQCA DFVSFYGGLA EASQRAELLG RLAQGFGVDH 70 80 90 100 110 120 GQVAEQSAGV LQLRQQAREA AVLLQAEDRL RYALVPRYRG LFHHISKLDG GVRFLVQLRA 130 140 150 160 170 180 DLLEAQALKL VEGPHVREMN GVLKSMLSEW FSSGFLNLER VTWHSPCEVL QKISECEAVH 190 200 210 220 230 240 PVKNWMDMKR RVGPYRRCYF FSHCSTPGEP LVVLHVALTG DISNNIQGIV KECPPTETEE 250 260 270 280 290 300 RNRIAAAIFY SISLTQQGLQ GVELGTFLIK RVVKELQKEF PQLGAFSSLS PIPGFTKWLL 310 320 330 340 350 360 GLLNVQGKEH GRNELFTDSE CQEISAVTGN PVHESLKGFL SSGEWVKSEK LTQALQGPLM 370 380 390 400 410 420 RLCAWYLYGE KHRGYALNPV ANFHLQNGAV MWRINWMADS SLKGLTSSCG LMVNYRYYLE 430 440 450 ETGPNSISYL GSKNIKASEQ ILSLVAQFQN NSKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129, C57BL/6J and FVB/N. Tissue: Mammary tumor.
[3]	"Mouse malonyl-CoA decarboxylase: genome structure, cDNA cloning, expression and promoter study." Kim N.H., Lee G.Y., Kim Y.S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-175. Strain: 129S6/SvEvTac.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK082479 mRNA. Translation: BAC38505.1. BC004764 mRNA. Translation: AAH04764.1. AY331094 Genomic DNA. Translation: AAP93335.2.
IPI	IPI00114866. IPI00759857.
RefSeq	NP_064350.2. NM_019966.2.
UniGene	Mm.423037.
3D structure databases
ProteinModelPortal	Q99J39.
SMR	Q99J39. Positions 38-486.
ModBase	Search...
PTM databases
PhosphoSite	Q99J39.
Proteomic databases
PaxDb	Q99J39.
PRIDE	Q99J39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000098367; ENSMUSP00000095970; ENSMUSG00000074064.
GeneID	56690.
KEGG	mmu:56690.
UCSC	uc009npn.1. mouse.
Organism-specific databases
CTD	23417.
MGI	MGI:1928485. Mlycd.
Phylogenomic databases
eggNOG	COG1593.
GeneTree	ENSGT00390000005410.
HOGENOM	HOG000141409.
HOVERGEN	HBG000825.
InParanoid	Q99J39.
KO	K01578.
OMA	APADRRC.
OrthoDB	EOG4RBQJF.
Enzyme and pathway databases
UniPathway	UPA00340; UER00710.
Gene expression databases
Bgee	Q99J39.
CleanEx	MM_MLYCD.
Genevestigator	Q99J39.
GermOnline	ENSMUSG00000074064. Mus musculus.
Family and domain databases
InterPro	IPR007956. Malonyl_CoA_deC. [Graphical view]
Pfam	PF05292. MCD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q99J39.
ChEMBL	CHEMBL1255162.
NextBio	313103.
SOURCE	Search...

Entry information

Entry name

DCMC_MOUSE

Accession

Primary (citable) accession number: Q99J39
Secondary accession number(s): Q7TNL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program