Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oligophrenin-1

Gene

Ophn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • GTPase activator activity Source: MGI
  • ionotropic glutamate receptor binding Source: Ensembl
  • phospholipid binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processEndocytosis, Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Oligophrenin-1
Gene namesi
Name:Ophn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2151070 Ophn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567611 – 802Oligophrenin-1Add BLAST802

Proteomic databases

MaxQBiQ99J31
PaxDbiQ99J31
PRIDEiQ99J31

PTM databases

iPTMnetiQ99J31
PhosphoSitePlusiQ99J31

Expressioni

Gene expression databases

BgeeiENSMUSG00000031214
CleanExiMM_OPHN1
ExpressionAtlasiQ99J31 baseline and differential
GenevisibleiQ99J31 MM

Interactioni

Subunit structurei

Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1) (By similarity). Interacts (via C-terminus) with NR1D1.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • ionotropic glutamate receptor binding Source: Ensembl

Protein-protein interaction databases

BioGridi220466, 1 interactor
IntActiQ99J31, 1 interactor
STRINGi10090.ENSMUSP00000033560

Structurei

3D structure databases

ProteinModelPortaliQ99J31
SMRiQ99J31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 368PHPROSITE-ProRule annotationAdd BLAST104
Domaini380 – 564Rho-GAPPROSITE-ProRule annotationAdd BLAST185

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi629 – 761Pro-richAdd BLAST133

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00890000139322
HOGENOMiHOG000018767
HOVERGENiHBG067993
InParanoidiQ99J31
KOiK20650
OMAiVRKCINA
OrthoDBiEOG091G01TT
PhylomeDBiQ99J31
TreeFamiTF316851

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q99J31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHPPLEFSD CYLDSPDFRQ RLKYYEEELE RTNKFIKDVI KDGSALISAM
60 70 80 90 100
RNYSSAVQKF SQTLQSFQFD FIGDTLTDDE INIAESFKEF AELLNEVENE
110 120 130 140 150
RMMMVQNASD LLIKPLETFR KEQIGFTKER KKKFEKDGER FYSLLDRHLH
160 170 180 190 200
LSSKKKESQL LEADLQVDKE RHNFFESSLD YVYQIQEVQE SKKFNIVEPV
210 220 230 240 250
LAFLHSLFIS NSLTVELTQD FLPYKQQLQL SLQNTRNHFS STREEMEELK
260 270 280 290 300
KRMKEAPQTC KLPGQPTIEG YLYTQEKWAL GISWAKYYCR YEKETRMLTM
310 320 330 340 350
IPMEQKPGAK QGPVDLTLKY CVRRKTESID KRFCFDIETN ERPGTITLQA
360 370 380 390 400
PSEANRRLWM EAMDGKEPIY HTPITKQEEM ELNEVGFKFV RKCINFIETK
410 420 430 440 450
GIKTEGLYRT VGSNIQVQKL LYAFFDPKCP GDVDFHNSDW DIKTITSSLK
460 470 480 490 500
FYLRNLSEPV MTYKLHKELV SAAKSDNLDY RLGAIHSLVY KLPEKNREML
510 520 530 540 550
ELLIKHLVNV CEHSKENLMT PSNMGVIFGP TLMRAQEDTV AAMMNIKFQN
560 570 580 590 600
IVVEILIEHF GKIYLGPPED SQVPPVPPPR VTARRHKPIT ISKRLLREKT
610 620 630 640 650
VFYTSSLDEN KDESHHQTPN GTITSNLDPP KLLQHLKPPM QKSGETDPGR
660 670 680 690 700
KSPSRPVSDC QSEPCLETDV GRLLFRLQDG GTKATPKASN GPVPGSGHTK
710 720 730 740 750
TSSFHIRRPA PRPMAHHKEG DTDGFSKVRP PGEKQTIIRP PVRPPDPPCR
760 770 780 790 800
SITPQKPEPK PETGSGNADE IPSSVVASRT RFFETASRKT GSSQGKLPGD

ES
Length:802
Mass (Da):91,985
Last modified:June 1, 2001 - v1
Checksum:i08ECD6694F19B69C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031419 mRNA Translation: BAC27395.1
AK036038 mRNA Translation: BAC29282.1
AK087469 mRNA Translation: BAC39887.1
BC004845 mRNA Translation: AAH04845.1
CCDSiCCDS30295.1
RefSeqiNP_001300683.1, NM_001313754.1
NP_001300684.1, NM_001313755.1
NP_001300685.1, NM_001313756.1
NP_443208.1, NM_052976.4
UniGeneiMm.254336
Mm.33536

Genome annotation databases

EnsembliENSMUST00000033560; ENSMUSP00000033560; ENSMUSG00000031214
ENSMUST00000113826; ENSMUSP00000109457; ENSMUSG00000031214
GeneIDi94190
KEGGimmu:94190
UCSCiuc009tux.1 mouse

Similar proteinsi

Entry informationi

Entry nameiOPHN1_MOUSE
AccessioniPrimary (citable) accession number: Q99J31
Secondary accession number(s): Q544K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health