ID   TEP1_HUMAN              Reviewed;        2627 AA.
AC   Q99973; A0AUV9;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   27-MAR-2024, entry version 195.
DE   RecName: Full=Telomerase protein component 1;
DE   AltName: Full=Telomerase-associated protein 1;
DE            Short=Telomerase protein 1;
DE   AltName: Full=p240;
DE   AltName: Full=p80 telomerase homolog;
GN   Name=TEP1; Synonyms=TLP1, TP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS
RP   PRO-116; GLY-553; CYS-1055; GLN-1155 AND PRO-1195.
RX   PubMed=9020079; DOI=10.1126/science.275.5302.973;
RA   Harrington L., McPhail T., Mar V., Zhou W., Oulton R., Bass M.B.,
RA   Arruda I., Robinson M.O.;
RT   "A mammalian telomerase-associated protein.";
RL   Science 275:973-977(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Cerebellum;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2288-2627 (ISOFORM 2).
RC   TISSUE=Salivary gland;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX.
RX   PubMed=9389643; DOI=10.1101/gad.11.23.3109;
RA   Harrington L., Zhou W., McPhail T., Oulton R., Yeung D.S., Mar V.,
RA   Bass M.B., Robinson M.O.;
RT   "Human telomerase contains evolutionarily conserved catalytic and
RT   structural subunits.";
RL   Genes Dev. 11:3109-3115(1997).
RN   [5]
RP   IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE, AND RNA-BINDING.
RX   PubMed=10551828; DOI=10.1074/jbc.274.46.32712;
RA   Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H.;
RT   "Vaults and telomerase share a common subunit, TEP1.";
RL   J. Biol. Chem. 274:32712-32717(1999).
RN   [6]
RP   IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX.
RX   PubMed=11029039; DOI=10.1091/mbc.11.10.3329;
RA   Beattie T.L., Zhou W., Robinson M.O., Harrington L.;
RT   "Polymerization defects within human telomerase are distinct from
RT   telomerase RNA and TEP1 binding.";
RL   Mol. Biol. Cell 11:3329-3340(2000).
RN   [7]
RP   IDENTIFICATION IN THE TELOMERASE HOLOENZYME COMPLEX.
RX   PubMed=19179534; DOI=10.1126/science.1165357;
RA   Venteicher A.S., Abreu E.B., Meng Z., McCann K.E., Terns R.M.,
RA   Veenstra T.D., Terns M.P., Artandi S.E.;
RT   "A human telomerase holoenzyme protein required for Cajal body localization
RT   and telomere synthesis.";
RL   Science 323:644-648(2009).
CC   -!- FUNCTION: Component of the telomerase ribonucleoprotein complex that is
CC       essential for the replication of chromosome termini (PubMed:19179534).
CC       Also a component of the ribonucleoprotein vaults particle, a multi-
CC       subunit structure involved in nucleo-cytoplasmic transport (By
CC       similarity). Responsible for the localizing and stabilizing vault RNA
CC       (vRNA) association in the vault ribonucleoprotein particle. Binds to
CC       TERC (By similarity). {ECO:0000250|UniProtKB:P97499,
CC       ECO:0000269|PubMed:19179534}.
CC   -!- SUBUNIT: Associated component of the telomerase holoenzyme complex
CC       (PubMed:19179534). Component of the vault ribonucleoprotein particle,
CC       at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs) (By
CC       similarity). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By
CC       similarity). {ECO:0000250|UniProtKB:P97499,
CC       ECO:0000269|PubMed:19179534}.
CC   -!- INTERACTION:
CC       Q99973; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-947859, EBI-372094;
CC       Q99973; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-947859, EBI-2514383;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q99973-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q99973-2; Sequence=VSP_010359;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9020079}.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to an exon inclusion.
CC       {ECO:0000305}.
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DR   EMBL; U86136; AAC51107.1; -; mRNA.
DR   EMBL; BC126107; AAI26108.1; -; mRNA.
DR   EMBL; BX640983; CAE45993.1; -; mRNA.
DR   CCDS; CCDS9548.1; -. [Q99973-1]
DR   RefSeq; NP_009041.2; NM_007110.4. [Q99973-1]
DR   RefSeq; XP_005268084.1; XM_005268027.4. [Q99973-1]
DR   AlphaFoldDB; Q99973; -.
DR   SMR; Q99973; -.
DR   BioGRID; 112870; 60.
DR   IntAct; Q99973; 7.
DR   STRING; 9606.ENSP00000262715; -.
DR   BindingDB; Q99973; -.
DR   GlyGen; Q99973; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q99973; -.
DR   PhosphoSitePlus; Q99973; -.
DR   SwissPalm; Q99973; -.
DR   BioMuta; TEP1; -.
DR   DMDM; 215273899; -.
DR   EPD; Q99973; -.
DR   jPOST; Q99973; -.
DR   MassIVE; Q99973; -.
DR   MaxQB; Q99973; -.
DR   PaxDb; 9606-ENSP00000262715; -.
DR   PeptideAtlas; Q99973; -.
DR   ProteomicsDB; 78559; -. [Q99973-1]
DR   ProteomicsDB; 78560; -. [Q99973-2]
DR   Pumba; Q99973; -.
DR   Antibodypedia; 6875; 126 antibodies from 27 providers.
DR   DNASU; 7011; -.
DR   Ensembl; ENST00000262715.10; ENSP00000262715.5; ENSG00000129566.13. [Q99973-1]
DR   Ensembl; ENST00000708760.1; ENSP00000517324.1; ENSG00000291791.1. [Q99973-1]
DR   GeneID; 7011; -.
DR   KEGG; hsa:7011; -.
DR   MANE-Select; ENST00000262715.10; ENSP00000262715.5; NM_007110.5; NP_009041.2.
DR   UCSC; uc001vxe.4; human. [Q99973-1]
DR   AGR; HGNC:11726; -.
DR   CTD; 7011; -.
DR   DisGeNET; 7011; -.
DR   GeneCards; TEP1; -.
DR   HGNC; HGNC:11726; TEP1.
DR   HPA; ENSG00000129566; Low tissue specificity.
DR   MIM; 601686; gene.
DR   neXtProt; NX_Q99973; -.
DR   OpenTargets; ENSG00000129566; -.
DR   PharmGKB; PA36443; -.
DR   VEuPathDB; HostDB:ENSG00000129566; -.
DR   eggNOG; KOG3602; Eukaryota.
DR   eggNOG; KOG4155; Eukaryota.
DR   GeneTree; ENSGT00940000161338; -.
DR   InParanoid; Q99973; -.
DR   OMA; WQILPKG; -.
DR   OrthoDB; 6431at2759; -.
DR   PhylomeDB; Q99973; -.
DR   TreeFam; TF328424; -.
DR   PathwayCommons; Q99973; -.
DR   SignaLink; Q99973; -.
DR   BioGRID-ORCS; 7011; 4 hits in 1159 CRISPR screens.
DR   ChiTaRS; TEP1; human.
DR   GeneWiki; TEP1; -.
DR   GenomeRNAi; 7011; -.
DR   Pharos; Q99973; Tbio.
DR   PRO; PR:Q99973; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q99973; Protein.
DR   Bgee; ENSG00000129566; Expressed in monocyte and 161 other cell types or tissues.
DR   ExpressionAtlas; Q99973; baseline and differential.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0016363; C:nuclear matrix; IDA:MGI.
DR   GO; GO:1990904; C:ribonucleoprotein complex; TAS:UniProtKB.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019899; F:enzyme binding; IPI:BHF-UCL.
DR   GO; GO:0002039; F:p53 binding; IPI:BHF-UCL.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0003720; F:telomerase activity; IEA:Ensembl.
DR   GO; GO:0070034; F:telomerase RNA binding; ISS:BHF-UCL.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IDA:UniProtKB.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.25.40.370; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR   InterPro; IPR025139; DUF4062.
DR   InterPro; IPR045804; DUF5920.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008850; TEP1_N.
DR   InterPro; IPR008858; TROVE_dom.
DR   InterPro; IPR037214; TROVE_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR44791:SF1; TELOMERASE PROTEIN COMPONENT 1; 1.
DR   PANTHER; PTHR44791; TELOMERASE PROTEIN COMPONENT 1 TEP1; 1.
DR   Pfam; PF13271; DUF4062; 1.
DR   Pfam; PF19334; DUF5920; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF05386; TEP1_N; 4.
DR   Pfam; PF05731; TROVE; 1.
DR   Pfam; PF00400; WD40; 7.
DR   SMART; SM00320; WD40; 18.
DR   SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF140864; TROVE domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 3.
DR   PROSITE; PS50837; NACHT; 1.
DR   PROSITE; PS51226; TEP1_N; 4.
DR   PROSITE; PS50988; TROVE; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   Genevisible; Q99973; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; ATP-binding; Chromosome; Nucleotide-binding; Nucleus;
KW   Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Telomere;
KW   WD repeat.
FT   CHAIN           1..2627
FT                   /note="Telomerase protein component 1"
FT                   /id="PRO_0000050982"
FT   REPEAT          1..30
FT                   /note="TEP1 N-terminal 1"
FT   REPEAT          31..60
FT                   /note="TEP1 N-terminal 2"
FT   REPEAT          61..90
FT                   /note="TEP1 N-terminal 3"
FT   REPEAT          91..120
FT                   /note="TEP1 N-terminal 4"
FT   DOMAIN          223..676
FT                   /note="TROVE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00343"
FT   DOMAIN          1162..1490
FT                   /note="NACHT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT   REPEAT          1411..1448
FT                   /note="WD 1"
FT   REPEAT          1674..1713
FT                   /note="WD 2"
FT   REPEAT          1716..1754
FT                   /note="WD 3"
FT   REPEAT          1757..1796
FT                   /note="WD 4"
FT   REPEAT          1798..1837
FT                   /note="WD 5"
FT   REPEAT          1840..1879
FT                   /note="WD 6"
FT   REPEAT          1882..1921
FT                   /note="WD 7"
FT   REPEAT          1925..1964
FT                   /note="WD 8"
FT   REPEAT          1967..2005
FT                   /note="WD 9"
FT   REPEAT          2008..2047
FT                   /note="WD 10"
FT   REPEAT          2059..2098
FT                   /note="WD 11"
FT   REPEAT          2105..2143
FT                   /note="WD 12"
FT   REPEAT          2146..2183
FT                   /note="WD 13"
FT   REPEAT          2185..2233
FT                   /note="WD 14"
FT   REPEAT          2236..2275
FT                   /note="WD 15"
FT   REPEAT          2278..2317
FT                   /note="WD 16"
FT   REPEAT          2319..2355
FT                   /note="WD 17"
FT   REPEAT          2368..2417
FT                   /note="WD 18"
FT   REPEAT          2459..2500
FT                   /note="WD 19"
FT   REPEAT          2553..2590
FT                   /note="WD 20"
FT   REPEAT          2592..2626
FT                   /note="WD 21"
FT   REGION          193..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2506..2551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2506..2538
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1168..1175
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT   VAR_SEQ         2475..2506
FT                   /note="ESSFLCASSDGILWNLAKCSPEGEWTTGNMWQ -> ALMGSYGTWPNAAQKE
FT                   NGPQVTCGR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_010359"
FT   VARIANT         116
FT                   /note="S -> P (in dbSNP:rs1760897)"
FT                   /evidence="ECO:0000269|PubMed:9020079"
FT                   /id="VAR_018490"
FT   VARIANT         137
FT                   /note="T -> M (in dbSNP:rs10083536)"
FT                   /id="VAR_047631"
FT   VARIANT         307
FT                   /note="N -> K (in dbSNP:rs1760898)"
FT                   /id="VAR_018491"
FT   VARIANT         368
FT                   /note="K -> R (in dbSNP:rs2228035)"
FT                   /id="VAR_047632"
FT   VARIANT         434
FT                   /note="K -> N (in dbSNP:rs17111188)"
FT                   /id="VAR_047633"
FT   VARIANT         510
FT                   /note="S -> L (in dbSNP:rs4982051)"
FT                   /id="VAR_047634"
FT   VARIANT         553
FT                   /note="A -> G (in dbSNP:rs76466486)"
FT                   /evidence="ECO:0000269|PubMed:9020079"
FT                   /id="VAR_047635"
FT   VARIANT         933
FT                   /note="R -> H (in dbSNP:rs34179031)"
FT                   /id="VAR_047636"
FT   VARIANT         1055
FT                   /note="R -> C (in dbSNP:rs1760903)"
FT                   /evidence="ECO:0000269|PubMed:9020079"
FT                   /id="VAR_018492"
FT   VARIANT         1155
FT                   /note="R -> Q (in dbSNP:rs2228041)"
FT                   /evidence="ECO:0000269|PubMed:9020079"
FT                   /id="VAR_047637"
FT   VARIANT         1195
FT                   /note="S -> P (in dbSNP:rs1760904)"
FT                   /evidence="ECO:0000269|PubMed:9020079"
FT                   /id="VAR_018493"
FT   VARIANT         1351
FT                   /note="R -> Q (in dbSNP:rs12886088)"
FT                   /id="VAR_047638"
FT   VARIANT         1408
FT                   /note="G -> R (in dbSNP:rs2229100)"
FT                   /id="VAR_047639"
FT   VARIANT         1447
FT                   /note="S -> T (in dbSNP:rs1713457)"
FT                   /id="VAR_018494"
FT   VARIANT         1468
FT                   /note="C -> Y (in dbSNP:rs1713456)"
FT                   /id="VAR_018495"
FT   VARIANT         1661
FT                   /note="R -> Q (in dbSNP:rs34401320)"
FT                   /id="VAR_047640"
FT   VARIANT         1772
FT                   /note="R -> Q (in dbSNP:rs8022805)"
FT                   /id="VAR_047641"
FT   VARIANT         2214
FT                   /note="V -> I (in dbSNP:rs1713449)"
FT                   /id="VAR_018496"
FT   VARIANT         2310
FT                   /note="A -> S (in dbSNP:rs35929175)"
FT                   /id="VAR_047642"
FT   VARIANT         2486
FT                   /note="I -> M (in dbSNP:rs938886)"
FT                   /id="VAR_018497"
FT   VARIANT         2562
FT                   /note="H -> R (in dbSNP:rs2104978)"
FT                   /id="VAR_018498"
SQ   SEQUENCE   2627 AA;  290490 MW;  32628238704A8860 CRC64;
     MEKLHGHVSA HPDILSLENR CLAMLPDLQP LEKLHQHVST HSDILSLKNQ CLATLPDLKT
     MEKPHGYVSA HPDILSLENQ CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLSSLKS
     TVSASPLFQS LQISHMTQAD LYRVNNSNCL LSEPPSWRAQ HFSKGLDLST CPIALKSISA
     TETAQEATLG RWFDSEEKKG AETQMPSYSL SLGEEEEVED LAVKLTSGDS ESHPEPTDHV
     LQEKKMALLS LLCSTLVSEV NMNNTSDPTL AAIFEICREL ALLEPEFILK ASLYARQQLN
     VRNVANNILA IAAFLPACRP HLRRYFCAIV QLPSDWIQVA ELYQSLAEGD KNKLVPLPAC
     LRTAMTDKFA QFDEYQLAKY NPRKHRAKRH PRRPPRSPGM EPPFSHRCFP RYIGFLREEQ
     RKFEKAGDTV SEKKNPPRFT LKKLVQRLHI HKPAQHVQAL LGYRYPSNLQ LFSRSRLPGP
     WDSSRAGKRM KLSRPETWER ELSLRGNKAS VWEELIENGK LPFMAMLRNL CNLLRVGISS
     RHHELILQRL QHAKSVIHSR QFPFRFLNAH DAIDALEAQL RNQALPFPSN ITLMRRILTR
     NEKNRPRRRF LCHLSRQQLR MAMRIPVLYE QLKREKLRVH KARQWKYDGE MLNRYRQALE
     TAVNLSVKHS LPLLPGRTVL VYLTDANADR LCPKSNPQGP PLNYALLLIG MMITRAEQVD
     VVLCGGDTLK TAVLKAEEGI LKTAIKLQAQ VQEFDENDGW SLNTFGKYLL SLAGQRVPVD
     RVILLGQSMD DGMINVAKQL YWQRVNSKCL FVGILLRRVQ YLSTDLNPND VTLSGCTDAI
     LKFIAEHGAS HLLEHVGQMD KIFKIPPPPG KTGVQSLRPL EEDTPSPLAP VSQQGWRSIR
     LFISSTFRDM HGERDLLLRS VLPALQARAA PHRISLHGID LRWGVTEEET RRNRQLEVCL
     GEVENAQLFV GILGSRYGYI PPSYNLPDHP HFHWAQQYPS GRSVTEMEVM QFLNRNQRLQ
     PSAQALIYFR DSSFLSSVPD AWKSDFVSES EEAARRISEL KSYLSRQKGI TCRRYPCEWG
     GVAAGRPYVG GLEEFGQLVL QDVWNMIQKL YLQPGALLEQ PVSIPDDDLV QATFQQLQKP
     PSPARPRLLQ DTVQRLMLPH GRLSLVTGQS GQGKTAFLAS LVSALQAPDG AKVASLVFFH
     FSGARPDQGL ALTLLRRLCT YLRGQLKEPG ALPSTYRSLV WELQQRLLPK SAESLHPGQT
     QVLIIDGADR LVDQNGQLIS DWIPKKLPRC VHLVLSVSSD AGLGETLEQS QGAHVLALGP
     LEASARARLV REELALYGKR LEESPFNNQM RLLLVKRESG RPLYLRLVTD HLRLFTLYEQ
     VSERLRTLPA TVPLLLQHIL STLEKEHGPD VLPQALTALE VTRSGLTVDQ LHGVLSVWRT
     LPKGTKSWEE AVAAGNSGDP YPMGPFACLV QSLRSLLGEG PLERPGARLC LPDGPLRTAA
     KRCYGKRPGL EDTAHILIAA QLWKTCDADA SGTFRSCPPE ALGDLPYHLL QSGNRGLLSK
     FLTNLHVVAA HLELGLVSRL LEAHALYASS VPKEEQKLPE ADVAVFRTFL RQQASILSQY
     PRLLPQQAAN QPLDSPLCHQ ASLLSRRWHL QHTLRWLNKP RTMKNQQSSS LSLAVSSSPT
     AVAFSTNGQR AAVGTANGTV YLLDLRTWQE EKSVVSGCDG ISACLFLSDD TLFLTAFDGL
     LELWDLQHGC RVLQTKAHQY QITGCCLSPD CRLLATVCLG GCLKLWDTVR GQLAFQHTYP
     KSLNCVAFHP EGQVIATGSW AGSISFFQVD GLKVTKDLGA PGASIRTLAF NVPGGVVAVG
     RLDSMVELWA WREGARLAAF PAHHGFVAAA LFLHAGCQLL TAGEDGKVQV WSGSLGRPRG
     HLGSLSLSPA LSVALSPDGD RVAVGYRADG IRIYKISSGS QGAQGQALDV AVSALAWLSP
     KVLVSGAEDG SLQGWALKEC SLQSLWLLSR FQKPVLGLAT SQELLASASE DFTVQLWPRQ
     LLTRPHKAED FPCGTELRGH EGPVSCCSFS TDGGSLATGG RDRSLLCWDV RTPKTPVLIH
     SFPACHRDWV TGCAWTKDNL LISCSSDGSV GLWDPESGQR LGQFLGHQSA VSAVAAVEEH
     VVSVSRDGTL KVWDHQGVEL TSIPAHSGPI SHCAAAMEPR AAGQPGSELL VVTVGLDGAT
     RLWHPLLVCQ THTLLGHSGP VRAAAVSETS GLMLTASEDG SVRLWQVPKE ADDTCIPRSS
     AAVTAVAWAP DGSMAVSGNQ AGELILWQEA KAVATAQAPG HIGALIWSSA HTFFVLSADE
     KISEWQVKLR KGSAPGNLSL HLNRILQEDL GVLTSLDWAP DGHFLILAKA DLKLLCMKPG
     DAPSEIWSSY TENPMILSTH KEYGIFVLQP KDPGVLSFLR QKESGEFEER LNFDINLENP
     SRTLISITQA KPESESSFLC ASSDGILWNL AKCSPEGEWT TGNMWQKKAN TPETQTPGTD
     PSTCRESDAS MDSDASMDSE PTPHLKTRQR RKIHSGSVTA LHVLPELLVT ASKDRDVKLW
     ERPSMQLLGL FRCEGSVSCL EPWLGANSTL QLAVGDVQGN VYFLNWE
//