SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99996

- AKAP9_HUMAN

UniProt

Q99996 - AKAP9_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
A-kinase anchor protein 9
Gene
AKAP9, AKAP350, AKAP450, KIAA0803
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.1 Publication

GO - Molecular functioni

  1. ion channel binding Source: BHF-UCL
  2. protein binding Source: UniProtKB
  3. protein complex scaffold Source: BHF-UCL
  4. receptor binding Source: ProtInc

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Reactome
  2. mitotic cell cycle Source: Reactome
  3. signal transduction Source: ProtInc
  4. synaptic transmission Source: Reactome
  5. transport Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinkiQ99996.

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 9
Short name:
AKAP-9
Alternative name(s):
A-kinase anchor protein 350 kDa
Short name:
AKAP 350
Short name:
hgAKAP 350
A-kinase anchor protein 450 kDa
Short name:
AKAP 450
AKAP 120-like protein
Centrosome- and Golgi-localized PKN-associated protein
Short name:
CG-NAP
Protein hyperion
Protein kinase A-anchoring protein 9
Short name:
PRKA9
Protein yotiao
Gene namesi
Name:AKAP9
Synonyms:AKAP350, AKAP450, KIAA0803
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:379. AKAP9.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Golgi apparatus
Note: Cytoplasmic in parietal cells.2 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. centrosome Source: UniProtKB
  3. cytoskeleton Source: ProtInc
  4. cytosol Source: Reactome
  5. intracellular membrane-bounded organelle Source: HPA
  6. pericentriolar material Source: Ensembl
  7. voltage-gated potassium channel complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Long QT syndrome 11 (LQT11) [MIM:611820]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1582 – 15821S → L in LQT11. 1 Publication
VAR_043489

Keywords - Diseasei

Disease mutation, Long QT syndrome

Organism-specific databases

MIMi611820. phenotype.
Orphaneti101016. Romano-Ward syndrome.
PharmGKBiPA24673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 39113911A-kinase anchor protein 9
PRO_0000064534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphoserine1 Publication
Modified residuei3846 – 38461Phosphoserine1 Publication
Modified residuei3869 – 38691Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99996.
PaxDbiQ99996.
PRIDEiQ99996.

PTM databases

PhosphoSiteiQ99996.

Expressioni

Tissue specificityi

Widely expressed. Isoform 4 is highly expressed in skeletal muscle and in pancreas.

Gene expression databases

ArrayExpressiQ99996.
BgeeiQ99996.
GenevestigatoriQ99996.

Organism-specific databases

HPAiCAB012909.
HPA008548.
HPA026109.

Interactioni

Subunit structurei

Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon. Interacts with CIP4 and FNBP1. Interacts with chloride intracellular channel proteins CLIC1, CLIC4 and CLIC5. CSNK1D binding promotes its centrosomal subcellular location.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-1048311,EBI-618309
KDM1AO603412EBI-1048311,EBI-710124

Protein-protein interaction databases

BioGridi115445. 35 interactions.
DIPiDIP-29942N.
IntActiQ99996. 22 interactions.
MINTiMINT-1174958.

Structurei

3D structure databases

ProteinModelPortaliQ99996.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2554 – 256714PKA-RII subunit binding domain
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili164 – 914751 Reviewed prediction
Add
BLAST
Coiled coili944 – 102279 Reviewed prediction
Add
BLAST
Coiled coili1100 – 118586 Reviewed prediction
Add
BLAST
Coiled coili1253 – 128028 Reviewed prediction
Add
BLAST
Coiled coili1336 – 139257 Reviewed prediction
Add
BLAST
Coiled coili1434 – 145926 Reviewed prediction
Add
BLAST
Coiled coili1585 – 165975 Reviewed prediction
Add
BLAST
Coiled coili1857 – 2455599 Reviewed prediction
Add
BLAST
Coiled coili2544 – 256118 Reviewed prediction
Add
BLAST
Coiled coili2603 – 2776174 Reviewed prediction
Add
BLAST
Coiled coili3065 – 309228 Reviewed prediction
Add
BLAST
Coiled coili3124 – 3470347 Reviewed prediction
Add
BLAST
Coiled coili3587 – 3689103 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi203 – 29290Gln-rich
Add
BLAST
Compositional biasi321 – 1010690Glu-rich
Add
BLAST
Compositional biasi1846 – 2772927Glu-rich
Add
BLAST
Compositional biasi3726 – 37305Poly-Leu

Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG050481.
KOiK16551.
OMAiKMRKFLD.
OrthoDBiEOG7VMP46.
PhylomeDBiQ99996.
TreeFamiTF105408.

Family and domain databases

InterProiIPR028745. AKAP9.
IPR019528. PACT_domain.
[Graphical view]
PANTHERiPTHR18932:SF10. PTHR18932:SF10. 1 hit.
PfamiPF10495. PACT_coil_coil. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99996-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDEERQKKL EAGKAKIEEL SLAFLVRQLA QFRQRKAQSD GQSPSKKQKK     50
KRKTSSSKHD VSAHHDLNID QSQCNEMYIN SSQRVESTVI PESTIMRTLH 100
SGEITSHEQG FSVELESEIS TTADDCSSEV NGCSFVMRTG KPTNLLREEE 150
FGVDDSYSEQ GAQDSPTHLE MMESELAGKQ HEIEELNREL EEMRVTYGTE 200
GLQQLQEFEA AIKQRDGIIT QLTANLQQAR REKDETMREF LELTEQSQKL 250
QIQFQQLQAS ETLRNSTHSS TAADLLQAKQ QILTHQQQLE EQDHLLEDYQ 300
KKKEDFTMQI SFLQEKIKVY EMEQDKKVEN SNKEEIQEKE TIIEELNTKI 350
IEEEKKTLEL KDKLTTADKL LGELQEQIVQ KNQEIKNMKL ELTNSKQKER 400
QSSEEIKQLM GTVEELQKRN HKDSQFETDI VQRMEQETQR KLEQLRAELD 450
EMYGQQIVQM KQELIRQHMA QMEEMKTRHK GEMENALRSY SNITVNEDQI 500
KLMNVAINEL NIKLQDTNSQ KEKLKEELGL ILEEKCALQR QLEDLVEELS 550
FSREQIQRAR QTIAEQESKL NEAHKSLSTV EDLKAEIVSA SESRKELELK 600
HEAEVTNYKI KLEMLEKEKN AVLDRMAESQ EAELERLRTQ LLFSHEEELS 650
KLKEDLEIEH RINIEKLKDN LGIHYKQQID GLQNEMSQKI ETMQFEKDNL 700
ITKQNQLILE ISKLKDLQQS LVNSKSEEMT LQINELQKEI EILRQEEKEK 750
GTLEQEVQEL QLKTELLEKQ MKEKENDLQE KFAQLEAENS ILKDEKKTLE 800
DMLKIHTPVS QEERLIFLDS IKSKSKDSVW EKEIEILIEE NEDLKQQCIQ 850
LNEEIEKQRN TFSFAEKNFE VNYQELQEEY ACLLKVKDDL EDSKNKQELE 900
YKSKLKALNE ELHLQRINPT TVKMKSSVFD EDKTFVAETL EMGEVVEKDT 950
TELMEKLEVT KREKLELSQR LSDLSEQLKQ KHGEISFLNE EVKSLKQEKE 1000
QVSLRCRELE IIINHNRAEN VQSCDTQVSS LLDGVVTMTS RGAEGSVSKV 1050
NKSFGEESKI MVEDKVSFEN MTVGEESKQE QLILDHLPSV TKESSLRATQ 1100
PSENDKLQKE LNVLKSEQND LRLQMEAQRI CLSLVYSTHV DQVREYMENE 1150
KDKALCSLKE ELIFAQEEKI KELQKIHQLE LQTMKTQETG DEGKPLHLLI 1200
GKLQKAVSEE CSYFLQTLCS VLGEYYTPAL KCEVNAEDKE NSGDYISENE 1250
DPELQDYRYE VQDFQENMHT LLNKVTEEYN KLLVLQTRLS KIWGQQTDGM 1300
KLEFGEENLP KEETEFLSIH SQMTNLEDID VNHKSKLSSL QDLEKTKLEE 1350
QVQELESLIS SLQQQLKETE QNYEAEIHCL QKRLQAVSES TVPPSLPVDS 1400
VVITESDAQR TMYPGSCVKK NIDGTIEFSG EFGVKEETNI VKLLEKQYQE 1450
QLEEEVAKVI VSMSIAFAQQ TELSRISGGK ENTASSKQAH AVCQQEQHYF 1500
NEMKLSQDQI GFQTFETVDV KFKEEFKPLS KELGEHGKEI LLSNSDPHDI 1550
PESKDCVLTI SEEMFSKDKT FIVRQSIHDE ISVSSMDASR QLMLNEEQLE 1600
DMRQELVRQY QEHQQATELL RQAHMRQMER QREDQEQLQE EIKRLNRQLA 1650
QRSSIDNENL VSERERVLLE ELEALKQLSL AGREKLCCEL RNSSTQTQNG 1700
NENQGEVEEQ TFKEKELDRK PEDVPPEILS NERYALQKAN NRLLKILLEV 1750
VKTTAAVEET IGRHVLGILD RSSKSQSSAS LIWRSEAEAS VKSCVHEEHT 1800
RVTDESIPSY SGSDMPRNDI NMWSKVTEEG TELSQRLVRS GFAGTEIDPE 1850
NEELMLNISS RLQAAVEKLL EAISETSSQL EHAKVTQTEL MRESFRQKQE 1900
ATESLKCQEE LRERLHEESR AREQLAVELS KAEGVIDGYA DEKTLFERQI 1950
QEKTDIIDRL EQELLCASNR LQELEAEQQQ IQEERELLSR QKEAMKAEAG 2000
PVEQQLLQET EKLMKEKLEV QCQAEKVRDD LQKQVKALEI DVEEQVSRFI 2050
ELEQEKNTEL MDLRQQNQAL EKQLEKMRKF LDEQAIDREH ERDVFQQEIQ 2100
KLEQQLKVVP RFQPISEHQT REVEQLANHL KEKTDKCSEL LLSKEQLQRD 2150
IQERNEEIEK LEFRVRELEQ ALLVSADTFQ KVEDRKHFGA VEAKPELSLE 2200
VQLQAERDAI DRKEKEITNL EEQLEQFREE LENKNEEVQQ LHMQLEIQKK 2250
ESTTRLQELE QENKLFKDDM EKLGLAIKES DAMSTQDQHV LFGKFAQIIQ 2300
EKEVEIDQLN EQVTKLQQQL KITTDNKVIE EKNELIRDLE TQIECLMSDQ 2350
ECVKRNREEE IEQLNEVIEK LQQELANIGQ KTSMNAHSLS EEADSLKHQL 2400
DVVIAEKLAL EQQVETANEE MTFMKNVLKE TNFKMNQLTQ ELFSLKRERE 2450
SVEKIQSIPE NSVNVAIDHL SKDKPELEVV LTEDALKSLE NQTYFKSFEE 2500
NGKGSIINLE TRLLQLESTV SAKDLELTQC YKQIKDMQEQ GQFETEMLQK 2550
KIVNLQKIVE EKVAAALVSQ IQLEAVQEYA KFCQDNQTIS SEPERTNIQN 2600
LNQLREDELG SDISALTLRI SELESQVVEM HTSLILEKEQ VEIAEKNVLE 2650
KEKKLLELQK LLEGNEKKQR EKEKKRSPQD VEVLKTTTEL FHSNEESGFF 2700
NELEALRAES VATKAELASY KEKAEKLQEE LLVKETNMTS LQKDLSQVRD 2750
HLAEAKEKLS ILEKEDETEV QESKKACMFE PLPIKLSKSI ASQTDGTLKI 2800
SSSNQTPQIL VKNAGIQINL QSECSSEEVT EIISQFTEKI EKMQELHAAE 2850
ILDMESRHIS ETETLKREHY VAVQLLKEEC GTLKAVIQCL RSKEVFGFYN 2900
MCFSTLCDSG SDWGQGIYLT HSQGFDIASE GRGEESESAT DSFPKKIKGL 2950
LRAVHNEGMQ VLSLTESPYS DGEDHSIQQV SEPWLEERKA YINTISSLKD 3000
LITKMQLQRE AEVYDSSQSH ESFSDWRGEL LLALQQVFLE ERSVLLAAFR 3050
TELTALGTTD AVGLLNCLEQ RIQEQGVEYQ AAMECLQKAD RRSLLSEIQA 3100
LHAQMNGRKI TLKREQESEK PSQELLEYNI QQKQSQMLEM QVELSSMKDR 3150
ATELQEQLSS EKMVVAELKS ELAQTKLELE TTLKAQHKHL KELEAFRLEV 3200
KDKTDEVHLL NDTLASEQKK SRELQWALEK EKAKLGRSEE RDKEELEDLK 3250
FSLESQKQRN LQLNLLLEQQ KQLLNESQQK IESQRMLYDA QLSEEQGRNL 3300
ELQVLLESEK VRIREMSSTL DRERELHAQL QSSDGTGQSR PPLPSEDLLK 3350
ELQKQLEEKH SRIVELLNET EKYKLDSLQT RQQMEKDRQV HRKTLQTEQE 3400
ANTEGQKKMH ELQSKVEDLQ RQLEEKRQQV YKLDLEGQRL QGIMQEFQKQ 3450
ELEREEKRES RRILYQNLNE PTTWSLTSDR TRNWVLQQKI EGETKESNYA 3500
KLIEMNGGGT GCNHELEMIR QKLQCVASKL QVLPQKASER LQFETADDED 3550
FIWVQENIDE IILQLQKLTG QQGEEPSLVS PSTSCGSLTE RLLRQNAELT 3600
GHISQLTEEK NDLRNMVMKL EEQIRWYRQT GAGRDNSSRF SLNGGANIEA 3650
IIASEKEVWN REKLTLQKSL KRAEAEVYKL KAELRNDSLL QTLSPDSEHV 3700
TLKRIYGKYL RAESFRKALI YQKKYLLLLL GGFQECEDAT LALLARMGGQ 3750
PAFTDLEVIT NRPKGFTRFR SAVRVSIAIS RMKFLVRRWH RVTGSVSINI 3800
NRDGFGLNQG AEKTDSFYHS SGGLELYGEP RHTTYRSRSD LDYIRSPLPF 3850
QNRYPGTPAD FNPGSLACSQ LQNYDPDRAL TDYITRLEAL QRRLGTIQSG 3900
STTQFHAGMR R 3911
Length:3,911
Mass (Da):453,667
Last modified:August 1, 1999 - v3
Checksum:i3FB1CB1C819B47AA
GO
Isoform 2 (identifier: Q99996-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-28: Missing.
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS

Show »
Length:3,907
Mass (Da):452,987
Checksum:i81761B4341430CDF
GO
Isoform 3 (identifier: Q99996-3) [UniParc]FASTAAdd to Basket

Also known as: CG-NAP

The sequence of this isoform differs from the canonical sequence as follows:
     17-28: Missing.
     2175-2182: Missing.
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS

Show »
Length:3,899
Mass (Da):452,110
Checksum:iF90C9F18B32FD314
GO
Isoform 4 (identifier: Q99996-4) [UniParc]FASTAAdd to Basket

Also known as: Yotiao

The sequence of this isoform differs from the canonical sequence as follows:
     1637-1643: QLQEEIK → LAQVRVL
     1644-3911: Missing.

Show »
Length:1,643
Mass (Da):191,308
Checksum:iC41FBD5551FB644E
GO
Isoform 5 (identifier: Q99996-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2895-2948: Missing.

Show »
Length:3,857
Mass (Da):447,753
Checksum:i6DEB35CA282A0FDD
GO
Isoform 6 (identifier: Q99996-6) [UniParc]FASTAAdd to Basket

Also known as: AKAP350

The sequence of this isoform differs from the canonical sequence as follows:
     2175-2183: SADTFQKVE → Q
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS
     3901-3911: STTQFHAGMRR → ALSLTTSWQHHSARPTAPLFFEILSHSLG

Show »
Length:3,929
Mass (Da):455,423
Checksum:iEE569AD99523AE2F
GO

Sequence cautioni

The sequence AAB86384.1 differs from that shown. Reason: Frameshift at position 1637.
The sequence AAC60380.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti475 – 4751M → I.1 Publication
Corresponds to variant rs6964587 [ dbSNP | Ensembl ].
VAR_024249
Natural varianti1347 – 13471K → KQ.1 Publication
VAR_010926
Natural varianti1582 – 15821S → L in LQT11. 1 Publication
VAR_043489
Natural varianti2421 – 24211M → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035785
Natural varianti2496 – 24961K → R.
Corresponds to variant rs35759833 [ dbSNP | Ensembl ].
VAR_043490
Natural varianti2804 – 28041N → S.
Corresponds to variant rs6960867 [ dbSNP | Ensembl ].
VAR_030162
Natural varianti2983 – 29831P → S.3 Publications
Corresponds to variant rs1063242 [ dbSNP | Ensembl ].
VAR_030163
Natural varianti3301 – 33011E → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_035786
Natural varianti3448 – 34481Q → R.
Corresponds to variant rs34956633 [ dbSNP | Ensembl ].
VAR_043491
Natural varianti3618 – 36181M → V.
Corresponds to variant rs34327395 [ dbSNP | Ensembl ].
VAR_043492

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei17 – 2812Missing in isoform 2 and isoform 3.
VSP_004102Add
BLAST
Alternative sequencei1637 – 16437QLQEEIK → LAQVRVL in isoform 4.
VSP_004103
Alternative sequencei1644 – 39112268Missing in isoform 4.
VSP_004104Add
BLAST
Alternative sequencei2175 – 21839SADTFQKVE → Q in isoform 6.
VSP_004106
Alternative sequencei2175 – 21828Missing in isoform 3.
VSP_004105
Alternative sequencei2895 – 294854Missing in isoform 5.
VSP_004108Add
BLAST
Alternative sequencei2895 – 290713VFGFY…FSTLC → GSSIPELAHSDAYQTREICS S in isoform 2, isoform 3 and isoform 6.
VSP_004107Add
BLAST
Alternative sequencei3901 – 391111STTQFHAGMRR → ALSLTTSWQHHSARPTAPLF FEILSHSLG in isoform 6.
VSP_004109Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761E → Q in BAA78718. 1 Publication
Sequence conflicti554 – 5541E → G in BAA78718. 1 Publication
Sequence conflicti638 – 6381R → S in BAA78718. 1 Publication
Sequence conflicti663 – 6631N → S in BAA78718. 1 Publication
Sequence conflicti913 – 9131H → N in BAA78718. 1 Publication
Sequence conflicti956 – 9561K → N in BAA78718. 1 Publication
Sequence conflicti980 – 9823QKH → PKP in AAB86384. 1 Publication
Sequence conflicti980 – 9823QKH → PKP in CAB40713. 1 Publication
Sequence conflicti997 – 9971Q → P in AAB86384. 1 Publication
Sequence conflicti997 – 9971Q → P in CAB40713. 1 Publication
Sequence conflicti1001 – 10011Q → P in AAB86384. 1 Publication
Sequence conflicti1001 – 10011Q → P in CAB40713. 1 Publication
Sequence conflicti1020 – 10201N → D in BAA78718. 1 Publication
Sequence conflicti1028 – 10281V → E in BAA78718. 1 Publication
Sequence conflicti1626 – 16261R → P in AAB86384. 1 Publication
Sequence conflicti1626 – 16261R → P in CAB40713. 1 Publication
Sequence conflicti1703 – 17031N → T in BAA78718. 1 Publication
Sequence conflicti1707 – 17071V → G in BAA78718. 1 Publication
Sequence conflicti1802 – 18032Missing in AAD22767. 1 Publication
Sequence conflicti1843 – 18431A → P in BAA78718. 1 Publication
Sequence conflicti1956 – 19561I → V in BAA78718. 1 Publication
Sequence conflicti2027 – 20271V → D in AAD22767. 1 Publication
Sequence conflicti2157 – 21582EI → HE in AAD39719. 1 Publication
Sequence conflicti2169 – 21691E → V in BAA78718. 1 Publication
Sequence conflicti2514 – 25141L → R in BAA78718. 1 Publication
Sequence conflicti2851 – 28511I → N in BAA34523. 1 Publication
Sequence conflicti2957 – 29571E → D in BAA78718. 1 Publication
Sequence conflicti3087 – 30871Q → H in BAA78718. 1 Publication
Sequence conflicti3218 – 32181Q → H in BAA78718. 1 Publication
Sequence conflicti3307 – 33093ESE → QSQ in BAA78718. 1 Publication
Sequence conflicti3751 – 37511P → A in BAA78718. 1 Publication
Sequence conflicti3833 – 38331T → S in BAA78718. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131693 mRNA. Translation: CAB40713.1.
AB019691 mRNA. Translation: BAA78718.1.
AJ010770 Genomic DNA. Translation: CAA09361.1.
AF026245 mRNA. Translation: AAB86384.1. Frameshift.
AC004013 Genomic DNA. Translation: AAB96867.2.
AC000066 Genomic DNA. Translation: AAC60380.1. Sequence problems.
AC000120 Genomic DNA. Translation: AAS07419.1.
CH236949 Genomic DNA. Translation: EAL24155.1.
CH236949 Genomic DNA. Translation: EAL24156.1.
CH236949 Genomic DNA. Translation: EAL24157.1.
AF083037 mRNA. Translation: AAD22767.1.
AF091711 mRNA. Translation: AAD39719.1.
AB018346 mRNA. Translation: BAA34523.1.
CCDSiCCDS5622.1. [Q99996-2]
PIRiT08880.
RefSeqiNP_005742.4. NM_005751.4. [Q99996-2]
NP_671714.1. NM_147185.2. [Q99996-3]
UniGeneiHs.651221.

Genome annotation databases

EnsembliENST00000356239; ENSP00000348573; ENSG00000127914. [Q99996-2]
ENST00000358100; ENSP00000350813; ENSG00000127914. [Q99996-5]
ENST00000359028; ENSP00000351922; ENSG00000127914. [Q99996-1]
GeneIDi10142.
KEGGihsa:10142.
UCSCiuc003ulf.3. human. [Q99996-3]
uc003ulg.3. human. [Q99996-2]

Polymorphism databases

DMDMi14194461.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131693 mRNA. Translation: CAB40713.1 .
AB019691 mRNA. Translation: BAA78718.1 .
AJ010770 Genomic DNA. Translation: CAA09361.1 .
AF026245 mRNA. Translation: AAB86384.1 . Frameshift.
AC004013 Genomic DNA. Translation: AAB96867.2 .
AC000066 Genomic DNA. Translation: AAC60380.1 . Sequence problems.
AC000120 Genomic DNA. Translation: AAS07419.1 .
CH236949 Genomic DNA. Translation: EAL24155.1 .
CH236949 Genomic DNA. Translation: EAL24156.1 .
CH236949 Genomic DNA. Translation: EAL24157.1 .
AF083037 mRNA. Translation: AAD22767.1 .
AF091711 mRNA. Translation: AAD39719.1 .
AB018346 mRNA. Translation: BAA34523.1 .
CCDSi CCDS5622.1. [Q99996-2 ]
PIRi T08880.
RefSeqi NP_005742.4. NM_005751.4. [Q99996-2 ]
NP_671714.1. NM_147185.2. [Q99996-3 ]
UniGenei Hs.651221.

3D structure databases

ProteinModelPortali Q99996.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115445. 35 interactions.
DIPi DIP-29942N.
IntActi Q99996. 22 interactions.
MINTi MINT-1174958.

PTM databases

PhosphoSitei Q99996.

Polymorphism databases

DMDMi 14194461.

Proteomic databases

MaxQBi Q99996.
PaxDbi Q99996.
PRIDEi Q99996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356239 ; ENSP00000348573 ; ENSG00000127914 . [Q99996-2 ]
ENST00000358100 ; ENSP00000350813 ; ENSG00000127914 . [Q99996-5 ]
ENST00000359028 ; ENSP00000351922 ; ENSG00000127914 . [Q99996-1 ]
GeneIDi 10142.
KEGGi hsa:10142.
UCSCi uc003ulf.3. human. [Q99996-3 ]
uc003ulg.3. human. [Q99996-2 ]

Organism-specific databases

CTDi 10142.
GeneCardsi GC07P091570.
GeneReviewsi AKAP9.
HGNCi HGNC:379. AKAP9.
HPAi CAB012909.
HPA008548.
HPA026109.
MIMi 604001. gene.
611820. phenotype.
neXtProti NX_Q99996.
Orphaneti 101016. Romano-Ward syndrome.
PharmGKBi PA24673.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG050481.
KOi K16551.
OMAi KMRKFLD.
OrthoDBi EOG7VMP46.
PhylomeDBi Q99996.
TreeFami TF105408.

Enzyme and pathway databases

Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinki Q99996.

Miscellaneous databases

ChiTaRSi AKAP9. human.
GeneWikii AKAP9.
GenomeRNAii 10142.
NextBioi 38371.
PROi Q99996.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99996.
Bgeei Q99996.
Genevestigatori Q99996.

Family and domain databases

InterProi IPR028745. AKAP9.
IPR019528. PACT_domain.
[Graphical view ]
PANTHERi PTHR18932:SF10. PTHR18932:SF10. 1 hit.
Pfami PF10495. PACT_coil_coil. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1."
    Lin J.W., Wyszynski M., Madhavan R., Sealock R., Kim J.U., Sheng M.
    J. Neurosci. 18:2017-2027(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Brain.
  2. "Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450."
    Witczak O., Skaalhegg B.S., Keryer G., Bornens M., Tasken K., Jahnsen T., Oerstavik S.
    EMBO J. 18:1858-1868(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-1347 INS.
  3. "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the Golgi apparatus."
    Takahashi M., Shibata H., Shimakawa M., Miyamoto M., Mukai H., Ono Y.
    J. Biol. Chem. 274:17267-17274(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS ILE-475 AND SER-2983.
    Tissue: Brain.
  4. "Cloning of Hyperion."
    Kemmner W.A., Deiss S., Schwarz U.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes."
    Schmidt P.H., Dransfield D.T., Claudio J.O., Hawley R.G., Trotter K.W., Milgram S.L., Goldenring J.R.
    J. Biol. Chem. 274:3055-3066(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 323-3911 (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 2157-3911 (ISOFORM 6), VARIANT SER-2983.
    Tissue: Gastric parietal cell and Lung.
  8. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2212-3911 (ISOFORMS 2/3), VARIANT SER-2983.
    Tissue: Brain.
  9. "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member."
    Shanks R.A., Larocca M.C., Berryman M., Edwards J.C., Urushidani T., Navarre J., Goldenring J.R.
    J. Biol. Chem. 277:40973-40980(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLIC1; CLIC4 AND CLIC5.
  10. "Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450."
    Sillibourne J.E., Milne D.M., Takahashi M., Ono Y., Meek D.W.
    J. Mol. Biol. 322:785-797(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CSNK1D, SUBCELLULAR LOCATION.
  11. "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus."
    Larocca M.C., Shanks R.A., Tian L., Nelson D.L., Stewart D.M., Goldenring J.R.
    Mol. Biol. Cell 15:2771-2781(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CIP4 AND FNBP1, SUBCELLULAR LOCATION.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3869, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-3846, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-2421 AND GLN-3301.
  16. Cited for: VARIANT LQT11 LEU-1582.

Entry informationi

Entry nameiAKAP9_HUMAN
AccessioniPrimary (citable) accession number: Q99996
Secondary accession number(s): A4D1F0
, A4D1F2, A4D1F4, O14869, O43355, O94895, Q75N20, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1999
Last modified: September 3, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi