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Q99996 (AKAP9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
A-kinase anchor protein 9

Short name=AKAP-9
Alternative name(s):
A-kinase anchor protein 350 kDa
Short name=AKAP 350
Short name=hgAKAP 350
A-kinase anchor protein 450 kDa
Short name=AKAP 450
AKAP 120-like protein
Centrosome- and Golgi-localized PKN-associated protein
Short name=CG-NAP
Protein hyperion
Protein kinase A-anchoring protein 9
Short name=PRKA9
Protein yotiao
Gene names
Name:AKAP9
Synonyms:AKAP350, AKAP450, KIAA0803
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3911 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Ref.11

Subunit structure

Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon. Interacts with CIP4 and FNBP1. Interacts with chloride intracellular channel proteins CLIC1, CLIC4 and CLIC5. CSNK1D binding promotes its centrosomal subcellular location. Ref.9 Ref.10 Ref.11

Subcellular location

Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Golgi apparatus. Note: Cytoplasmic in parietal cells. Ref.10 Ref.11

Tissue specificity

Widely expressed. Isoform 4 is highly expressed in skeletal muscle and in pancreas.

Domain

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Involvement in disease

Long QT syndrome 11 (LQT11) [MIM:611820]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16

Sequence caution

The sequence AAB86384.1 differs from that shown. Reason: Frameshift at position 1637.

The sequence AAC60380.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Golgi apparatus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
Long QT syndrome
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG2/M transition of mitotic cell cycle

Traceable author statement. Source: Reactome

mitotic cell cycle

Traceable author statement. Source: Reactome

signal transduction

Traceable author statement PubMed 10390370. Source: ProtInc

synaptic transmission

Traceable author statement. Source: Reactome

transport

Traceable author statement PubMed 10390370. Source: ProtInc

   Cellular_componentGolgi apparatus

Inferred from direct assay Ref.9. Source: UniProtKB

centrosome

Inferred from direct assay PubMed 21399614. Source: UniProtKB

cytoskeleton

Traceable author statement Ref.1. Source: ProtInc

cytosol

Traceable author statement. Source: Reactome

intracellular membrane-bounded organelle

Inferred from direct assay. Source: HPA

pericentriolar material

Inferred from electronic annotation. Source: Ensembl

voltage-gated potassium channel complex

Inferred from direct assay PubMed 11799244. Source: BHF-UCL

   Molecular_functionion channel binding

Inferred from physical interaction PubMed 11799244. Source: BHF-UCL

protein binding

Inferred from physical interaction Ref.9PubMed 16980960PubMed 20466722. Source: UniProtKB

protein complex scaffold

Inferred from direct assay PubMed 11799244. Source: BHF-UCL

receptor binding

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GOLGA2Q083793EBI-1048311,EBI-618309
KDM1AO603412EBI-1048311,EBI-710124

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q99996-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q99996-2)

The sequence of this isoform differs from the canonical sequence as follows:
     17-28: Missing.
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS
Isoform 3 (identifier: Q99996-3)

Also known as: CG-NAP;

The sequence of this isoform differs from the canonical sequence as follows:
     17-28: Missing.
     2175-2182: Missing.
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS
Isoform 4 (identifier: Q99996-4)

Also known as: Yotiao;

The sequence of this isoform differs from the canonical sequence as follows:
     1637-1643: QLQEEIK → LAQVRVL
     1644-3911: Missing.
Isoform 5 (identifier: Q99996-5)

The sequence of this isoform differs from the canonical sequence as follows:
     2895-2948: Missing.
Isoform 6 (identifier: Q99996-6)

Also known as: AKAP350;

The sequence of this isoform differs from the canonical sequence as follows:
     2175-2183: SADTFQKVE → Q
     2895-2907: VFGFYNMCFSTLC → GSSIPELAHSDAYQTREICSS
     3901-3911: STTQFHAGMRR → ALSLTTSWQHHSARPTAPLFFEILSHSLG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 39113911A-kinase anchor protein 9
PRO_0000064534

Regions

Region2554 – 256714PKA-RII subunit binding domain
Coiled coil164 – 914751 Potential
Coiled coil944 – 102279 Potential
Coiled coil1100 – 118586 Potential
Coiled coil1253 – 128028 Potential
Coiled coil1336 – 139257 Potential
Coiled coil1434 – 145926 Potential
Coiled coil1585 – 165975 Potential
Coiled coil1857 – 2455599 Potential
Coiled coil2544 – 256118 Potential
Coiled coil2603 – 2776174 Potential
Coiled coil3065 – 309228 Potential
Coiled coil3124 – 3470347 Potential
Coiled coil3587 – 3689103 Potential
Compositional bias203 – 29290Gln-rich
Compositional bias321 – 1010690Glu-rich
Compositional bias1846 – 2772927Glu-rich
Compositional bias3726 – 37305Poly-Leu

Amino acid modifications

Modified residue1651Phosphoserine Ref.13
Modified residue38461Phosphoserine Ref.13
Modified residue38691Phosphoserine Ref.12

Natural variations

Alternative sequence17 – 2812Missing in isoform 2 and isoform 3.
VSP_004102
Alternative sequence1637 – 16437QLQEEIK → LAQVRVL in isoform 4.
VSP_004103
Alternative sequence1644 – 39112268Missing in isoform 4.
VSP_004104
Alternative sequence2175 – 21839SADTFQKVE → Q in isoform 6.
VSP_004106
Alternative sequence2175 – 21828Missing in isoform 3.
VSP_004105
Alternative sequence2895 – 294854Missing in isoform 5.
VSP_004108
Alternative sequence2895 – 290713VFGFY…FSTLC → GSSIPELAHSDAYQTREICS S in isoform 2, isoform 3 and isoform 6.
VSP_004107
Alternative sequence3901 – 391111STTQFHAGMRR → ALSLTTSWQHHSARPTAPLF FEILSHSLG in isoform 6.
VSP_004109
Natural variant4751M → I. Ref.3
Corresponds to variant rs6964587 [ dbSNP | Ensembl ].
VAR_024249
Natural variant13471K → KQ. Ref.2
VAR_010926
Natural variant15821S → L in LQT11. Ref.16
VAR_043489
Natural variant24211M → I in a colorectal cancer sample; somatic mutation. Ref.15
VAR_035785
Natural variant24961K → R.
Corresponds to variant rs35759833 [ dbSNP | Ensembl ].
VAR_043490
Natural variant28041N → S.
Corresponds to variant rs6960867 [ dbSNP | Ensembl ].
VAR_030162
Natural variant29831P → S. Ref.3 Ref.7 Ref.8
Corresponds to variant rs1063242 [ dbSNP | Ensembl ].
VAR_030163
Natural variant33011E → Q in a breast cancer sample; somatic mutation. Ref.15
VAR_035786
Natural variant34481Q → R.
Corresponds to variant rs34956633 [ dbSNP | Ensembl ].
VAR_043491
Natural variant36181M → V.
Corresponds to variant rs34327395 [ dbSNP | Ensembl ].
VAR_043492

Experimental info

Sequence conflict761E → Q in BAA78718. Ref.3
Sequence conflict5541E → G in BAA78718. Ref.3
Sequence conflict6381R → S in BAA78718. Ref.3
Sequence conflict6631N → S in BAA78718. Ref.3
Sequence conflict9131H → N in BAA78718. Ref.3
Sequence conflict9561K → N in BAA78718. Ref.3
Sequence conflict980 – 9823QKH → PKP in AAB86384. Ref.1
Sequence conflict980 – 9823QKH → PKP in CAB40713. Ref.2
Sequence conflict9971Q → P in AAB86384. Ref.1
Sequence conflict9971Q → P in CAB40713. Ref.2
Sequence conflict10011Q → P in AAB86384. Ref.1
Sequence conflict10011Q → P in CAB40713. Ref.2
Sequence conflict10201N → D in BAA78718. Ref.3
Sequence conflict10281V → E in BAA78718. Ref.3
Sequence conflict16261R → P in AAB86384. Ref.1
Sequence conflict16261R → P in CAB40713. Ref.2
Sequence conflict17031N → T in BAA78718. Ref.3
Sequence conflict17071V → G in BAA78718. Ref.3
Sequence conflict1802 – 18032Missing in AAD22767. Ref.7
Sequence conflict18431A → P in BAA78718. Ref.3
Sequence conflict19561I → V in BAA78718. Ref.3
Sequence conflict20271V → D in AAD22767. Ref.7
Sequence conflict2157 – 21582EI → HE in AAD39719. Ref.7
Sequence conflict21691E → V in BAA78718. Ref.3
Sequence conflict25141L → R in BAA78718. Ref.3
Sequence conflict28511I → N in BAA34523. Ref.8
Sequence conflict29571E → D in BAA78718. Ref.3
Sequence conflict30871Q → H in BAA78718. Ref.3
Sequence conflict32181Q → H in BAA78718. Ref.3
Sequence conflict3307 – 33093ESE → QSQ in BAA78718. Ref.3
Sequence conflict37511P → A in BAA78718. Ref.3
Sequence conflict38331T → S in BAA78718. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1999. Version 3.
Checksum: 3FB1CB1C819B47AA

FASTA3,911453,667
        10         20         30         40         50         60 
MEDEERQKKL EAGKAKIEEL SLAFLVRQLA QFRQRKAQSD GQSPSKKQKK KRKTSSSKHD 

        70         80         90        100        110        120 
VSAHHDLNID QSQCNEMYIN SSQRVESTVI PESTIMRTLH SGEITSHEQG FSVELESEIS 

       130        140        150        160        170        180 
TTADDCSSEV NGCSFVMRTG KPTNLLREEE FGVDDSYSEQ GAQDSPTHLE MMESELAGKQ 

       190        200        210        220        230        240 
HEIEELNREL EEMRVTYGTE GLQQLQEFEA AIKQRDGIIT QLTANLQQAR REKDETMREF 

       250        260        270        280        290        300 
LELTEQSQKL QIQFQQLQAS ETLRNSTHSS TAADLLQAKQ QILTHQQQLE EQDHLLEDYQ 

       310        320        330        340        350        360 
KKKEDFTMQI SFLQEKIKVY EMEQDKKVEN SNKEEIQEKE TIIEELNTKI IEEEKKTLEL 

       370        380        390        400        410        420 
KDKLTTADKL LGELQEQIVQ KNQEIKNMKL ELTNSKQKER QSSEEIKQLM GTVEELQKRN 

       430        440        450        460        470        480 
HKDSQFETDI VQRMEQETQR KLEQLRAELD EMYGQQIVQM KQELIRQHMA QMEEMKTRHK 

       490        500        510        520        530        540 
GEMENALRSY SNITVNEDQI KLMNVAINEL NIKLQDTNSQ KEKLKEELGL ILEEKCALQR 

       550        560        570        580        590        600 
QLEDLVEELS FSREQIQRAR QTIAEQESKL NEAHKSLSTV EDLKAEIVSA SESRKELELK 

       610        620        630        640        650        660 
HEAEVTNYKI KLEMLEKEKN AVLDRMAESQ EAELERLRTQ LLFSHEEELS KLKEDLEIEH 

       670        680        690        700        710        720 
RINIEKLKDN LGIHYKQQID GLQNEMSQKI ETMQFEKDNL ITKQNQLILE ISKLKDLQQS 

       730        740        750        760        770        780 
LVNSKSEEMT LQINELQKEI EILRQEEKEK GTLEQEVQEL QLKTELLEKQ MKEKENDLQE 

       790        800        810        820        830        840 
KFAQLEAENS ILKDEKKTLE DMLKIHTPVS QEERLIFLDS IKSKSKDSVW EKEIEILIEE 

       850        860        870        880        890        900 
NEDLKQQCIQ LNEEIEKQRN TFSFAEKNFE VNYQELQEEY ACLLKVKDDL EDSKNKQELE 

       910        920        930        940        950        960 
YKSKLKALNE ELHLQRINPT TVKMKSSVFD EDKTFVAETL EMGEVVEKDT TELMEKLEVT 

       970        980        990       1000       1010       1020 
KREKLELSQR LSDLSEQLKQ KHGEISFLNE EVKSLKQEKE QVSLRCRELE IIINHNRAEN 

      1030       1040       1050       1060       1070       1080 
VQSCDTQVSS LLDGVVTMTS RGAEGSVSKV NKSFGEESKI MVEDKVSFEN MTVGEESKQE 

      1090       1100       1110       1120       1130       1140 
QLILDHLPSV TKESSLRATQ PSENDKLQKE LNVLKSEQND LRLQMEAQRI CLSLVYSTHV 

      1150       1160       1170       1180       1190       1200 
DQVREYMENE KDKALCSLKE ELIFAQEEKI KELQKIHQLE LQTMKTQETG DEGKPLHLLI 

      1210       1220       1230       1240       1250       1260 
GKLQKAVSEE CSYFLQTLCS VLGEYYTPAL KCEVNAEDKE NSGDYISENE DPELQDYRYE 

      1270       1280       1290       1300       1310       1320 
VQDFQENMHT LLNKVTEEYN KLLVLQTRLS KIWGQQTDGM KLEFGEENLP KEETEFLSIH 

      1330       1340       1350       1360       1370       1380 
SQMTNLEDID VNHKSKLSSL QDLEKTKLEE QVQELESLIS SLQQQLKETE QNYEAEIHCL 

      1390       1400       1410       1420       1430       1440 
QKRLQAVSES TVPPSLPVDS VVITESDAQR TMYPGSCVKK NIDGTIEFSG EFGVKEETNI 

      1450       1460       1470       1480       1490       1500 
VKLLEKQYQE QLEEEVAKVI VSMSIAFAQQ TELSRISGGK ENTASSKQAH AVCQQEQHYF 

      1510       1520       1530       1540       1550       1560 
NEMKLSQDQI GFQTFETVDV KFKEEFKPLS KELGEHGKEI LLSNSDPHDI PESKDCVLTI 

      1570       1580       1590       1600       1610       1620 
SEEMFSKDKT FIVRQSIHDE ISVSSMDASR QLMLNEEQLE DMRQELVRQY QEHQQATELL 

      1630       1640       1650       1660       1670       1680 
RQAHMRQMER QREDQEQLQE EIKRLNRQLA QRSSIDNENL VSERERVLLE ELEALKQLSL 

      1690       1700       1710       1720       1730       1740 
AGREKLCCEL RNSSTQTQNG NENQGEVEEQ TFKEKELDRK PEDVPPEILS NERYALQKAN 

      1750       1760       1770       1780       1790       1800 
NRLLKILLEV VKTTAAVEET IGRHVLGILD RSSKSQSSAS LIWRSEAEAS VKSCVHEEHT 

      1810       1820       1830       1840       1850       1860 
RVTDESIPSY SGSDMPRNDI NMWSKVTEEG TELSQRLVRS GFAGTEIDPE NEELMLNISS 

      1870       1880       1890       1900       1910       1920 
RLQAAVEKLL EAISETSSQL EHAKVTQTEL MRESFRQKQE ATESLKCQEE LRERLHEESR 

      1930       1940       1950       1960       1970       1980 
AREQLAVELS KAEGVIDGYA DEKTLFERQI QEKTDIIDRL EQELLCASNR LQELEAEQQQ 

      1990       2000       2010       2020       2030       2040 
IQEERELLSR QKEAMKAEAG PVEQQLLQET EKLMKEKLEV QCQAEKVRDD LQKQVKALEI 

      2050       2060       2070       2080       2090       2100 
DVEEQVSRFI ELEQEKNTEL MDLRQQNQAL EKQLEKMRKF LDEQAIDREH ERDVFQQEIQ 

      2110       2120       2130       2140       2150       2160 
KLEQQLKVVP RFQPISEHQT REVEQLANHL KEKTDKCSEL LLSKEQLQRD IQERNEEIEK 

      2170       2180       2190       2200       2210       2220 
LEFRVRELEQ ALLVSADTFQ KVEDRKHFGA VEAKPELSLE VQLQAERDAI DRKEKEITNL 

      2230       2240       2250       2260       2270       2280 
EEQLEQFREE LENKNEEVQQ LHMQLEIQKK ESTTRLQELE QENKLFKDDM EKLGLAIKES 

      2290       2300       2310       2320       2330       2340 
DAMSTQDQHV LFGKFAQIIQ EKEVEIDQLN EQVTKLQQQL KITTDNKVIE EKNELIRDLE 

      2350       2360       2370       2380       2390       2400 
TQIECLMSDQ ECVKRNREEE IEQLNEVIEK LQQELANIGQ KTSMNAHSLS EEADSLKHQL 

      2410       2420       2430       2440       2450       2460 
DVVIAEKLAL EQQVETANEE MTFMKNVLKE TNFKMNQLTQ ELFSLKRERE SVEKIQSIPE 

      2470       2480       2490       2500       2510       2520 
NSVNVAIDHL SKDKPELEVV LTEDALKSLE NQTYFKSFEE NGKGSIINLE TRLLQLESTV 

      2530       2540       2550       2560       2570       2580 
SAKDLELTQC YKQIKDMQEQ GQFETEMLQK KIVNLQKIVE EKVAAALVSQ IQLEAVQEYA 

      2590       2600       2610       2620       2630       2640 
KFCQDNQTIS SEPERTNIQN LNQLREDELG SDISALTLRI SELESQVVEM HTSLILEKEQ 

      2650       2660       2670       2680       2690       2700 
VEIAEKNVLE KEKKLLELQK LLEGNEKKQR EKEKKRSPQD VEVLKTTTEL FHSNEESGFF 

      2710       2720       2730       2740       2750       2760 
NELEALRAES VATKAELASY KEKAEKLQEE LLVKETNMTS LQKDLSQVRD HLAEAKEKLS 

      2770       2780       2790       2800       2810       2820 
ILEKEDETEV QESKKACMFE PLPIKLSKSI ASQTDGTLKI SSSNQTPQIL VKNAGIQINL 

      2830       2840       2850       2860       2870       2880 
QSECSSEEVT EIISQFTEKI EKMQELHAAE ILDMESRHIS ETETLKREHY VAVQLLKEEC 

      2890       2900       2910       2920       2930       2940 
GTLKAVIQCL RSKEVFGFYN MCFSTLCDSG SDWGQGIYLT HSQGFDIASE GRGEESESAT 

      2950       2960       2970       2980       2990       3000 
DSFPKKIKGL LRAVHNEGMQ VLSLTESPYS DGEDHSIQQV SEPWLEERKA YINTISSLKD 

      3010       3020       3030       3040       3050       3060 
LITKMQLQRE AEVYDSSQSH ESFSDWRGEL LLALQQVFLE ERSVLLAAFR TELTALGTTD 

      3070       3080       3090       3100       3110       3120 
AVGLLNCLEQ RIQEQGVEYQ AAMECLQKAD RRSLLSEIQA LHAQMNGRKI TLKREQESEK 

      3130       3140       3150       3160       3170       3180 
PSQELLEYNI QQKQSQMLEM QVELSSMKDR ATELQEQLSS EKMVVAELKS ELAQTKLELE 

      3190       3200       3210       3220       3230       3240 
TTLKAQHKHL KELEAFRLEV KDKTDEVHLL NDTLASEQKK SRELQWALEK EKAKLGRSEE 

      3250       3260       3270       3280       3290       3300 
RDKEELEDLK FSLESQKQRN LQLNLLLEQQ KQLLNESQQK IESQRMLYDA QLSEEQGRNL 

      3310       3320       3330       3340       3350       3360 
ELQVLLESEK VRIREMSSTL DRERELHAQL QSSDGTGQSR PPLPSEDLLK ELQKQLEEKH 

      3370       3380       3390       3400       3410       3420 
SRIVELLNET EKYKLDSLQT RQQMEKDRQV HRKTLQTEQE ANTEGQKKMH ELQSKVEDLQ 

      3430       3440       3450       3460       3470       3480 
RQLEEKRQQV YKLDLEGQRL QGIMQEFQKQ ELEREEKRES RRILYQNLNE PTTWSLTSDR 

      3490       3500       3510       3520       3530       3540 
TRNWVLQQKI EGETKESNYA KLIEMNGGGT GCNHELEMIR QKLQCVASKL QVLPQKASER 

      3550       3560       3570       3580       3590       3600 
LQFETADDED FIWVQENIDE IILQLQKLTG QQGEEPSLVS PSTSCGSLTE RLLRQNAELT 

      3610       3620       3630       3640       3650       3660 
GHISQLTEEK NDLRNMVMKL EEQIRWYRQT GAGRDNSSRF SLNGGANIEA IIASEKEVWN 

      3670       3680       3690       3700       3710       3720 
REKLTLQKSL KRAEAEVYKL KAELRNDSLL QTLSPDSEHV TLKRIYGKYL RAESFRKALI 

      3730       3740       3750       3760       3770       3780 
YQKKYLLLLL GGFQECEDAT LALLARMGGQ PAFTDLEVIT NRPKGFTRFR SAVRVSIAIS 

      3790       3800       3810       3820       3830       3840 
RMKFLVRRWH RVTGSVSINI NRDGFGLNQG AEKTDSFYHS SGGLELYGEP RHTTYRSRSD 

      3850       3860       3870       3880       3890       3900 
LDYIRSPLPF QNRYPGTPAD FNPGSLACSQ LQNYDPDRAL TDYITRLEAL QRRLGTIQSG 

      3910 
STTQFHAGMR R 

« Hide

Isoform 2 [UniParc].

Checksum: 81761B4341430CDF
Show »

FASTA3,907452,987
Isoform 3 (CG-NAP) [UniParc].

Checksum: F90C9F18B32FD314
Show »

FASTA3,899452,110
Isoform 4 (Yotiao) [UniParc].

Checksum: C41FBD5551FB644E
Show »

FASTA1,643191,308
Isoform 5 [UniParc].

Checksum: 6DEB35CA282A0FDD
Show »

FASTA3,857447,753
Isoform 6 (AKAP350) [UniParc].

Checksum: EE569AD99523AE2F
Show »

FASTA3,929455,423

References

« Hide 'large scale' references
[1]"Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1."
Lin J.W., Wyszynski M., Madhavan R., Sealock R., Kim J.U., Sheng M.
J. Neurosci. 18:2017-2027(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
Tissue: Brain.
[2]"Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450."
Witczak O., Skaalhegg B.S., Keryer G., Bornens M., Tasken K., Jahnsen T., Oerstavik S.
EMBO J. 18:1858-1868(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-1347 INS.
[3]"Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the Golgi apparatus."
Takahashi M., Shibata H., Shimakawa M., Miyamoto M., Mukai H., Ono Y.
J. Biol. Chem. 274:17267-17274(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS ILE-475 AND SER-2983.
Tissue: Brain.
[4]"Cloning of Hyperion."
Kemmner W.A., Deiss S., Schwarz U.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes."
Schmidt P.H., Dransfield D.T., Claudio J.O., Hawley R.G., Trotter K.W., Milgram S.L., Goldenring J.R.
J. Biol. Chem. 274:3055-3066(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 323-3911 (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 2157-3911 (ISOFORM 6), VARIANT SER-2983.
Tissue: Gastric parietal cell and Lung.
[8]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2212-3911 (ISOFORMS 2/3), VARIANT SER-2983.
Tissue: Brain.
[9]"AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member."
Shanks R.A., Larocca M.C., Berryman M., Edwards J.C., Urushidani T., Navarre J., Goldenring J.R.
J. Biol. Chem. 277:40973-40980(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLIC1; CLIC4 AND CLIC5.
[10]"Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450."
Sillibourne J.E., Milne D.M., Takahashi M., Ono Y., Meek D.W.
J. Mol. Biol. 322:785-797(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CSNK1D, SUBCELLULAR LOCATION.
[11]"AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus."
Larocca M.C., Shanks R.A., Tian L., Nelson D.L., Stewart D.M., Goldenring J.R.
Mol. Biol. Cell 15:2771-2781(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CIP4 AND FNBP1, SUBCELLULAR LOCATION.
[12]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3869, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[13]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-3846, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-2421 AND GLN-3301.
[16]"Mutation of an A-kinase-anchoring protein causes long-QT syndrome."
Chen L., Marquardt M.L., Tester D.J., Sampson K.J., Ackerman M.J., Kass R.S.
Proc. Natl. Acad. Sci. U.S.A. 104:20990-20995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LQT11 LEU-1582.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ131693 mRNA. Translation: CAB40713.1.
AB019691 mRNA. Translation: BAA78718.1.
AJ010770 Genomic DNA. Translation: CAA09361.1.
AF026245 mRNA. Translation: AAB86384.1. Frameshift.
AC004013 Genomic DNA. Translation: AAB96867.2.
AC000066 Genomic DNA. Translation: AAC60380.1. Sequence problems.
AC000120 Genomic DNA. Translation: AAS07419.1.
CH236949 Genomic DNA. Translation: EAL24155.1.
CH236949 Genomic DNA. Translation: EAL24156.1.
CH236949 Genomic DNA. Translation: EAL24157.1.
AF083037 mRNA. Translation: AAD22767.1.
AF091711 mRNA. Translation: AAD39719.1.
AB018346 mRNA. Translation: BAA34523.1.
CCDSCCDS5622.1. [Q99996-2]
PIRT08880.
RefSeqNP_005742.4. NM_005751.4. [Q99996-2]
NP_671714.1. NM_147185.2. [Q99996-3]
UniGeneHs.651221.

3D structure databases

ProteinModelPortalQ99996.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115445. 36 interactions.
DIPDIP-29942N.
IntActQ99996. 22 interactions.
MINTMINT-1174958.

PTM databases

PhosphoSiteQ99996.

Polymorphism databases

DMDM14194461.

Proteomic databases

MaxQBQ99996.
PaxDbQ99996.
PRIDEQ99996.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356239; ENSP00000348573; ENSG00000127914. [Q99996-2]
ENST00000358100; ENSP00000350813; ENSG00000127914. [Q99996-5]
ENST00000359028; ENSP00000351922; ENSG00000127914. [Q99996-1]
GeneID10142.
KEGGhsa:10142.
UCSCuc003ulf.3. human. [Q99996-3]
uc003ulg.3. human. [Q99996-2]

Organism-specific databases

CTD10142.
GeneCardsGC07P091570.
GeneReviewsAKAP9.
HGNCHGNC:379. AKAP9.
HPACAB012909.
HPA008548.
HPA026109.
MIM604001. gene.
611820. phenotype.
neXtProtNX_Q99996.
Orphanet101016. Romano-Ward syndrome.
PharmGKBPA24673.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOVERGENHBG050481.
KOK16551.
OMAKMRKFLD.
OrthoDBEOG7VMP46.
PhylomeDBQ99996.
TreeFamTF105408.

Enzyme and pathway databases

ReactomeREACT_115566. Cell Cycle.
REACT_13685. Neuronal System.
SignaLinkQ99996.

Gene expression databases

ArrayExpressQ99996.
BgeeQ99996.
GenevestigatorQ99996.

Family and domain databases

InterProIPR028745. AKAP9.
IPR019528. PACT_domain.
[Graphical view]
PANTHERPTHR18932:SF10. PTHR18932:SF10. 1 hit.
PfamPF10495. PACT_coil_coil. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAKAP9. human.
GeneWikiAKAP9.
GenomeRNAi10142.
NextBio38371.
PROQ99996.
SOURCESearch...

Entry information

Entry nameAKAP9_HUMAN
AccessionPrimary (citable) accession number: Q99996
Secondary accession number(s): A4D1F0 expand/collapse secondary AC list , A4D1F2, A4D1F4, O14869, O43355, O94895, Q75N20, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1999
Last modified: July 9, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM