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Protein

Osteomodulin

Gene

OMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127083-MONOMER.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-3656225. Defective CHST6 causes MCDC1.
R-HSA-3656243. Defective ST3GAL3 causes MCT12 and EIEE15.
R-HSA-3656244. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
SIGNORiQ99983.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name:
KSPG osteomodulin
Osteoadherin
Short name:
OSAD
Gene namesi
Name:OMD
Synonyms:SLRR2C
ORF Names:UNQ190/PRO216
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8134. OMD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4958.
OpenTargetsiENSG00000127083.
PharmGKBiPA31921.

Polymorphism and mutation databases

BioMutaiOMD.
DMDMi20138850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003275421 – 421OsteomodulinAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Sulfotyrosine1 Publication1
Modified residuei25Sulfotyrosine1 Publication1
Modified residuei31Sulfotyrosine1 Publication1
Modified residuei39Sulfotyrosine1 Publication1
Modified residuei51Sulfotyrosine1 Publication1
Modified residuei58Sulfotyrosine1 Publication1
Modified residuei77Sulfotyrosine1 Publication1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi321 ↔ 353By similarity
Modified residuei416Sulfotyrosine1 Publication1
Modified residuei417Sulfotyrosine1 Publication1

Post-translational modificationi

Binds keratan sulfate chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDbiQ99983.
PeptideAtlasiQ99983.
PRIDEiQ99983.

Expressioni

Tissue specificityi

Bone specific.

Gene expression databases

BgeeiENSG00000127083.
CleanExiHS_OMD.
GenevisibleiQ99983. HS.

Organism-specific databases

HPAiHPA005731.

Interactioni

Subunit structurei

Binds the alpha(V)beta(3)-integrin.By similarity

Protein-protein interaction databases

BioGridi111011. 4 interactors.
STRINGi9606.ENSP00000364700.

Structurei

3D structure databases

ProteinModelPortaliQ99983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 91LRRNTAdd BLAST39
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 129LRR 2Add BLAST14
Repeati142 – 164LRR 3Add BLAST23
Repeati165 – 184LRR 4Add BLAST20
Repeati187 – 210LRR 5Add BLAST24
Repeati213 – 233LRR 6Add BLAST21
Repeati234 – 255LRR 7Add BLAST22
Repeati258 – 280LRR 8Add BLAST23
Repeati281 – 294LRR 9Add BLAST14
Repeati301 – 321LRR 10Add BLAST21
Repeati331 – 353LRR 11Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 78Cys-richAdd BLAST17
Compositional biasi385 – 409Asp/Glu-rich (acidic)Add BLAST25

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiQ99983.
KOiK08124.
OMAiLKQAFYI.
OrthoDBiEOG091G044B.
PhylomeDBiQ99983.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR030705. Osteomodulin.
[Graphical view]
PANTHERiPTHR24373:SF155. PTHR24373:SF155. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLSPIYVI FFFFGVKVHC QYETYQWDED YDQEPDDDYQ TGFPFRQNVD
60 70 80 90 100
YGVPFHQYTL GCVSECFCPT NFPSSMYCDN RKLKTIPNIP MHIQQLYLQF
110 120 130 140 150
NEIEAVTANS FINATHLKEI NLSHNKIKSQ KIDYGVFAKL PNLLQLHLEH
160 170 180 190 200
NNLEEFPFPL PKSLERLLLG YNEISKLQTN AMDGLVNLTM LDLCYNYLHD
210 220 230 240 250
SLLKDKIFAK MEKLMQLNLC SNRLESMPPG LPSSLMYLSL ENNSISSIPE
260 270 280 290 300
KYFDKLPKLH TLRMSHNKLQ DIPYNIFNLP NIVELSVGHN KLKQAFYIPR
310 320 330 340 350
NLEHLYLQNN EIEKMNLTVM CPSIDPLHYH HLTYIRVDQN KLKEPISSYI
360 370 380 390 400
FFCFPHIHTI YYGEQRSTNG QTIQLKTQVF RRFPDDDDES EDHDDPDNAH
410 420
ESPEQEGAEG HFDLHYYENQ E
Length:421
Mass (Da):49,492
Last modified:May 1, 1997 - v1
Checksum:iCED47B2BC33BB872
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052014200D → G.Corresponds to variant rs34069871dbSNPEnsembl.1
Natural variantiVAR_052015212E → G.Corresponds to variant rs34413259dbSNPEnsembl.1
Natural variantiVAR_052016221S → N.Corresponds to variant rs34860658dbSNPEnsembl.1
Natural variantiVAR_052017282I → T.Corresponds to variant rs35779901dbSNPEnsembl.1
Natural variantiVAR_052018353C → W.Corresponds to variant rs34059114dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000114 mRNA. Translation: BAA19055.1.
AB009589 Genomic DNA. Translation: BAA23982.1.
AY358872 mRNA. Translation: AAQ89231.1.
AL137848 Genomic DNA. Translation: CAI16696.1.
CH471089 Genomic DNA. Translation: EAW62821.1.
BC046356 mRNA. Translation: AAH46356.1.
CCDSiCCDS6696.1.
RefSeqiNP_005005.1. NM_005014.2.
UniGeneiHs.94070.

Genome annotation databases

EnsembliENST00000375550; ENSP00000364700; ENSG00000127083.
GeneIDi4958.
KEGGihsa:4958.
UCSCiuc004asd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000114 mRNA. Translation: BAA19055.1.
AB009589 Genomic DNA. Translation: BAA23982.1.
AY358872 mRNA. Translation: AAQ89231.1.
AL137848 Genomic DNA. Translation: CAI16696.1.
CH471089 Genomic DNA. Translation: EAW62821.1.
BC046356 mRNA. Translation: AAH46356.1.
CCDSiCCDS6696.1.
RefSeqiNP_005005.1. NM_005014.2.
UniGeneiHs.94070.

3D structure databases

ProteinModelPortaliQ99983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111011. 4 interactors.
STRINGi9606.ENSP00000364700.

Polymorphism and mutation databases

BioMutaiOMD.
DMDMi20138850.

Proteomic databases

PaxDbiQ99983.
PeptideAtlasiQ99983.
PRIDEiQ99983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375550; ENSP00000364700; ENSG00000127083.
GeneIDi4958.
KEGGihsa:4958.
UCSCiuc004asd.5. human.

Organism-specific databases

CTDi4958.
DisGeNETi4958.
GeneCardsiOMD.
HGNCiHGNC:8134. OMD.
HPAiHPA005731.
neXtProtiNX_Q99983.
OpenTargetsiENSG00000127083.
PharmGKBiPA31921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiQ99983.
KOiK08124.
OMAiLKQAFYI.
OrthoDBiEOG091G044B.
PhylomeDBiQ99983.
TreeFamiTF334562.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127083-MONOMER.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-3656225. Defective CHST6 causes MCDC1.
R-HSA-3656243. Defective ST3GAL3 causes MCT12 and EIEE15.
R-HSA-3656244. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
SIGNORiQ99983.

Miscellaneous databases

GeneWikiiOMD_(gene).
GenomeRNAii4958.
PROiQ99983.

Gene expression databases

BgeeiENSG00000127083.
CleanExiHS_OMD.
GenevisibleiQ99983. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR030705. Osteomodulin.
[Graphical view]
PANTHERiPTHR24373:SF155. PTHR24373:SF155. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMD_HUMAN
AccessioniPrimary (citable) accession number: Q99983
Secondary accession number(s): Q5TBF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.