ID   RARR2_HUMAN             Reviewed;         163 AA.
AC   Q99969;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   19-JAN-2010, entry version 76.
DE   RecName: Full=Retinoic acid receptor responder protein 2;
DE   AltName: Full=Tazarotene-induced gene 2 protein;
DE   AltName: Full=RAR-responsive protein TIG2;
DE   Flags: Precursor;
GN   Name=RARRES2; Synonyms=TIG2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   TISSUE=Skin;
RX   MEDLINE=97348957; PubMed=9204961; DOI=10.1111/1523-1747.ep12276660;
RA   Nagpal S., Patel S., Jacobe H., DiSepio D., Ghosn C., Malhotra M.,
RA   Teng M., Duvic M., Chandraratna R.A.S.;
RT   "Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in
RT   skin.";
RL   J. Invest. Dermatol. 109:91-95(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Gastric adenocarcinoma;
RX   MEDLINE=99173880; PubMed=10072769; DOI=10.1016/S0378-1119(99)00004-9;
RA   Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.;
RT   "Selection of cDNAs encoding putative type II membrane proteins on the
RT   cell surface from a human full-length cDNA bank.";
RL   Gene 228:161-167(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Highly expressed in skin (basal and suprabasal
CC       layers of the epidermis, hair follicles and endothelial cells).
CC       Also found in pancreas, liver, spleen, prostate, ovary, small
CC       intestine and colon.
CC   -!- INDUCTION: Inhibited in psoriatic lesions. Activated by tazarotene
CC       in skin rafts and in the epidermis of psoriatic lesions.
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DR   EMBL; U77594; AAB47975.1; -; mRNA.
DR   EMBL; AB015632; BAA76499.1; -; mRNA.
DR   EMBL; BC000069; AAH00069.1; -; mRNA.
DR   IPI; IPI00019176; -.
DR   RefSeq; NP_002880.1; -.
DR   UniGene; Hs.647064; -.
DR   STRING; Q99969; -.
DR   PeptideAtlas; Q99969; -.
DR   PRIDE; Q99969; -.
DR   Ensembl; ENST00000223271; ENSP00000223271; ENSG00000106538; Homo sapiens.
DR   Ensembl; ENST00000466675; ENSP00000418009; ENSG00000106538; Homo sapiens.
DR   Ensembl; ENST00000482669; ENSP00000418483; ENSG00000106538; Homo sapiens.
DR   GeneID; 5919; -.
DR   KEGG; hsa:5919; -.
DR   UCSC; uc003wha.1; human.
DR   CTD; 5919; -.
DR   GeneCards; GC07M149666; -.
DR   H-InvDB; HIX0007202; -.
DR   HGNC; HGNC:9868; RARRES2.
DR   MIM; 601973; gene.
DR   PharmGKB; PA34229; -.
DR   HOGENOM; HBG505723; -.
DR   HOVERGEN; Q99969; -.
DR   InParanoid; Q99969; -.
DR   OMA; CLACIKL; -.
DR   OrthoDB; EOG90KBK1; -.
DR   PhylomeDB; Q99969; -.
DR   NextBio; 23048; -.
DR   ArrayExpress; Q99969; -.
DR   Bgee; Q99969; -.
DR   CleanEx; HS_RARRES2; -.
DR   Genevestigator; Q99969; -.
DR   GermOnline; ENSG00000106538; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001523; P:retinoid metabolic process; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Complete proteome; Secreted; Signal.
FT   SIGNAL        1     16       Potential.
FT   CHAIN        17    163       Retinoic acid receptor responder protein
FT                                2.
FT                                /FTId=PRO_0000022529.
SQ   SEQUENCE   163 AA;  18618 MW;  A96EB7D0999EC3DB CRC64;
     MRRLLIPLAL WLGAVGVGVA ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF
     PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE
     TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFSKAL PRS
//