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Q99962

- SH3G2_HUMAN

UniProt

Q99962 - SH3G2_HUMAN

Protein

Endophilin-A1

Gene

SH3GL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. lipid binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. axon guidance Source: Reactome
    3. central nervous system development Source: ProtInc
    4. epidermal growth factor receptor signaling pathway Source: Reactome
    5. membrane organization Source: Reactome
    6. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
    7. neurotrophin TRK receptor signaling pathway Source: Reactome
    8. post-Golgi vesicle-mediated transport Source: Reactome
    9. regulation of receptor internalization Source: Ensembl
    10. signal transduction Source: ProtInc
    11. synaptic vesicle endocytosis Source: Ensembl

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12484. EGFR downregulation.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.
    REACT_22365. Recycling pathway of L1.
    SignaLinkiQ99962.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endophilin-A1
    Alternative name(s):
    EEN-B1
    Endophilin-1
    SH3 domain protein 2A
    SH3 domain-containing GRB2-like protein 2
    Gene namesi
    Name:SH3GL2
    Synonyms:CNSA2, SH3D2A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:10831. SH3GL2.

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein
    Note: Concentrated in presynaptic nerve terminals in neurons.

    GO - Cellular componenti

    1. clathrin-coated endocytic vesicle membrane Source: Reactome
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi membrane Source: Reactome
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi63 – 631A → S: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-66 or with S-66 and Q-70. 1 Publication
    Mutagenesisi66 – 661A → D: Loss of tubulation of liposomes, no effect on liposome binding. 1 Publication
    Mutagenesisi66 – 661A → S: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-63 or with S-63 and Q-70. 1 Publication
    Mutagenesisi66 – 661A → W: Vesiculation of liposomes, no effect on liposome binding, indol ring located in hydrophobic core of the membrane. 1 Publication
    Mutagenesisi70 – 701M → Q: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-63 and S-66. 1 Publication
    Mutagenesisi202 – 2021F → W: No effect. Indol ring not associated with the membrane. 1 Publication

    Organism-specific databases

    PharmGKBiPA35737.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Endophilin-A1PRO_0000146747Add
    BLAST

    Proteomic databases

    MaxQBiQ99962.
    PaxDbiQ99962.
    PRIDEiQ99962.

    PTM databases

    PhosphoSiteiQ99962.

    Expressioni

    Tissue specificityi

    Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.

    Gene expression databases

    ArrayExpressiQ99962.
    BgeeiQ99962.
    CleanExiHS_SH3GL2.
    GenevestigatoriQ99962.

    Organism-specific databases

    HPAiCAB010056.
    HPA026685.

    Interactioni

    Subunit structurei

    Monomer; in cytoplasm. Homodimer; when associated with membranes By similarity. Interacts with OPHN1 By similarity. Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP. Interacts with ATX2. Interacts with ADAM9 and ADAM15 cytoplasmic tails. Interacts with BIN2.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-77938,EBI-77938
    ADAM15Q134442EBI-77938,EBI-77818
    ADAM9Q134432EBI-77938,EBI-77903
    ATXN2Q997009EBI-77938,EBI-697691
    DNM2P505702EBI-77938,EBI-346547
    EMDP504022EBI-77938,EBI-489887
    LRRK2Q5S0072EBI-77938,EBI-5323863
    PTPN23Q9H3S72EBI-77938,EBI-724478
    SH3GL1Q999613EBI-77938,EBI-697911
    SH3GL3Q999635EBI-77938,EBI-473910
    SH3KBP1Q96B972EBI-77938,EBI-346595
    Synj1Q629102EBI-77938,EBI-1149123From a different organism.

    Protein-protein interaction databases

    BioGridi112353. 59 interactions.
    DIPiDIP-30996N.
    IntActiQ99962. 43 interactions.
    MINTiMINT-108776.
    STRINGi9606.ENSP00000369981.

    Structurei

    Secondary structure

    1
    352
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 2110
    Helixi24 – 5835
    Helixi62 – 643
    Helixi65 – 684
    Helixi89 – 10416
    Beta strandi106 – 1094
    Helixi110 – 13829
    Helixi140 – 1489
    Helixi150 – 17526
    Helixi180 – 24667

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X03X-ray3.10A1-247[»]
    1X04X-ray2.90A1-58[»]
    A89-247[»]
    2D4CX-ray2.40A/B/C/D1-247[»]
    2DBMNMR-A293-352[»]
    ProteinModelPortaliQ99962.
    SMRiQ99962. Positions 26-247, 293-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ99962.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 249232BARPROSITE-ProRule annotationAdd
    BLAST
    Domaini290 – 34960SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 125125Binds and tubulates liposomesBy similarityAdd
    BLAST
    Regioni1 – 2121Membrane-binding amphipathic helixAdd
    BLAST
    Regioni60 – 8728Required for dimerization upon membrane associationBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili181 – 24868Sequence AnalysisAdd
    BLAST

    Domaini

    An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.1 Publication

    Sequence similaritiesi

    Belongs to the endophilin family.Curated
    Contains 1 BAR domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG307129.
    HOGENOMiHOG000231641.
    HOVERGENiHBG052866.
    InParanoidiQ99962.
    KOiK11247.
    OMAiSESHNGG.
    OrthoDBiEOG7G1V6H.
    PhylomeDBiQ99962.
    TreeFamiTF313281.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR028501. Endophilin-A.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    [Graphical view]
    PANTHERiPTHR10661:SF113. PTHR10661:SF113. 1 hit.
    PfamiPF03114. BAR. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTiSM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99962-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI    50
    MTKTIEYLQP NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF 100
    GRELGDDCNF GPALGEVGEA MRELSEVKDS LDIEVKQNFI DPLQNLHDKD 150
    LREIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF DESKEIAESS 200
    MFNLLEMDIE QVSQLSALVQ AQLEYHKQAV QILQQVTVRL EERIRQASSQ 250
    PRREYQPKPR MSLEFPTGDS TQPNGGLSHT GTPKPSGVQM DQPCCRALYD 300
    FEPENEGELG FKEGDIITLT NQIDENWYEG MLHGHSGFFP INYVEILVAL 350
    PH 352
    Length:352
    Mass (Da):39,962
    Last modified:May 1, 1997 - v1
    Checksum:iF3AE2353E1EB7CF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99657 mRNA. Translation: CAA67971.1.
    AF036268 mRNA. Translation: AAC04764.1.
    CR542086 mRNA. Translation: CAG46883.1.
    CR542102 mRNA. Translation: CAG46899.1.
    BT019682 mRNA. Translation: AAV38488.1.
    AK312400 mRNA. Translation: BAG35315.1.
    AL139115, AL133214 Genomic DNA. Translation: CAB92765.2.
    AL133214, AL139115 Genomic DNA. Translation: CAH70742.1.
    CH471071 Genomic DNA. Translation: EAW58661.1.
    CCDSiCCDS6483.1.
    RefSeqiNP_003017.1. NM_003026.3.
    UniGeneiHs.75149.

    Genome annotation databases

    EnsembliENST00000380607; ENSP00000369981; ENSG00000107295.
    GeneIDi6456.
    KEGGihsa:6456.
    UCSCiuc003zna.3. human.

    Polymorphism databases

    DMDMi10720276.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99657 mRNA. Translation: CAA67971.1 .
    AF036268 mRNA. Translation: AAC04764.1 .
    CR542086 mRNA. Translation: CAG46883.1 .
    CR542102 mRNA. Translation: CAG46899.1 .
    BT019682 mRNA. Translation: AAV38488.1 .
    AK312400 mRNA. Translation: BAG35315.1 .
    AL139115 , AL133214 Genomic DNA. Translation: CAB92765.2 .
    AL133214 , AL139115 Genomic DNA. Translation: CAH70742.1 .
    CH471071 Genomic DNA. Translation: EAW58661.1 .
    CCDSi CCDS6483.1.
    RefSeqi NP_003017.1. NM_003026.3.
    UniGenei Hs.75149.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X03 X-ray 3.10 A 1-247 [» ]
    1X04 X-ray 2.90 A 1-58 [» ]
    A 89-247 [» ]
    2D4C X-ray 2.40 A/B/C/D 1-247 [» ]
    2DBM NMR - A 293-352 [» ]
    ProteinModelPortali Q99962.
    SMRi Q99962. Positions 26-247, 293-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112353. 59 interactions.
    DIPi DIP-30996N.
    IntActi Q99962. 43 interactions.
    MINTi MINT-108776.
    STRINGi 9606.ENSP00000369981.

    PTM databases

    PhosphoSitei Q99962.

    Polymorphism databases

    DMDMi 10720276.

    Proteomic databases

    MaxQBi Q99962.
    PaxDbi Q99962.
    PRIDEi Q99962.

    Protocols and materials databases

    DNASUi 6456.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380607 ; ENSP00000369981 ; ENSG00000107295 .
    GeneIDi 6456.
    KEGGi hsa:6456.
    UCSCi uc003zna.3. human.

    Organism-specific databases

    CTDi 6456.
    GeneCardsi GC09P017569.
    HGNCi HGNC:10831. SH3GL2.
    HPAi CAB010056.
    HPA026685.
    MIMi 604465. gene.
    neXtProti NX_Q99962.
    PharmGKBi PA35737.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307129.
    HOGENOMi HOG000231641.
    HOVERGENi HBG052866.
    InParanoidi Q99962.
    KOi K11247.
    OMAi SESHNGG.
    OrthoDBi EOG7G1V6H.
    PhylomeDBi Q99962.
    TreeFami TF313281.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12484. EGFR downregulation.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.
    REACT_22365. Recycling pathway of L1.
    SignaLinki Q99962.

    Miscellaneous databases

    EvolutionaryTracei Q99962.
    GeneWikii SH3GL2.
    GenomeRNAii 6456.
    NextBioi 25093.
    PROi Q99962.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99962.
    Bgeei Q99962.
    CleanExi HS_SH3GL2.
    Genevestigatori Q99962.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR028501. Endophilin-A.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    [Graphical view ]
    PANTHERi PTHR10661:SF113. PTHR10661:SF113. 1 hit.
    Pfami PF03114. BAR. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTi SM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel SH3-containing human gene family preferentially expressed in the central nervous system."
      Giachino C., Lantelme E., Lanzetti L., Saccone S., Della Valle G., Migone N.
      Genomics 41:427-434(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "A family of EEN-like genes coding for SH3-domain containing proteins are preferentially expressed in human brain."
      So C.W., So C.K.C., Sham M.H., Chan L.C.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
      Howard L., Nelson K.K., Maciewicz R.A., Blobel C.P.
      J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ADAM9 AND ADAM15.
    9. "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity."
      Cestra G., Castagnoli L., Dente L., Minenkova O., Petrelli A., Migone N., Hoffmueller U., Schneider-Mergener J., Cesareni G.
      J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYNJ1.
    10. "Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding."
      Fisher R.D., Chung H.Y., Zhai Q., Robinson H., Sundquist W.I., Hill C.P.
      Cell 128:841-852(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDCD6IP.
    11. "Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking."
      Nonis D., Schmidt M.H., van de Loo S., Eich F., Dikic I., Nowock J., Auburger G.
      Cell. Signal. 20:1725-1739(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATX2.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
      Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
      PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BIN2.
    14. "Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms."
      Masuda M., Takeda S., Sone M., Ohki T., Mori H., Kamioka Y., Mochizuki N.
      EMBO J. 25:2889-2897(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-247, DOMAIN, MUTAGENESIS OF ALA-63; ALA-66; MET-70 AND PHE-202.
    15. "Solution structures of the SH3 domain of human SH3-containing GRB2-like protein 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (DEC-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 293-352.

    Entry informationi

    Entry nameiSH3G2_HUMAN
    AccessioniPrimary (citable) accession number: Q99962
    Secondary accession number(s): B2R618, Q9NQK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3