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Q99J27

- ACATN_MOUSE

UniProt

Q99J27 - ACATN_MOUSE

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Protein

Acetyl-coenzyme A transporter 1

Gene
Slc33a1, Acatn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.1 Publication

GO - Molecular functioni

  1. acetyl-CoA transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A transporter 1
Short name:
AT-1
Short name:
Acetyl-CoA transporter 1
Alternative name(s):
Solute carrier family 33 member 1
Gene namesi
Name:Slc33a1
Synonyms:Acatn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1332247. Slc33a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei75 – 9521Helical; Reviewed predictionAdd
BLAST
Topological domaini96 – 11318Extracellular Reviewed predictionAdd
BLAST
Transmembranei114 – 13421Helical; Reviewed predictionAdd
BLAST
Topological domaini135 – 1417Cytoplasmic Reviewed prediction
Transmembranei142 – 16221Helical; Reviewed predictionAdd
BLAST
Topological domaini163 – 17513Extracellular Reviewed predictionAdd
BLAST
Transmembranei176 – 19621Helical; Reviewed predictionAdd
BLAST
Topological domaini197 – 21721Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei218 – 23821Helical; Reviewed predictionAdd
BLAST
Topological domaini239 – 25618Extracellular Reviewed predictionAdd
BLAST
Transmembranei257 – 27721Helical; Reviewed predictionAdd
BLAST
Topological domaini278 – 30023Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei301 – 32121Helical; Reviewed predictionAdd
BLAST
Topological domaini322 – 34423Extracellular Reviewed predictionAdd
BLAST
Transmembranei345 – 36521Helical; Reviewed predictionAdd
BLAST
Topological domaini366 – 37510Cytoplasmic Reviewed prediction
Transmembranei376 – 39621Helical; Reviewed predictionAdd
BLAST
Topological domaini397 – 4059Extracellular Reviewed prediction
Transmembranei406 – 42621Helical; Reviewed predictionAdd
BLAST
Topological domaini427 – 50983Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei510 – 53021Helical; Reviewed predictionAdd
BLAST
Topological domaini531 – 55020Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Acetyl-coenzyme A transporter 1PRO_0000076166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphoserine1 Publication
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99J27.
PaxDbiQ99J27.
PRIDEiQ99J27.

PTM databases

PhosphoSiteiQ99J27.

Expressioni

Tissue specificityi

Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney.1 Publication

Developmental stagei

Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development.1 Publication

Gene expression databases

ArrayExpressiQ99J27.
BgeeiQ99J27.
GenevestigatoriQ99J27.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029402.

Structurei

3D structure databases

ProteinModelPortaliQ99J27.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ99J27.
KOiK03372.
OMAiYSLKLFW.
OrthoDBiEOG747PHW.
PhylomeDBiQ99J27.
TreeFamiTF300008.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERiPTHR12778:SF3. PTHR12778:SF3. 1 hit.
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99J27-1 [UniParc]FASTAAdd to Basket

« Hide

MSPTISHKDS SRQRRSGMFS HALDMKSGPL PPGGWDDSRR DSVGGEGDRE    50
VLLGDAGPGD LPKAPRSYRS ELSSILLLLF LYVLQGIPLG LAGSIPLILQ 100
SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYFKNFGRR KSWLVPTQYT 150
LGIFMIYLST QVDRLLGNID GRTPDVVALT VTFFLFEFLA ATQDIAVDGW 200
ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ 250
PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENREASIVKE ETQGITDTYK 300
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA 350
VPMVPLQIIL PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK 400
VEHQGGFPLY YYIIVLLSYA LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM 450
TLLNTVSNLG GNWPSTVALW LVDPLTVKEC VGASNQNCRT PDAIELCKKL 500
GGSCVTALDG YYVESIICVL IGFGWWFFLG PKFKKLQDEG PSSWKCKRNN 550
Length:550
Mass (Da):61,075
Last modified:June 1, 2001 - v1
Checksum:i5A55A7F40A2A9661
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2573VTL → GNP1 Publication
Sequence conflicti255 – 2573VTL → GNP1 Publication
Sequence conflicti274 – 2752LV → SL1 Publication
Sequence conflicti274 – 2752LV → SL1 Publication
Sequence conflicti293 – 2931Q → P1 Publication
Sequence conflicti293 – 2931Q → P1 Publication
Sequence conflicti337 – 3371V → E1 Publication
Sequence conflicti337 – 3371V → E1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016795 mRNA. Translation: BAA76933.1.
AB037368 Genomic DNA. Translation: BAA93087.1.
BC005616 mRNA. Translation: AAH05616.1.
BC054395 mRNA. Translation: AAH54395.1.
BC063104 mRNA. Translation: AAH63104.1.
CCDSiCCDS17382.1.
RefSeqiNP_001258964.1. NM_001272035.1.
NP_056543.2. NM_015728.5.
UniGeneiMm.135619.

Genome annotation databases

EnsembliENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822.
ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822.
ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822.
GeneIDi11416.
KEGGimmu:11416.
UCSCiuc008pkc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016795 mRNA. Translation: BAA76933.1 .
AB037368 Genomic DNA. Translation: BAA93087.1 .
BC005616 mRNA. Translation: AAH05616.1 .
BC054395 mRNA. Translation: AAH54395.1 .
BC063104 mRNA. Translation: AAH63104.1 .
CCDSi CCDS17382.1.
RefSeqi NP_001258964.1. NM_001272035.1.
NP_056543.2. NM_015728.5.
UniGenei Mm.135619.

3D structure databases

ProteinModelPortali Q99J27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029402.

PTM databases

PhosphoSitei Q99J27.

Proteomic databases

MaxQBi Q99J27.
PaxDbi Q99J27.
PRIDEi Q99J27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029402 ; ENSMUSP00000029402 ; ENSMUSG00000027822 .
ENSMUST00000160883 ; ENSMUSP00000125713 ; ENSMUSG00000027822 .
ENSMUST00000161659 ; ENSMUSP00000123986 ; ENSMUSG00000027822 .
GeneIDi 11416.
KEGGi mmu:11416.
UCSCi uc008pkc.1. mouse.

Organism-specific databases

CTDi 9197.
MGIi MGI:1332247. Slc33a1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00730000111115.
HOGENOMi HOG000194770.
HOVERGENi HBG052723.
InParanoidi Q99J27.
KOi K03372.
OMAi YSLKLFW.
OrthoDBi EOG747PHW.
PhylomeDBi Q99J27.
TreeFami TF300008.

Miscellaneous databases

ChiTaRSi SLC33A1. mouse.
NextBioi 278654.
PROi Q99J27.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99J27.
Bgeei Q99J27.
Genevestigatori Q99J27.

Family and domain databases

InterProi IPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
PANTHERi PTHR12778:SF3. PTHR12778:SF3. 1 hit.
Pfami PF13000. Acatn. 2 hits.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00901. 2A0125. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA."
    Bora R.S., Kanamori A., Hirabayashi Y.
    Gene 238:455-462(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Tissue: Melanoma.
  2. "Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene."
    Bora R.S., Ichikawa S., Kanamori A., Hirabayashi Y.
    FEBS Lett. 473:169-172(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129 and FVB/N.
    Tissue: Eye, Kidney and Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACATN_MOUSE
AccessioniPrimary (citable) accession number: Q99J27
Secondary accession number(s): Q9WTN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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