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Protein

Oligophrenin-1

Gene

Ophn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • GTPase activator activity Source: MGI
  • phospholipid binding Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • negative regulation of proteasomal protein catabolic process Source: UniProtKB
  • nervous system development Source: UniProtKB-KW
  • regulation of endocytosis Source: MGI
  • regulation of synaptic transmission, glutamatergic Source: MGI
  • signal transduction Source: InterPro
  • synaptic vesicle endocytosis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Endocytosis, Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligophrenin-1
Gene namesi
Name:Ophn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2151070. Ophn1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • cytosol Source: GOC
  • dendrite Source: UniProtKB
  • dendritic spine Source: UniProtKB
  • terminal bouton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Oligophrenin-1PRO_0000056761Add
BLAST

Proteomic databases

MaxQBiQ99J31.
PaxDbiQ99J31.
PRIDEiQ99J31.

PTM databases

iPTMnetiQ99J31.
PhosphoSiteiQ99J31.

Expressioni

Gene expression databases

BgeeiQ99J31.
CleanExiMM_OPHN1.
ExpressionAtlasiQ99J31. baseline and differential.
GenevisibleiQ99J31. MM.

Interactioni

Subunit structurei

Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1) (By similarity). Interacts (via C-terminus) with NR1D1.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033560.

Structurei

3D structure databases

ProteinModelPortaliQ99J31.
SMRiQ99J31. Positions 14-364, 381-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 368104PHPROSITE-ProRule annotationAdd
BLAST
Domaini380 – 564185Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi629 – 761133Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1451. Eukaryota.
ENOG410YJPS. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000018767.
HOVERGENiHBG067993.
InParanoidiQ99J31.
OMAiNVCEHSR.
OrthoDBiEOG71VSS5.
PhylomeDBiQ99J31.
TreeFamiTF316851.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99J31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHPPLEFSD CYLDSPDFRQ RLKYYEEELE RTNKFIKDVI KDGSALISAM
60 70 80 90 100
RNYSSAVQKF SQTLQSFQFD FIGDTLTDDE INIAESFKEF AELLNEVENE
110 120 130 140 150
RMMMVQNASD LLIKPLETFR KEQIGFTKER KKKFEKDGER FYSLLDRHLH
160 170 180 190 200
LSSKKKESQL LEADLQVDKE RHNFFESSLD YVYQIQEVQE SKKFNIVEPV
210 220 230 240 250
LAFLHSLFIS NSLTVELTQD FLPYKQQLQL SLQNTRNHFS STREEMEELK
260 270 280 290 300
KRMKEAPQTC KLPGQPTIEG YLYTQEKWAL GISWAKYYCR YEKETRMLTM
310 320 330 340 350
IPMEQKPGAK QGPVDLTLKY CVRRKTESID KRFCFDIETN ERPGTITLQA
360 370 380 390 400
PSEANRRLWM EAMDGKEPIY HTPITKQEEM ELNEVGFKFV RKCINFIETK
410 420 430 440 450
GIKTEGLYRT VGSNIQVQKL LYAFFDPKCP GDVDFHNSDW DIKTITSSLK
460 470 480 490 500
FYLRNLSEPV MTYKLHKELV SAAKSDNLDY RLGAIHSLVY KLPEKNREML
510 520 530 540 550
ELLIKHLVNV CEHSKENLMT PSNMGVIFGP TLMRAQEDTV AAMMNIKFQN
560 570 580 590 600
IVVEILIEHF GKIYLGPPED SQVPPVPPPR VTARRHKPIT ISKRLLREKT
610 620 630 640 650
VFYTSSLDEN KDESHHQTPN GTITSNLDPP KLLQHLKPPM QKSGETDPGR
660 670 680 690 700
KSPSRPVSDC QSEPCLETDV GRLLFRLQDG GTKATPKASN GPVPGSGHTK
710 720 730 740 750
TSSFHIRRPA PRPMAHHKEG DTDGFSKVRP PGEKQTIIRP PVRPPDPPCR
760 770 780 790 800
SITPQKPEPK PETGSGNADE IPSSVVASRT RFFETASRKT GSSQGKLPGD

ES
Length:802
Mass (Da):91,985
Last modified:June 1, 2001 - v1
Checksum:i08ECD6694F19B69C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031419 mRNA. Translation: BAC27395.1.
AK036038 mRNA. Translation: BAC29282.1.
AK087469 mRNA. Translation: BAC39887.1.
BC004845 mRNA. Translation: AAH04845.1.
CCDSiCCDS30295.1.
RefSeqiNP_001300683.1. NM_001313754.1.
NP_001300684.1. NM_001313755.1.
NP_001300685.1. NM_001313756.1.
NP_443208.1. NM_052976.4.
UniGeneiMm.254336.
Mm.33536.

Genome annotation databases

EnsembliENSMUST00000033560; ENSMUSP00000033560; ENSMUSG00000031214.
ENSMUST00000113826; ENSMUSP00000109457; ENSMUSG00000031214.
GeneIDi94190.
KEGGimmu:94190.
UCSCiuc009tux.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031419 mRNA. Translation: BAC27395.1.
AK036038 mRNA. Translation: BAC29282.1.
AK087469 mRNA. Translation: BAC39887.1.
BC004845 mRNA. Translation: AAH04845.1.
CCDSiCCDS30295.1.
RefSeqiNP_001300683.1. NM_001313754.1.
NP_001300684.1. NM_001313755.1.
NP_001300685.1. NM_001313756.1.
NP_443208.1. NM_052976.4.
UniGeneiMm.254336.
Mm.33536.

3D structure databases

ProteinModelPortaliQ99J31.
SMRiQ99J31. Positions 14-364, 381-569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033560.

PTM databases

iPTMnetiQ99J31.
PhosphoSiteiQ99J31.

Proteomic databases

MaxQBiQ99J31.
PaxDbiQ99J31.
PRIDEiQ99J31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033560; ENSMUSP00000033560; ENSMUSG00000031214.
ENSMUST00000113826; ENSMUSP00000109457; ENSMUSG00000031214.
GeneIDi94190.
KEGGimmu:94190.
UCSCiuc009tux.1. mouse.

Organism-specific databases

CTDi4983.
MGIiMGI:2151070. Ophn1.

Phylogenomic databases

eggNOGiKOG1451. Eukaryota.
ENOG410YJPS. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000018767.
HOVERGENiHBG067993.
InParanoidiQ99J31.
OMAiNVCEHSR.
OrthoDBiEOG71VSS5.
PhylomeDBiQ99J31.
TreeFamiTF316851.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

PROiQ99J31.
SOURCEiSearch...

Gene expression databases

BgeeiQ99J31.
CleanExiMM_OPHN1.
ExpressionAtlasiQ99J31. baseline and differential.
GenevisibleiQ99J31. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Eye and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Kidney.
  4. "A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha."
    Valnegri P., Khelfaoui M., Dorseuil O., Bassani S., Lagneaux C., Gianfelice A., Benfante R., Chelly J., Billuart P., Sala C., Passafaro M.
    Nat. Neurosci. 14:1293-1301(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NR1D1.

Entry informationi

Entry nameiOPHN1_MOUSE
AccessioniPrimary (citable) accession number: Q99J31
Secondary accession number(s): Q544K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.