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Q99J27

- ACATN_MOUSE

UniProt

Q99J27 - ACATN_MOUSE

Protein

Acetyl-coenzyme A transporter 1

Gene

Slc33a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.1 Publication

    GO - Molecular functioni

    1. acetyl-CoA transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-coenzyme A transporter 1
    Short name:
    AT-1
    Short name:
    Acetyl-CoA transporter 1
    Alternative name(s):
    Solute carrier family 33 member 1
    Gene namesi
    Name:Slc33a1
    Synonyms:Acatn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1332247. Slc33a1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Acetyl-coenzyme A transporter 1PRO_0000076166Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei42 – 421Phosphoserine1 Publication
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ99J27.
    PaxDbiQ99J27.
    PRIDEiQ99J27.

    PTM databases

    PhosphoSiteiQ99J27.

    Expressioni

    Tissue specificityi

    Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney.1 Publication

    Developmental stagei

    Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development.1 Publication

    Gene expression databases

    ArrayExpressiQ99J27.
    BgeeiQ99J27.
    GenevestigatoriQ99J27.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029402.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99J27.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 11318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 1417CytoplasmicSequence Analysis
    Topological domaini163 – 17513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini239 – 25618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini278 – 30023CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini322 – 34423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini366 – 37510CytoplasmicSequence Analysis
    Topological domaini397 – 4059ExtracellularSequence Analysis
    Topological domaini427 – 50983CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini531 – 55020ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei406 – 42621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei510 – 53021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC33A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00730000111115.
    HOGENOMiHOG000194770.
    HOVERGENiHBG052723.
    InParanoidiQ99J27.
    KOiK03372.
    OMAiYSLKLFW.
    OrthoDBiEOG747PHW.
    PhylomeDBiQ99J27.
    TreeFamiTF300008.

    Family and domain databases

    InterProiIPR024371. Acetyl-CoA_trnpstr_1.
    IPR004752. AmpG_permease/AT-1.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PANTHERiPTHR12778:SF3. PTHR12778:SF3. 1 hit.
    PfamiPF13000. Acatn. 2 hits.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00901. 2A0125. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99J27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPTISHKDS SRQRRSGMFS HALDMKSGPL PPGGWDDSRR DSVGGEGDRE    50
    VLLGDAGPGD LPKAPRSYRS ELSSILLLLF LYVLQGIPLG LAGSIPLILQ 100
    SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYFKNFGRR KSWLVPTQYT 150
    LGIFMIYLST QVDRLLGNID GRTPDVVALT VTFFLFEFLA ATQDIAVDGW 200
    ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ 250
    PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENREASIVKE ETQGITDTYK 300
    LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA 350
    VPMVPLQIIL PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK 400
    VEHQGGFPLY YYIIVLLSYA LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM 450
    TLLNTVSNLG GNWPSTVALW LVDPLTVKEC VGASNQNCRT PDAIELCKKL 500
    GGSCVTALDG YYVESIICVL IGFGWWFFLG PKFKKLQDEG PSSWKCKRNN 550
    Length:550
    Mass (Da):61,075
    Last modified:June 1, 2001 - v1
    Checksum:i5A55A7F40A2A9661
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2573VTL → GNP(PubMed:10570973)Curated
    Sequence conflicti255 – 2573VTL → GNP(PubMed:10812068)Curated
    Sequence conflicti274 – 2752LV → SL(PubMed:10570973)Curated
    Sequence conflicti274 – 2752LV → SL(PubMed:10812068)Curated
    Sequence conflicti293 – 2931Q → P(PubMed:10570973)Curated
    Sequence conflicti293 – 2931Q → P(PubMed:10812068)Curated
    Sequence conflicti337 – 3371V → E(PubMed:10570973)Curated
    Sequence conflicti337 – 3371V → E(PubMed:10812068)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016795 mRNA. Translation: BAA76933.1.
    AB037368 Genomic DNA. Translation: BAA93087.1.
    BC005616 mRNA. Translation: AAH05616.1.
    BC054395 mRNA. Translation: AAH54395.1.
    BC063104 mRNA. Translation: AAH63104.1.
    CCDSiCCDS17382.1.
    RefSeqiNP_001258964.1. NM_001272035.1.
    NP_056543.2. NM_015728.5.
    UniGeneiMm.135619.

    Genome annotation databases

    EnsembliENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822.
    ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822.
    ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822.
    GeneIDi11416.
    KEGGimmu:11416.
    UCSCiuc008pkc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016795 mRNA. Translation: BAA76933.1 .
    AB037368 Genomic DNA. Translation: BAA93087.1 .
    BC005616 mRNA. Translation: AAH05616.1 .
    BC054395 mRNA. Translation: AAH54395.1 .
    BC063104 mRNA. Translation: AAH63104.1 .
    CCDSi CCDS17382.1.
    RefSeqi NP_001258964.1. NM_001272035.1.
    NP_056543.2. NM_015728.5.
    UniGenei Mm.135619.

    3D structure databases

    ProteinModelPortali Q99J27.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029402.

    PTM databases

    PhosphoSitei Q99J27.

    Proteomic databases

    MaxQBi Q99J27.
    PaxDbi Q99J27.
    PRIDEi Q99J27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029402 ; ENSMUSP00000029402 ; ENSMUSG00000027822 .
    ENSMUST00000160883 ; ENSMUSP00000125713 ; ENSMUSG00000027822 .
    ENSMUST00000161659 ; ENSMUSP00000123986 ; ENSMUSG00000027822 .
    GeneIDi 11416.
    KEGGi mmu:11416.
    UCSCi uc008pkc.1. mouse.

    Organism-specific databases

    CTDi 9197.
    MGIi MGI:1332247. Slc33a1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00730000111115.
    HOGENOMi HOG000194770.
    HOVERGENi HBG052723.
    InParanoidi Q99J27.
    KOi K03372.
    OMAi YSLKLFW.
    OrthoDBi EOG747PHW.
    PhylomeDBi Q99J27.
    TreeFami TF300008.

    Miscellaneous databases

    ChiTaRSi SLC33A1. mouse.
    NextBioi 278654.
    PROi Q99J27.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99J27.
    Bgeei Q99J27.
    Genevestigatori Q99J27.

    Family and domain databases

    InterProi IPR024371. Acetyl-CoA_trnpstr_1.
    IPR004752. AmpG_permease/AT-1.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    PANTHERi PTHR12778:SF3. PTHR12778:SF3. 1 hit.
    Pfami PF13000. Acatn. 2 hits.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00901. 2A0125. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA."
      Bora R.S., Kanamori A., Hirabayashi Y.
      Gene 238:455-462(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Tissue: Melanoma.
    2. "Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene."
      Bora R.S., Ichikawa S., Kanamori A., Hirabayashi Y.
      FEBS Lett. 473:169-172(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129 and FVB/N.
      Tissue: Eye, Kidney and Mammary tumor.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiACATN_MOUSE
    AccessioniPrimary (citable) accession number: Q99J27
    Secondary accession number(s): Q9WTN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3