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Q99J27 (ACATN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A transporter 1

Short name=AT-1
Short name=Acetyl-CoA transporter 1
Alternative name(s):
Solute carrier family 33 member 1
Gene names
Name:Slc33a1
Synonyms:Acatn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Ref.1

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney. Ref.1

Developmental stage

Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development. Ref.1

Sequence similarities

Belongs to the SLC33A transporter family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Acetyl-coenzyme A transporter 1
PRO_0000076166

Regions

Topological domain1 – 7474Cytoplasmic Potential
Transmembrane75 – 9521Helical; Potential
Topological domain96 – 11318Extracellular Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 1417Cytoplasmic Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 17513Extracellular Potential
Transmembrane176 – 19621Helical; Potential
Topological domain197 – 21721Cytoplasmic Potential
Transmembrane218 – 23821Helical; Potential
Topological domain239 – 25618Extracellular Potential
Transmembrane257 – 27721Helical; Potential
Topological domain278 – 30023Cytoplasmic Potential
Transmembrane301 – 32121Helical; Potential
Topological domain322 – 34423Extracellular Potential
Transmembrane345 – 36521Helical; Potential
Topological domain366 – 37510Cytoplasmic Potential
Transmembrane376 – 39621Helical; Potential
Topological domain397 – 4059Extracellular Potential
Transmembrane406 – 42621Helical; Potential
Topological domain427 – 50983Cytoplasmic Potential
Transmembrane510 – 53021Helical; Potential
Topological domain531 – 55020Extracellular Potential

Amino acid modifications

Modified residue421Phosphoserine Ref.4
Glycosylation1031N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict255 – 2573VTL → GNP Ref.1
Sequence conflict255 – 2573VTL → GNP Ref.2
Sequence conflict274 – 2752LV → SL Ref.1
Sequence conflict274 – 2752LV → SL Ref.2
Sequence conflict2931Q → P Ref.1
Sequence conflict2931Q → P Ref.2
Sequence conflict3371V → E Ref.1
Sequence conflict3371V → E Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q99J27 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 5A55A7F40A2A9661

FASTA55061,075
        10         20         30         40         50         60 
MSPTISHKDS SRQRRSGMFS HALDMKSGPL PPGGWDDSRR DSVGGEGDRE VLLGDAGPGD 

        70         80         90        100        110        120 
LPKAPRSYRS ELSSILLLLF LYVLQGIPLG LAGSIPLILQ SKNVSYTDQA FFSFVFWPFS 

       130        140        150        160        170        180 
LKLLWAPLVD AVYFKNFGRR KSWLVPTQYT LGIFMIYLST QVDRLLGNID GRTPDVVALT 

       190        200        210        220        230        240 
VTFFLFEFLA ATQDIAVDGW ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF 

       250        260        270        280        290        300 
CNKYLRFQPQ PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENREASIVKE ETQGITDTYK 

       310        320        330        340        350        360 
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA VPMVPLQIIL 

       370        380        390        400        410        420 
PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK VEHQGGFPLY YYIIVLLSYA 

       430        440        450        460        470        480 
LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM TLLNTVSNLG GNWPSTVALW LVDPLTVKEC 

       490        500        510        520        530        540 
VGASNQNCRT PDAIELCKKL GGSCVTALDG YYVESIICVL IGFGWWFFLG PKFKKLQDEG 

       550 
PSSWKCKRNN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA."
Bora R.S., Kanamori A., Hirabayashi Y.
Gene 238:455-462(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Tissue: Melanoma.
[2]"Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene."
Bora R.S., Ichikawa S., Kanamori A., Hirabayashi Y.
FEBS Lett. 473:169-172(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129 and FVB/N.
Tissue: Eye, Kidney and Mammary tumor.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB016795 mRNA. Translation: BAA76933.1.
AB037368 Genomic DNA. Translation: BAA93087.1.
BC005616 mRNA. Translation: AAH05616.1.
BC054395 mRNA. Translation: AAH54395.1.
BC063104 mRNA. Translation: AAH63104.1.
CCDSCCDS17382.1.
RefSeqNP_001258964.1. NM_001272035.1.
NP_056543.2. NM_015728.5.
UniGeneMm.135619.

3D structure databases

ProteinModelPortalQ99J27.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029402.

PTM databases

PhosphoSiteQ99J27.

Proteomic databases

MaxQBQ99J27.
PaxDbQ99J27.
PRIDEQ99J27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822.
ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822.
ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822.
GeneID11416.
KEGGmmu:11416.
UCSCuc008pkc.1. mouse.

Organism-specific databases

CTD9197.
MGIMGI:1332247. Slc33a1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00730000111115.
HOGENOMHOG000194770.
HOVERGENHBG052723.
InParanoidQ99J27.
KOK03372.
OMAYSLKLFW.
OrthoDBEOG747PHW.
PhylomeDBQ99J27.
TreeFamTF300008.

Gene expression databases

ArrayExpressQ99J27.
BgeeQ99J27.
GenevestigatorQ99J27.

Family and domain databases

InterProIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERPTHR12778:SF3. PTHR12778:SF3. 1 hit.
PfamPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00901. 2A0125. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC33A1. mouse.
NextBio278654.
PROQ99J27.
SOURCESearch...

Entry information

Entry nameACATN_MOUSE
AccessionPrimary (citable) accession number: Q99J27
Secondary accession number(s): Q9WTN1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot