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Q99990

- VGLL1_HUMAN

UniProt

Q99990 - VGLL1_HUMAN

Protein

Transcription cofactor vestigial-like protein 1

Gene

VGLL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    May act as a specific coactivator for the mammalian TEFs.1 Publication

    GO - Molecular functioni

    1. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription cofactor vestigial-like protein 1
    Short name:
    Vgl-1
    Alternative name(s):
    Protein TONDU
    Gene namesi
    Name:VGLL1
    Synonyms:TDU
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:20985. VGLL1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134923162.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Transcription cofactor vestigial-like protein 1PRO_0000191347Add
    BLAST

    Proteomic databases

    MaxQBiQ99990.
    PaxDbiQ99990.
    PRIDEiQ99990.

    PTM databases

    PhosphoSiteiQ99990.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99990.
    BgeeiQ99990.
    CleanExiHS_VGLL1.
    GenevestigatoriQ99990.

    Organism-specific databases

    HPAiHPA042403.

    Interactioni

    Subunit structurei

    Interacts with TEFs.1 Publication

    Protein-protein interaction databases

    BioGridi119544. 4 interactions.
    STRINGi9606.ENSP00000359668.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99990.
    SMRiQ99990. Positions 20-49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vestigial family.Curated

    Phylogenomic databases

    eggNOGiNOG45658.
    HOGENOMiHOG000231385.
    HOVERGENiHBG055872.
    InParanoidiQ99990.
    OMAiEPGYSHA.
    OrthoDBiEOG7K9K52.
    PhylomeDBiQ99990.
    TreeFamiTF326340.

    Family and domain databases

    InterProiIPR006627. TDU_repeat.
    IPR011520. Vg_Tdu.
    [Graphical view]
    PANTHERiPTHR15950. PTHR15950. 1 hit.
    PfamiPF07545. Vg_Tdu. 1 hit.
    [Graphical view]
    SMARTiSM00711. TDU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99990-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS    50
    NIKSPQELTP SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA 100
    NCNLHVPGPM AVNQFSPSLA RRASVRPGEL WHFSSLAGTS SLEPGYSHPF 150
    PARHLVPEPQ PDGKREPLLS LLQQDRCLAR PQESAARENG NPGQIAGSTG 200
    LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY SLTPPNHWGH 250
    PHRYLQHL 258
    Length:258
    Mass (Da):28,707
    Last modified:May 1, 1997 - v1
    Checksum:iEA688B03E04AAD7F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591T → I.
    Corresponds to variant rs3027860 [ dbSNP | Ensembl ].
    VAR_053735

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137387 mRNA. Translation: AAF13149.1.
    AC000115 Genomic DNA. Translation: AAB46354.1.
    Z97632 Genomic DNA. Translation: CAB10728.1.
    CH471150 Genomic DNA. Translation: EAW88467.1.
    BC000045 mRNA. Translation: AAH00045.1.
    BC003362 mRNA. Translation: AAH03362.1.
    CCDSiCCDS14658.1.
    RefSeqiNP_057351.1. NM_016267.3.
    UniGeneiHs.496843.

    Genome annotation databases

    EnsembliENST00000370634; ENSP00000359668; ENSG00000102243.
    GeneIDi51442.
    KEGGihsa:51442.
    UCSCiuc004ezy.3. human.

    Polymorphism databases

    DMDMi50401655.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137387 mRNA. Translation: AAF13149.1 .
    AC000115 Genomic DNA. Translation: AAB46354.1 .
    Z97632 Genomic DNA. Translation: CAB10728.1 .
    CH471150 Genomic DNA. Translation: EAW88467.1 .
    BC000045 mRNA. Translation: AAH00045.1 .
    BC003362 mRNA. Translation: AAH03362.1 .
    CCDSi CCDS14658.1.
    RefSeqi NP_057351.1. NM_016267.3.
    UniGenei Hs.496843.

    3D structure databases

    ProteinModelPortali Q99990.
    SMRi Q99990. Positions 20-49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119544. 4 interactions.
    STRINGi 9606.ENSP00000359668.

    PTM databases

    PhosphoSitei Q99990.

    Polymorphism databases

    DMDMi 50401655.

    Proteomic databases

    MaxQBi Q99990.
    PaxDbi Q99990.
    PRIDEi Q99990.

    Protocols and materials databases

    DNASUi 51442.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370634 ; ENSP00000359668 ; ENSG00000102243 .
    GeneIDi 51442.
    KEGGi hsa:51442.
    UCSCi uc004ezy.3. human.

    Organism-specific databases

    CTDi 51442.
    GeneCardsi GC0XP135614.
    HGNCi HGNC:20985. VGLL1.
    HPAi HPA042403.
    MIMi 300583. gene.
    neXtProti NX_Q99990.
    PharmGKBi PA134923162.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45658.
    HOGENOMi HOG000231385.
    HOVERGENi HBG055872.
    InParanoidi Q99990.
    OMAi EPGYSHA.
    OrthoDBi EOG7K9K52.
    PhylomeDBi Q99990.
    TreeFami TF326340.

    Miscellaneous databases

    ChiTaRSi VGLL1. human.
    GenomeRNAii 51442.
    NextBioi 55031.
    PROi Q99990.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99990.
    Bgeei Q99990.
    CleanExi HS_VGLL1.
    Genevestigatori Q99990.

    Family and domain databases

    InterProi IPR006627. TDU_repeat.
    IPR011520. Vg_Tdu.
    [Graphical view ]
    PANTHERi PTHR15950. PTHR15950. 1 hit.
    Pfami PF07545. Vg_Tdu. 1 hit.
    [Graphical view ]
    SMARTi SM00711. TDU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation."
      Vaudin P., Delanoue R., Davidson I., Silber J., Zider A.
      Development 126:4807-4816(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TEFS.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiVGLL1_HUMAN
    AccessioniPrimary (citable) accession number: Q99990
    Secondary accession number(s): Q5H915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3