Q99973 (TEP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Telomerase protein component 1

Alternative name(s):
Telomerase-associated protein 1
Short name=Telomerase protein 1
p240
p80 telomerase homolog

Gene names

Name:	TEP1
Synonyms:	TLP1, TP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2627 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC By similarity.
Subunit structure	Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs By similarity. Ref.4 Ref.5 Ref.6 Ref.7
Subcellular location	Nucleus Probable. Chromosome › telomere.
Tissue specificity	Ubiquitous. Ref.1
Sequence similarities	Contains 1 NACHT domain. Contains 4 TEP1 N-terminal repeats. Contains 1 TROVE domain. Contains 21 WD repeats.

Ontologies

Keywords
Cellular component	Chromosome Nucleus Telomere
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Ligand	ATP-binding Nucleotide-binding RNA-binding
Molecular function	Ribonucleoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	telomere maintenance via recombination Inferred from direct assay PubMed 10810353. Source: UniProtKB
Cellular_component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from direct assay PubMed 7876352. Source: MGI nuclear matrix Inferred from direct assay PubMed 7876352. Source: MGI telomerase holoenzyme complex Inferred from direct assay PubMed 12135483. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99973-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99973-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2475-2506: ESSFLCASSDGILWNLAKCSPEGEWTTGNMWQ → ALMGSYGTWPNAAQKENGPQVTCGR

Note: May be due to an exon inclusion.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2627	2627	Telomerase protein component 1		PRO_0000050982
Regions
	Repeat	1 – 30	30	TEP1 N-terminal 1
	Repeat	31 – 60	30	TEP1 N-terminal 2
	Repeat	61 – 90	30	TEP1 N-terminal 3
	Repeat	91 – 120	30	TEP1 N-terminal 4
	Domain	223 – 676	454	TROVE
	Domain	1162 – 1490	329	NACHT
	Repeat	1411 – 1448	38	WD 1
	Repeat	1674 – 1713	40	WD 2
	Repeat	1716 – 1754	39	WD 3
	Repeat	1757 – 1796	40	WD 4
	Repeat	1798 – 1837	40	WD 5
	Repeat	1840 – 1879	40	WD 6
	Repeat	1882 – 1921	40	WD 7
	Repeat	1925 – 1964	40	WD 8
	Repeat	1967 – 2005	39	WD 9
	Repeat	2008 – 2047	40	WD 10
	Repeat	2059 – 2098	40	WD 11
	Repeat	2105 – 2143	39	WD 12
	Repeat	2146 – 2183	38	WD 13
	Repeat	2185 – 2233	49	WD 14
	Repeat	2236 – 2275	40	WD 15
	Repeat	2278 – 2317	40	WD 16
	Repeat	2319 – 2355	37	WD 17
	Repeat	2368 – 2417	50	WD 18
	Repeat	2459 – 2500	42	WD 19
	Repeat	2553 – 2590	38	WD 20
	Repeat	2592 – 2626	35	WD 21
	Nucleotide binding	1168 – 1175	8	ATP Potential
Natural variations
	Alternative sequence	2475 – 2506	32	ESSFL…GNMWQ → ALMGSYGTWPNAAQKENGPQ VTCGR in isoform 2.		VSP_010359
	Natural variant	116	1	S → P. Ref.1 Corresponds to variant rs1760897 [ dbSNP | Ensembl ].		VAR_018490
	Natural variant	137	1	T → M. Corresponds to variant rs10083536 [ dbSNP | Ensembl ].		VAR_047631
	Natural variant	307	1	N → K. Corresponds to variant rs1760898 [ dbSNP | Ensembl ].		VAR_018491
	Natural variant	368	1	K → R. Corresponds to variant rs2228035 [ dbSNP | Ensembl ].		VAR_047632
	Natural variant	434	1	K → N. Corresponds to variant rs17111188 [ dbSNP | Ensembl ].		VAR_047633
	Natural variant	510	1	S → L. Corresponds to variant rs4982051 [ dbSNP | Ensembl ].		VAR_047634
	Natural variant	553	1	A → G. Ref.1 Corresponds to variant rs2228040 [ dbSNP | Ensembl ].		VAR_047635
	Natural variant	933	1	R → H. Corresponds to variant rs34179031 [ dbSNP | Ensembl ].		VAR_047636
	Natural variant	1055	1	R → C. Ref.1 Corresponds to variant rs1760903 [ dbSNP | Ensembl ].		VAR_018492
	Natural variant	1155	1	R → Q. Ref.1 Corresponds to variant rs2228041 [ dbSNP | Ensembl ].		VAR_047637
	Natural variant	1195	1	S → P. Ref.1 Corresponds to variant rs1760904 [ dbSNP | Ensembl ].		VAR_018493
	Natural variant	1351	1	R → Q. Corresponds to variant rs12886088 [ dbSNP | Ensembl ].		VAR_047638
	Natural variant	1408	1	G → R. Corresponds to variant rs2229100 [ dbSNP | Ensembl ].		VAR_047639
	Natural variant	1447	1	S → T. Corresponds to variant rs1713457 [ dbSNP | Ensembl ].		VAR_018494
	Natural variant	1468	1	C → Y. Corresponds to variant rs1713456 [ dbSNP | Ensembl ].		VAR_018495
	Natural variant	1661	1	R → Q. Corresponds to variant rs34401320 [ dbSNP | Ensembl ].		VAR_047640
	Natural variant	1772	1	R → Q. Corresponds to variant rs8022805 [ dbSNP | Ensembl ].		VAR_047641
	Natural variant	2214	1	V → I. Corresponds to variant rs1713449 [ dbSNP | Ensembl ].		VAR_018496
	Natural variant	2310	1	A → S. Corresponds to variant rs35929175 [ dbSNP | Ensembl ].		VAR_047642
	Natural variant	2486	1	I → M. Corresponds to variant rs938886 [ dbSNP | Ensembl ].		VAR_018497
	Natural variant	2562	1	H → R. Corresponds to variant rs2104978 [ dbSNP | Ensembl ].		VAR_018498

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 32628238704A8860	FASTA	2,627	290,490
	10 20 30 40 50 60 MEKLHGHVSA HPDILSLENR CLAMLPDLQP LEKLHQHVST HSDILSLKNQ CLATLPDLKT 70 80 90 100 110 120 MEKPHGYVSA HPDILSLENQ CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLSSLKS 130 140 150 160 170 180 TVSASPLFQS LQISHMTQAD LYRVNNSNCL LSEPPSWRAQ HFSKGLDLST CPIALKSISA 190 200 210 220 230 240 TETAQEATLG RWFDSEEKKG AETQMPSYSL SLGEEEEVED LAVKLTSGDS ESHPEPTDHV 250 260 270 280 290 300 LQEKKMALLS LLCSTLVSEV NMNNTSDPTL AAIFEICREL ALLEPEFILK ASLYARQQLN 310 320 330 340 350 360 VRNVANNILA IAAFLPACRP HLRRYFCAIV QLPSDWIQVA ELYQSLAEGD KNKLVPLPAC 370 380 390 400 410 420 LRTAMTDKFA QFDEYQLAKY NPRKHRAKRH PRRPPRSPGM EPPFSHRCFP RYIGFLREEQ 430 440 450 460 470 480 RKFEKAGDTV SEKKNPPRFT LKKLVQRLHI HKPAQHVQAL LGYRYPSNLQ LFSRSRLPGP 490 500 510 520 530 540 WDSSRAGKRM KLSRPETWER ELSLRGNKAS VWEELIENGK LPFMAMLRNL CNLLRVGISS 550 560 570 580 590 600 RHHELILQRL QHAKSVIHSR QFPFRFLNAH DAIDALEAQL RNQALPFPSN ITLMRRILTR 610 620 630 640 650 660 NEKNRPRRRF LCHLSRQQLR MAMRIPVLYE QLKREKLRVH KARQWKYDGE MLNRYRQALE 670 680 690 700 710 720 TAVNLSVKHS LPLLPGRTVL VYLTDANADR LCPKSNPQGP PLNYALLLIG MMITRAEQVD 730 740 750 760 770 780 VVLCGGDTLK TAVLKAEEGI LKTAIKLQAQ VQEFDENDGW SLNTFGKYLL SLAGQRVPVD 790 800 810 820 830 840 RVILLGQSMD DGMINVAKQL YWQRVNSKCL FVGILLRRVQ YLSTDLNPND VTLSGCTDAI 850 860 870 880 890 900 LKFIAEHGAS HLLEHVGQMD KIFKIPPPPG KTGVQSLRPL EEDTPSPLAP VSQQGWRSIR 910 920 930 940 950 960 LFISSTFRDM HGERDLLLRS VLPALQARAA PHRISLHGID LRWGVTEEET RRNRQLEVCL 970 980 990 1000 1010 1020 GEVENAQLFV GILGSRYGYI PPSYNLPDHP HFHWAQQYPS GRSVTEMEVM QFLNRNQRLQ 1030 1040 1050 1060 1070 1080 PSAQALIYFR DSSFLSSVPD AWKSDFVSES EEAARRISEL KSYLSRQKGI TCRRYPCEWG 1090 1100 1110 1120 1130 1140 GVAAGRPYVG GLEEFGQLVL QDVWNMIQKL YLQPGALLEQ PVSIPDDDLV QATFQQLQKP 1150 1160 1170 1180 1190 1200 PSPARPRLLQ DTVQRLMLPH GRLSLVTGQS GQGKTAFLAS LVSALQAPDG AKVASLVFFH 1210 1220 1230 1240 1250 1260 FSGARPDQGL ALTLLRRLCT YLRGQLKEPG ALPSTYRSLV WELQQRLLPK SAESLHPGQT 1270 1280 1290 1300 1310 1320 QVLIIDGADR LVDQNGQLIS DWIPKKLPRC VHLVLSVSSD AGLGETLEQS QGAHVLALGP 1330 1340 1350 1360 1370 1380 LEASARARLV REELALYGKR LEESPFNNQM RLLLVKRESG RPLYLRLVTD HLRLFTLYEQ 1390 1400 1410 1420 1430 1440 VSERLRTLPA TVPLLLQHIL STLEKEHGPD VLPQALTALE VTRSGLTVDQ LHGVLSVWRT 1450 1460 1470 1480 1490 1500 LPKGTKSWEE AVAAGNSGDP YPMGPFACLV QSLRSLLGEG PLERPGARLC LPDGPLRTAA 1510 1520 1530 1540 1550 1560 KRCYGKRPGL EDTAHILIAA QLWKTCDADA SGTFRSCPPE ALGDLPYHLL QSGNRGLLSK 1570 1580 1590 1600 1610 1620 FLTNLHVVAA HLELGLVSRL LEAHALYASS VPKEEQKLPE ADVAVFRTFL RQQASILSQY 1630 1640 1650 1660 1670 1680 PRLLPQQAAN QPLDSPLCHQ ASLLSRRWHL QHTLRWLNKP RTMKNQQSSS LSLAVSSSPT 1690 1700 1710 1720 1730 1740 AVAFSTNGQR AAVGTANGTV YLLDLRTWQE EKSVVSGCDG ISACLFLSDD TLFLTAFDGL 1750 1760 1770 1780 1790 1800 LELWDLQHGC RVLQTKAHQY QITGCCLSPD CRLLATVCLG GCLKLWDTVR GQLAFQHTYP 1810 1820 1830 1840 1850 1860 KSLNCVAFHP EGQVIATGSW AGSISFFQVD GLKVTKDLGA PGASIRTLAF NVPGGVVAVG 1870 1880 1890 1900 1910 1920 RLDSMVELWA WREGARLAAF PAHHGFVAAA LFLHAGCQLL TAGEDGKVQV WSGSLGRPRG 1930 1940 1950 1960 1970 1980 HLGSLSLSPA LSVALSPDGD RVAVGYRADG IRIYKISSGS QGAQGQALDV AVSALAWLSP 1990 2000 2010 2020 2030 2040 KVLVSGAEDG SLQGWALKEC SLQSLWLLSR FQKPVLGLAT SQELLASASE DFTVQLWPRQ 2050 2060 2070 2080 2090 2100 LLTRPHKAED FPCGTELRGH EGPVSCCSFS TDGGSLATGG RDRSLLCWDV RTPKTPVLIH 2110 2120 2130 2140 2150 2160 SFPACHRDWV TGCAWTKDNL LISCSSDGSV GLWDPESGQR LGQFLGHQSA VSAVAAVEEH 2170 2180 2190 2200 2210 2220 VVSVSRDGTL KVWDHQGVEL TSIPAHSGPI SHCAAAMEPR AAGQPGSELL VVTVGLDGAT 2230 2240 2250 2260 2270 2280 RLWHPLLVCQ THTLLGHSGP VRAAAVSETS GLMLTASEDG SVRLWQVPKE ADDTCIPRSS 2290 2300 2310 2320 2330 2340 AAVTAVAWAP DGSMAVSGNQ AGELILWQEA KAVATAQAPG HIGALIWSSA HTFFVLSADE 2350 2360 2370 2380 2390 2400 KISEWQVKLR KGSAPGNLSL HLNRILQEDL GVLTSLDWAP DGHFLILAKA DLKLLCMKPG 2410 2420 2430 2440 2450 2460 DAPSEIWSSY TENPMILSTH KEYGIFVLQP KDPGVLSFLR QKESGEFEER LNFDINLENP 2470 2480 2490 2500 2510 2520 SRTLISITQA KPESESSFLC ASSDGILWNL AKCSPEGEWT TGNMWQKKAN TPETQTPGTD 2530 2540 2550 2560 2570 2580 PSTCRESDAS MDSDASMDSE PTPHLKTRQR RKIHSGSVTA LHVLPELLVT ASKDRDVKLW 2590 2600 2610 2620 ERPSMQLLGL FRCEGSVSCL EPWLGANSTL QLAVGDVQGN VYFLNWE
	Isoform 2 [UniParc]. Checksum: D512FB76402A71C4	FASTA	2,620	289,578
	10 20 30 40 50 60 MEKLHGHVSA HPDILSLENR CLAMLPDLQP LEKLHQHVST HSDILSLKNQ CLATLPDLKT 70 80 90 100 110 120 MEKPHGYVSA HPDILSLENQ CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLSSLKS 130 140 150 160 170 180 TVSASPLFQS LQISHMTQAD LYRVNNSNCL LSEPPSWRAQ HFSKGLDLST CPIALKSISA 190 200 210 220 230 240 TETAQEATLG RWFDSEEKKG AETQMPSYSL SLGEEEEVED LAVKLTSGDS ESHPEPTDHV 250 260 270 280 290 300 LQEKKMALLS LLCSTLVSEV NMNNTSDPTL AAIFEICREL ALLEPEFILK ASLYARQQLN 310 320 330 340 350 360 VRNVANNILA IAAFLPACRP HLRRYFCAIV QLPSDWIQVA ELYQSLAEGD KNKLVPLPAC 370 380 390 400 410 420 LRTAMTDKFA QFDEYQLAKY NPRKHRAKRH PRRPPRSPGM EPPFSHRCFP RYIGFLREEQ 430 440 450 460 470 480 RKFEKAGDTV SEKKNPPRFT LKKLVQRLHI HKPAQHVQAL LGYRYPSNLQ LFSRSRLPGP 490 500 510 520 530 540 WDSSRAGKRM KLSRPETWER ELSLRGNKAS VWEELIENGK LPFMAMLRNL CNLLRVGISS 550 560 570 580 590 600 RHHELILQRL QHAKSVIHSR QFPFRFLNAH DAIDALEAQL RNQALPFPSN ITLMRRILTR 610 620 630 640 650 660 NEKNRPRRRF LCHLSRQQLR MAMRIPVLYE QLKREKLRVH KARQWKYDGE MLNRYRQALE 670 680 690 700 710 720 TAVNLSVKHS LPLLPGRTVL VYLTDANADR LCPKSNPQGP PLNYALLLIG MMITRAEQVD 730 740 750 760 770 780 VVLCGGDTLK TAVLKAEEGI LKTAIKLQAQ VQEFDENDGW SLNTFGKYLL SLAGQRVPVD 790 800 810 820 830 840 RVILLGQSMD DGMINVAKQL YWQRVNSKCL FVGILLRRVQ YLSTDLNPND VTLSGCTDAI 850 860 870 880 890 900 LKFIAEHGAS HLLEHVGQMD KIFKIPPPPG KTGVQSLRPL EEDTPSPLAP VSQQGWRSIR 910 920 930 940 950 960 LFISSTFRDM HGERDLLLRS VLPALQARAA PHRISLHGID LRWGVTEEET RRNRQLEVCL 970 980 990 1000 1010 1020 GEVENAQLFV GILGSRYGYI PPSYNLPDHP HFHWAQQYPS GRSVTEMEVM QFLNRNQRLQ 1030 1040 1050 1060 1070 1080 PSAQALIYFR DSSFLSSVPD AWKSDFVSES EEAARRISEL KSYLSRQKGI TCRRYPCEWG 1090 1100 1110 1120 1130 1140 GVAAGRPYVG GLEEFGQLVL QDVWNMIQKL YLQPGALLEQ PVSIPDDDLV QATFQQLQKP 1150 1160 1170 1180 1190 1200 PSPARPRLLQ DTVQRLMLPH GRLSLVTGQS GQGKTAFLAS LVSALQAPDG AKVASLVFFH 1210 1220 1230 1240 1250 1260 FSGARPDQGL ALTLLRRLCT YLRGQLKEPG ALPSTYRSLV WELQQRLLPK SAESLHPGQT 1270 1280 1290 1300 1310 1320 QVLIIDGADR LVDQNGQLIS DWIPKKLPRC VHLVLSVSSD AGLGETLEQS QGAHVLALGP 1330 1340 1350 1360 1370 1380 LEASARARLV REELALYGKR LEESPFNNQM RLLLVKRESG RPLYLRLVTD HLRLFTLYEQ 1390 1400 1410 1420 1430 1440 VSERLRTLPA TVPLLLQHIL STLEKEHGPD VLPQALTALE VTRSGLTVDQ LHGVLSVWRT 1450 1460 1470 1480 1490 1500 LPKGTKSWEE AVAAGNSGDP YPMGPFACLV QSLRSLLGEG PLERPGARLC LPDGPLRTAA 1510 1520 1530 1540 1550 1560 KRCYGKRPGL EDTAHILIAA QLWKTCDADA SGTFRSCPPE ALGDLPYHLL QSGNRGLLSK 1570 1580 1590 1600 1610 1620 FLTNLHVVAA HLELGLVSRL LEAHALYASS VPKEEQKLPE ADVAVFRTFL RQQASILSQY 1630 1640 1650 1660 1670 1680 PRLLPQQAAN QPLDSPLCHQ ASLLSRRWHL QHTLRWLNKP RTMKNQQSSS LSLAVSSSPT 1690 1700 1710 1720 1730 1740 AVAFSTNGQR AAVGTANGTV YLLDLRTWQE EKSVVSGCDG ISACLFLSDD TLFLTAFDGL 1750 1760 1770 1780 1790 1800 LELWDLQHGC RVLQTKAHQY QITGCCLSPD CRLLATVCLG GCLKLWDTVR GQLAFQHTYP 1810 1820 1830 1840 1850 1860 KSLNCVAFHP EGQVIATGSW AGSISFFQVD GLKVTKDLGA PGASIRTLAF NVPGGVVAVG 1870 1880 1890 1900 1910 1920 RLDSMVELWA WREGARLAAF PAHHGFVAAA LFLHAGCQLL TAGEDGKVQV WSGSLGRPRG 1930 1940 1950 1960 1970 1980 HLGSLSLSPA LSVALSPDGD RVAVGYRADG IRIYKISSGS QGAQGQALDV AVSALAWLSP 1990 2000 2010 2020 2030 2040 KVLVSGAEDG SLQGWALKEC SLQSLWLLSR FQKPVLGLAT SQELLASASE DFTVQLWPRQ 2050 2060 2070 2080 2090 2100 LLTRPHKAED FPCGTELRGH EGPVSCCSFS TDGGSLATGG RDRSLLCWDV RTPKTPVLIH 2110 2120 2130 2140 2150 2160 SFPACHRDWV TGCAWTKDNL LISCSSDGSV GLWDPESGQR LGQFLGHQSA VSAVAAVEEH 2170 2180 2190 2200 2210 2220 VVSVSRDGTL KVWDHQGVEL TSIPAHSGPI SHCAAAMEPR AAGQPGSELL VVTVGLDGAT 2230 2240 2250 2260 2270 2280 RLWHPLLVCQ THTLLGHSGP VRAAAVSETS GLMLTASEDG SVRLWQVPKE ADDTCIPRSS 2290 2300 2310 2320 2330 2340 AAVTAVAWAP DGSMAVSGNQ AGELILWQEA KAVATAQAPG HIGALIWSSA HTFFVLSADE 2350 2360 2370 2380 2390 2400 KISEWQVKLR KGSAPGNLSL HLNRILQEDL GVLTSLDWAP DGHFLILAKA DLKLLCMKPG 2410 2420 2430 2440 2450 2460 DAPSEIWSSY TENPMILSTH KEYGIFVLQP KDPGVLSFLR QKESGEFEER LNFDINLENP 2470 2480 2490 2500 2510 2520 SRTLISITQA KPESALMGSY GTWPNAAQKE NGPQVTCGRK KANTPETQTP GTDPSTCRES 2530 2540 2550 2560 2570 2580 DASMDSDASM DSEPTPHLKT RQRRKIHSGS VTALHVLPEL LVTASKDRDV KLWERPSMQL 2590 2600 2610 2620 LGLFRCEGSV SCLEPWLGAN STLQLAVGDV QGNVYFLNWE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A mammalian telomerase-associated protein." Harrington L., McPhail T., Mar V., Zhou W., Oulton R., Bass M.B., Arruda I., Robinson M.O. Science 275:973-977(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS PRO-116; GLY-553; CYS-1055; GLN-1155 AND PRO-1195.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2288-2627 (ISOFORM 2). Tissue: Salivary gland.
[4]	"Human telomerase contains evolutionarily conserved catalytic and structural subunits." Harrington L., Zhou W., McPhail T., Oulton R., Yeung D.S., Mar V., Bass M.B., Robinson M.O. Genes Dev. 11:3109-3115(1997) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX.
[5]	"Vaults and telomerase share a common subunit, TEP1." Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H. J. Biol. Chem. 274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE, RNA-BINDING.
[6]	"Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding." Beattie T.L., Zhou W., Robinson M.O., Harrington L. Mol. Biol. Cell 11:3329-3340(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX.
[7]	"A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis." Venteicher A.S., Abreu E.B., Meng Z., McCann K.E., Terns R.M., Veenstra T.D., Terns M.P., Artandi S.E. Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE TELOMERASE HOLOENZYME COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U86136 mRNA. Translation: AAC51107.1. BC126107 mRNA. Translation: AAI26108.1. BX640983 mRNA. Translation: CAE45993.1.
IPI	IPI00294519. IPI00413874.
RefSeq	NP_009041.2. NM_007110.4.
UniGene	Hs.508835.
3D structure databases
ProteinModelPortal	Q99973.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99973. 1 interaction.
STRING	9606.ENSP00000262715.
PTM databases
PhosphoSite	Q99973.
Polymorphism databases
DMDM	215273899.
Proteomic databases
PaxDb	Q99973.
PRIDE	Q99973.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262715; ENSP00000262715; ENSG00000129566.
GeneID	7011.
KEGG	hsa:7011.
UCSC	uc001vxe.3. human.
Organism-specific databases
CTD	7011.
GeneCards	GC14M020833.
H-InvDB	HIX0026646.
HGNC	HGNC:11726. TEP1.
HPA	HPA029206.
MIM	601686. gene.
neXtProt	NX_Q99973.
PharmGKB	PA36443.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000154545.
HOVERGEN	HBG059633.
InParanoid	Q99973.
KO	K11127.
OMA	SVPDAWK.
OrthoDB	EOG4001HG.
PhylomeDB	Q99973.
Gene expression databases
ArrayExpress	Q99973.
Bgee	Q99973.
CleanEx	HS_TEP1.
Genevestigator	Q99973.
GermOnline	ENSG00000129566. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 7 hits.
InterPro	IPR025139. DUF4062. IPR007111. NACHT_NTPase. IPR008850. TEP1_N. IPR008858. TROVE. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF13271. DUF4062. 1 hit. PF05386. TEP1_N. 4 hits. PF05731. TROVE. 1 hit. PF00400. WD40. 8 hits. [Graphical view]
SMART	SM00320. WD40. 18 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 3 hits.
PROSITE	PS50837. NACHT. 1 hit. PS51226. TEP1_N. 4 hits. PS50988. TROVE. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 7 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TEP1. human.
GenomeRNAi	7011.
NextBio	27388.
SOURCE	Search...

Entry information

Entry name

TEP1_HUMAN

Accession

Primary (citable) accession number: Q99973
Secondary accession number(s): A0AUV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.