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Q99967

- CITE2_HUMAN

UniProt

Q99967 - CITE2_HUMAN

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Protein

Cbp/p300-interacting transactivator 2

Gene
CITED2, MRG1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. histone acetyltransferase binding Source: BHF-UCL
  3. LBD domain binding Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. RNA polymerase II transcription coactivator activity Source: Ensembl
  6. RNA polymerase II transcription corepressor activity Source: BHF-UCL
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription coactivator activity Source: UniProtKB
  9. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. adrenal cortex formation Source: UniProtKB
  2. bone morphogenesis Source: Ensembl
  3. cardiac neural crest cell development involved in heart development Source: Ensembl
  4. cell aging Source: Ensembl
  5. cell proliferation Source: UniProtKB
  6. central nervous system development Source: Ensembl
  7. cranial nerve morphogenesis Source: Ensembl
  8. decidualization Source: Ensembl
  9. determination of left/right symmetry Source: UniProtKB
  10. embryonic camera-type eye morphogenesis Source: Ensembl
  11. embryonic heart tube left/right pattern formation Source: BHF-UCL
  12. embryonic placenta development Source: Ensembl
  13. embryonic process involved in female pregnancy Source: Ensembl
  14. endocardial cushion development Source: Ensembl
  15. erythrocyte development Source: Ensembl
  16. granulocyte differentiation Source: Ensembl
  17. heart development Source: UniProtKB
  18. heart looping Source: Ensembl
  19. hematopoietic progenitor cell differentiation Source: Ensembl
  20. left/right axis specification Source: BHF-UCL
  21. lens morphogenesis in camera-type eye Source: Ensembl
  22. liver development Source: BHF-UCL
  23. male gonad development Source: Ensembl
  24. negative regulation of apoptotic process Source: BHF-UCL
  25. negative regulation of cell migration Source: BHF-UCL
  26. negative regulation of gene expression Source: UniProtKB
  27. negative regulation of transcription, DNA-templated Source: UniProtKB
  28. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  29. negative regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: BHF-UCL
  30. neural tube closure Source: Ensembl
  31. nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
  32. outflow tract morphogenesis Source: BHF-UCL
  33. peripheral nervous system development Source: Ensembl
  34. positive regulation of cell-cell adhesion Source: BHF-UCL
  35. positive regulation of cell cycle Source: UniProtKB
  36. positive regulation of gene expression Source: UniProtKB
  37. positive regulation of male gonad development Source: UniProtKB
  38. positive regulation of peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
  39. positive regulation of transcription, DNA-templated Source: UniProtKB
  40. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  41. positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  42. pulmonary artery morphogenesis Source: Ensembl
  43. regulation of organ formation Source: UniProtKB
  44. regulation of RNA biosynthetic process Source: GOC
  45. response to estrogen Source: UniProtKB
  46. response to fluid shear stress Source: BHF-UCL
  47. response to hypoxia Source: UniProtKB
  48. response to mechanical stimulus Source: Ensembl
  49. sex determination Source: UniProtKB
  50. skeletal muscle cell differentiation Source: Ensembl
  51. spleen development Source: BHF-UCL
  52. thymus development Source: Ensembl
  53. transforming growth factor beta receptor signaling pathway Source: Ensembl
  54. trophectodermal cell differentiation Source: Ensembl
  55. vasculogenesis Source: Ensembl
  56. ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Stress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 2
Alternative name(s):
MSG-related protein 1
Short name:
MRG-1
P35srj
Gene namesi
Name:CITED2
Synonyms:MRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1987. CITED2.

Subcellular locationi

Nucleus
Note: Colocalizes with EP300 in dot-like structures.3 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear chromatin Source: BHF-UCL
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Ventricular septal defect 2 (VSD2) [MIM:614431]: A common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1789Missing in VSD2; reduces coactivation of the TFAP2C gene to 50% of that obtained with wild-type and represses HIF1A with about 60% efficiency compared to wild-type.
VAR_067583
Atrial septal defect 8 (ASD8) [MIM:614433]: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791S → GGSSTPGGS in ASD8; demonstrates only about 75% of the repressive activity of wild-type.
VAR_067584
Natural varianti198 – 1992Missing in ASD8; demonstrates only about 75% of the repressive activity of wild-type.
VAR_067585

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi243 – 2464Missing: Inhibits transactivation activity. 1 Publication
Mutagenesisi243 – 2431L → E: Inhibits transactivation activity; when associated with E-246. 1 Publication
Mutagenesisi246 – 2461L → E: Inhibits transactivation activity; when associated with E-243. 1 Publication

Keywords - Diseasei

Atrial septal defect, Disease mutation

Organism-specific databases

MIMi614431. phenotype.
614433. phenotype.
Orphaneti99103. Atrial septal defect, ostium secundum type.
99105. Atrial septal defect, sinus venosus type.
99097. Single ventricular septal defect.
101063. Situs inversus totalis.
3303. Tetralogy of Fallot.
PharmGKBiPA26524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Cbp/p300-interacting transactivator 2PRO_0000144726Add
BLAST

Proteomic databases

PaxDbiQ99967.
PRIDEiQ99967.

Expressioni

Inductioni

By hypoxia and deferoxamine.1 Publication

Gene expression databases

ArrayExpressiQ99967.
BgeeiQ99967.
CleanExiHS_CITED2.
GenevestigatoriQ99967.

Organism-specific databases

HPAiCAB016157.

Interactioni

Subunit structurei

Interacts (via C-terminus) with SMAD2. Interacts (via C-terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 By similarity. Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EP300Q094723EBI-937732,EBI-447295
HNF4AP412353EBI-937732,EBI-1049011
TFAP2CQ927542EBI-937732,EBI-937309

Protein-protein interaction databases

BioGridi115649. 11 interactions.
IntActiQ99967. 7 interactions.
MINTiMINT-112487.
STRINGi9606.ENSP00000356623.

Structurei

Secondary structure

1
270
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi221 – 2233
Helixi227 – 2359
Beta strandi237 – 2393
Helixi251 – 2533
Helixi254 – 2563
Helixi266 – 2683

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P4QNMR-A216-259[»]
1R8UNMR-A220-269[»]
DisProtiDP00356.
ProteinModelPortaliQ99967.
SMRiQ99967. Positions 220-269.

Miscellaneous databases

EvolutionaryTraceiQ99967.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 5737His-richAdd
BLAST
Compositional biasi162 – 19938Gly-richAdd
BLAST
Compositional biasi219 – 25840Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the CITED family.

Phylogenomic databases

eggNOGiNOG44915.
HOGENOMiHOG000231079.
HOVERGENiHBG075182.
InParanoidiQ99967.
OMAiDHIHYGA.
OrthoDBiEOG72NRRB.
PhylomeDBiQ99967.
TreeFamiTF331915.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99967-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA    50
LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG 100
PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN 150
QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN 200
MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ 250
NEFDFMTDFV CKQQPSRVSC 270
Length:270
Mass (Da):28,497
Last modified:June 20, 2002 - v2
Checksum:i45DDE3A9E2B4C472
GO
Isoform 2 (identifier: Q99967-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-215: Missing.

Show »
Length:213
Mass (Da):23,732
Checksum:iC91FAABA3D2A9AD1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1789Missing in VSD2; reduces coactivation of the TFAP2C gene to 50% of that obtained with wild-type and represses HIF1A with about 60% efficiency compared to wild-type.
VAR_067583
Natural varianti179 – 1791S → GGSSTPGGS in ASD8; demonstrates only about 75% of the repressive activity of wild-type.
VAR_067584
Natural varianti198 – 1992Missing in ASD8; demonstrates only about 75% of the repressive activity of wild-type.
VAR_067585

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei159 – 21557Missing in isoform 2. VSP_001089Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65093 mRNA. Translation: AAC51114.1.
AF129290 Genomic DNA. Translation: AAF01263.1.
AF129290 Genomic DNA. Translation: AAF01264.1.
AF109161 mRNA. Translation: AAD10055.1.
AL592429 Genomic DNA. Translation: CAH70354.1.
BC004377 mRNA. Translation: AAH04377.1.
CCDSiCCDS5195.1. [Q99967-1]
RefSeqiNP_001161860.1. NM_001168388.2. [Q99967-1]
NP_001161861.2. NM_001168389.2.
NP_006070.2. NM_006079.4. [Q99967-1]
UniGeneiHs.82071.

Genome annotation databases

EnsembliENST00000367651; ENSP00000356623; ENSG00000164442. [Q99967-1]
ENST00000536159; ENSP00000442831; ENSG00000164442. [Q99967-1]
ENST00000537332; ENSP00000444198; ENSG00000164442. [Q99967-1]
GeneIDi10370.
KEGGihsa:10370.
UCSCiuc003qip.2. human. [Q99967-1]

Polymorphism databases

DMDMi21542403.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65093 mRNA. Translation: AAC51114.1 .
AF129290 Genomic DNA. Translation: AAF01263.1 .
AF129290 Genomic DNA. Translation: AAF01264.1 .
AF109161 mRNA. Translation: AAD10055.1 .
AL592429 Genomic DNA. Translation: CAH70354.1 .
BC004377 mRNA. Translation: AAH04377.1 .
CCDSi CCDS5195.1. [Q99967-1 ]
RefSeqi NP_001161860.1. NM_001168388.2. [Q99967-1 ]
NP_001161861.2. NM_001168389.2.
NP_006070.2. NM_006079.4. [Q99967-1 ]
UniGenei Hs.82071.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1P4Q NMR - A 216-259 [» ]
1R8U NMR - A 220-269 [» ]
DisProti DP00356.
ProteinModelPortali Q99967.
SMRi Q99967. Positions 220-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115649. 11 interactions.
IntActi Q99967. 7 interactions.
MINTi MINT-112487.
STRINGi 9606.ENSP00000356623.

Polymorphism databases

DMDMi 21542403.

Proteomic databases

PaxDbi Q99967.
PRIDEi Q99967.

Protocols and materials databases

DNASUi 10370.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367651 ; ENSP00000356623 ; ENSG00000164442 . [Q99967-1 ]
ENST00000536159 ; ENSP00000442831 ; ENSG00000164442 . [Q99967-1 ]
ENST00000537332 ; ENSP00000444198 ; ENSG00000164442 . [Q99967-1 ]
GeneIDi 10370.
KEGGi hsa:10370.
UCSCi uc003qip.2. human. [Q99967-1 ]

Organism-specific databases

CTDi 10370.
GeneCardsi GC06M139735.
H-InvDB HIX0006261.
HGNCi HGNC:1987. CITED2.
HPAi CAB016157.
MIMi 602937. gene.
614431. phenotype.
614433. phenotype.
neXtProti NX_Q99967.
Orphaneti 99103. Atrial septal defect, ostium secundum type.
99105. Atrial septal defect, sinus venosus type.
99097. Single ventricular septal defect.
101063. Situs inversus totalis.
3303. Tetralogy of Fallot.
PharmGKBi PA26524.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44915.
HOGENOMi HOG000231079.
HOVERGENi HBG075182.
InParanoidi Q99967.
OMAi DHIHYGA.
OrthoDBi EOG72NRRB.
PhylomeDBi Q99967.
TreeFami TF331915.

Miscellaneous databases

ChiTaRSi CITED2. human.
EvolutionaryTracei Q99967.
GeneWikii CITED2.
GenomeRNAii 10370.
NextBioi 39307.
PROi Q99967.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99967.
Bgeei Q99967.
CleanExi HS_CITED2.
Genevestigatori Q99967.

Family and domain databases

InterProi IPR007576. CITED.
[Graphical view ]
PANTHERi PTHR17045. PTHR17045. 1 hit.
Pfami PF04487. CITED. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation."
    Shioda T., Fenner M.H., Isselbacher K.J.
    Proc. Natl. Acad. Sci. U.S.A. 93:12298-12303(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
  2. "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1."
    Leung M.K., Jones T., Michels C.L., Livingston D.M., Bhattacharya S.
    Genomics 61:307-313(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1."
    Bhattacharya S., Michels C.M., Leung M.K., Arany Z.P., Kung A.L., Livingston D.M.
    Genes Dev. 13:64-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH EP300, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  6. "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein."
    Yahata T., Shao W., Endoh H., Hur J., Coser K.R., Sun H., Ueda Y., Kato S., Isselbacher K.J., Brown M., Shioda T.
    Genes Dev. 15:2598-2612(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator."
    Bamforth S.D., Braganca J., Eloranta J.J., Murdoch J.N., Marques F.I., Kranc K.R., Farza H., Henderson D.J., Hurst H.C., Bhattacharya S.
    Nat. Genet. 29:469-474(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TFAP2A; TFAP2B AND TFAP2C.
  8. "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2."
    Braganca J., Eloranta J.J., Bamforth S.D., Ibbitt J.C., Hurst H.C., Bhattacharya S.
    J. Biol. Chem. 278:16021-16029(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EP300; TFAP2A; TFAP2B AND TFAP2C.
  9. "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator."
    Tien E.S., Davis J.W., Vanden Heuvel J.P.
    J. Biol. Chem. 279:24053-24063(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PPARA.
  10. "Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2."
    Freedman S.J., Sun Z.Y., Kung A.L., France D.S., Wagner G., Eck M.J.
    Nat. Struct. Biol. 10:504-512(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 216-259 IN COMPLEX WITH 323-423 OF EP300 AND ZINC IONS, INTERACTION WITH EP300, MUTAGENESIS OF 243-LEU--LEU-246; LEU-243 AND LEU-246.
  11. "Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites."
    De Guzman R.N., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
    J. Biol. Chem. 279:3042-3049(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 220-269 IN COMPLEX WITH 340-439 OF CREBBP AND ZINC IONS.
  12. "Identification and functional analysis of CITED2 mutations in patients with congenital heart defects."
    Sperling S., Grimm C.H., Dunkel I., Mebus S., Sperling H.P., Ebner A., Galli R., Lehrach H., Fusch C., Berger F., Hammer S.
    Hum. Mutat. 26:575-582(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VSD2 170-SER--GLY-178 DEL, VARIANTS ASD8 GLY-GLY-SER-SER-THR-PRO-GLY-GLY-SER-179 INS AND 198-SER-GLY-199 DEL, CHARACTERIZATION OF VARIANT VSD2 170-SER--GLY-178 DEL, CHARACTERIZATION OF VARIANTS ASD8 GLY-GLY-SER-SER-THR-PRO-GLY-GLY-SER-179 INS AND 198-SER-GLY-199 DEL.

Entry informationi

Entry nameiCITE2_HUMAN
AccessioniPrimary (citable) accession number: Q99967
Secondary accession number(s): O95426, Q5VTF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 20, 2002
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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