Q99990 (VGLL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription cofactor vestigial-like protein 1
Short name=Vgl-1

Alternative name(s):
Protein TONDU

Gene names

Name:	VGLL1
Synonyms:	TDU

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a specific coactivator for the mammalian TEFs. Ref.1
Subunit structure	Interacts with TEFs. Ref.1
Subcellular location	Nucleus.
Sequence similarities	Belongs to the vestigial family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Non-traceable author statement Ref.1. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	transcription coactivator activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Transcription cofactor vestigial-like protein 1		PRO_0000191347
Natural variations
	Natural variant	59	1	T → I. Corresponds to variant rs3027860 [ dbSNP | Ensembl ].		VAR_053735

Sequences

	Sequence		Length	Mass (Da)
	Q99990 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: EA688B03E04AAD7F	FASTA	258	28,707
	10 20 30 40 50 60 MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS NIKSPQELTP 70 80 90 100 110 120 SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA NCNLHVPGPM AVNQFSPSLA 130 140 150 160 170 180 RRASVRPGEL WHFSSLAGTS SLEPGYSHPF PARHLVPEPQ PDGKREPLLS LLQQDRCLAR 190 200 210 220 230 240 PQESAARENG NPGQIAGSTG LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY 250 SLTPPNHWGH PHRYLQHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation." Vaudin P., Delanoue R., Davidson I., Silber J., Zider A. Development 126:4807-4816(1999) [PubMed: 10518497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TEFS.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF137387 mRNA. Translation: AAF13149.1. AC000115 Genomic DNA. Translation: AAB46354.1. Z97632 Genomic DNA. Translation: CAB10728.1. CH471150 Genomic DNA. Translation: EAW88467.1. BC000045 mRNA. Translation: AAH00045.1. BC003362 mRNA. Translation: AAH03362.1.
IPI	IPI00008333.
RefSeq	NP_057351.1. NM_016267.3.
UniGene	Hs.496843.
3D structure databases
ProteinModelPortal	Q99990.
ModBase	Search...
Protein-protein interaction databases
STRING	Q99990.
Polymorphism databases
DMDM	50401655.
Proteomic databases
PRIDE	Q99990.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370634; ENSP00000359668; ENSG00000102243.
GeneID	51442.
KEGG	hsa:51442.
UCSC	uc004ezy.1. human.
Organism-specific databases
CTD	51442.
GeneCards	GC0XP135614.
H-InvDB	HIX0017081.
HGNC	HGNC:20985. VGLL1.
MIM	300583. gene.
neXtProt	NX_Q99990.
PharmGKB	PA134923162.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063353.
HOGENOM	HBG268358.
HOVERGEN	HBG055872.
InParanoid	Q99990.
OMA	EPGYSHA.
OrthoDB	EOG4XWG0B.
PhylomeDB	Q99990.
Gene expression databases
ArrayExpress	Q99990.
Bgee	Q99990.
CleanEx	HS_VGLL1.
Genevestigator	Q99990.
GermOnline	ENSG00000102243. Homo sapiens.
Family and domain databases
InterPro	IPR006627. TDU_repeat. IPR011520. Vg_Tdu. [Graphical view]
Pfam	PF07545. Vg_Tdu. 1 hit. [Graphical view]
SMART	SM00711. TDU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	55031.
SOURCE	Search...

Entry information

Entry name

VGLL1_HUMAN

Accession

Primary (citable) accession number: Q99990
Secondary accession number(s): Q5H915

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.