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Protein

rRNA methyltransferase 1, mitochondrial

Gene

Mrm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.By similarity

Catalytic activityi

S-adenosyl-L-methionine + guanosine(1145) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(1145) in 16S rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 1, mitochondrial1 Publication (EC:2.1.1.-By similarity)
Alternative name(s):
16S rRNA (guanosine(1145)-2'-O)-methyltransferaseBy similarity
16S rRNA [Gm1145] 2'-O-methyltransferaseBy similarity
Gene namesi
Name:Mrm1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443470. Mrm1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717MitochondrionSequence analysisAdd
BLAST
Chaini18 – 320303rRNA methyltransferase 1, mitochondrialPRO_0000273203Add
BLAST

Proteomic databases

EPDiQ99J25.
MaxQBiQ99J25.
PaxDbiQ99J25.
PeptideAtlasiQ99J25.
PRIDEiQ99J25.

PTM databases

PhosphoSiteiQ99J25.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018405.
GenevisibleiQ99J25. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018549.

Structurei

3D structure databases

ProteinModelPortaliQ99J25.
SMRiQ99J25. Positions 48-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0838. Eukaryota.
COG0566. LUCA.
GeneTreeiENSGT00390000018761.
HOGENOMiHOG000004826.
HOVERGENiHBG081986.
InParanoidiQ99J25.
KOiK15507.
OMAiERNIWVI.
OrthoDBiEOG091G0IW1.
PhylomeDBiQ99J25.
TreeFamiTF315167.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.40.1280.10. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR029064. L30e-like.
IPR001537. SpoU_MeTrfase.
IPR013123. SpoU_subst-bd.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF00588. SpoU_methylase. 1 hit.
PF08032. SpoU_sub_bind. 1 hit.
[Graphical view]
SMARTiSM00967. SpoU_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF75217. SSF75217. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99J25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLWTVGCF SRLIARHFSS VARRGERPGG EELSRLLLDD LAPAQRLERL
60 70 80 90 100
FGLSPCLLAL RAARRRVARL LLQAGKAGLQ GERAELLRVA EARGIPVLRP
110 120 130 140 150
RRQKLDALCG YQVHQGVCME VSPLRPRPCD EAADTSSGDD PQQLWLVLEG
160 170 180 190 200
LQDPRNLGAV MRSAHFLGVD RVITSQRNSC PLTPVVSKAS AGAMEVMDVF
210 220 230 240 250
ATPDLPGFLQ AKAQQGWLVV GTVGCPGPEI SQSSKVPITS CLEFVWDRPT
260 270 280 290 300
LLVLGSEGSG LSQEVFASCQ LLLTILPRRH LPPGLESLNV SVATGILLHS
310 320
ICSQKKGFPV QERGQLLQDS
Length:320
Mass (Da):34,843
Last modified:September 19, 2006 - v2
Checksum:i361D26D155A233D8
GO

Sequence cautioni

The sequence BAE33706 differs from that shown. Reason: Frameshift at positions 214 and 223. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156416 mRNA. Translation: BAE33706.1. Frameshift.
AK164059 mRNA. Translation: BAE37607.1.
AK163986 mRNA. Translation: BAE37571.1.
AL596083 Genomic DNA. Translation: CAI35310.2.
BC005625 mRNA. Translation: AAH05625.2.
CCDSiCCDS36260.1.
RefSeqiNP_663408.2. NM_145433.1.
UniGeneiMm.280825.

Genome annotation databases

EnsembliENSMUST00000018549; ENSMUSP00000018549; ENSMUSG00000018405.
GeneIDi217038.
KEGGimmu:217038.
UCSCiuc007kqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156416 mRNA. Translation: BAE33706.1. Frameshift.
AK164059 mRNA. Translation: BAE37607.1.
AK163986 mRNA. Translation: BAE37571.1.
AL596083 Genomic DNA. Translation: CAI35310.2.
BC005625 mRNA. Translation: AAH05625.2.
CCDSiCCDS36260.1.
RefSeqiNP_663408.2. NM_145433.1.
UniGeneiMm.280825.

3D structure databases

ProteinModelPortaliQ99J25.
SMRiQ99J25. Positions 48-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018549.

PTM databases

PhosphoSiteiQ99J25.

Proteomic databases

EPDiQ99J25.
MaxQBiQ99J25.
PaxDbiQ99J25.
PeptideAtlasiQ99J25.
PRIDEiQ99J25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018549; ENSMUSP00000018549; ENSMUSG00000018405.
GeneIDi217038.
KEGGimmu:217038.
UCSCiuc007kqr.1. mouse.

Organism-specific databases

CTDi79922.
MGIiMGI:2443470. Mrm1.

Phylogenomic databases

eggNOGiKOG0838. Eukaryota.
COG0566. LUCA.
GeneTreeiENSGT00390000018761.
HOGENOMiHOG000004826.
HOVERGENiHBG081986.
InParanoidiQ99J25.
KOiK15507.
OMAiERNIWVI.
OrthoDBiEOG091G0IW1.
PhylomeDBiQ99J25.
TreeFamiTF315167.

Miscellaneous databases

ChiTaRSiMrm1. mouse.
PROiQ99J25.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018405.
GenevisibleiQ99J25. MM.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.40.1280.10. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR029064. L30e-like.
IPR001537. SpoU_MeTrfase.
IPR013123. SpoU_subst-bd.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF00588. SpoU_methylase. 1 hit.
PF08032. SpoU_sub_bind. 1 hit.
[Graphical view]
SMARTiSM00967. SpoU_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF75217. SSF75217. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMRM1_MOUSE
AccessioniPrimary (citable) accession number: Q99J25
Secondary accession number(s): Q3TPX8, Q3U0Z5, Q5ND22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 19, 2006
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.