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Q99985

- SEM3C_HUMAN

UniProt

Q99985 - SEM3C_HUMAN

Protein

Semaphorin-3C

Gene

SEMA3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance By similarity.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. axon guidance Source: UniProtKB
    2. blood vessel remodeling Source: Ensembl
    3. cardiac right ventricle morphogenesis Source: Ensembl
    4. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
    5. immune response Source: ProtInc
    6. limb bud formation Source: Ensembl
    7. neural crest cell migration Source: Ensembl
    8. neural tube development Source: Ensembl
    9. outflow tract morphogenesis Source: Ensembl
    10. post-embryonic development Source: Ensembl
    11. pulmonary myocardium development Source: Ensembl
    12. response to drug Source: ProtInc
    13. somitogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-3C
    Alternative name(s):
    Semaphorin-E
    Short name:
    Sema E
    Gene namesi
    Name:SEMA3C
    Synonyms:SEMAE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:10725. SEMA3C.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35647.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 751731Semaphorin-3CPRO_0000032311Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 112By similarity
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi130 ↔ 139By similarity
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi266 ↔ 378By similarity
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 338By similarity
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi514 ↔ 532By similarity
    Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi643 ↔ 709By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ99985.
    PeptideAtlasiQ99985.
    PRIDEiQ99985.

    PTM databases

    PhosphoSiteiQ99985.

    Expressioni

    Tissue specificityi

    Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

    Gene expression databases

    ArrayExpressiQ99985.
    BgeeiQ99985.
    CleanExiHS_SEMA3C.
    GenevestigatoriQ99985.

    Organism-specific databases

    HPAiHPA042418.

    Interactioni

    Subunit structurei

    Interacts with PLXND1.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000265361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99985.
    SMRiQ99985. Positions 28-657.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 511484SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini571 – 65585Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi724 – 74522Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG247865.
    HOVERGENiHBG055071.
    InParanoidiQ99985.
    KOiK06840.
    OrthoDBiEOG7034G7.
    PhylomeDBiQ99985.
    TreeFamiTF352628.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99985-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFRTICVLV GVFICSICVK GSSQPQARVY LTFDELRETK TSEYFSLSHH    50
    PLDYRILLMD EDQDRIYVGS KDHILSLNIN NISQEALSVF WPASTIKVEE 100
    CKMAGKDPTH GCGNFVRVIQ TFNRTHLYVC GSGAFSPVCT YLNRGRRSED 150
    QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN EELFSGMYID FMGTDAAIFR 200
    SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV YFFFKEKLTD 250
    NNRSTKQIHS MIARICPNDT GGLRSLVNKW TTFLKARLVC SVTDEDGPET 300
    HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN 350
    GPFAHKEGPN HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KEFPDDVVTF 400
    IRNHPLMYNS IYPIHKRPLI VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG 450
    TDRGTVQKVV VLPTNNSVSG ELILEELEVF KNHAPITTMK ISSKKQQLYV 500
    SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS RFYPTGKRRS 550
    RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVKNNTTFL ECAPKSPQAS 600
    IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQGSDQGL YHCIATENSF 650
    KQTIAKINFK VLDSEMVAVV TDKWSPWTWA SSVRALPFHP KDIMGAFSHS 700
    EMQMINQYCK DTRQQHQQGD ESQKMRGDYG KLKALINSRK SRNRRNQLPE 750
    S 751
    Length:751
    Mass (Da):85,207
    Last modified:November 1, 1998 - v2
    Checksum:iAA68A21FEF20C033
    GO
    Isoform 2 (identifier: Q99985-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-149: Missing.
         378-381: CPGG → NTCV
         382-751: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:233
    Mass (Da):26,255
    Checksum:i10D521391C76311A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti302 – 3021F → S.
    Corresponds to variant rs35070362 [ dbSNP | Ensembl ].
    VAR_051928
    Natural varianti337 – 3371V → M.
    Corresponds to variant rs1527482 [ dbSNP | Ensembl ].
    VAR_020346

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 149148Missing in isoform 2. 1 PublicationVSP_055886Add
    BLAST
    Alternative sequencei378 – 3814CPGG → NTCV in isoform 2. 1 PublicationVSP_055887
    Alternative sequencei382 – 751370Missing in isoform 2. 1 PublicationVSP_055888Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000220 mRNA. Translation: BAA32398.1.
    AK299322 mRNA. Translation: BAG61330.1.
    AC004880 Genomic DNA. No translation available.
    AC004972 Genomic DNA. No translation available.
    AC073850 Genomic DNA. No translation available.
    AC093683 Genomic DNA. No translation available.
    BC030690 mRNA. Translation: AAH30690.1.
    CCDSiCCDS5596.1.
    RefSeqiNP_006370.1. NM_006379.3.
    UniGeneiHs.269109.

    Genome annotation databases

    EnsembliENST00000265361; ENSP00000265361; ENSG00000075223. [Q99985-1]
    ENST00000419255; ENSP00000411193; ENSG00000075223. [Q99985-1]
    GeneIDi10512.
    KEGGihsa:10512.
    UCSCiuc003uhj.3. human.

    Polymorphism databases

    DMDMi8134685.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000220 mRNA. Translation: BAA32398.1 .
    AK299322 mRNA. Translation: BAG61330.1 .
    AC004880 Genomic DNA. No translation available.
    AC004972 Genomic DNA. No translation available.
    AC073850 Genomic DNA. No translation available.
    AC093683 Genomic DNA. No translation available.
    BC030690 mRNA. Translation: AAH30690.1 .
    CCDSi CCDS5596.1.
    RefSeqi NP_006370.1. NM_006379.3.
    UniGenei Hs.269109.

    3D structure databases

    ProteinModelPortali Q99985.
    SMRi Q99985. Positions 28-657.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000265361.

    PTM databases

    PhosphoSitei Q99985.

    Polymorphism databases

    DMDMi 8134685.

    Proteomic databases

    PaxDbi Q99985.
    PeptideAtlasi Q99985.
    PRIDEi Q99985.

    Protocols and materials databases

    DNASUi 10512.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265361 ; ENSP00000265361 ; ENSG00000075223 . [Q99985-1 ]
    ENST00000419255 ; ENSP00000411193 ; ENSG00000075223 . [Q99985-1 ]
    GeneIDi 10512.
    KEGGi hsa:10512.
    UCSCi uc003uhj.3. human.

    Organism-specific databases

    CTDi 10512.
    GeneCardsi GC07M080371.
    HGNCi HGNC:10725. SEMA3C.
    HPAi HPA042418.
    MIMi 602645. gene.
    neXtProti NX_Q99985.
    PharmGKBi PA35647.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247865.
    HOVERGENi HBG055071.
    InParanoidi Q99985.
    KOi K06840.
    OrthoDBi EOG7034G7.
    PhylomeDBi Q99985.
    TreeFami TF352628.

    Miscellaneous databases

    ChiTaRSi SEMA3C. human.
    GeneWikii SEMA3C.
    GenomeRNAii 10512.
    NextBioi 39868.
    PROi Q99985.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99985.
    Bgeei Q99985.
    CleanExi HS_SEMA3C.
    Genevestigatori Q99985.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers."
      Yamada T., Endo R., Gotoh M., Hirohashi S.
      Proc. Natl. Acad. Sci. U.S.A. 94:14713-14718(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiSEM3C_HUMAN
    AccessioniPrimary (citable) accession number: Q99985
    Secondary accession number(s): B4DRL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3