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Protein

SEC14-like protein 2

Gene

Sec14l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 2
Alternative name(s):
Alpha-tocopherol-associated protein
Short name:
TAP
Gene namesi
Name:Sec14l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915065. Sec14l2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403SEC14-like protein 2PRO_0000210756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111N6-succinyllysineCombined sources
Modified residuei51 – 511N6-succinyllysineCombined sources
Modified residuei253 – 2531N6-succinyllysineCombined sources
Modified residuei257 – 2571N6-succinyllysineCombined sources
Modified residuei393 – 3931N6-succinyllysineCombined sources

Proteomic databases

EPDiQ99J08.
MaxQBiQ99J08.
PaxDbiQ99J08.
PeptideAtlasiQ99J08.
PRIDEiQ99J08.

PTM databases

iPTMnetiQ99J08.
PhosphoSiteiQ99J08.
SwissPalmiQ99J08.

Expressioni

Gene expression databases

BgeeiQ99J08.
CleanExiMM_SEC14L2.
GenevisibleiQ99J08. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ99J08. 2 interactions.
MINTiMINT-1869735.
STRINGi10090.ENSMUSP00000003681.

Structurei

3D structure databases

ProteinModelPortaliQ99J08.
SMRiQ99J08. Positions 1-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 249174CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini275 – 383109GOLDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ99J08.
OMAiQYEHTVQ.
OrthoDBiEOG7N8ZVD.
PhylomeDBiQ99J08.
TreeFamiTF313988.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99J08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRVGDLSP KQEEALAKFR ENVQDVLPTL PNPDDYFLLR WLRARSFDLQ
60 70 80 90 100
KSEAMLRKHV EFRKQKDIDK IISWQPPEVI QQYLSGGRCG YDLDGCPVWY
110 120 130 140 150
DIIGPLDAKG LLFSASKQDL LRTKMRDCEL LLQECIQQTT KLGKKIETIT
160 170 180 190 200
MIYDCEGLGL KHLWKPAVEA YGEFLTMFEE NYPETLKRLF VVKAPKLFPV
210 220 230 240 250
AYNLIKPFLS EDTRRKIMVL GANWKEVLLK HISPDQLPVE YGGTMTDPDG
260 270 280 290 300
NPKCKSKINY GGDIPKQYYV RDQVKQQYEH TVQVSRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFMSE GSDVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHMVPED
360 370 380 390 400
GTLTCSEPGI YVLRFDNTYS FIHAKKVSFT VEVLLPDKAA EEKMNQQGAD

TPK
Length:403
Mass (Da):46,300
Last modified:June 1, 2001 - v1
Checksum:i42E0BBAFE3004841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005759 mRNA. Translation: AAH05759.1.
CCDSiCCDS24377.1.
RefSeqiNP_653103.1. NM_144520.2.
UniGeneiMm.253922.

Genome annotation databases

EnsembliENSMUST00000003681; ENSMUSP00000003681; ENSMUSG00000003585.
GeneIDi67815.
KEGGimmu:67815.
UCSCiuc007huh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005759 mRNA. Translation: AAH05759.1.
CCDSiCCDS24377.1.
RefSeqiNP_653103.1. NM_144520.2.
UniGeneiMm.253922.

3D structure databases

ProteinModelPortaliQ99J08.
SMRiQ99J08. Positions 1-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99J08. 2 interactions.
MINTiMINT-1869735.
STRINGi10090.ENSMUSP00000003681.

PTM databases

iPTMnetiQ99J08.
PhosphoSiteiQ99J08.
SwissPalmiQ99J08.

Proteomic databases

EPDiQ99J08.
MaxQBiQ99J08.
PaxDbiQ99J08.
PeptideAtlasiQ99J08.
PRIDEiQ99J08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003681; ENSMUSP00000003681; ENSMUSG00000003585.
GeneIDi67815.
KEGGimmu:67815.
UCSCiuc007huh.1. mouse.

Organism-specific databases

CTDi23541.
MGIiMGI:1915065. Sec14l2.

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ99J08.
OMAiQYEHTVQ.
OrthoDBiEOG7N8ZVD.
PhylomeDBiQ99J08.
TreeFamiTF313988.

Miscellaneous databases

ChiTaRSiSec14l2. mouse.
PROiQ99J08.
SOURCEiSearch...

Gene expression databases

BgeeiQ99J08.
CleanExiMM_SEC14L2.
GenevisibleiQ99J08. MM.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Liver, Lung, Pancreas and Spleen.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-11; LYS-51; LYS-253; LYS-257 AND LYS-393, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiS14L2_MOUSE
AccessioniPrimary (citable) accession number: Q99J08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.