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Q99985 (SEM3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Semaphorin-3C
Alternative name(s):
Semaphorin-E
Short name=Sema E
Gene names
Name:SEMA3C
Synonyms:SEMAE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length751 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance By similarity.

Subunit structure

Interacts with PLXND1 By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 PSI domain.

Contains 1 Sema domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from sequence or structural similarity. Source: UniProtKB

blood vessel remodeling

Inferred from electronic annotation. Source: Compara

cardiac right ventricle morphogenesis

Inferred from electronic annotation. Source: Compara

dichotomous subdivision of terminal units involved in salivary gland branching

Inferred from electronic annotation. Source: Compara

immune response

Traceable author statement PubMed 9168980. Source: ProtInc

limb bud formation

Inferred from electronic annotation. Source: Compara

neural crest cell migration

Inferred from electronic annotation. Source: Compara

neural tube development

Inferred from electronic annotation. Source: Compara

outflow tract morphogenesis

Inferred from electronic annotation. Source: Compara

post-embryonic development

Inferred from electronic annotation. Source: Compara

pulmonary myocardium development

Inferred from electronic annotation. Source: Compara

response to drug

Traceable author statement Ref.1. Source: ProtInc

somitogenesis

Inferred from electronic annotation. Source: Compara

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Compara

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 751731Semaphorin-3C
PRO_0000032311

Regions

Domain28 – 511484Sema
Domain571 – 65585Ig-like C2-type
Compositional bias724 – 74522Arg/Lys-rich (basic)

Amino acid modifications

Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation2681N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential
Glycosylation5851N-linked (GlcNAc...) Potential
Glycosylation5861N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 112 By similarity
Disulfide bond130 ↔ 139 By similarity
Disulfide bond266 ↔ 378 By similarity
Disulfide bond290 ↔ 338 By similarity
Disulfide bond514 ↔ 532 By similarity
Disulfide bond643 ↔ 709 By similarity

Natural variations

Natural variant3021F → S.
Corresponds to variant rs35070362 [ dbSNP | Ensembl ].
VAR_051928
Natural variant3371V → M.
Corresponds to variant rs1527482 [ dbSNP | Ensembl ].
VAR_020346

Sequences

Sequence LengthMass (Da)Tools
Q99985 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: AA68A21FEF20C033

FASTA75185,207
        10         20         30         40         50         60 
MAFRTICVLV GVFICSICVK GSSQPQARVY LTFDELRETK TSEYFSLSHH PLDYRILLMD 

        70         80         90        100        110        120 
EDQDRIYVGS KDHILSLNIN NISQEALSVF WPASTIKVEE CKMAGKDPTH GCGNFVRVIQ 

       130        140        150        160        170        180 
TFNRTHLYVC GSGAFSPVCT YLNRGRRSED QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN 

       190        200        210        220        230        240 
EELFSGMYID FMGTDAAIFR SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV 

       250        260        270        280        290        300 
YFFFKEKLTD NNRSTKQIHS MIARICPNDT GGLRSLVNKW TTFLKARLVC SVTDEDGPET 

       310        320        330        340        350        360 
HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN GPFAHKEGPN 

       370        380        390        400        410        420 
HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KEFPDDVVTF IRNHPLMYNS IYPIHKRPLI 

       430        440        450        460        470        480 
VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG TDRGTVQKVV VLPTNNSVSG ELILEELEVF 

       490        500        510        520        530        540 
KNHAPITTMK ISSKKQQLYV SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS 

       550        560        570        580        590        600 
RFYPTGKRRS RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVKNNTTFL ECAPKSPQAS 

       610        620        630        640        650        660 
IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQGSDQGL YHCIATENSF KQTIAKINFK 

       670        680        690        700        710        720 
VLDSEMVAVV TDKWSPWTWA SSVRALPFHP KDIMGAFSHS EMQMINQYCK DTRQQHQQGD 

       730        740        750 
ESQKMRGDYG KLKALINSRK SRNRRNQLPE S

« Hide

References

« Hide 'large scale' references
[1]"Identification of semaphorin E as a non-MDR drug resistance gene of human cancers."
Yamada T., Endo R., Gotoh M., Hirohashi S.
Proc. Natl. Acad. Sci. U.S.A. 94:14713-14718(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB000220 mRNA. Translation: BAA32398.1.
BC030690 mRNA. Translation: AAH30690.1.
IPIIPI01014918.
RefSeqNP_006370.1. NM_006379.3.
UniGeneHs.269109.

3D structure databases

ProteinModelPortalQ99985.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000265361.

PTM databases

PhosphoSiteQ99985.

Polymorphism databases

DMDM8134685.

Proteomic databases

PaxDbQ99985.
PeptideAtlasQ99985.
PRIDEQ99985.

Protocols and materials databases

DNASU10512.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265361; ENSP00000265361; ENSG00000075223.
ENST00000419255; ENSP00000411193; ENSG00000075223.
GeneID10512.
KEGGhsa:10512.
UCSCuc003uhj.3. human.

Organism-specific databases

CTD10512.
GeneCardsGC07M080371.
HGNCHGNC:10725. SEMA3C.
HPAHPA042418.
MIM602645. gene.
neXtProtNX_Q99985.
PharmGKBPA35647.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247865.
HOVERGENHBG055071.
InParanoidQ99985.
KOK06840.
OrthoDBEOG49CQ71.
PhylomeDBQ99985.

Gene expression databases

ArrayExpressQ99985.
BgeeQ99985.
CleanExHS_SEMA3C.
GenevestigatorQ99985.
GermOnlineENSG00000075223. Homo sapiens.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR027231. Semaphorin.
IPR001627. Semaphorin/CD100_Ag.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR11036. PTHR11036. 1 hit.
PfamPF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF103575. Plexin-like_fold. 1 hit.
SSF101912. Sema. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSEMA3C. human.
GenomeRNAi10512.
NextBio39868.
SOURCESearch...

Entry information

Entry nameSEM3C_HUMAN
AccessionPrimary (citable) accession number: Q99985
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 1, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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