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Q99985

- SEM3C_HUMAN

UniProt

Q99985 - SEM3C_HUMAN

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Protein
Semaphorin-3C
Gene
SEMA3C, SEMAE
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance By similarity.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: UniProtKB
  2. blood vessel remodeling Source: Ensembl
  3. cardiac right ventricle morphogenesis Source: Ensembl
  4. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  5. immune response Source: ProtInc
  6. limb bud formation Source: Ensembl
  7. neural crest cell migration Source: Ensembl
  8. neural tube development Source: Ensembl
  9. outflow tract morphogenesis Source: Ensembl
  10. post-embryonic development Source: Ensembl
  11. pulmonary myocardium development Source: Ensembl
  12. response to drug Source: ProtInc
  13. somitogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3C
Alternative name(s):
Semaphorin-E
Short name:
Sema E
Gene namesi
Name:SEMA3C
Synonyms:SEMAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:10725. SEMA3C.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 751731Semaphorin-3C
PRO_0000032311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi101 ↔ 112 By similarity
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi130 ↔ 139 By similarity
Glycosylationi252 – 2521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi266 ↔ 378 By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi290 ↔ 338 By similarity
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi514 ↔ 532 By similarity
Glycosylationi585 – 5851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi586 – 5861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi643 ↔ 709 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99985.
PeptideAtlasiQ99985.
PRIDEiQ99985.

PTM databases

PhosphoSiteiQ99985.

Expressioni

Tissue specificityi

Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

Gene expression databases

ArrayExpressiQ99985.
BgeeiQ99985.
CleanExiHS_SEMA3C.
GenevestigatoriQ99985.

Organism-specific databases

HPAiHPA042418.

Interactioni

Subunit structurei

Interacts with PLXND1 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000265361.

Structurei

3D structure databases

ProteinModelPortaliQ99985.
SMRiQ99985. Positions 28-657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 511484Sema
Add
BLAST
Domaini571 – 65585Ig-like C2-type
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi724 – 74522Arg/Lys-rich (basic)
Add
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG247865.
HOVERGENiHBG055071.
InParanoidiQ99985.
KOiK06840.
OrthoDBiEOG7034G7.
PhylomeDBiQ99985.
TreeFamiTF352628.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99985-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAFRTICVLV GVFICSICVK GSSQPQARVY LTFDELRETK TSEYFSLSHH    50
PLDYRILLMD EDQDRIYVGS KDHILSLNIN NISQEALSVF WPASTIKVEE 100
CKMAGKDPTH GCGNFVRVIQ TFNRTHLYVC GSGAFSPVCT YLNRGRRSED 150
QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN EELFSGMYID FMGTDAAIFR 200
SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV YFFFKEKLTD 250
NNRSTKQIHS MIARICPNDT GGLRSLVNKW TTFLKARLVC SVTDEDGPET 300
HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN 350
GPFAHKEGPN HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KEFPDDVVTF 400
IRNHPLMYNS IYPIHKRPLI VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG 450
TDRGTVQKVV VLPTNNSVSG ELILEELEVF KNHAPITTMK ISSKKQQLYV 500
SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS RFYPTGKRRS 550
RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVKNNTTFL ECAPKSPQAS 600
IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQGSDQGL YHCIATENSF 650
KQTIAKINFK VLDSEMVAVV TDKWSPWTWA SSVRALPFHP KDIMGAFSHS 700
EMQMINQYCK DTRQQHQQGD ESQKMRGDYG KLKALINSRK SRNRRNQLPE 750
S 751
Length:751
Mass (Da):85,207
Last modified:November 1, 1998 - v2
Checksum:iAA68A21FEF20C033
GO
Isoform 2 (identifier: Q99985-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-149: Missing.
     378-381: CPGG → NTCV
     382-751: Missing.

Note: No experimental confirmation available.

Show »
Length:233
Mass (Da):26,255
Checksum:i10D521391C76311A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti302 – 3021F → S.
Corresponds to variant rs35070362 [ dbSNP | Ensembl ].
VAR_051928
Natural varianti337 – 3371V → M.
Corresponds to variant rs1527482 [ dbSNP | Ensembl ].
VAR_020346

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 149148Missing in isoform 2.
VSP_055886Add
BLAST
Alternative sequencei378 – 3814CPGG → NTCV in isoform 2.
VSP_055887
Alternative sequencei382 – 751370Missing in isoform 2.
VSP_055888Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000220 mRNA. Translation: BAA32398.1.
AK299322 mRNA. Translation: BAG61330.1.
AC004880 Genomic DNA. No translation available.
AC004972 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC093683 Genomic DNA. No translation available.
BC030690 mRNA. Translation: AAH30690.1.
CCDSiCCDS5596.1.
RefSeqiNP_006370.1. NM_006379.3.
UniGeneiHs.269109.

Genome annotation databases

EnsembliENST00000265361; ENSP00000265361; ENSG00000075223.
ENST00000419255; ENSP00000411193; ENSG00000075223.
ENST00000536800; ENSP00000438258; ENSG00000075223.
GeneIDi10512.
KEGGihsa:10512.
UCSCiuc003uhj.3. human.

Polymorphism databases

DMDMi8134685.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000220 mRNA. Translation: BAA32398.1 .
AK299322 mRNA. Translation: BAG61330.1 .
AC004880 Genomic DNA. No translation available.
AC004972 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC093683 Genomic DNA. No translation available.
BC030690 mRNA. Translation: AAH30690.1 .
CCDSi CCDS5596.1.
RefSeqi NP_006370.1. NM_006379.3.
UniGenei Hs.269109.

3D structure databases

ProteinModelPortali Q99985.
SMRi Q99985. Positions 28-657.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000265361.

PTM databases

PhosphoSitei Q99985.

Polymorphism databases

DMDMi 8134685.

Proteomic databases

PaxDbi Q99985.
PeptideAtlasi Q99985.
PRIDEi Q99985.

Protocols and materials databases

DNASUi 10512.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265361 ; ENSP00000265361 ; ENSG00000075223 .
ENST00000419255 ; ENSP00000411193 ; ENSG00000075223 .
ENST00000536800 ; ENSP00000438258 ; ENSG00000075223 .
GeneIDi 10512.
KEGGi hsa:10512.
UCSCi uc003uhj.3. human.

Organism-specific databases

CTDi 10512.
GeneCardsi GC07M080371.
HGNCi HGNC:10725. SEMA3C.
HPAi HPA042418.
MIMi 602645. gene.
neXtProti NX_Q99985.
PharmGKBi PA35647.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247865.
HOVERGENi HBG055071.
InParanoidi Q99985.
KOi K06840.
OrthoDBi EOG7034G7.
PhylomeDBi Q99985.
TreeFami TF352628.

Miscellaneous databases

ChiTaRSi SEMA3C. human.
GeneWikii SEMA3C.
GenomeRNAii 10512.
NextBioi 39868.
PROi Q99985.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99985.
Bgeei Q99985.
CleanExi HS_SEMA3C.
Genevestigatori Q99985.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers."
    Yamada T., Endo R., Gotoh M., Hirohashi S.
    Proc. Natl. Acad. Sci. U.S.A. 94:14713-14718(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiSEM3C_HUMAN
AccessioniPrimary (citable) accession number: Q99985
Secondary accession number(s): B4DRL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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