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Protein

Transcription cofactor vestigial-like protein 1

Gene

VGLL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.1 Publication

GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 1
Short name:
Vgl-1
Alternative name(s):
Protein TONDU
Gene namesi
Name:VGLL1
Synonyms:TDU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:20985. VGLL1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923162.

Polymorphism and mutation databases

BioMutaiVGLL1.
DMDMi50401655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Transcription cofactor vestigial-like protein 1PRO_0000191347Add
BLAST

Proteomic databases

MaxQBiQ99990.
PaxDbiQ99990.
PRIDEiQ99990.

PTM databases

PhosphoSiteiQ99990.

Expressioni

Gene expression databases

BgeeiQ99990.
CleanExiHS_VGLL1.
ExpressionAtlasiQ99990. baseline and differential.
GenevisibleiQ99990. HS.

Organism-specific databases

HPAiHPA042403.

Interactioni

Subunit structurei

Interacts with TEFs.1 Publication

Protein-protein interaction databases

BioGridi119544. 4 interactions.
STRINGi9606.ENSP00000359668.

Structurei

3D structure databases

ProteinModelPortaliQ99990.
SMRiQ99990. Positions 20-49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiNOG45658.
GeneTreeiENSGT00730000111322.
HOGENOMiHOG000231385.
HOVERGENiHBG055872.
InParanoidiQ99990.
OMAiEPGYSHA.
OrthoDBiEOG7K9K52.
PhylomeDBiQ99990.
TreeFamiTF326340.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS
60 70 80 90 100
NIKSPQELTP SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA
110 120 130 140 150
NCNLHVPGPM AVNQFSPSLA RRASVRPGEL WHFSSLAGTS SLEPGYSHPF
160 170 180 190 200
PARHLVPEPQ PDGKREPLLS LLQQDRCLAR PQESAARENG NPGQIAGSTG
210 220 230 240 250
LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY SLTPPNHWGH

PHRYLQHL
Length:258
Mass (Da):28,707
Last modified:May 1, 1997 - v1
Checksum:iEA688B03E04AAD7F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591T → I.
Corresponds to variant rs3027860 [ dbSNP | Ensembl ].
VAR_053735

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137387 mRNA. Translation: AAF13149.1.
AC000115 Genomic DNA. Translation: AAB46354.1.
Z97632 Genomic DNA. Translation: CAB10728.1.
CH471150 Genomic DNA. Translation: EAW88467.1.
BC000045 mRNA. Translation: AAH00045.1.
BC003362 mRNA. Translation: AAH03362.1.
CCDSiCCDS14658.1.
RefSeqiNP_057351.1. NM_016267.3.
UniGeneiHs.496843.

Genome annotation databases

EnsembliENST00000370634; ENSP00000359668; ENSG00000102243.
GeneIDi51442.
KEGGihsa:51442.
UCSCiuc004ezy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137387 mRNA. Translation: AAF13149.1.
AC000115 Genomic DNA. Translation: AAB46354.1.
Z97632 Genomic DNA. Translation: CAB10728.1.
CH471150 Genomic DNA. Translation: EAW88467.1.
BC000045 mRNA. Translation: AAH00045.1.
BC003362 mRNA. Translation: AAH03362.1.
CCDSiCCDS14658.1.
RefSeqiNP_057351.1. NM_016267.3.
UniGeneiHs.496843.

3D structure databases

ProteinModelPortaliQ99990.
SMRiQ99990. Positions 20-49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119544. 4 interactions.
STRINGi9606.ENSP00000359668.

PTM databases

PhosphoSiteiQ99990.

Polymorphism and mutation databases

BioMutaiVGLL1.
DMDMi50401655.

Proteomic databases

MaxQBiQ99990.
PaxDbiQ99990.
PRIDEiQ99990.

Protocols and materials databases

DNASUi51442.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370634; ENSP00000359668; ENSG00000102243.
GeneIDi51442.
KEGGihsa:51442.
UCSCiuc004ezy.3. human.

Organism-specific databases

CTDi51442.
GeneCardsiGC0XP135614.
HGNCiHGNC:20985. VGLL1.
HPAiHPA042403.
MIMi300583. gene.
neXtProtiNX_Q99990.
PharmGKBiPA134923162.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45658.
GeneTreeiENSGT00730000111322.
HOGENOMiHOG000231385.
HOVERGENiHBG055872.
InParanoidiQ99990.
OMAiEPGYSHA.
OrthoDBiEOG7K9K52.
PhylomeDBiQ99990.
TreeFamiTF326340.

Miscellaneous databases

ChiTaRSiVGLL1. human.
GenomeRNAii51442.
NextBioi55031.
PROiQ99990.
SOURCEiSearch...

Gene expression databases

BgeeiQ99990.
CleanExiHS_VGLL1.
ExpressionAtlasiQ99990. baseline and differential.
GenevisibleiQ99990. HS.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation."
    Vaudin P., Delanoue R., Davidson I., Silber J., Zider A.
    Development 126:4807-4816(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TEFS.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiVGLL1_HUMAN
AccessioniPrimary (citable) accession number: Q99990
Secondary accession number(s): Q5H915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1997
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.