Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99962

- SH3G2_HUMAN

UniProt

Q99962 - SH3G2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endophilin-A1

Gene

SH3GL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. axon guidance Source: Reactome
  3. central nervous system development Source: ProtInc
  4. epidermal growth factor receptor signaling pathway Source: Reactome
  5. membrane organization Source: Reactome
  6. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  7. neurotrophin TRK receptor signaling pathway Source: Reactome
  8. post-Golgi vesicle-mediated transport Source: Reactome
  9. regulation of receptor internalization Source: Ensembl
  10. signal transduction Source: ProtInc
  11. synaptic vesicle endocytosis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.
REACT_22365. Recycling pathway of L1.
SignaLinkiQ99962.

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-A1
Alternative name(s):
EEN-B1
Endophilin-1
SH3 domain protein 2A
SH3 domain-containing GRB2-like protein 2
Gene namesi
Name:SH3GL2
Synonyms:CNSA2, SH3D2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:10831. SH3GL2.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein
Note: Concentrated in presynaptic nerve terminals in neurons.

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Reactome
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. Golgi membrane Source: Reactome
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi63 – 631A → S: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-66 or with S-66 and Q-70. 1 Publication
Mutagenesisi66 – 661A → D: Loss of tubulation of liposomes, no effect on liposome binding. 1 Publication
Mutagenesisi66 – 661A → S: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-63 or with S-63 and Q-70. 1 Publication
Mutagenesisi66 – 661A → W: Vesiculation of liposomes, no effect on liposome binding, indol ring located in hydrophobic core of the membrane. 1 Publication
Mutagenesisi70 – 701M → Q: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-63 and S-66. 1 Publication
Mutagenesisi202 – 2021F → W: No effect. Indol ring not associated with the membrane. 1 Publication

Organism-specific databases

PharmGKBiPA35737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Endophilin-A1PRO_0000146747Add
BLAST

Proteomic databases

MaxQBiQ99962.
PaxDbiQ99962.
PRIDEiQ99962.

PTM databases

PhosphoSiteiQ99962.

Expressioni

Tissue specificityi

Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.

Gene expression databases

BgeeiQ99962.
CleanExiHS_SH3GL2.
ExpressionAtlasiQ99962. baseline and differential.
GenevestigatoriQ99962.

Organism-specific databases

HPAiCAB010056.
HPA026685.

Interactioni

Subunit structurei

Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with OPHN1 (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP. Interacts with ATX2. Interacts with ADAM9 and ADAM15 cytoplasmic tails. Interacts with BIN2.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-77938,EBI-77938
ADAM15Q134442EBI-77938,EBI-77818
ADAM9Q134432EBI-77938,EBI-77903
ATXN2Q997009EBI-77938,EBI-697691
DNM2P505702EBI-77938,EBI-346547
EMDP504022EBI-77938,EBI-489887
LRRK2Q5S0072EBI-77938,EBI-5323863
PTPN23Q9H3S72EBI-77938,EBI-724478
RAPH1Q70E734EBI-77938,EBI-3940924
SH3GL1Q999613EBI-77938,EBI-697911
SH3GL3Q999635EBI-77938,EBI-473910
SH3KBP1Q96B972EBI-77938,EBI-346595
Synj1Q629102EBI-77938,EBI-1149123From a different organism.

Protein-protein interaction databases

BioGridi112353. 62 interactions.
DIPiDIP-30996N.
IntActiQ99962. 45 interactions.
MINTiMINT-108776.
STRINGi9606.ENSP00000369981.

Structurei

Secondary structure

1
352
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 2110Combined sources
Helixi24 – 5835Combined sources
Helixi62 – 643Combined sources
Helixi65 – 684Combined sources
Helixi89 – 10416Combined sources
Beta strandi106 – 1094Combined sources
Helixi110 – 13829Combined sources
Helixi140 – 1489Combined sources
Helixi150 – 17526Combined sources
Helixi180 – 24667Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X03X-ray3.10A1-247[»]
1X04X-ray2.90A1-58[»]
A89-247[»]
2D4CX-ray2.40A/B/C/D1-247[»]
2DBMNMR-A293-352[»]
ProteinModelPortaliQ99962.
SMRiQ99962. Positions 26-247, 293-352.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99962.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 249232BARPROSITE-ProRule annotationAdd
BLAST
Domaini290 – 34960SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 125125Binds and tubulates liposomesBy similarityAdd
BLAST
Regioni1 – 2121Membrane-binding amphipathic helixAdd
BLAST
Regioni60 – 8728Required for dimerization upon membrane associationBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 24868Sequence AnalysisAdd
BLAST

Domaini

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.1 Publication

Sequence similaritiesi

Belongs to the endophilin family.Curated
Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG307129.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000231641.
HOVERGENiHBG052866.
InParanoidiQ99962.
KOiK11247.
OMAiSESHNGG.
OrthoDBiEOG7G1V6H.
PhylomeDBiQ99962.
TreeFamiTF313281.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR028501. Endophilin-A.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PANTHERiPTHR10661:SF113. PTHR10661:SF113. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99962-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI
60 70 80 90 100
MTKTIEYLQP NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF
110 120 130 140 150
GRELGDDCNF GPALGEVGEA MRELSEVKDS LDIEVKQNFI DPLQNLHDKD
160 170 180 190 200
LREIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF DESKEIAESS
210 220 230 240 250
MFNLLEMDIE QVSQLSALVQ AQLEYHKQAV QILQQVTVRL EERIRQASSQ
260 270 280 290 300
PRREYQPKPR MSLEFPTGDS TQPNGGLSHT GTPKPSGVQM DQPCCRALYD
310 320 330 340 350
FEPENEGELG FKEGDIITLT NQIDENWYEG MLHGHSGFFP INYVEILVAL

PH
Length:352
Mass (Da):39,962
Last modified:May 1, 1997 - v1
Checksum:iF3AE2353E1EB7CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99657 mRNA. Translation: CAA67971.1.
AF036268 mRNA. Translation: AAC04764.1.
CR542086 mRNA. Translation: CAG46883.1.
CR542102 mRNA. Translation: CAG46899.1.
BT019682 mRNA. Translation: AAV38488.1.
AK312400 mRNA. Translation: BAG35315.1.
AL139115, AL133214 Genomic DNA. Translation: CAB92765.2.
AL133214, AL139115 Genomic DNA. Translation: CAH70742.1.
CH471071 Genomic DNA. Translation: EAW58661.1.
CCDSiCCDS6483.1.
RefSeqiNP_003017.1. NM_003026.3.
UniGeneiHs.743740.
Hs.75149.

Genome annotation databases

EnsembliENST00000380607; ENSP00000369981; ENSG00000107295.
GeneIDi6456.
KEGGihsa:6456.
UCSCiuc003zna.3. human.

Polymorphism databases

DMDMi10720276.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99657 mRNA. Translation: CAA67971.1 .
AF036268 mRNA. Translation: AAC04764.1 .
CR542086 mRNA. Translation: CAG46883.1 .
CR542102 mRNA. Translation: CAG46899.1 .
BT019682 mRNA. Translation: AAV38488.1 .
AK312400 mRNA. Translation: BAG35315.1 .
AL139115 , AL133214 Genomic DNA. Translation: CAB92765.2 .
AL133214 , AL139115 Genomic DNA. Translation: CAH70742.1 .
CH471071 Genomic DNA. Translation: EAW58661.1 .
CCDSi CCDS6483.1.
RefSeqi NP_003017.1. NM_003026.3.
UniGenei Hs.743740.
Hs.75149.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X03 X-ray 3.10 A 1-247 [» ]
1X04 X-ray 2.90 A 1-58 [» ]
A 89-247 [» ]
2D4C X-ray 2.40 A/B/C/D 1-247 [» ]
2DBM NMR - A 293-352 [» ]
ProteinModelPortali Q99962.
SMRi Q99962. Positions 26-247, 293-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112353. 62 interactions.
DIPi DIP-30996N.
IntActi Q99962. 45 interactions.
MINTi MINT-108776.
STRINGi 9606.ENSP00000369981.

PTM databases

PhosphoSitei Q99962.

Polymorphism databases

DMDMi 10720276.

Proteomic databases

MaxQBi Q99962.
PaxDbi Q99962.
PRIDEi Q99962.

Protocols and materials databases

DNASUi 6456.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380607 ; ENSP00000369981 ; ENSG00000107295 .
GeneIDi 6456.
KEGGi hsa:6456.
UCSCi uc003zna.3. human.

Organism-specific databases

CTDi 6456.
GeneCardsi GC09P017569.
HGNCi HGNC:10831. SH3GL2.
HPAi CAB010056.
HPA026685.
MIMi 604465. gene.
neXtProti NX_Q99962.
PharmGKBi PA35737.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307129.
GeneTreei ENSGT00550000074464.
HOGENOMi HOG000231641.
HOVERGENi HBG052866.
InParanoidi Q99962.
KOi K11247.
OMAi SESHNGG.
OrthoDBi EOG7G1V6H.
PhylomeDBi Q99962.
TreeFami TF313281.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.
REACT_22365. Recycling pathway of L1.
SignaLinki Q99962.

Miscellaneous databases

ChiTaRSi SH3GL2. human.
EvolutionaryTracei Q99962.
GeneWikii SH3GL2.
GenomeRNAii 6456.
NextBioi 25093.
PROi Q99962.
SOURCEi Search...

Gene expression databases

Bgeei Q99962.
CleanExi HS_SH3GL2.
ExpressionAtlasi Q99962. baseline and differential.
Genevestigatori Q99962.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR028501. Endophilin-A.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view ]
PANTHERi PTHR10661:SF113. PTHR10661:SF113. 1 hit.
Pfami PF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTi SM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel SH3-containing human gene family preferentially expressed in the central nervous system."
    Giachino C., Lantelme E., Lanzetti L., Saccone S., Della Valle G., Migone N.
    Genomics 41:427-434(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "A family of EEN-like genes coding for SH3-domain containing proteins are preferentially expressed in human brain."
    So C.W., So C.K.C., Sham M.H., Chan L.C.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
    Howard L., Nelson K.K., Maciewicz R.A., Blobel C.P.
    J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADAM9 AND ADAM15.
  9. "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity."
    Cestra G., Castagnoli L., Dente L., Minenkova O., Petrelli A., Migone N., Hoffmueller U., Schneider-Mergener J., Cesareni G.
    J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYNJ1.
  10. "Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding."
    Fisher R.D., Chung H.Y., Zhai Q., Robinson H., Sundquist W.I., Hill C.P.
    Cell 128:841-852(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDCD6IP.
  11. "Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking."
    Nonis D., Schmidt M.H., van de Loo S., Eich F., Dikic I., Nowock J., Auburger G.
    Cell. Signal. 20:1725-1739(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATX2.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
    Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
    PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BIN2.
  14. "Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms."
    Masuda M., Takeda S., Sone M., Ohki T., Mori H., Kamioka Y., Mochizuki N.
    EMBO J. 25:2889-2897(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-247, DOMAIN, MUTAGENESIS OF ALA-63; ALA-66; MET-70 AND PHE-202.
  15. "Solution structures of the SH3 domain of human SH3-containing GRB2-like protein 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (DEC-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 293-352.

Entry informationi

Entry nameiSH3G2_HUMAN
AccessioniPrimary (citable) accession number: Q99962
Secondary accession number(s): B2R618, Q9NQK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3