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Protein

Acetyl-coenzyme A transporter 1

Gene

Slc33a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:10570973). Negatively regulates BMP signaling (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_316120. Transport of vitamins, nucleosides, and related molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A transporter 1
Short name:
AT-1
Short name:
Acetyl-CoA transporter 1
Alternative name(s):
Solute carrier family 33 member 1
Gene namesi
Name:Slc33a1
Synonyms:Acatn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1332247. Slc33a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 11318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 1417CytoplasmicSequence Analysis
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 17513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 21721CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Topological domaini239 – 25618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Topological domaini278 – 30023CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST
Topological domaini322 – 34423ExtracellularSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Topological domaini366 – 37510CytoplasmicSequence Analysis
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Topological domaini397 – 4059ExtracellularSequence Analysis
Transmembranei406 – 42621HelicalSequence AnalysisAdd
BLAST
Topological domaini427 – 50983CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence AnalysisAdd
BLAST
Topological domaini531 – 55020ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Acetyl-coenzyme A transporter 1PRO_0000076166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphoserine1 Publication
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99J27.
PaxDbiQ99J27.
PRIDEiQ99J27.

PTM databases

PhosphoSiteiQ99J27.

Expressioni

Tissue specificityi

Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney.1 Publication

Developmental stagei

Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development.1 Publication

Gene expression databases

BgeeiQ99J27.
ExpressionAtlasiQ99J27. baseline and differential.
GenevisibleiQ99J27. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029402.

Structurei

3D structure databases

ProteinModelPortaliQ99J27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC33A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ99J27.
KOiK03372.
OMAiTNLGGNW.
OrthoDBiEOG747PHW.
PhylomeDBiQ99J27.
TreeFamiTF300008.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR12778:SF3. PTHR12778:SF3. 1 hit.
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99J27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPTISHKDS SRQRRSGMFS HALDMKSGPL PPGGWDDSRR DSVGGEGDRE
60 70 80 90 100
VLLGDAGPGD LPKAPRSYRS ELSSILLLLF LYVLQGIPLG LAGSIPLILQ
110 120 130 140 150
SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYFKNFGRR KSWLVPTQYT
160 170 180 190 200
LGIFMIYLST QVDRLLGNID GRTPDVVALT VTFFLFEFLA ATQDIAVDGW
210 220 230 240 250
ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ
260 270 280 290 300
PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENREASIVKE ETQGITDTYK
310 320 330 340 350
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA
360 370 380 390 400
VPMVPLQIIL PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK
410 420 430 440 450
VEHQGGFPLY YYIIVLLSYA LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM
460 470 480 490 500
TLLNTVSNLG GNWPSTVALW LVDPLTVKEC VGASNQNCRT PDAIELCKKL
510 520 530 540 550
GGSCVTALDG YYVESIICVL IGFGWWFFLG PKFKKLQDEG PSSWKCKRNN
Length:550
Mass (Da):61,075
Last modified:June 1, 2001 - v1
Checksum:i5A55A7F40A2A9661
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2573VTL → GNP (PubMed:10570973).Curated
Sequence conflicti255 – 2573VTL → GNP (PubMed:10812068).Curated
Sequence conflicti274 – 2752LV → SL (PubMed:10570973).Curated
Sequence conflicti274 – 2752LV → SL (PubMed:10812068).Curated
Sequence conflicti293 – 2931Q → P (PubMed:10570973).Curated
Sequence conflicti293 – 2931Q → P (PubMed:10812068).Curated
Sequence conflicti337 – 3371V → E (PubMed:10570973).Curated
Sequence conflicti337 – 3371V → E (PubMed:10812068).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016795 mRNA. Translation: BAA76933.1.
AB037368 Genomic DNA. Translation: BAA93087.1.
BC005616 mRNA. Translation: AAH05616.1.
BC054395 mRNA. Translation: AAH54395.1.
BC063104 mRNA. Translation: AAH63104.1.
CCDSiCCDS17382.1.
RefSeqiNP_001258964.1. NM_001272035.1.
NP_056543.2. NM_015728.5.
UniGeneiMm.135619.

Genome annotation databases

EnsembliENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822.
ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822.
ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822.
GeneIDi11416.
KEGGimmu:11416.
UCSCiuc008pkd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016795 mRNA. Translation: BAA76933.1.
AB037368 Genomic DNA. Translation: BAA93087.1.
BC005616 mRNA. Translation: AAH05616.1.
BC054395 mRNA. Translation: AAH54395.1.
BC063104 mRNA. Translation: AAH63104.1.
CCDSiCCDS17382.1.
RefSeqiNP_001258964.1. NM_001272035.1.
NP_056543.2. NM_015728.5.
UniGeneiMm.135619.

3D structure databases

ProteinModelPortaliQ99J27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029402.

PTM databases

PhosphoSiteiQ99J27.

Proteomic databases

MaxQBiQ99J27.
PaxDbiQ99J27.
PRIDEiQ99J27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822.
ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822.
ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822.
GeneIDi11416.
KEGGimmu:11416.
UCSCiuc008pkd.2. mouse.

Organism-specific databases

CTDi9197.
MGIiMGI:1332247. Slc33a1.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ99J27.
KOiK03372.
OMAiTNLGGNW.
OrthoDBiEOG747PHW.
PhylomeDBiQ99J27.
TreeFamiTF300008.

Enzyme and pathway databases

ReactomeiREACT_316120. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

ChiTaRSiSlc33a1. mouse.
NextBioi278654.
PROiQ99J27.
SOURCEiSearch...

Gene expression databases

BgeeiQ99J27.
ExpressionAtlasiQ99J27. baseline and differential.
GenevisibleiQ99J27. MM.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR12778:SF3. PTHR12778:SF3. 1 hit.
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA."
    Bora R.S., Kanamori A., Hirabayashi Y.
    Gene 238:455-462(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Tissue: Melanoma.
  2. "Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene."
    Bora R.S., Ichikawa S., Kanamori A., Hirabayashi Y.
    FEBS Lett. 473:169-172(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129 and FVB/N.
    Tissue: Eye, Kidney and Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACATN_MOUSE
AccessioniPrimary (citable) accession number: Q99J27
Secondary accession number(s): Q9WTN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.