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Q99990

- VGLL1_HUMAN

UniProt

Q99990 - VGLL1_HUMAN

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Protein

Transcription cofactor vestigial-like protein 1

Gene

VGLL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.1 Publication

GO - Molecular functioni

  1. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 1
Short name:
Vgl-1
Alternative name(s):
Protein TONDU
Gene namesi
Name:VGLL1
Synonyms:TDU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:20985. VGLL1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Transcription cofactor vestigial-like protein 1PRO_0000191347Add
BLAST

Proteomic databases

MaxQBiQ99990.
PaxDbiQ99990.
PRIDEiQ99990.

PTM databases

PhosphoSiteiQ99990.

Expressioni

Gene expression databases

BgeeiQ99990.
CleanExiHS_VGLL1.
ExpressionAtlasiQ99990. baseline and differential.
GenevestigatoriQ99990.

Organism-specific databases

HPAiHPA042403.

Interactioni

Subunit structurei

Interacts with TEFs.1 Publication

Protein-protein interaction databases

BioGridi119544. 4 interactions.
STRINGi9606.ENSP00000359668.

Structurei

3D structure databases

ProteinModelPortaliQ99990.
SMRiQ99990. Positions 20-49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiNOG45658.
GeneTreeiENSGT00730000111322.
HOGENOMiHOG000231385.
HOVERGENiHBG055872.
InParanoidiQ99990.
OMAiEPGYSHA.
OrthoDBiEOG7K9K52.
PhylomeDBiQ99990.
TreeFamiTF326340.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99990-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS
60 70 80 90 100
NIKSPQELTP SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA
110 120 130 140 150
NCNLHVPGPM AVNQFSPSLA RRASVRPGEL WHFSSLAGTS SLEPGYSHPF
160 170 180 190 200
PARHLVPEPQ PDGKREPLLS LLQQDRCLAR PQESAARENG NPGQIAGSTG
210 220 230 240 250
LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY SLTPPNHWGH

PHRYLQHL
Length:258
Mass (Da):28,707
Last modified:May 1, 1997 - v1
Checksum:iEA688B03E04AAD7F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591T → I.
Corresponds to variant rs3027860 [ dbSNP | Ensembl ].
VAR_053735

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137387 mRNA. Translation: AAF13149.1.
AC000115 Genomic DNA. Translation: AAB46354.1.
Z97632 Genomic DNA. Translation: CAB10728.1.
CH471150 Genomic DNA. Translation: EAW88467.1.
BC000045 mRNA. Translation: AAH00045.1.
BC003362 mRNA. Translation: AAH03362.1.
CCDSiCCDS14658.1.
RefSeqiNP_057351.1. NM_016267.3.
UniGeneiHs.496843.

Genome annotation databases

EnsembliENST00000370634; ENSP00000359668; ENSG00000102243.
GeneIDi51442.
KEGGihsa:51442.
UCSCiuc004ezy.3. human.

Polymorphism databases

DMDMi50401655.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137387 mRNA. Translation: AAF13149.1 .
AC000115 Genomic DNA. Translation: AAB46354.1 .
Z97632 Genomic DNA. Translation: CAB10728.1 .
CH471150 Genomic DNA. Translation: EAW88467.1 .
BC000045 mRNA. Translation: AAH00045.1 .
BC003362 mRNA. Translation: AAH03362.1 .
CCDSi CCDS14658.1.
RefSeqi NP_057351.1. NM_016267.3.
UniGenei Hs.496843.

3D structure databases

ProteinModelPortali Q99990.
SMRi Q99990. Positions 20-49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119544. 4 interactions.
STRINGi 9606.ENSP00000359668.

PTM databases

PhosphoSitei Q99990.

Polymorphism databases

DMDMi 50401655.

Proteomic databases

MaxQBi Q99990.
PaxDbi Q99990.
PRIDEi Q99990.

Protocols and materials databases

DNASUi 51442.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370634 ; ENSP00000359668 ; ENSG00000102243 .
GeneIDi 51442.
KEGGi hsa:51442.
UCSCi uc004ezy.3. human.

Organism-specific databases

CTDi 51442.
GeneCardsi GC0XP135614.
HGNCi HGNC:20985. VGLL1.
HPAi HPA042403.
MIMi 300583. gene.
neXtProti NX_Q99990.
PharmGKBi PA134923162.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45658.
GeneTreei ENSGT00730000111322.
HOGENOMi HOG000231385.
HOVERGENi HBG055872.
InParanoidi Q99990.
OMAi EPGYSHA.
OrthoDBi EOG7K9K52.
PhylomeDBi Q99990.
TreeFami TF326340.

Miscellaneous databases

ChiTaRSi VGLL1. human.
GenomeRNAii 51442.
NextBioi 55031.
PROi Q99990.
SOURCEi Search...

Gene expression databases

Bgeei Q99990.
CleanExi HS_VGLL1.
ExpressionAtlasi Q99990. baseline and differential.
Genevestigatori Q99990.

Family and domain databases

InterProi IPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view ]
PANTHERi PTHR15950. PTHR15950. 1 hit.
Pfami PF07545. Vg_Tdu. 1 hit.
[Graphical view ]
SMARTi SM00711. TDU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation."
    Vaudin P., Delanoue R., Davidson I., Silber J., Zider A.
    Development 126:4807-4816(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TEFS.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiVGLL1_HUMAN
AccessioniPrimary (citable) accession number: Q99990
Secondary accession number(s): Q5H915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3