Q99967 (CITE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cbp/p300-interacting transactivator 2

Alternative name(s):
MSG-related protein 1
Short name=MRG-1
P35srj

Gene names

Name:	CITED2
Synonyms:	MRG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. Ref.6 Ref.8 Ref.9
Subunit structure	Interacts (via C-terminus) with SMAD2. Interacts (via C-terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 By similarity. Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C. Ref.3 Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location	Nucleus. Note: Colocalizes with EP300 in dot-like structures. Ref.1 Ref.3 Ref.8
Induction	By hypoxia and deferoxamine. Ref.3
Involvement in disease	Ventricular septal defect 2 (VSD2) [MIM:614431]: A common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Atrial septal defect 8 (ASD8) [MIM:614433]: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12
Sequence similarities	Belongs to the CITED family.

Ontologies

Keywords
Biological process	Differentiation Stress response Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Disease	Atrial septal defect Disease mutation
Molecular function	Activator Developmental protein Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adrenal cortex formation Inferred from sequence or structural similarity. Source: UniProtKB bone morphogenesis Inferred from electronic annotation. Source: Compara cardiac neural crest cell development involved in heart development Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara cell proliferation Inferred from direct assay Ref.9. Source: UniProtKB central nervous system development Inferred from electronic annotation. Source: Compara cranial nerve morphogenesis Inferred from electronic annotation. Source: Compara decidualization Inferred from electronic annotation. Source: Compara embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara embryonic heart tube left/right pattern formation Inferred from sequence or structural similarity. Source: BHF-UCL embryonic placenta development Inferred from electronic annotation. Source: Compara embryonic process involved in female pregnancy Inferred from electronic annotation. Source: Compara endocardial cushion development Inferred from electronic annotation. Source: Compara erythrocyte development Inferred from electronic annotation. Source: Compara granulocyte differentiation Inferred from electronic annotation. Source: Compara heart looping Inferred from electronic annotation. Source: Compara hematopoietic progenitor cell differentiation Inferred from electronic annotation. Source: Compara left/right axis specification Inferred from sequence or structural similarity. Source: BHF-UCL lens morphogenesis in camera-type eye Inferred from electronic annotation. Source: Compara liver development Inferred from sequence or structural similarity. Source: BHF-UCL male gonad development Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cell migration Inferred from mutant phenotype PubMed 18054336. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter in response to hypoxia Inferred from direct assay PubMed 22735262. Source: BHF-UCL neural tube closure Inferred from electronic annotation. Source: Compara nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Inferred from sequence or structural similarity. Source: BHF-UCL outflow tract morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL peripheral nervous system development Inferred from electronic annotation. Source: Compara positive regulation of cell cycle Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell-cell adhesion Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of male gonad development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of peroxisome proliferator activated receptor signaling pathway Inferred from direct assay Ref.9. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 22735262. Source: BHF-UCL positive regulation of transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB pulmonary artery morphogenesis Inferred from electronic annotation. Source: Compara regulation of organ formation Inferred from sequence or structural similarity. Source: UniProtKB response to estrogen stimulus Inferred from direct assay Ref.6. Source: UniProtKB response to fluid shear stress Inferred from mutant phenotype PubMed 12960175. Source: BHF-UCL response to hypoxia Inferred from direct assay Ref.3. Source: UniProtKB response to mechanical stimulus Inferred from electronic annotation. Source: Compara sex determination Inferred from sequence or structural similarity. Source: UniProtKB spleen development Inferred from sequence or structural similarity. Source: BHF-UCL thymus development Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara trophectodermal cell differentiation Inferred from electronic annotation. Source: Compara vasculogenesis Inferred from electronic annotation. Source: Compara ventricular septum morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	cytoplasm Inferred from mutant phenotype Ref.8. Source: UniProtKB nuclear chromatin Inferred from sequence or structural similarity. Source: BHF-UCL nucleus Inferred from mutant phenotype Ref.8. Source: UniProtKB
Molecular_function	RNA polymerase II transcription coactivator activity Inferred from electronic annotation. Source: Compara RNA polymerase II transcription corepressor activity Inferred from direct assay PubMed 22735262. Source: BHF-UCL chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB histone acetyltransferase binding Inferred from direct assay PubMed 22735262. Source: BHF-UCL sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB transcription coactivator activity Inferred from direct assay Ref.6Ref.7Ref.9Ref.8. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EP300	Q09472	3	EBI-937732,EBI-447295
TFAP2C	Q92754	2	EBI-937732,EBI-937309

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99967-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99967-2)

The sequence of this isoform differs from the canonical sequence as follows:
     159-215: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 270

270

Cbp/p300-interacting transactivator 2

PRO_0000144726

Regions

Compositional bias

21 – 57

37

His-rich

Compositional bias

162 – 199

38

Gly-rich

Compositional bias

219 – 258

40

Asp/Glu-rich (acidic)

Natural variations

Alternative sequence

159 – 215

57

Missing in isoform 2.

VSP_001089

Natural variant

170 – 178

9

Missing in VSD2; reduces coactivation of the TFAP2C gene to 50% of that obtained with wild-type and represses HIF1A with about 60% efficiency compared to wild-type.

VAR_067583

Natural variant

179

1

S → GGSSTPGGS in ASD8; demonstrates only about 75% of the repressive activity of wild-type.

VAR_067584

Natural variant

198 – 199

2

Missing in ASD8; demonstrates only about 75% of the repressive activity of wild-type.

VAR_067585

Experimental info

Mutagenesis

243 – 246

4

Missing: Inhibits transactivation activity. Ref.10

Mutagenesis

243

1

L → E: Inhibits transactivation activity; when associated with E-246. Ref.10

Mutagenesis

246

1

L → E: Inhibits transactivation activity; when associated with E-243. Ref.10

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

270

Helix Strand Turn

Details...

Beta strand

221 – 223

3

Helix

227 – 235

9

Beta strand

237 – 239

3

Helix

251 – 253

3

Helix

254 – 256

3

Helix

266 – 268

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 20, 2002. Version 2. Checksum: 45DDE3A9E2B4C472	FASTA	270	28,497
	10 20 30 40 50 60 MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA 70 80 90 100 110 120 GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN 130 140 150 160 170 180 NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG 190 200 210 220 230 240 SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI 250 260 270 KELPELWLGQ NEFDFMTDFV CKQQPSRVSC
	Isoform 2 [UniParc]. Checksum: C91FAABA3D2A9AD1	FASTA	213	23,732
	10 20 30 40 50 60 MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA 70 80 90 100 110 120 GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN 130 140 150 160 170 180 NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPNV IDTDFIDEEV LMSLVIEMGL 190 200 210 DRIKELPELW LGQNEFDFMT DFVCKQQPSR VSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation." Shioda T., Fenner M.H., Isselbacher K.J. Proc. Natl. Acad. Sci. U.S.A. 93:12298-12303(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
[2]	"Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1." Leung M.K., Jones T., Michels C.L., Livingston D.M., Bhattacharya S. Genomics 61:307-313(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1." Bhattacharya S., Michels C.M., Leung M.K., Arany Z.P., Kung A.L., Livingston D.M. Genes Dev. 13:64-75(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH EP300, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas.
[6]	"Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein." Yahata T., Shao W., Endoh H., Hur J., Coser K.R., Sun H., Ueda Y., Kato S., Isselbacher K.J., Brown M., Shioda T. Genes Dev. 15:2598-2612(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator." Bamforth S.D., Braganca J., Eloranta J.J., Murdoch J.N., Marques F.I., Kranc K.R., Farza H., Henderson D.J., Hurst H.C., Bhattacharya S. Nat. Genet. 29:469-474(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TFAP2A; TFAP2B AND TFAP2C.
[8]	"Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2." Braganca J., Eloranta J.J., Bamforth S.D., Ibbitt J.C., Hurst H.C., Bhattacharya S. J. Biol. Chem. 278:16021-16029(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EP300; TFAP2A; TFAP2B AND TFAP2C.
[9]	"Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator." Tien E.S., Davis J.W., Vanden Heuvel J.P. J. Biol. Chem. 279:24053-24063(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PPARA.
[10]	"Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2." Freedman S.J., Sun Z.Y., Kung A.L., France D.S., Wagner G., Eck M.J. Nat. Struct. Biol. 10:504-512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 216-259 IN COMPLEX WITH 323-423 OF EP300 AND ZINC IONS, INTERACTION WITH EP300, MUTAGENESIS OF 243-LEU--LEU-246; LEU-243 AND LEU-246.
[11]	"Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites." De Guzman R.N., Martinez-Yamout M.A., Dyson H.J., Wright P.E. J. Biol. Chem. 279:3042-3049(2004) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 220-269 IN COMPLEX WITH 340-439 OF CREBBP AND ZINC IONS.
[12]	"Identification and functional analysis of CITED2 mutations in patients with congenital heart defects." Sperling S., Grimm C.H., Dunkel I., Mebus S., Sperling H.P., Ebner A., Galli R., Lehrach H., Fusch C., Berger F., Hammer S. Hum. Mutat. 26:575-582(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT VSD2 170-SER--GLY-178 DEL, VARIANTS ASD8 GLY-GLY-SER-SER-THR-PRO-GLY-GLY-SER-179 INS AND 198-SER-GLY-199 DEL, CHARACTERIZATION OF VARIANT VSD2 170-SER--GLY-178 DEL, CHARACTERIZATION OF VARIANTS ASD8 GLY-GLY-SER-SER-THR-PRO-GLY-GLY-SER-179 INS AND 198-SER-GLY-199 DEL.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U65093 mRNA. Translation: AAC51114.1.
AF129290 Genomic DNA. Translation: AAF01263.1.
AF129290 Genomic DNA. Translation: AAF01264.1.
AF109161 mRNA. Translation: AAD10055.1.
AL592429 Genomic DNA. Translation: CAH70354.1.
BC004377 mRNA. Translation: AAH04377.1.

IPI

IPI00019175.
IPI00216547.

RefSeq

NP_001161860.1. NM_001168388.2.
NP_001161861.2. NM_001168389.2.
NP_006070.2. NM_006079.4.

UniGene

Hs.82071.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1P4Q	NMR	-	A	216-259	[»]
1R8U	NMR	-	A	220-269	[»]

DisProt

DP00356.

ProteinModelPortal

Q99967.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q99967. 6 interactions.

MINT

MINT-112487.

STRING

9606.ENSP00000356623.

Polymorphism databases

DMDM

21542403.

Proteomic databases

PaxDb

Q99967.

PRIDE

Q99967.

Protocols and materials databases

DNASU

10370.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000367651; ENSP00000356623; ENSG00000164442.
ENST00000536159; ENSP00000442831; ENSG00000164442.
ENST00000537332; ENSP00000444198; ENSG00000164442.

GeneID

10370.

KEGG

hsa:10370.

UCSC

uc003qip.1. human.

Organism-specific databases

CTD

10370.

GeneCards

GC06M139735.

H-InvDB

HIX0006261.

HGNC

HGNC:1987. CITED2.

HPA

CAB016157.

MIM

602937. gene.
614431. phenotype.
614433. phenotype.

neXtProt

NX_Q99967.

Orphanet

99103. Atrial septal defect, ostium secundum type.
99105. Atrial septal defect, sinus venosus type.
99097. Single ventricular septal defect.
101063. Situs inversus totalis.
3303. Tetralogy of Fallot.
1480. Ventricular septal defect.

PharmGKB

PA26524.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG44915.

HOGENOM

HOG000231079.

HOVERGEN

HBG075182.

InParanoid

Q99967.

OMA

DHIHYGA.

OrthoDB

EOG4WQ144.

PhylomeDB

Q99967.

Enzyme and pathway databases

Pathway_Interaction_DB

hif1_tfpathway. HIF-1-alpha transcription factor network.

Gene expression databases

ArrayExpress

Q99967.

Bgee

Q99967.

CleanEx

HS_CITED2.

Genevestigator

Q99967.

GermOnline

ENSG00000164442. Homo sapiens.

Family and domain databases

InterPro

IPR007576. CITED.
[Graphical view]

PANTHER

PTHR17045. PTHR17045. 1 hit.

Pfam

PF04487. CITED. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CITED2. human.

EvolutionaryTrace

Q99967.

GenomeRNAi

10370.

NextBio

39307.

SOURCE

Search...

Entry information

Entry name

CITE2_HUMAN

Accession

Primary (citable) accession number: Q99967
Secondary accession number(s): O95426, Q5VTF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 20, 2002
Last modified:	May 1, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.