Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99985

- SEM3C_HUMAN

UniProt

Q99985 - SEM3C_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Semaphorin-3C

Gene

SEMA3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: UniProtKB
  2. blood vessel remodeling Source: Ensembl
  3. cardiac right ventricle morphogenesis Source: Ensembl
  4. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  5. immune response Source: ProtInc
  6. limb bud formation Source: Ensembl
  7. neural crest cell migration Source: Ensembl
  8. neural tube development Source: Ensembl
  9. outflow tract morphogenesis Source: Ensembl
  10. post-embryonic development Source: Ensembl
  11. pulmonary myocardium development Source: Ensembl
  12. response to drug Source: ProtInc
  13. somitogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3C
Alternative name(s):
Semaphorin-E
Short name:
Sema E
Gene namesi
Name:SEMA3C
Synonyms:SEMAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:10725. SEMA3C.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: UniProtKB
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 751731Semaphorin-3CPRO_0000032311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 112By similarity
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 139By similarity
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi266 ↔ 378By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi290 ↔ 338By similarity
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi514 ↔ 532By similarity
Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi643 ↔ 709By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ99985.
PaxDbiQ99985.
PeptideAtlasiQ99985.
PRIDEiQ99985.

PTM databases

PhosphoSiteiQ99985.

Expressioni

Tissue specificityi

Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

Gene expression databases

BgeeiQ99985.
CleanExiHS_SEMA3C.
ExpressionAtlasiQ99985. baseline and differential.
GenevestigatoriQ99985.

Organism-specific databases

HPAiHPA042418.

Interactioni

Subunit structurei

Interacts with PLXND1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000265361.

Structurei

3D structure databases

ProteinModelPortaliQ99985.
SMRiQ99985. Positions 28-657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 511484SemaPROSITE-ProRule annotationAdd
BLAST
Domaini571 – 65585Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi724 – 74522Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG247865.
GeneTreeiENSGT00760000118854.
HOVERGENiHBG055071.
InParanoidiQ99985.
KOiK06840.
OrthoDBiEOG7034G7.
PhylomeDBiQ99985.
TreeFamiTF352628.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99985) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFRTICVLV GVFICSICVK GSSQPQARVY LTFDELRETK TSEYFSLSHH
60 70 80 90 100
PLDYRILLMD EDQDRIYVGS KDHILSLNIN NISQEALSVF WPASTIKVEE
110 120 130 140 150
CKMAGKDPTH GCGNFVRVIQ TFNRTHLYVC GSGAFSPVCT YLNRGRRSED
160 170 180 190 200
QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN EELFSGMYID FMGTDAAIFR
210 220 230 240 250
SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV YFFFKEKLTD
260 270 280 290 300
NNRSTKQIHS MIARICPNDT GGLRSLVNKW TTFLKARLVC SVTDEDGPET
310 320 330 340 350
HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN
360 370 380 390 400
GPFAHKEGPN HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KEFPDDVVTF
410 420 430 440 450
IRNHPLMYNS IYPIHKRPLI VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG
460 470 480 490 500
TDRGTVQKVV VLPTNNSVSG ELILEELEVF KNHAPITTMK ISSKKQQLYV
510 520 530 540 550
SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS RFYPTGKRRS
560 570 580 590 600
RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVKNNTTFL ECAPKSPQAS
610 620 630 640 650
IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQGSDQGL YHCIATENSF
660 670 680 690 700
KQTIAKINFK VLDSEMVAVV TDKWSPWTWA SSVRALPFHP KDIMGAFSHS
710 720 730 740 750
EMQMINQYCK DTRQQHQQGD ESQKMRGDYG KLKALINSRK SRNRRNQLPE

S
Length:751
Mass (Da):85,207
Last modified:November 1, 1998 - v2
Checksum:iAA68A21FEF20C033
GO
Isoform 2 (identifier: Q99985-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-149: Missing.
     378-381: CPGG → NTCV
     382-751: Missing.

Note: No experimental confirmation available.

Show »
Length:233
Mass (Da):26,255
Checksum:i10D521391C76311A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti302 – 3021F → S.
Corresponds to variant rs35070362 [ dbSNP | Ensembl ].
VAR_051928
Natural varianti337 – 3371V → M.
Corresponds to variant rs1527482 [ dbSNP | Ensembl ].
VAR_020346

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 149148Missing in isoform 2. 1 PublicationVSP_055886Add
BLAST
Alternative sequencei378 – 3814CPGG → NTCV in isoform 2. 1 PublicationVSP_055887
Alternative sequencei382 – 751370Missing in isoform 2. 1 PublicationVSP_055888Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000220 mRNA. Translation: BAA32398.1.
AK299322 mRNA. Translation: BAG61330.1.
AC004880 Genomic DNA. No translation available.
AC004972 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC093683 Genomic DNA. No translation available.
BC030690 mRNA. Translation: AAH30690.1.
CCDSiCCDS5596.1. [Q99985-1]
RefSeqiNP_006370.1. NM_006379.3. [Q99985-1]
UniGeneiHs.269109.

Genome annotation databases

EnsembliENST00000265361; ENSP00000265361; ENSG00000075223. [Q99985-1]
ENST00000419255; ENSP00000411193; ENSG00000075223. [Q99985-1]
GeneIDi10512.
KEGGihsa:10512.
UCSCiuc003uhj.3. human. [Q99985-1]

Polymorphism databases

DMDMi8134685.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000220 mRNA. Translation: BAA32398.1 .
AK299322 mRNA. Translation: BAG61330.1 .
AC004880 Genomic DNA. No translation available.
AC004972 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC093683 Genomic DNA. No translation available.
BC030690 mRNA. Translation: AAH30690.1 .
CCDSi CCDS5596.1. [Q99985-1 ]
RefSeqi NP_006370.1. NM_006379.3. [Q99985-1 ]
UniGenei Hs.269109.

3D structure databases

ProteinModelPortali Q99985.
SMRi Q99985. Positions 28-657.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000265361.

PTM databases

PhosphoSitei Q99985.

Polymorphism databases

DMDMi 8134685.

Proteomic databases

MaxQBi Q99985.
PaxDbi Q99985.
PeptideAtlasi Q99985.
PRIDEi Q99985.

Protocols and materials databases

DNASUi 10512.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265361 ; ENSP00000265361 ; ENSG00000075223 . [Q99985-1 ]
ENST00000419255 ; ENSP00000411193 ; ENSG00000075223 . [Q99985-1 ]
GeneIDi 10512.
KEGGi hsa:10512.
UCSCi uc003uhj.3. human. [Q99985-1 ]

Organism-specific databases

CTDi 10512.
GeneCardsi GC07M080371.
HGNCi HGNC:10725. SEMA3C.
HPAi HPA042418.
MIMi 602645. gene.
neXtProti NX_Q99985.
PharmGKBi PA35647.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247865.
GeneTreei ENSGT00760000118854.
HOVERGENi HBG055071.
InParanoidi Q99985.
KOi K06840.
OrthoDBi EOG7034G7.
PhylomeDBi Q99985.
TreeFami TF352628.

Miscellaneous databases

ChiTaRSi SEMA3C. human.
GeneWikii SEMA3C.
GenomeRNAii 10512.
NextBioi 35474419.
PROi Q99985.
SOURCEi Search...

Gene expression databases

Bgeei Q99985.
CleanExi HS_SEMA3C.
ExpressionAtlasi Q99985. baseline and differential.
Genevestigatori Q99985.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers."
    Yamada T., Endo R., Gotoh M., Hirohashi S.
    Proc. Natl. Acad. Sci. U.S.A. 94:14713-14718(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiSEM3C_HUMAN
AccessioniPrimary (citable) accession number: Q99985
Secondary accession number(s): B4DRL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3