Q99996 (AKAP9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
A-kinase anchor protein 9
Short name=AKAP-9

Alternative name(s):
A-kinase anchor protein 350 kDa
Short name=AKAP 350
Short name=hgAKAP 350
A-kinase anchor protein 450 kDa
Short name=AKAP 450
AKAP 120-like protein
Centrosome- and Golgi-localized PKN-associated protein
Short name=CG-NAP
Protein hyperion
Protein kinase A-anchoring protein 9
Short name=PRKA9
Protein yotiao

Gene names

Name:	AKAP9
Synonyms:	AKAP350, AKAP450, KIAA0803

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3911 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Ref.11
Subunit structure	Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon. Interacts with CIP4 and FNBP1. Interacts with chloride intracellular channel proteins CLIC1, CLIC4 and CLIC5. CSNK1D binding promotes its centrosomal subcellular location. Ref.9 Ref.10 Ref.11
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Golgi apparatus. Note: Cytoplasmic in parietal cells. Ref.10 Ref.11
Tissue specificity	Widely expressed. Isoform 4 is highly expressed in skeletal muscle and in pancreas.
Domain	RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Involvement in disease	Long QT syndrome 11 (LQT11) [MIM:611820]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16
Sequence caution	The sequence AAB86384.1 differs from that shown. Reason: Frameshift at position 1637. The sequence AAC60380.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Long QT syndrome
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G2/M transition of mitotic cell cycle Traceable author statement. Source: Reactome signal transduction Traceable author statement PubMed 10390370. Source: ProtInc synaptic transmission Traceable author statement Ref.1. Source: ProtInc transport Traceable author statement PubMed 10390370. Source: ProtInc
Cellular_component	Golgi apparatus Inferred from direct assay Ref.9. Source: UniProtKB centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB cytosol Traceable author statement. Source: Reactome pericentriolar material Inferred from electronic annotation. Source: Compara
Molecular_function	receptor binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99996-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99996-2)

The sequence of this isoform differs from the canonical sequence as follows:
     17-28: Missing.
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS

Isoform 3 (identifier: Q99996-3)

Also known as: CG-NAP;

The sequence of this isoform differs from the canonical sequence as follows:
     17-28: Missing.
     2175-2182: Missing.
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS

Isoform 4 (identifier: Q99996-4)

Also known as: Yotiao;

The sequence of this isoform differs from the canonical sequence as follows:
     1637-1643: QLQEEIK → LAQVRVL
     1644-3911: Missing.

Isoform 5 (identifier: Q99996-5)

The sequence of this isoform differs from the canonical sequence as follows:
     2895-2948: Missing.

Isoform 6 (identifier: Q99996-6)

Also known as: AKAP350;

The sequence of this isoform differs from the canonical sequence as follows:
     2175-2183: SADTFQKVE → Q
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS
     3901-3911: STTQFHAGMRR → ALSLTTSWQHHSARPTAPLFFEILSHSLG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3911	3911	A-kinase anchor protein 9		PRO_0000064534
Regions
	Region	2554 – 2567	14	PKA-RII subunit binding domain
	Coiled coil	164 – 914	751	Potential
	Coiled coil	944 – 1022	79	Potential
	Coiled coil	1100 – 1185	86	Potential
	Coiled coil	1253 – 1280	28	Potential
	Coiled coil	1336 – 1392	57	Potential
	Coiled coil	1434 – 1459	26	Potential
	Coiled coil	1585 – 1659	75	Potential
	Coiled coil	1857 – 2455	599	Potential
	Coiled coil	2544 – 2561	18	Potential
	Coiled coil	2603 – 2776	174	Potential
	Coiled coil	3065 – 3092	28	Potential
	Coiled coil	3124 – 3470	347	Potential
	Coiled coil	3587 – 3689	103	Potential
	Compositional bias	203 – 292	90	Gln-rich
	Compositional bias	321 – 1010	690	Glu-rich
	Compositional bias	1846 – 2772	927	Glu-rich
	Compositional bias	3726 – 3730	5	Poly-Leu
Amino acid modifications
	Modified residue	165	1	Phosphoserine Ref.13
	Modified residue	3846	1	Phosphoserine Ref.13
	Modified residue	3869	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	17 – 28	12	Missing in isoform 2 and isoform 3.		VSP_004102
	Alternative sequence	1637 – 1643	7	QLQEEIK → LAQVRVL in isoform 4.		VSP_004103
	Alternative sequence	1644 – 3911	2268	Missing in isoform 4.		VSP_004104
	Alternative sequence	2175 – 2183	9	SADTFQKVE → Q in isoform 6.		VSP_004106
	Alternative sequence	2175 – 2182	8	Missing in isoform 3.		VSP_004105
	Alternative sequence	2895 – 2948	54	Missing in isoform 5.		VSP_004108
	Alternative sequence	2895 – 2907	13	VFGFY…FSTLC → GSSIPELAHSDAYQTREICS S in isoform 2, isoform 3 and isoform 6.		VSP_004107
	Alternative sequence	3901 – 3911	11	STTQFHAGMRR → ALSLTTSWQHHSARPTAPLF FEILSHSLG in isoform 6.		VSP_004109
	Natural variant	475	1	M → I. Ref.3 Corresponds to variant rs6964587 [ dbSNP | Ensembl ].		VAR_024249
	Natural variant	1347	1	K → KQ. Ref.2		VAR_010926
	Natural variant	1582	1	S → L in LQT11. Ref.16		VAR_043489
	Natural variant	2421	1	M → I in a colorectal cancer sample; somatic mutation. Ref.15		VAR_035785
	Natural variant	2496	1	K → R. Corresponds to variant rs35759833 [ dbSNP | Ensembl ].		VAR_043490
	Natural variant	2804	1	N → S. Corresponds to variant rs6960867 [ dbSNP | Ensembl ].		VAR_030162
	Natural variant	2983	1	P → S. Ref.3 Ref.7 Ref.8 Corresponds to variant rs1063242 [ dbSNP | Ensembl ].		VAR_030163
	Natural variant	3301	1	E → Q in a breast cancer sample; somatic mutation. Ref.15		VAR_035786
	Natural variant	3448	1	Q → R. Corresponds to variant rs34956633 [ dbSNP | Ensembl ].		VAR_043491
	Natural variant	3618	1	M → V. Corresponds to variant rs34327395 [ dbSNP | Ensembl ].		VAR_043492
Experimental info
	Sequence conflict	76	1	E → Q in BAA78718. Ref.3
	Sequence conflict	554	1	E → G in BAA78718. Ref.3
	Sequence conflict	638	1	R → S in BAA78718. Ref.3
	Sequence conflict	663	1	N → S in BAA78718. Ref.3
	Sequence conflict	913	1	H → N in BAA78718. Ref.3
	Sequence conflict	956	1	K → N in BAA78718. Ref.3
	Sequence conflict	980 – 982	3	QKH → PKP in AAB86384. Ref.1
	Sequence conflict	980 – 982	3	QKH → PKP in CAB40713. Ref.2
	Sequence conflict	997	1	Q → P in AAB86384. Ref.1
	Sequence conflict	997	1	Q → P in CAB40713. Ref.2
	Sequence conflict	1001	1	Q → P in AAB86384. Ref.1
	Sequence conflict	1001	1	Q → P in CAB40713. Ref.2
	Sequence conflict	1020	1	N → D in BAA78718. Ref.3
	Sequence conflict	1028	1	V → E in BAA78718. Ref.3
	Sequence conflict	1626	1	R → P in AAB86384. Ref.1
	Sequence conflict	1626	1	R → P in CAB40713. Ref.2
	Sequence conflict	1703	1	N → T in BAA78718. Ref.3
	Sequence conflict	1707	1	V → G in BAA78718. Ref.3
	Sequence conflict	1802 – 1803	2	Missing in AAD22767. Ref.7
	Sequence conflict	1843	1	A → P in BAA78718. Ref.3
	Sequence conflict	1956	1	I → V in BAA78718. Ref.3
	Sequence conflict	2027	1	V → D in AAD22767. Ref.7
	Sequence conflict	2157 – 2158	2	EI → HE in AAD39719. Ref.7
	Sequence conflict	2169	1	E → V in BAA78718. Ref.3
	Sequence conflict	2514	1	L → R in BAA78718. Ref.3
	Sequence conflict	2851	1	I → N in BAA34523. Ref.8
	Sequence conflict	2957	1	E → D in BAA78718. Ref.3
	Sequence conflict	3087	1	Q → H in BAA78718. Ref.3
	Sequence conflict	3218	1	Q → H in BAA78718. Ref.3
	Sequence conflict	3307 – 3309	3	ESE → QSQ in BAA78718. Ref.3
	Sequence conflict	3751	1	P → A in BAA78718. Ref.3
	Sequence conflict	3833	1	T → S in BAA78718. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1999. Version 3. Checksum: 3FB1CB1C819B47AA	FASTA	3,911	453,667
	10 20 30 40 50 60 MEDEERQKKL EAGKAKIEEL SLAFLVRQLA QFRQRKAQSD GQSPSKKQKK KRKTSSSKHD 70 80 90 100 110 120 VSAHHDLNID QSQCNEMYIN SSQRVESTVI PESTIMRTLH SGEITSHEQG FSVELESEIS 130 140 150 160 170 180 TTADDCSSEV NGCSFVMRTG KPTNLLREEE FGVDDSYSEQ GAQDSPTHLE MMESELAGKQ 190 200 210 220 230 240 HEIEELNREL EEMRVTYGTE GLQQLQEFEA AIKQRDGIIT QLTANLQQAR REKDETMREF 250 260 270 280 290 300 LELTEQSQKL QIQFQQLQAS ETLRNSTHSS TAADLLQAKQ QILTHQQQLE EQDHLLEDYQ 310 320 330 340 350 360 KKKEDFTMQI SFLQEKIKVY EMEQDKKVEN SNKEEIQEKE TIIEELNTKI IEEEKKTLEL 370 380 390 400 410 420 KDKLTTADKL LGELQEQIVQ KNQEIKNMKL ELTNSKQKER QSSEEIKQLM GTVEELQKRN 430 440 450 460 470 480 HKDSQFETDI VQRMEQETQR KLEQLRAELD EMYGQQIVQM KQELIRQHMA QMEEMKTRHK 490 500 510 520 530 540 GEMENALRSY SNITVNEDQI KLMNVAINEL NIKLQDTNSQ KEKLKEELGL ILEEKCALQR 550 560 570 580 590 600 QLEDLVEELS FSREQIQRAR QTIAEQESKL NEAHKSLSTV EDLKAEIVSA SESRKELELK 610 620 630 640 650 660 HEAEVTNYKI KLEMLEKEKN AVLDRMAESQ EAELERLRTQ LLFSHEEELS KLKEDLEIEH 670 680 690 700 710 720 RINIEKLKDN LGIHYKQQID GLQNEMSQKI ETMQFEKDNL ITKQNQLILE ISKLKDLQQS 730 740 750 760 770 780 LVNSKSEEMT LQINELQKEI EILRQEEKEK GTLEQEVQEL QLKTELLEKQ MKEKENDLQE 790 800 810 820 830 840 KFAQLEAENS ILKDEKKTLE DMLKIHTPVS QEERLIFLDS IKSKSKDSVW EKEIEILIEE 850 860 870 880 890 900 NEDLKQQCIQ LNEEIEKQRN TFSFAEKNFE VNYQELQEEY ACLLKVKDDL EDSKNKQELE 910 920 930 940 950 960 YKSKLKALNE ELHLQRINPT TVKMKSSVFD EDKTFVAETL EMGEVVEKDT TELMEKLEVT 970 980 990 1000 1010 1020 KREKLELSQR LSDLSEQLKQ KHGEISFLNE EVKSLKQEKE QVSLRCRELE IIINHNRAEN 1030 1040 1050 1060 1070 1080 VQSCDTQVSS LLDGVVTMTS RGAEGSVSKV NKSFGEESKI MVEDKVSFEN MTVGEESKQE 1090 1100 1110 1120 1130 1140 QLILDHLPSV TKESSLRATQ PSENDKLQKE LNVLKSEQND LRLQMEAQRI CLSLVYSTHV 1150 1160 1170 1180 1190 1200 DQVREYMENE KDKALCSLKE ELIFAQEEKI KELQKIHQLE LQTMKTQETG DEGKPLHLLI 1210 1220 1230 1240 1250 1260 GKLQKAVSEE CSYFLQTLCS VLGEYYTPAL KCEVNAEDKE NSGDYISENE DPELQDYRYE 1270 1280 1290 1300 1310 1320 VQDFQENMHT LLNKVTEEYN KLLVLQTRLS KIWGQQTDGM KLEFGEENLP KEETEFLSIH 1330 1340 1350 1360 1370 1380 SQMTNLEDID VNHKSKLSSL QDLEKTKLEE QVQELESLIS SLQQQLKETE QNYEAEIHCL 1390 1400 1410 1420 1430 1440 QKRLQAVSES TVPPSLPVDS VVITESDAQR TMYPGSCVKK NIDGTIEFSG EFGVKEETNI 1450 1460 1470 1480 1490 1500 VKLLEKQYQE QLEEEVAKVI VSMSIAFAQQ TELSRISGGK ENTASSKQAH AVCQQEQHYF 1510 1520 1530 1540 1550 1560 NEMKLSQDQI GFQTFETVDV KFKEEFKPLS KELGEHGKEI LLSNSDPHDI PESKDCVLTI 1570 1580 1590 1600 1610 1620 SEEMFSKDKT FIVRQSIHDE ISVSSMDASR QLMLNEEQLE DMRQELVRQY QEHQQATELL 1630 1640 1650 1660 1670 1680 RQAHMRQMER QREDQEQLQE EIKRLNRQLA QRSSIDNENL VSERERVLLE ELEALKQLSL 1690 1700 1710 1720 1730 1740 AGREKLCCEL RNSSTQTQNG NENQGEVEEQ TFKEKELDRK PEDVPPEILS NERYALQKAN 1750 1760 1770 1780 1790 1800 NRLLKILLEV VKTTAAVEET IGRHVLGILD RSSKSQSSAS LIWRSEAEAS VKSCVHEEHT 1810 1820 1830 1840 1850 1860 RVTDESIPSY SGSDMPRNDI NMWSKVTEEG TELSQRLVRS GFAGTEIDPE NEELMLNISS 1870 1880 1890 1900 1910 1920 RLQAAVEKLL EAISETSSQL EHAKVTQTEL MRESFRQKQE ATESLKCQEE LRERLHEESR 1930 1940 1950 1960 1970 1980 AREQLAVELS KAEGVIDGYA DEKTLFERQI QEKTDIIDRL EQELLCASNR LQELEAEQQQ 1990 2000 2010 2020 2030 2040 IQEERELLSR QKEAMKAEAG PVEQQLLQET EKLMKEKLEV QCQAEKVRDD LQKQVKALEI 2050 2060 2070 2080 2090 2100 DVEEQVSRFI ELEQEKNTEL MDLRQQNQAL EKQLEKMRKF LDEQAIDREH ERDVFQQEIQ 2110 2120 2130 2140 2150 2160 KLEQQLKVVP RFQPISEHQT REVEQLANHL KEKTDKCSEL LLSKEQLQRD IQERNEEIEK 2170 2180 2190 2200 2210 2220 LEFRVRELEQ ALLVSADTFQ KVEDRKHFGA VEAKPELSLE VQLQAERDAI DRKEKEITNL 2230 2240 2250 2260 2270 2280 EEQLEQFREE LENKNEEVQQ LHMQLEIQKK ESTTRLQELE QENKLFKDDM EKLGLAIKES 2290 2300 2310 2320 2330 2340 DAMSTQDQHV LFGKFAQIIQ EKEVEIDQLN EQVTKLQQQL KITTDNKVIE EKNELIRDLE 2350 2360 2370 2380 2390 2400 TQIECLMSDQ ECVKRNREEE IEQLNEVIEK LQQELANIGQ KTSMNAHSLS EEADSLKHQL 2410 2420 2430 2440 2450 2460 DVVIAEKLAL EQQVETANEE MTFMKNVLKE TNFKMNQLTQ ELFSLKRERE SVEKIQSIPE 2470 2480 2490 2500 2510 2520 NSVNVAIDHL SKDKPELEVV LTEDALKSLE NQTYFKSFEE NGKGSIINLE TRLLQLESTV 2530 2540 2550 2560 2570 2580 SAKDLELTQC YKQIKDMQEQ GQFETEMLQK KIVNLQKIVE EKVAAALVSQ IQLEAVQEYA 2590 2600 2610 2620 2630 2640 KFCQDNQTIS SEPERTNIQN LNQLREDELG SDISALTLRI SELESQVVEM HTSLILEKEQ 2650 2660 2670 2680 2690 2700 VEIAEKNVLE KEKKLLELQK LLEGNEKKQR EKEKKRSPQD VEVLKTTTEL FHSNEESGFF 2710 2720 2730 2740 2750 2760 NELEALRAES VATKAELASY KEKAEKLQEE LLVKETNMTS LQKDLSQVRD HLAEAKEKLS 2770 2780 2790 2800 2810 2820 ILEKEDETEV QESKKACMFE PLPIKLSKSI ASQTDGTLKI SSSNQTPQIL VKNAGIQINL 2830 2840 2850 2860 2870 2880 QSECSSEEVT EIISQFTEKI EKMQELHAAE ILDMESRHIS ETETLKREHY VAVQLLKEEC 2890 2900 2910 2920 2930 2940 GTLKAVIQCL RSKEVFGFYN MCFSTLCDSG SDWGQGIYLT HSQGFDIASE GRGEESESAT 2950 2960 2970 2980 2990 3000 DSFPKKIKGL LRAVHNEGMQ VLSLTESPYS DGEDHSIQQV SEPWLEERKA YINTISSLKD 3010 3020 3030 3040 3050 3060 LITKMQLQRE AEVYDSSQSH ESFSDWRGEL LLALQQVFLE ERSVLLAAFR TELTALGTTD 3070 3080 3090 3100 3110 3120 AVGLLNCLEQ RIQEQGVEYQ AAMECLQKAD RRSLLSEIQA LHAQMNGRKI TLKREQESEK 3130 3140 3150 3160 3170 3180 PSQELLEYNI QQKQSQMLEM QVELSSMKDR ATELQEQLSS EKMVVAELKS ELAQTKLELE 3190 3200 3210 3220 3230 3240 TTLKAQHKHL KELEAFRLEV KDKTDEVHLL NDTLASEQKK SRELQWALEK EKAKLGRSEE 3250 3260 3270 3280 3290 3300 RDKEELEDLK FSLESQKQRN LQLNLLLEQQ KQLLNESQQK IESQRMLYDA QLSEEQGRNL 3310 3320 3330 3340 3350 3360 ELQVLLESEK VRIREMSSTL DRERELHAQL QSSDGTGQSR PPLPSEDLLK ELQKQLEEKH 3370 3380 3390 3400 3410 3420 SRIVELLNET EKYKLDSLQT RQQMEKDRQV HRKTLQTEQE ANTEGQKKMH ELQSKVEDLQ 3430 3440 3450 3460 3470 3480 RQLEEKRQQV YKLDLEGQRL QGIMQEFQKQ ELEREEKRES RRILYQNLNE PTTWSLTSDR 3490 3500 3510 3520 3530 3540 TRNWVLQQKI EGETKESNYA KLIEMNGGGT GCNHELEMIR QKLQCVASKL QVLPQKASER 3550 3560 3570 3580 3590 3600 LQFETADDED FIWVQENIDE IILQLQKLTG QQGEEPSLVS PSTSCGSLTE RLLRQNAELT 3610 3620 3630 3640 3650 3660 GHISQLTEEK NDLRNMVMKL EEQIRWYRQT GAGRDNSSRF SLNGGANIEA IIASEKEVWN 3670 3680 3690 3700 3710 3720 REKLTLQKSL KRAEAEVYKL KAELRNDSLL QTLSPDSEHV TLKRIYGKYL RAESFRKALI 3730 3740 3750 3760 3770 3780 YQKKYLLLLL GGFQECEDAT LALLARMGGQ PAFTDLEVIT NRPKGFTRFR SAVRVSIAIS 3790 3800 3810 3820 3830 3840 RMKFLVRRWH RVTGSVSINI NRDGFGLNQG AEKTDSFYHS SGGLELYGEP RHTTYRSRSD 3850 3860 3870 3880 3890 3900 LDYIRSPLPF QNRYPGTPAD FNPGSLACSQ LQNYDPDRAL TDYITRLEAL QRRLGTIQSG 3910 STTQFHAGMR R
	Isoform 2 [UniParc]. Checksum: 81761B4341430CDF	FASTA	3,907	452,987
	10 20 30 40 50 60 MEDEERQKKL EAGKAKLAQF RQRKAQSDGQ SPSKKQKKKR KTSSSKHDVS AHHDLNIDQS 70 80 90 100 110 120 QCNEMYINSS QRVESTVIPE STIMRTLHSG EITSHEQGFS VELESEISTT ADDCSSEVNG 130 140 150 160 170 180 CSFVMRTGKP TNLLREEEFG VDDSYSEQGA QDSPTHLEMM ESELAGKQHE IEELNRELEE 190 200 210 220 230 240 MRVTYGTEGL QQLQEFEAAI KQRDGIITQL TANLQQARRE KDETMREFLE LTEQSQKLQI 250 260 270 280 290 300 QFQQLQASET LRNSTHSSTA ADLLQAKQQI LTHQQQLEEQ DHLLEDYQKK KEDFTMQISF 310 320 330 340 350 360 LQEKIKVYEM EQDKKVENSN KEEIQEKETI IEELNTKIIE EEKKTLELKD KLTTADKLLG 370 380 390 400 410 420 ELQEQIVQKN QEIKNMKLEL TNSKQKERQS SEEIKQLMGT VEELQKRNHK DSQFETDIVQ 430 440 450 460 470 480 RMEQETQRKL EQLRAELDEM YGQQIVQMKQ ELIRQHMAQM EEMKTRHKGE MENALRSYSN 490 500 510 520 530 540 ITVNEDQIKL MNVAINELNI KLQDTNSQKE KLKEELGLIL EEKCALQRQL EDLVEELSFS 550 560 570 580 590 600 REQIQRARQT IAEQESKLNE AHKSLSTVED LKAEIVSASE SRKELELKHE AEVTNYKIKL 610 620 630 640 650 660 EMLEKEKNAV LDRMAESQEA ELERLRTQLL FSHEEELSKL KEDLEIEHRI NIEKLKDNLG 670 680 690 700 710 720 IHYKQQIDGL QNEMSQKIET MQFEKDNLIT KQNQLILEIS KLKDLQQSLV NSKSEEMTLQ 730 740 750 760 770 780 INELQKEIEI LRQEEKEKGT LEQEVQELQL KTELLEKQMK EKENDLQEKF AQLEAENSIL 790 800 810 820 830 840 KDEKKTLEDM LKIHTPVSQE ERLIFLDSIK SKSKDSVWEK EIEILIEENE DLKQQCIQLN 850 860 870 880 890 900 EEIEKQRNTF SFAEKNFEVN YQELQEEYAC LLKVKDDLED SKNKQELEYK SKLKALNEEL 910 920 930 940 950 960 HLQRINPTTV KMKSSVFDED KTFVAETLEM GEVVEKDTTE LMEKLEVTKR EKLELSQRLS 970 980 990 1000 1010 1020 DLSEQLKQKH GEISFLNEEV KSLKQEKEQV SLRCRELEII INHNRAENVQ SCDTQVSSLL 1030 1040 1050 1060 1070 1080 DGVVTMTSRG AEGSVSKVNK SFGEESKIMV EDKVSFENMT VGEESKQEQL ILDHLPSVTK 1090 1100 1110 1120 1130 1140 ESSLRATQPS ENDKLQKELN VLKSEQNDLR LQMEAQRICL SLVYSTHVDQ VREYMENEKD 1150 1160 1170 1180 1190 1200 KALCSLKEEL IFAQEEKIKE LQKIHQLELQ TMKTQETGDE GKPLHLLIGK LQKAVSEECS 1210 1220 1230 1240 1250 1260 YFLQTLCSVL GEYYTPALKC EVNAEDKENS GDYISENEDP ELQDYRYEVQ DFQENMHTLL 1270 1280 1290 1300 1310 1320 NKVTEEYNKL LVLQTRLSKI WGQQTDGMKL EFGEENLPKE ETEFLSIHSQ MTNLEDIDVN 1330 1340 1350 1360 1370 1380 HKSKLSSLQD LEKTKLEEQV QELESLISSL QQQLKETEQN YEAEIHCLQK RLQAVSESTV 1390 1400 1410 1420 1430 1440 PPSLPVDSVV ITESDAQRTM YPGSCVKKNI DGTIEFSGEF GVKEETNIVK LLEKQYQEQL 1450 1460 1470 1480 1490 1500 EEEVAKVIVS MSIAFAQQTE LSRISGGKEN TASSKQAHAV CQQEQHYFNE MKLSQDQIGF 1510 1520 1530 1540 1550 1560 QTFETVDVKF KEEFKPLSKE LGEHGKEILL SNSDPHDIPE SKDCVLTISE EMFSKDKTFI 1570 1580 1590 1600 1610 1620 VRQSIHDEIS VSSMDASRQL MLNEEQLEDM RQELVRQYQE HQQATELLRQ AHMRQMERQR 1630 1640 1650 1660 1670 1680 EDQEQLQEEI KRLNRQLAQR SSIDNENLVS ERERVLLEEL EALKQLSLAG REKLCCELRN 1690 1700 1710 1720 1730 1740 SSTQTQNGNE NQGEVEEQTF KEKELDRKPE DVPPEILSNE RYALQKANNR LLKILLEVVK 1750 1760 1770 1780 1790 1800 TTAAVEETIG RHVLGILDRS SKSQSSASLI WRSEAEASVK SCVHEEHTRV TDESIPSYSG 1810 1820 1830 1840 1850 1860 SDMPRNDINM WSKVTEEGTE LSQRLVRSGF AGTEIDPENE ELMLNISSRL QAAVEKLLEA 1870 1880 1890 1900 1910 1920 ISETSSQLEH AKVTQTELMR ESFRQKQEAT ESLKCQEELR ERLHEESRAR EQLAVELSKA 1930 1940 1950 1960 1970 1980 EGVIDGYADE KTLFERQIQE KTDIIDRLEQ ELLCASNRLQ ELEAEQQQIQ EERELLSRQK 1990 2000 2010 2020 2030 2040 EAMKAEAGPV EQQLLQETEK LMKEKLEVQC QAEKVRDDLQ KQVKALEIDV EEQVSRFIEL 2050 2060 2070 2080 2090 2100 EQEKNTELMD LRQQNQALEK QLEKMRKFLD EQAIDREHER DVFQQEIQKL EQQLKVVPRF 2110 2120 2130 2140 2150 2160 QPISEHQTRE VEQLANHLKE KTDKCSELLL SKEQLQRDIQ ERNEEIEKLE FRVRELEQAL 2170 2180 2190 2200 2210 2220 LVSADTFQKV EDRKHFGAVE AKPELSLEVQ LQAERDAIDR KEKEITNLEE QLEQFREELE 2230 2240 2250 2260 2270 2280 NKNEEVQQLH MQLEIQKKES TTRLQELEQE NKLFKDDMEK LGLAIKESDA MSTQDQHVLF 2290 2300 2310 2320 2330 2340 GKFAQIIQEK EVEIDQLNEQ VTKLQQQLKI TTDNKVIEEK NELIRDLETQ IECLMSDQEC 2350 2360 2370 2380 2390 2400 VKRNREEEIE QLNEVIEKLQ QELANIGQKT SMNAHSLSEE ADSLKHQLDV VIAEKLALEQ 2410 2420 2430 2440 2450 2460 QVETANEEMT FMKNVLKETN FKMNQLTQEL FSLKRERESV EKIQSIPENS VNVAIDHLSK 2470 2480 2490 2500 2510 2520 DKPELEVVLT EDALKSLENQ TYFKSFEENG KGSIINLETR LLQLESTVSA KDLELTQCYK 2530 2540 2550 2560 2570 2580 QIKDMQEQGQ FETEMLQKKI VNLQKIVEEK VAAALVSQIQ LEAVQEYAKF CQDNQTISSE 2590 2600 2610 2620 2630 2640 PERTNIQNLN QLREDELGSD ISALTLRISE LESQVVEMHT SLILEKEQVE IAEKNVLEKE 2650 2660 2670 2680 2690 2700 KKLLELQKLL EGNEKKQREK EKKRSPQDVE VLKTTTELFH SNEESGFFNE LEALRAESVA 2710 2720 2730 2740 2750 2760 TKAELASYKE KAEKLQEELL VKETNMTSLQ KDLSQVRDHL AEAKEKLSIL EKEDETEVQE 2770 2780 2790 2800 2810 2820 SKKACMFEPL PIKLSKSIAS QTDGTLKISS SNQTPQILVK NAGIQINLQS ECSSEEVTEI 2830 2840 2850 2860 2870 2880 ISQFTEKIEK MQELHAAEIL DMESRHISET ETLKREHYVA VQLLKEECGT LKAVIQCLRS 2890 2900 2910 2920 2930 2940 KEGSSIPELA HSDAYQTREI CSSDSGSDWG QGIYLTHSQG FDIASEGRGE ESESATDSFP 2950 2960 2970 2980 2990 3000 KKIKGLLRAV HNEGMQVLSL TESPYSDGED HSIQQVSEPW LEERKAYINT ISSLKDLITK 3010 3020 3030 3040 3050 3060 MQLQREAEVY DSSQSHESFS DWRGELLLAL QQVFLEERSV LLAAFRTELT ALGTTDAVGL 3070 3080 3090 3100 3110 3120 LNCLEQRIQE QGVEYQAAME CLQKADRRSL LSEIQALHAQ MNGRKITLKR EQESEKPSQE 3130 3140 3150 3160 3170 3180 LLEYNIQQKQ SQMLEMQVEL SSMKDRATEL QEQLSSEKMV VAELKSELAQ TKLELETTLK 3190 3200 3210 3220 3230 3240 AQHKHLKELE AFRLEVKDKT DEVHLLNDTL ASEQKKSREL QWALEKEKAK LGRSEERDKE 3250 3260 3270 3280 3290 3300 ELEDLKFSLE SQKQRNLQLN LLLEQQKQLL NESQQKIESQ RMLYDAQLSE EQGRNLELQV 3310 3320 3330 3340 3350 3360 LLESEKVRIR EMSSTLDRER ELHAQLQSSD GTGQSRPPLP SEDLLKELQK QLEEKHSRIV 3370 3380 3390 3400 3410 3420 ELLNETEKYK LDSLQTRQQM EKDRQVHRKT LQTEQEANTE GQKKMHELQS KVEDLQRQLE 3430 3440 3450 3460 3470 3480 EKRQQVYKLD LEGQRLQGIM QEFQKQELER EEKRESRRIL YQNLNEPTTW SLTSDRTRNW 3490 3500 3510 3520 3530 3540 VLQQKIEGET KESNYAKLIE MNGGGTGCNH ELEMIRQKLQ CVASKLQVLP QKASERLQFE 3550 3560 3570 3580 3590 3600 TADDEDFIWV QENIDEIILQ LQKLTGQQGE EPSLVSPSTS CGSLTERLLR QNAELTGHIS 3610 3620 3630 3640 3650 3660 QLTEEKNDLR NMVMKLEEQI RWYRQTGAGR DNSSRFSLNG GANIEAIIAS EKEVWNREKL 3670 3680 3690 3700 3710 3720 TLQKSLKRAE AEVYKLKAEL RNDSLLQTLS PDSEHVTLKR IYGKYLRAES FRKALIYQKK 3730 3740 3750 3760 3770 3780 YLLLLLGGFQ ECEDATLALL ARMGGQPAFT DLEVITNRPK GFTRFRSAVR VSIAISRMKF 3790 3800 3810 3820 3830 3840 LVRRWHRVTG SVSININRDG FGLNQGAEKT DSFYHSSGGL ELYGEPRHTT YRSRSDLDYI 3850 3860 3870 3880 3890 3900 RSPLPFQNRY PGTPADFNPG SLACSQLQNY DPDRALTDYI TRLEALQRRL GTIQSGSTTQ FHAGMRR
	Isoform 3 (CG-NAP) [UniParc]. Checksum: F90C9F18B32FD314	FASTA	3,899	452,110
	10 20 30 40 50 60 MEDEERQKKL EAGKAKLAQF RQRKAQSDGQ SPSKKQKKKR KTSSSKHDVS AHHDLNIDQS 70 80 90 100 110 120 QCNEMYINSS QRVESTVIPE STIMRTLHSG EITSHEQGFS VELESEISTT ADDCSSEVNG 130 140 150 160 170 180 CSFVMRTGKP TNLLREEEFG VDDSYSEQGA QDSPTHLEMM ESELAGKQHE IEELNRELEE 190 200 210 220 230 240 MRVTYGTEGL QQLQEFEAAI KQRDGIITQL TANLQQARRE KDETMREFLE LTEQSQKLQI 250 260 270 280 290 300 QFQQLQASET LRNSTHSSTA ADLLQAKQQI LTHQQQLEEQ DHLLEDYQKK KEDFTMQISF 310 320 330 340 350 360 LQEKIKVYEM EQDKKVENSN KEEIQEKETI IEELNTKIIE EEKKTLELKD KLTTADKLLG 370 380 390 400 410 420 ELQEQIVQKN QEIKNMKLEL TNSKQKERQS SEEIKQLMGT VEELQKRNHK DSQFETDIVQ 430 440 450 460 470 480 RMEQETQRKL EQLRAELDEM YGQQIVQMKQ ELIRQHMAQM EEMKTRHKGE MENALRSYSN 490 500 510 520 530 540 ITVNEDQIKL MNVAINELNI KLQDTNSQKE KLKEELGLIL EEKCALQRQL EDLVEELSFS 550 560 570 580 590 600 REQIQRARQT IAEQESKLNE AHKSLSTVED LKAEIVSASE SRKELELKHE AEVTNYKIKL 610 620 630 640 650 660 EMLEKEKNAV LDRMAESQEA ELERLRTQLL FSHEEELSKL KEDLEIEHRI NIEKLKDNLG 670 680 690 700 710 720 IHYKQQIDGL QNEMSQKIET MQFEKDNLIT KQNQLILEIS KLKDLQQSLV NSKSEEMTLQ 730 740 750 760 770 780 INELQKEIEI LRQEEKEKGT LEQEVQELQL KTELLEKQMK EKENDLQEKF AQLEAENSIL 790 800 810 820 830 840 KDEKKTLEDM LKIHTPVSQE ERLIFLDSIK SKSKDSVWEK EIEILIEENE DLKQQCIQLN 850 860 870 880 890 900 EEIEKQRNTF SFAEKNFEVN YQELQEEYAC LLKVKDDLED SKNKQELEYK SKLKALNEEL 910 920 930 940 950 960 HLQRINPTTV KMKSSVFDED KTFVAETLEM GEVVEKDTTE LMEKLEVTKR EKLELSQRLS 970 980 990 1000 1010 1020 DLSEQLKQKH GEISFLNEEV KSLKQEKEQV SLRCRELEII INHNRAENVQ SCDTQVSSLL 1030 1040 1050 1060 1070 1080 DGVVTMTSRG AEGSVSKVNK SFGEESKIMV EDKVSFENMT VGEESKQEQL ILDHLPSVTK 1090 1100 1110 1120 1130 1140 ESSLRATQPS ENDKLQKELN VLKSEQNDLR LQMEAQRICL SLVYSTHVDQ VREYMENEKD 1150 1160 1170 1180 1190 1200 KALCSLKEEL IFAQEEKIKE LQKIHQLELQ TMKTQETGDE GKPLHLLIGK LQKAVSEECS 1210 1220 1230 1240 1250 1260 YFLQTLCSVL GEYYTPALKC EVNAEDKENS GDYISENEDP ELQDYRYEVQ DFQENMHTLL 1270 1280 1290 1300 1310 1320 NKVTEEYNKL LVLQTRLSKI WGQQTDGMKL EFGEENLPKE ETEFLSIHSQ MTNLEDIDVN 1330 1340 1350 1360 1370 1380 HKSKLSSLQD LEKTKLEEQV QELESLISSL QQQLKETEQN YEAEIHCLQK RLQAVSESTV 1390 1400 1410 1420 1430 1440 PPSLPVDSVV ITESDAQRTM YPGSCVKKNI DGTIEFSGEF GVKEETNIVK LLEKQYQEQL 1450 1460 1470 1480 1490 1500 EEEVAKVIVS MSIAFAQQTE LSRISGGKEN TASSKQAHAV CQQEQHYFNE MKLSQDQIGF 1510 1520 1530 1540 1550 1560 QTFETVDVKF KEEFKPLSKE LGEHGKEILL SNSDPHDIPE SKDCVLTISE EMFSKDKTFI 1570 1580 1590 1600 1610 1620 VRQSIHDEIS VSSMDASRQL MLNEEQLEDM RQELVRQYQE HQQATELLRQ AHMRQMERQR 1630 1640 1650 1660 1670 1680 EDQEQLQEEI KRLNRQLAQR SSIDNENLVS ERERVLLEEL EALKQLSLAG REKLCCELRN 1690 1700 1710 1720 1730 1740 SSTQTQNGNE NQGEVEEQTF KEKELDRKPE DVPPEILSNE RYALQKANNR LLKILLEVVK 1750 1760 1770 1780 1790 1800 TTAAVEETIG RHVLGILDRS SKSQSSASLI WRSEAEASVK SCVHEEHTRV TDESIPSYSG 1810 1820 1830 1840 1850 1860 SDMPRNDINM WSKVTEEGTE LSQRLVRSGF AGTEIDPENE ELMLNISSRL QAAVEKLLEA 1870 1880 1890 1900 1910 1920 ISETSSQLEH AKVTQTELMR ESFRQKQEAT ESLKCQEELR ERLHEESRAR EQLAVELSKA 1930 1940 1950 1960 1970 1980 EGVIDGYADE KTLFERQIQE KTDIIDRLEQ ELLCASNRLQ ELEAEQQQIQ EERELLSRQK 1990 2000 2010 2020 2030 2040 EAMKAEAGPV EQQLLQETEK LMKEKLEVQC QAEKVRDDLQ KQVKALEIDV EEQVSRFIEL 2050 2060 2070 2080 2090 2100 EQEKNTELMD LRQQNQALEK QLEKMRKFLD EQAIDREHER DVFQQEIQKL EQQLKVVPRF 2110 2120 2130 2140 2150 2160 QPISEHQTRE VEQLANHLKE KTDKCSELLL SKEQLQRDIQ ERNEEIEKLE FRVRELEQAL 2170 2180 2190 2200 2210 2220 LVEDRKHFGA VEAKPELSLE VQLQAERDAI DRKEKEITNL EEQLEQFREE LENKNEEVQQ 2230 2240 2250 2260 2270 2280 LHMQLEIQKK ESTTRLQELE QENKLFKDDM EKLGLAIKES DAMSTQDQHV LFGKFAQIIQ 2290 2300 2310 2320 2330 2340 EKEVEIDQLN EQVTKLQQQL KITTDNKVIE EKNELIRDLE TQIECLMSDQ ECVKRNREEE 2350 2360 2370 2380 2390 2400 IEQLNEVIEK LQQELANIGQ KTSMNAHSLS EEADSLKHQL DVVIAEKLAL EQQVETANEE 2410 2420 2430 2440 2450 2460 MTFMKNVLKE TNFKMNQLTQ ELFSLKRERE SVEKIQSIPE NSVNVAIDHL SKDKPELEVV 2470 2480 2490 2500 2510 2520 LTEDALKSLE NQTYFKSFEE NGKGSIINLE TRLLQLESTV SAKDLELTQC YKQIKDMQEQ 2530 2540 2550 2560 2570 2580 GQFETEMLQK KIVNLQKIVE EKVAAALVSQ IQLEAVQEYA KFCQDNQTIS SEPERTNIQN 2590 2600 2610 2620 2630 2640 LNQLREDELG SDISALTLRI SELESQVVEM HTSLILEKEQ VEIAEKNVLE KEKKLLELQK 2650 2660 2670 2680 2690 2700 LLEGNEKKQR EKEKKRSPQD VEVLKTTTEL FHSNEESGFF NELEALRAES VATKAELASY 2710 2720 2730 2740 2750 2760 KEKAEKLQEE LLVKETNMTS LQKDLSQVRD HLAEAKEKLS ILEKEDETEV QESKKACMFE 2770 2780 2790 2800 2810 2820 PLPIKLSKSI ASQTDGTLKI SSSNQTPQIL VKNAGIQINL QSECSSEEVT EIISQFTEKI 2830 2840 2850 2860 2870 2880 EKMQELHAAE ILDMESRHIS ETETLKREHY VAVQLLKEEC GTLKAVIQCL RSKEGSSIPE 2890 2900 2910 2920 2930 2940 LAHSDAYQTR EICSSDSGSD WGQGIYLTHS QGFDIASEGR GEESESATDS FPKKIKGLLR 2950 2960 2970 2980 2990 3000 AVHNEGMQVL SLTESPYSDG EDHSIQQVSE PWLEERKAYI NTISSLKDLI TKMQLQREAE 3010 3020 3030 3040 3050 3060 VYDSSQSHES FSDWRGELLL ALQQVFLEER SVLLAAFRTE LTALGTTDAV GLLNCLEQRI 3070 3080 3090 3100 3110 3120 QEQGVEYQAA MECLQKADRR SLLSEIQALH AQMNGRKITL KREQESEKPS QELLEYNIQQ 3130 3140 3150 3160 3170 3180 KQSQMLEMQV ELSSMKDRAT ELQEQLSSEK MVVAELKSEL AQTKLELETT LKAQHKHLKE 3190 3200 3210 3220 3230 3240 LEAFRLEVKD KTDEVHLLND TLASEQKKSR ELQWALEKEK AKLGRSEERD KEELEDLKFS 3250 3260 3270 3280 3290 3300 LESQKQRNLQ LNLLLEQQKQ LLNESQQKIE SQRMLYDAQL SEEQGRNLEL QVLLESEKVR 3310 3320 3330 3340 3350 3360 IREMSSTLDR ERELHAQLQS SDGTGQSRPP LPSEDLLKEL QKQLEEKHSR IVELLNETEK 3370 3380 3390 3400 3410 3420 YKLDSLQTRQ QMEKDRQVHR KTLQTEQEAN TEGQKKMHEL QSKVEDLQRQ LEEKRQQVYK 3430 3440 3450 3460 3470 3480 LDLEGQRLQG IMQEFQKQEL EREEKRESRR ILYQNLNEPT TWSLTSDRTR NWVLQQKIEG 3490 3500 3510 3520 3530 3540 ETKESNYAKL IEMNGGGTGC NHELEMIRQK LQCVASKLQV LPQKASERLQ FETADDEDFI 3550 3560 3570 3580 3590 3600 WVQENIDEII LQLQKLTGQQ GEEPSLVSPS TSCGSLTERL LRQNAELTGH ISQLTEEKND 3610 3620 3630 3640 3650 3660 LRNMVMKLEE QIRWYRQTGA GRDNSSRFSL NGGANIEAII ASEKEVWNRE KLTLQKSLKR 3670 3680 3690 3700 3710 3720 AEAEVYKLKA ELRNDSLLQT LSPDSEHVTL KRIYGKYLRA ESFRKALIYQ KKYLLLLLGG 3730 3740 3750 3760 3770 3780 FQECEDATLA LLARMGGQPA FTDLEVITNR PKGFTRFRSA VRVSIAISRM KFLVRRWHRV 3790 3800 3810 3820 3830 3840 TGSVSININR DGFGLNQGAE KTDSFYHSSG GLELYGEPRH TTYRSRSDLD YIRSPLPFQN 3850 3860 3870 3880 3890 RYPGTPADFN PGSLACSQLQ NYDPDRALTD YITRLEALQR RLGTIQSGST TQFHAGMRR
	Isoform 4 (Yotiao) [UniParc]. Checksum: C41FBD5551FB644E	FASTA	1,643	191,308
	10 20 30 40 50 60 MEDEERQKKL EAGKAKIEEL SLAFLVRQLA QFRQRKAQSD GQSPSKKQKK KRKTSSSKHD 70 80 90 100 110 120 VSAHHDLNID QSQCNEMYIN SSQRVESTVI PESTIMRTLH SGEITSHEQG FSVELESEIS 130 140 150 160 170 180 TTADDCSSEV NGCSFVMRTG KPTNLLREEE FGVDDSYSEQ GAQDSPTHLE MMESELAGKQ 190 200 210 220 230 240 HEIEELNREL EEMRVTYGTE GLQQLQEFEA AIKQRDGIIT QLTANLQQAR REKDETMREF 250 260 270 280 290 300 LELTEQSQKL QIQFQQLQAS ETLRNSTHSS TAADLLQAKQ QILTHQQQLE EQDHLLEDYQ 310 320 330 340 350 360 KKKEDFTMQI SFLQEKIKVY EMEQDKKVEN SNKEEIQEKE TIIEELNTKI IEEEKKTLEL 370 380 390 400 410 420 KDKLTTADKL LGELQEQIVQ KNQEIKNMKL ELTNSKQKER QSSEEIKQLM GTVEELQKRN 430 440 450 460 470 480 HKDSQFETDI VQRMEQETQR KLEQLRAELD EMYGQQIVQM KQELIRQHMA QMEEMKTRHK 490 500 510 520 530 540 GEMENALRSY SNITVNEDQI KLMNVAINEL NIKLQDTNSQ KEKLKEELGL ILEEKCALQR 550 560 570 580 590 600 QLEDLVEELS FSREQIQRAR QTIAEQESKL NEAHKSLSTV EDLKAEIVSA SESRKELELK 610 620 630 640 650 660 HEAEVTNYKI KLEMLEKEKN AVLDRMAESQ EAELERLRTQ LLFSHEEELS KLKEDLEIEH 670 680 690 700 710 720 RINIEKLKDN LGIHYKQQID GLQNEMSQKI ETMQFEKDNL ITKQNQLILE ISKLKDLQQS 730 740 750 760 770 780 LVNSKSEEMT LQINELQKEI EILRQEEKEK GTLEQEVQEL QLKTELLEKQ MKEKENDLQE 790 800 810 820 830 840 KFAQLEAENS ILKDEKKTLE DMLKIHTPVS QEERLIFLDS IKSKSKDSVW EKEIEILIEE 850 860 870 880 890 900 NEDLKQQCIQ LNEEIEKQRN TFSFAEKNFE VNYQELQEEY ACLLKVKDDL EDSKNKQELE 910 920 930 940 950 960 YKSKLKALNE ELHLQRINPT TVKMKSSVFD EDKTFVAETL EMGEVVEKDT TELMEKLEVT 970 980 990 1000 1010 1020 KREKLELSQR LSDLSEQLKQ KHGEISFLNE EVKSLKQEKE QVSLRCRELE IIINHNRAEN 1030 1040 1050 1060 1070 1080 VQSCDTQVSS LLDGVVTMTS RGAEGSVSKV NKSFGEESKI MVEDKVSFEN MTVGEESKQE 1090 1100 1110 1120 1130 1140 QLILDHLPSV TKESSLRATQ PSENDKLQKE LNVLKSEQND LRLQMEAQRI CLSLVYSTHV 1150 1160 1170 1180 1190 1200 DQVREYMENE KDKALCSLKE ELIFAQEEKI KELQKIHQLE LQTMKTQETG DEGKPLHLLI 1210 1220 1230 1240 1250 1260 GKLQKAVSEE CSYFLQTLCS VLGEYYTPAL KCEVNAEDKE NSGDYISENE DPELQDYRYE 1270 1280 1290 1300 1310 1320 VQDFQENMHT LLNKVTEEYN KLLVLQTRLS KIWGQQTDGM KLEFGEENLP KEETEFLSIH 1330 1340 1350 1360 1370 1380 SQMTNLEDID VNHKSKLSSL QDLEKTKLEE QVQELESLIS SLQQQLKETE QNYEAEIHCL 1390 1400 1410 1420 1430 1440 QKRLQAVSES TVPPSLPVDS VVITESDAQR TMYPGSCVKK NIDGTIEFSG EFGVKEETNI 1450 1460 1470 1480 1490 1500 VKLLEKQYQE QLEEEVAKVI VSMSIAFAQQ TELSRISGGK ENTASSKQAH AVCQQEQHYF 1510 1520 1530 1540 1550 1560 NEMKLSQDQI GFQTFETVDV KFKEEFKPLS KELGEHGKEI LLSNSDPHDI PESKDCVLTI 1570 1580 1590 1600 1610 1620 SEEMFSKDKT FIVRQSIHDE ISVSSMDASR QLMLNEEQLE DMRQELVRQY QEHQQATELL 1630 1640 RQAHMRQMER QREDQELAQV RVL
	Isoform 5 [UniParc]. Checksum: 6DEB35CA282A0FDD	FASTA	3,857	447,753
	10 20 30 40 50 60 MEDEERQKKL EAGKAKIEEL SLAFLVRQLA QFRQRKAQSD GQSPSKKQKK KRKTSSSKHD 70 80 90 100 110 120 VSAHHDLNID QSQCNEMYIN SSQRVESTVI PESTIMRTLH SGEITSHEQG FSVELESEIS 130 140 150 160 170 180 TTADDCSSEV NGCSFVMRTG KPTNLLREEE FGVDDSYSEQ GAQDSPTHLE MMESELAGKQ 190 200 210 220 230 240 HEIEELNREL EEMRVTYGTE GLQQLQEFEA AIKQRDGIIT QLTANLQQAR REKDETMREF 250 260 270 280 290 300 LELTEQSQKL QIQFQQLQAS ETLRNSTHSS TAADLLQAKQ QILTHQQQLE EQDHLLEDYQ 310 320 330 340 350 360 KKKEDFTMQI SFLQEKIKVY EMEQDKKVEN SNKEEIQEKE TIIEELNTKI IEEEKKTLEL 370 380 390 400 410 420 KDKLTTADKL LGELQEQIVQ KNQEIKNMKL ELTNSKQKER QSSEEIKQLM GTVEELQKRN 430 440 450 460 470 480 HKDSQFETDI VQRMEQETQR KLEQLRAELD EMYGQQIVQM KQELIRQHMA QMEEMKTRHK 490 500 510 520 530 540 GEMENALRSY SNITVNEDQI KLMNVAINEL NIKLQDTNSQ KEKLKEELGL ILEEKCALQR 550 560 570 580 590 600 QLEDLVEELS FSREQIQRAR QTIAEQESKL NEAHKSLSTV EDLKAEIVSA SESRKELELK 610 620 630 640 650 660 HEAEVTNYKI KLEMLEKEKN AVLDRMAESQ EAELERLRTQ LLFSHEEELS KLKEDLEIEH 670 680 690 700 710 720 RINIEKLKDN LGIHYKQQID GLQNEMSQKI ETMQFEKDNL ITKQNQLILE ISKLKDLQQS 730 740 750 760 770 780 LVNSKSEEMT LQINELQKEI EILRQEEKEK GTLEQEVQEL QLKTELLEKQ MKEKENDLQE 790 800 810 820 830 840 KFAQLEAENS ILKDEKKTLE DMLKIHTPVS QEERLIFLDS IKSKSKDSVW EKEIEILIEE 850 860 870 880 890 900 NEDLKQQCIQ LNEEIEKQRN TFSFAEKNFE VNYQELQEEY ACLLKVKDDL EDSKNKQELE 910 920 930 940 950 960 YKSKLKALNE ELHLQRINPT TVKMKSSVFD EDKTFVAETL EMGEVVEKDT TELMEKLEVT 970 980 990 1000 1010 1020 KREKLELSQR LSDLSEQLKQ KHGEISFLNE EVKSLKQEKE QVSLRCRELE IIINHNRAEN 1030 1040 1050 1060 1070 1080 VQSCDTQVSS LLDGVVTMTS RGAEGSVSKV NKSFGEESKI MVEDKVSFEN MTVGEESKQE 1090 1100 1110 1120 1130 1140 QLILDHLPSV TKESSLRATQ PSENDKLQKE LNVLKSEQND LRLQMEAQRI CLSLVYSTHV 1150 1160 1170 1180 1190 1200 DQVREYMENE KDKALCSLKE ELIFAQEEKI KELQKIHQLE LQTMKTQETG DEGKPLHLLI 1210 1220 1230 1240 1250 1260 GKLQKAVSEE CSYFLQTLCS VLGEYYTPAL KCEVNAEDKE NSGDYISENE DPELQDYRYE 1270 1280 1290 1300 1310 1320 VQDFQENMHT LLNKVTEEYN KLLVLQTRLS KIWGQQTDGM KLEFGEENLP KEETEFLSIH 1330 1340 1350 1360 1370 1380 SQMTNLEDID VNHKSKLSSL QDLEKTKLEE QVQELESLIS SLQQQLKETE QNYEAEIHCL 1390 1400 1410 1420 1430 1440 QKRLQAVSES TVPPSLPVDS VVITESDAQR TMYPGSCVKK NIDGTIEFSG EFGVKEETNI 1450 1460 1470 1480 1490 1500 VKLLEKQYQE QLEEEVAKVI VSMSIAFAQQ TELSRISGGK ENTASSKQAH AVCQQEQHYF 1510 1520 1530 1540 1550 1560 NEMKLSQDQI GFQTFETVDV KFKEEFKPLS KELGEHGKEI LLSNSDPHDI PESKDCVLTI 1570 1580 1590 1600 1610 1620 SEEMFSKDKT FIVRQSIHDE ISVSSMDASR QLMLNEEQLE DMRQELVRQY QEHQQATELL 1630 1640 1650 1660 1670 1680 RQAHMRQMER QREDQEQLQE EIKRLNRQLA QRSSIDNENL VSERERVLLE ELEALKQLSL 1690 1700 1710 1720 1730 1740 AGREKLCCEL RNSSTQTQNG NENQGEVEEQ TFKEKELDRK PEDVPPEILS NERYALQKAN 1750 1760 1770 1780 1790 1800 NRLLKILLEV VKTTAAVEET IGRHVLGILD RSSKSQSSAS LIWRSEAEAS VKSCVHEEHT 1810 1820 1830 1840 1850 1860 RVTDESIPSY SGSDMPRNDI NMWSKVTEEG TELSQRLVRS GFAGTEIDPE NEELMLNISS 1870 1880 1890 1900 1910 1920 RLQAAVEKLL EAISETSSQL EHAKVTQTEL MRESFRQKQE ATESLKCQEE LRERLHEESR 1930 1940 1950 1960 1970 1980 AREQLAVELS KAEGVIDGYA DEKTLFERQI QEKTDIIDRL EQELLCASNR LQELEAEQQQ 1990 2000 2010 2020 2030 2040 IQEERELLSR QKEAMKAEAG PVEQQLLQET EKLMKEKLEV QCQAEKVRDD LQKQVKALEI 2050 2060 2070 2080 2090 2100 DVEEQVSRFI ELEQEKNTEL MDLRQQNQAL EKQLEKMRKF LDEQAIDREH ERDVFQQEIQ 2110 2120 2130 2140 2150 2160 KLEQQLKVVP RFQPISEHQT REVEQLANHL KEKTDKCSEL LLSKEQLQRD IQERNEEIEK 2170 2180 2190 2200 2210 2220 LEFRVRELEQ ALLVSADTFQ KVEDRKHFGA VEAKPELSLE VQLQAERDAI DRKEKEITNL 2230 2240 2250 2260 2270 2280 EEQLEQFREE LENKNEEVQQ LHMQLEIQKK ESTTRLQELE QENKLFKDDM EKLGLAIKES 2290 2300 2310 2320 2330 2340 DAMSTQDQHV LFGKFAQIIQ EKEVEIDQLN EQVTKLQQQL KITTDNKVIE EKNELIRDLE 2350 2360 2370 2380 2390 2400 TQIECLMSDQ ECVKRNREEE IEQLNEVIEK LQQELANIGQ KTSMNAHSLS EEADSLKHQL 2410 2420 2430 2440 2450 2460 DVVIAEKLAL EQQVETANEE MTFMKNVLKE TNFKMNQLTQ ELFSLKRERE SVEKIQSIPE 2470 2480 2490 2500 2510 2520 NSVNVAIDHL SKDKPELEVV LTEDALKSLE NQTYFKSFEE NGKGSIINLE TRLLQLESTV 2530 2540 2550 2560 2570 2580 SAKDLELTQC YKQIKDMQEQ GQFETEMLQK KIVNLQKIVE EKVAAALVSQ IQLEAVQEYA 2590 2600 2610 2620 2630 2640 KFCQDNQTIS SEPERTNIQN LNQLREDELG SDISALTLRI SELESQVVEM HTSLILEKEQ 2650 2660 2670 2680 2690 2700 VEIAEKNVLE KEKKLLELQK LLEGNEKKQR EKEKKRSPQD VEVLKTTTEL FHSNEESGFF 2710 2720 2730 2740 2750 2760 NELEALRAES VATKAELASY KEKAEKLQEE LLVKETNMTS LQKDLSQVRD HLAEAKEKLS 2770 2780 2790 2800 2810 2820 ILEKEDETEV QESKKACMFE PLPIKLSKSI ASQTDGTLKI SSSNQTPQIL VKNAGIQINL 2830 2840 2850 2860 2870 2880 QSECSSEEVT EIISQFTEKI EKMQELHAAE ILDMESRHIS ETETLKREHY VAVQLLKEEC 2890 2900 2910 2920 2930 2940 GTLKAVIQCL RSKEGLLRAV HNEGMQVLSL TESPYSDGED HSIQQVSEPW LEERKAYINT 2950 2960 2970 2980 2990 3000 ISSLKDLITK MQLQREAEVY DSSQSHESFS DWRGELLLAL QQVFLEERSV LLAAFRTELT 3010 3020 3030 3040 3050 3060 ALGTTDAVGL LNCLEQRIQE QGVEYQAAME CLQKADRRSL LSEIQALHAQ MNGRKITLKR 3070 3080 3090 3100 3110 3120 EQESEKPSQE LLEYNIQQKQ SQMLEMQVEL SSMKDRATEL QEQLSSEKMV VAELKSELAQ 3130 3140 3150 3160 3170 3180 TKLELETTLK AQHKHLKELE AFRLEVKDKT DEVHLLNDTL ASEQKKSREL QWALEKEKAK 3190 3200 3210 3220 3230 3240 LGRSEERDKE ELEDLKFSLE SQKQRNLQLN LLLEQQKQLL NESQQKIESQ RMLYDAQLSE 3250 3260 3270 3280 3290 3300 EQGRNLELQV LLESEKVRIR EMSSTLDRER ELHAQLQSSD GTGQSRPPLP SEDLLKELQK 3310 3320 3330 3340 3350 3360 QLEEKHSRIV ELLNETEKYK LDSLQTRQQM EKDRQVHRKT LQTEQEANTE GQKKMHELQS 3370 3380 3390 3400 3410 3420 KVEDLQRQLE EKRQQVYKLD LEGQRLQGIM QEFQKQELER EEKRESRRIL YQNLNEPTTW 3430 3440 3450 3460 3470 3480 SLTSDRTRNW VLQQKIEGET KESNYAKLIE MNGGGTGCNH ELEMIRQKLQ CVASKLQVLP 3490 3500 3510 3520 3530 3540 QKASERLQFE TADDEDFIWV QENIDEIILQ LQKLTGQQGE EPSLVSPSTS CGSLTERLLR 3550 3560 3570 3580 3590 3600 QNAELTGHIS QLTEEKNDLR NMVMKLEEQI RWYRQTGAGR DNSSRFSLNG GANIEAIIAS 3610 3620 3630 3640 3650 3660 EKEVWNREKL TLQKSLKRAE AEVYKLKAEL RNDSLLQTLS PDSEHVTLKR IYGKYLRAES 3670 3680 3690 3700 3710 3720 FRKALIYQKK YLLLLLGGFQ ECEDATLALL ARMGGQPAFT DLEVITNRPK GFTRFRSAVR 3730 3740 3750 3760 3770 3780 VSIAISRMKF LVRRWHRVTG SVSININRDG FGLNQGAEKT DSFYHSSGGL ELYGEPRHTT 3790 3800 3810 3820 3830 3840 YRSRSDLDYI RSPLPFQNRY PGTPADFNPG SLACSQLQNY DPDRALTDYI TRLEALQRRL 3850 GTIQSGSTTQ FHAGMRR
	Isoform 6 (AKAP350) [UniParc]. Checksum: EE569AD99523AE2F	FASTA	3,929	455,423
	10 20 30 40 50 60 MEDEERQKKL EAGKAKIEEL SLAFLVRQLA QFRQRKAQSD GQSPSKKQKK KRKTSSSKHD 70 80 90 100 110 120 VSAHHDLNID QSQCNEMYIN SSQRVESTVI PESTIMRTLH SGEITSHEQG FSVELESEIS 130 140 150 160 170 180 TTADDCSSEV NGCSFVMRTG KPTNLLREEE FGVDDSYSEQ GAQDSPTHLE MMESELAGKQ 190 200 210 220 230 240 HEIEELNREL EEMRVTYGTE GLQQLQEFEA AIKQRDGIIT QLTANLQQAR REKDETMREF 250 260 270 280 290 300 LELTEQSQKL QIQFQQLQAS ETLRNSTHSS TAADLLQAKQ QILTHQQQLE EQDHLLEDYQ 310 320 330 340 350 360 KKKEDFTMQI SFLQEKIKVY EMEQDKKVEN SNKEEIQEKE TIIEELNTKI IEEEKKTLEL 370 380 390 400 410 420 KDKLTTADKL LGELQEQIVQ KNQEIKNMKL ELTNSKQKER QSSEEIKQLM GTVEELQKRN 430 440 450 460 470 480 HKDSQFETDI VQRMEQETQR KLEQLRAELD EMYGQQIVQM KQELIRQHMA QMEEMKTRHK 490 500 510 520 530 540 GEMENALRSY SNITVNEDQI KLMNVAINEL NIKLQDTNSQ KEKLKEELGL ILEEKCALQR 550 560 570 580 590 600 QLEDLVEELS FSREQIQRAR QTIAEQESKL NEAHKSLSTV EDLKAEIVSA SESRKELELK 610 620 630 640 650 660 HEAEVTNYKI KLEMLEKEKN AVLDRMAESQ EAELERLRTQ LLFSHEEELS KLKEDLEIEH 670 680 690 700 710 720 RINIEKLKDN LGIHYKQQID GLQNEMSQKI ETMQFEKDNL ITKQNQLILE ISKLKDLQQS 730 740 750 760 770 780 LVNSKSEEMT LQINELQKEI EILRQEEKEK GTLEQEVQEL QLKTELLEKQ MKEKENDLQE 790 800 810 820 830 840 KFAQLEAENS ILKDEKKTLE DMLKIHTPVS QEERLIFLDS IKSKSKDSVW EKEIEILIEE 850 860 870 880 890 900 NEDLKQQCIQ LNEEIEKQRN TFSFAEKNFE VNYQELQEEY ACLLKVKDDL EDSKNKQELE 910 920 930 940 950 960 YKSKLKALNE ELHLQRINPT TVKMKSSVFD EDKTFVAETL EMGEVVEKDT TELMEKLEVT 970 980 990 1000 1010 1020 KREKLELSQR LSDLSEQLKQ KHGEISFLNE EVKSLKQEKE QVSLRCRELE IIINHNRAEN 1030 1040 1050 1060 1070 1080 VQSCDTQVSS LLDGVVTMTS RGAEGSVSKV NKSFGEESKI MVEDKVSFEN MTVGEESKQE 1090 1100 1110 1120 1130 1140 QLILDHLPSV TKESSLRATQ PSENDKLQKE LNVLKSEQND LRLQMEAQRI CLSLVYSTHV 1150 1160 1170 1180 1190 1200 DQVREYMENE KDKALCSLKE ELIFAQEEKI KELQKIHQLE LQTMKTQETG DEGKPLHLLI 1210 1220 1230 1240 1250 1260 GKLQKAVSEE CSYFLQTLCS VLGEYYTPAL KCEVNAEDKE NSGDYISENE DPELQDYRYE 1270 1280 1290 1300 1310 1320 VQDFQENMHT LLNKVTEEYN KLLVLQTRLS KIWGQQTDGM KLEFGEENLP KEETEFLSIH 1330 1340 1350 1360 1370 1380 SQMTNLEDID VNHKSKLSSL QDLEKTKLEE QVQELESLIS SLQQQLKETE QNYEAEIHCL 1390 1400 1410 1420 1430 1440 QKRLQAVSES TVPPSLPVDS VVITESDAQR TMYPGSCVKK NIDGTIEFSG EFGVKEETNI 1450 1460 1470 1480 1490 1500 VKLLEKQYQE QLEEEVAKVI VSMSIAFAQQ TELSRISGGK ENTASSKQAH AVCQQEQHYF 1510 1520 1530 1540 1550 1560 NEMKLSQDQI GFQTFETVDV KFKEEFKPLS KELGEHGKEI LLSNSDPHDI PESKDCVLTI 1570 1580 1590 1600 1610 1620 SEEMFSKDKT FIVRQSIHDE ISVSSMDASR QLMLNEEQLE DMRQELVRQY QEHQQATELL 1630 1640 1650 1660 1670 1680 RQAHMRQMER QREDQEQLQE EIKRLNRQLA QRSSIDNENL VSERERVLLE ELEALKQLSL 1690 1700 1710 1720 1730 1740 AGREKLCCEL RNSSTQTQNG NENQGEVEEQ TFKEKELDRK PEDVPPEILS NERYALQKAN 1750 1760 1770 1780 1790 1800 NRLLKILLEV VKTTAAVEET IGRHVLGILD RSSKSQSSAS LIWRSEAEAS VKSCVHEEHT 1810 1820 1830 1840 1850 1860 RVTDESIPSY SGSDMPRNDI NMWSKVTEEG TELSQRLVRS GFAGTEIDPE NEELMLNISS 1870 1880 1890 1900 1910 1920 RLQAAVEKLL EAISETSSQL EHAKVTQTEL MRESFRQKQE ATESLKCQEE LRERLHEESR 1930 1940 1950 1960 1970 1980 AREQLAVELS KAEGVIDGYA DEKTLFERQI QEKTDIIDRL EQELLCASNR LQELEAEQQQ 1990 2000 2010 2020 2030 2040 IQEERELLSR QKEAMKAEAG PVEQQLLQET EKLMKEKLEV QCQAEKVRDD LQKQVKALEI 2050 2060 2070 2080 2090 2100 DVEEQVSRFI ELEQEKNTEL MDLRQQNQAL EKQLEKMRKF LDEQAIDREH ERDVFQQEIQ 2110 2120 2130 2140 2150 2160 KLEQQLKVVP RFQPISEHQT REVEQLANHL KEKTDKCSEL LLSKEQLQRD IQERNEEIEK 2170 2180 2190 2200 2210 2220 LEFRVRELEQ ALLVQDRKHF GAVEAKPELS LEVQLQAERD AIDRKEKEIT NLEEQLEQFR 2230 2240 2250 2260 2270 2280 EELENKNEEV QQLHMQLEIQ KKESTTRLQE LEQENKLFKD DMEKLGLAIK ESDAMSTQDQ 2290 2300 2310 2320 2330 2340 HVLFGKFAQI IQEKEVEIDQ LNEQVTKLQQ QLKITTDNKV IEEKNELIRD LETQIECLMS 2350 2360 2370 2380 2390 2400 DQECVKRNRE EEIEQLNEVI EKLQQELANI GQKTSMNAHS LSEEADSLKH QLDVVIAEKL 2410 2420 2430 2440 2450 2460 ALEQQVETAN EEMTFMKNVL KETNFKMNQL TQELFSLKRE RESVEKIQSI PENSVNVAID 2470 2480 2490 2500 2510 2520 HLSKDKPELE VVLTEDALKS LENQTYFKSF EENGKGSIIN LETRLLQLES TVSAKDLELT 2530 2540 2550 2560 2570 2580 QCYKQIKDMQ EQGQFETEML QKKIVNLQKI VEEKVAAALV SQIQLEAVQE YAKFCQDNQT 2590 2600 2610 2620 2630 2640 ISSEPERTNI QNLNQLREDE LGSDISALTL RISELESQVV EMHTSLILEK EQVEIAEKNV 2650 2660 2670 2680 2690 2700 LEKEKKLLEL QKLLEGNEKK QREKEKKRSP QDVEVLKTTT ELFHSNEESG FFNELEALRA 2710 2720 2730 2740 2750 2760 ESVATKAELA SYKEKAEKLQ EELLVKETNM TSLQKDLSQV RDHLAEAKEK LSILEKEDET 2770 2780 2790 2800 2810 2820 EVQESKKACM FEPLPIKLSK SIASQTDGTL KISSSNQTPQ ILVKNAGIQI NLQSECSSEE 2830 2840 2850 2860 2870 2880 VTEIISQFTE KIEKMQELHA AEILDMESRH ISETETLKRE HYVAVQLLKE ECGTLKAVIQ 2890 2900 2910 2920 2930 2940 CLRSKEGSSI PELAHSDAYQ TREICSSDSG SDWGQGIYLT HSQGFDIASE GRGEESESAT 2950 2960 2970 2980 2990 3000 DSFPKKIKGL LRAVHNEGMQ VLSLTESPYS DGEDHSIQQV SEPWLEERKA YINTISSLKD 3010 3020 3030 3040 3050 3060 LITKMQLQRE AEVYDSSQSH ESFSDWRGEL LLALQQVFLE ERSVLLAAFR TELTALGTTD 3070 3080 3090 3100 3110 3120 AVGLLNCLEQ RIQEQGVEYQ AAMECLQKAD RRSLLSEIQA LHAQMNGRKI TLKREQESEK 3130 3140 3150 3160 3170 3180 PSQELLEYNI QQKQSQMLEM QVELSSMKDR ATELQEQLSS EKMVVAELKS ELAQTKLELE 3190 3200 3210 3220 3230 3240 TTLKAQHKHL KELEAFRLEV KDKTDEVHLL NDTLASEQKK SRELQWALEK EKAKLGRSEE 3250 3260 3270 3280 3290 3300 RDKEELEDLK FSLESQKQRN LQLNLLLEQQ KQLLNESQQK IESQRMLYDA QLSEEQGRNL 3310 3320 3330 3340 3350 3360 ELQVLLESEK VRIREMSSTL DRERELHAQL QSSDGTGQSR PPLPSEDLLK ELQKQLEEKH 3370 3380 3390 3400 3410 3420 SRIVELLNET EKYKLDSLQT RQQMEKDRQV HRKTLQTEQE ANTEGQKKMH ELQSKVEDLQ 3430 3440 3450 3460 3470 3480 RQLEEKRQQV YKLDLEGQRL QGIMQEFQKQ ELEREEKRES RRILYQNLNE PTTWSLTSDR 3490 3500 3510 3520 3530 3540 TRNWVLQQKI EGETKESNYA KLIEMNGGGT GCNHELEMIR QKLQCVASKL QVLPQKASER 3550 3560 3570 3580 3590 3600 LQFETADDED FIWVQENIDE IILQLQKLTG QQGEEPSLVS PSTSCGSLTE RLLRQNAELT 3610 3620 3630 3640 3650 3660 GHISQLTEEK NDLRNMVMKL EEQIRWYRQT GAGRDNSSRF SLNGGANIEA IIASEKEVWN 3670 3680 3690 3700 3710 3720 REKLTLQKSL KRAEAEVYKL KAELRNDSLL QTLSPDSEHV TLKRIYGKYL RAESFRKALI 3730 3740 3750 3760 3770 3780 YQKKYLLLLL GGFQECEDAT LALLARMGGQ PAFTDLEVIT NRPKGFTRFR SAVRVSIAIS 3790 3800 3810 3820 3830 3840 RMKFLVRRWH RVTGSVSINI NRDGFGLNQG AEKTDSFYHS SGGLELYGEP RHTTYRSRSD 3850 3860 3870 3880 3890 3900 LDYIRSPLPF QNRYPGTPAD FNPGSLACSQ LQNYDPDRAL TDYITRLEAL QRRLGTIQSG 3910 3920 ALSLTTSWQH HSARPTAPLF FEILSHSLG

References

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[2]	"Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450." Witczak O., Skaalhegg B.S., Keryer G., Bornens M., Tasken K., Jahnsen T., Oerstavik S. EMBO J. 18:1858-1868(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-1347 INS.
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[4]	"Cloning of Hyperion." Kemmner W.A., Deiss S., Schwarz U. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
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[6]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes." Schmidt P.H., Dransfield D.T., Claudio J.O., Hawley R.G., Trotter K.W., Milgram S.L., Goldenring J.R. J. Biol. Chem. 274:3055-3066(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 323-3911 (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 2157-3911 (ISOFORM 6), VARIANT SER-2983. Tissue: Gastric parietal cell and Lung.
[8]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2212-3911 (ISOFORMS 2/3), VARIANT SER-2983. Tissue: Brain.
[9]	"AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member." Shanks R.A., Larocca M.C., Berryman M., Edwards J.C., Urushidani T., Navarre J., Goldenring J.R. J. Biol. Chem. 277:40973-40980(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CLIC1; CLIC4 AND CLIC5.
[10]	"Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450." Sillibourne J.E., Milne D.M., Takahashi M., Ono Y., Meek D.W. J. Mol. Biol. 322:785-797(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CSNK1D, SUBCELLULAR LOCATION.
[11]	"AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus." Larocca M.C., Shanks R.A., Tian L., Nelson D.L., Stewart D.M., Goldenring J.R. Mol. Biol. Cell 15:2771-2781(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CIP4 AND FNBP1, SUBCELLULAR LOCATION.
[12]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3869, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-3846, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-2421 AND GLN-3301.
[16]	"Mutation of an A-kinase-anchoring protein causes long-QT syndrome." Chen L., Marquardt M.L., Tester D.J., Sampson K.J., Ackerman M.J., Kass R.S. Proc. Natl. Acad. Sci. U.S.A. 104:20990-20995(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LQT11 LEU-1582.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ131693 mRNA. Translation: CAB40713.1. AB019691 mRNA. Translation: BAA78718.1. AJ010770 Genomic DNA. Translation: CAA09361.1. AF026245 mRNA. Translation: AAB86384.1. Frameshift. AC004013 Genomic DNA. Translation: AAB96867.2. AC000066 Genomic DNA. Translation: AAC60380.1. Sequence problems. AC000120 Genomic DNA. Translation: AAS07419.1. CH236949 Genomic DNA. Translation: EAL24155.1. CH236949 Genomic DNA. Translation: EAL24156.1. CH236949 Genomic DNA. Translation: EAL24157.1. AF083037 mRNA. Translation: AAD22767.1. AF091711 mRNA. Translation: AAD39719.1. AB018346 mRNA. Translation: BAA34523.1.
IPI	IPI00019223. IPI00220624. IPI00220625. IPI00220627. IPI00220628. IPI00793082.
PIR	T08880.
RefSeq	NP_005742.4. NM_005751.4. NP_671714.1. NM_147185.2.
UniGene	Hs.651221.
3D structure databases
ProteinModelPortal	Q99996.
SMR	Q99996. Positions 153-186.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29942N.
IntAct	Q99996. 12 interactions.
PTM databases
PhosphoSite	Q99996.
Polymorphism databases
DMDM	14194461.
Proteomic databases
PaxDb	Q99996.
PRIDE	Q99996.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356239; ENSP00000348573; ENSG00000127914. ENST00000358100; ENSP00000350813; ENSG00000127914. ENST00000359028; ENSP00000351922; ENSG00000127914.
GeneID	10142.
KEGG	hsa:10142.
UCSC	uc003ulf.3. human. uc003ulg.3. human.
Organism-specific databases
CTD	10142.
GeneCards	GC07P091570.
HGNC	HGNC:379. AKAP9.
HPA	CAB012909. HPA008548. HPA026109.
MIM	604001. gene. 611820. phenotype.
neXtProt	NX_Q99996.
PharmGKB	PA24673.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOVERGEN	HBG050481.
KO	K16551.
OMA	KMRKFLD.
Enzyme and pathway databases
Reactome	REACT_115566. Cell Cycle.
Gene expression databases
ArrayExpress	Q99996.
Bgee	Q99996.
Genevestigator	Q99996.
GermOnline	ENSG00000127914. Homo sapiens.
Family and domain databases
InterPro	IPR019528. PACT_domain. [Graphical view]
Pfam	PF10495. PACT_coil_coil. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	AKAP9. human.
GenomeRNAi	10142.
NextBio	38371.
SOURCE	Search...

Entry information

Entry name

AKAP9_HUMAN

Accession

Primary (citable) accession number: Q99996
Secondary accession number(s): A4D1F0 , A4D1F2, A4D1F4, O14869, O43355, O94895, Q75N20, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	August 1, 1999
Last modified:	May 1, 2013
This is version 127 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.