Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99J27

- ACATN_MOUSE

UniProt

Q99J27 - ACATN_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acetyl-coenzyme A transporter 1

Gene

Slc33a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.1 Publication

GO - Molecular functioni

  1. acetyl-CoA transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_232951. Transport of vitamins, nucleosides, and related molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A transporter 1
Short name:
AT-1
Short name:
Acetyl-CoA transporter 1
Alternative name(s):
Solute carrier family 33 member 1
Gene namesi
Name:Slc33a1
Synonyms:Acatn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1332247. Slc33a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 11318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 1417CytoplasmicSequence Analysis
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 17513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 21721CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Topological domaini239 – 25618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Topological domaini278 – 30023CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST
Topological domaini322 – 34423ExtracellularSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Topological domaini366 – 37510CytoplasmicSequence Analysis
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Topological domaini397 – 4059ExtracellularSequence Analysis
Transmembranei406 – 42621HelicalSequence AnalysisAdd
BLAST
Topological domaini427 – 50983CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence AnalysisAdd
BLAST
Topological domaini531 – 55020ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Acetyl-coenzyme A transporter 1PRO_0000076166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphoserine1 Publication
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99J27.
PaxDbiQ99J27.
PRIDEiQ99J27.

PTM databases

PhosphoSiteiQ99J27.

Expressioni

Tissue specificityi

Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney.1 Publication

Developmental stagei

Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development.1 Publication

Gene expression databases

BgeeiQ99J27.
ExpressionAtlasiQ99J27. baseline and differential.
GenevestigatoriQ99J27.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029402.

Structurei

3D structure databases

ProteinModelPortaliQ99J27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC33A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00730000111115.
HOGENOMiHOG000194770.
HOVERGENiHBG052723.
InParanoidiQ99J27.
KOiK03372.
OMAiYSLKLFW.
OrthoDBiEOG747PHW.
PhylomeDBiQ99J27.
TreeFamiTF300008.

Family and domain databases

InterProiIPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERiPTHR12778:SF3. PTHR12778:SF3. 1 hit.
PfamiPF13000. Acatn. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99J27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPTISHKDS SRQRRSGMFS HALDMKSGPL PPGGWDDSRR DSVGGEGDRE
60 70 80 90 100
VLLGDAGPGD LPKAPRSYRS ELSSILLLLF LYVLQGIPLG LAGSIPLILQ
110 120 130 140 150
SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYFKNFGRR KSWLVPTQYT
160 170 180 190 200
LGIFMIYLST QVDRLLGNID GRTPDVVALT VTFFLFEFLA ATQDIAVDGW
210 220 230 240 250
ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ
260 270 280 290 300
PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENREASIVKE ETQGITDTYK
310 320 330 340 350
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA
360 370 380 390 400
VPMVPLQIIL PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK
410 420 430 440 450
VEHQGGFPLY YYIIVLLSYA LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM
460 470 480 490 500
TLLNTVSNLG GNWPSTVALW LVDPLTVKEC VGASNQNCRT PDAIELCKKL
510 520 530 540 550
GGSCVTALDG YYVESIICVL IGFGWWFFLG PKFKKLQDEG PSSWKCKRNN
Length:550
Mass (Da):61,075
Last modified:June 1, 2001 - v1
Checksum:i5A55A7F40A2A9661
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2573VTL → GNP(PubMed:10570973)Curated
Sequence conflicti255 – 2573VTL → GNP(PubMed:10812068)Curated
Sequence conflicti274 – 2752LV → SL(PubMed:10570973)Curated
Sequence conflicti274 – 2752LV → SL(PubMed:10812068)Curated
Sequence conflicti293 – 2931Q → P(PubMed:10570973)Curated
Sequence conflicti293 – 2931Q → P(PubMed:10812068)Curated
Sequence conflicti337 – 3371V → E(PubMed:10570973)Curated
Sequence conflicti337 – 3371V → E(PubMed:10812068)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016795 mRNA. Translation: BAA76933.1.
AB037368 Genomic DNA. Translation: BAA93087.1.
BC005616 mRNA. Translation: AAH05616.1.
BC054395 mRNA. Translation: AAH54395.1.
BC063104 mRNA. Translation: AAH63104.1.
CCDSiCCDS17382.1.
RefSeqiNP_001258964.1. NM_001272035.1.
NP_056543.2. NM_015728.5.
UniGeneiMm.135619.

Genome annotation databases

EnsembliENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822.
ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822.
ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822.
GeneIDi11416.
KEGGimmu:11416.
UCSCiuc008pkc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016795 mRNA. Translation: BAA76933.1 .
AB037368 Genomic DNA. Translation: BAA93087.1 .
BC005616 mRNA. Translation: AAH05616.1 .
BC054395 mRNA. Translation: AAH54395.1 .
BC063104 mRNA. Translation: AAH63104.1 .
CCDSi CCDS17382.1.
RefSeqi NP_001258964.1. NM_001272035.1.
NP_056543.2. NM_015728.5.
UniGenei Mm.135619.

3D structure databases

ProteinModelPortali Q99J27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029402.

PTM databases

PhosphoSitei Q99J27.

Proteomic databases

MaxQBi Q99J27.
PaxDbi Q99J27.
PRIDEi Q99J27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029402 ; ENSMUSP00000029402 ; ENSMUSG00000027822 .
ENSMUST00000160883 ; ENSMUSP00000125713 ; ENSMUSG00000027822 .
ENSMUST00000161659 ; ENSMUSP00000123986 ; ENSMUSG00000027822 .
GeneIDi 11416.
KEGGi mmu:11416.
UCSCi uc008pkc.1. mouse.

Organism-specific databases

CTDi 9197.
MGIi MGI:1332247. Slc33a1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00730000111115.
HOGENOMi HOG000194770.
HOVERGENi HBG052723.
InParanoidi Q99J27.
KOi K03372.
OMAi YSLKLFW.
OrthoDBi EOG747PHW.
PhylomeDBi Q99J27.
TreeFami TF300008.

Enzyme and pathway databases

Reactomei REACT_232951. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

ChiTaRSi Slc33a1. mouse.
NextBioi 278654.
PROi Q99J27.
SOURCEi Search...

Gene expression databases

Bgeei Q99J27.
ExpressionAtlasi Q99J27. baseline and differential.
Genevestigatori Q99J27.

Family and domain databases

InterProi IPR024371. Acetyl-CoA_trnpstr_1.
IPR004752. AmpG_permease/AT-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
PANTHERi PTHR12778:SF3. PTHR12778:SF3. 1 hit.
Pfami PF13000. Acatn. 2 hits.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00901. 2A0125. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA."
    Bora R.S., Kanamori A., Hirabayashi Y.
    Gene 238:455-462(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Tissue: Melanoma.
  2. "Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene."
    Bora R.S., Ichikawa S., Kanamori A., Hirabayashi Y.
    FEBS Lett. 473:169-172(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129 and FVB/N.
    Tissue: Eye, Kidney and Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACATN_MOUSE
AccessioniPrimary (citable) accession number: Q99J27
Secondary accession number(s): Q9WTN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3