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Q99990 (VGLL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription cofactor vestigial-like protein 1

Short name=Vgl-1
Alternative name(s):
Protein TONDU
Gene names
Name:VGLL1
Synonyms:TDU
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a specific coactivator for the mammalian TEFs. Ref.1

Subunit structure

Interacts with TEFs. Ref.1

Subcellular location

Nucleus.

Sequence similarities

Belongs to the vestigial family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Non-traceable author statement Ref.1. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functiontranscription coactivator activity

Traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Transcription cofactor vestigial-like protein 1
PRO_0000191347

Natural variations

Natural variant591T → I.
Corresponds to variant rs3027860 [ dbSNP | Ensembl ].
VAR_053735

Sequences

Sequence LengthMass (Da)Tools
Q99990 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: EA688B03E04AAD7F

FASTA25828,707
        10         20         30         40         50         60 
MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS NIKSPQELTP 

        70         80         90        100        110        120 
SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA NCNLHVPGPM AVNQFSPSLA 

       130        140        150        160        170        180 
RRASVRPGEL WHFSSLAGTS SLEPGYSHPF PARHLVPEPQ PDGKREPLLS LLQQDRCLAR 

       190        200        210        220        230        240 
PQESAARENG NPGQIAGSTG LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY 

       250 
SLTPPNHWGH PHRYLQHL 

« Hide

References

« Hide 'large scale' references
[1]"TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation."
Vaudin P., Delanoue R., Davidson I., Silber J., Zider A.
Development 126:4807-4816(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TEFS.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF137387 mRNA. Translation: AAF13149.1.
AC000115 Genomic DNA. Translation: AAB46354.1.
Z97632 Genomic DNA. Translation: CAB10728.1.
CH471150 Genomic DNA. Translation: EAW88467.1.
BC000045 mRNA. Translation: AAH00045.1.
BC003362 mRNA. Translation: AAH03362.1.
RefSeqNP_057351.1. NM_016267.3.
UniGeneHs.496843.

3D structure databases

ProteinModelPortalQ99990.
SMRQ99990. Positions 20-49.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119544. 4 interactions.
STRING9606.ENSP00000359668.

PTM databases

PhosphoSiteQ99990.

Polymorphism databases

DMDM50401655.

Proteomic databases

PaxDbQ99990.
PRIDEQ99990.

Protocols and materials databases

DNASU51442.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370634; ENSP00000359668; ENSG00000102243.
GeneID51442.
KEGGhsa:51442.
UCSCuc004ezy.3. human.

Organism-specific databases

CTD51442.
GeneCardsGC0XP135614.
HGNCHGNC:20985. VGLL1.
HPAHPA042403.
MIM300583. gene.
neXtProtNX_Q99990.
PharmGKBPA134923162.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45658.
HOGENOMHOG000231385.
HOVERGENHBG055872.
InParanoidQ99990.
OMAEPGYSHA.
OrthoDBEOG7K9K52.
PhylomeDBQ99990.
TreeFamTF326340.

Gene expression databases

ArrayExpressQ99990.
BgeeQ99990.
CleanExHS_VGLL1.
GenevestigatorQ99990.

Family and domain databases

InterProIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERPTHR15950. PTHR15950. 1 hit.
PfamPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTSM00711. TDU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVGLL1. human.
GenomeRNAi51442.
NextBio55031.
PROQ99990.
SOURCESearch...

Entry information

Entry nameVGLL1_HUMAN
AccessionPrimary (citable) accession number: Q99990
Secondary accession number(s): Q5H915
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM