Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endophilin-A2

Gene

SH3GL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei15 – 162Breakpoint for translocation to form KMT2A/MLL1-EEN oncogene

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • central nervous system development Source: ProtInc
  • endocytosis Source: UniProtKB-KW
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-A2
Alternative name(s):
EEN fusion partner of MLL
Endophilin-2
Extra eleven-nineteen leukemia fusion gene protein
Short name:
EEN
SH3 domain protein 2B
SH3 domain-containing GRB2-like protein 1
Gene namesi
Name:SH3GL1
Synonyms:CNSA1, SH3D2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10830. SH3GL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA35736.

Polymorphism and mutation databases

BioMutaiSH3GL1.
DMDMi12643797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Endophilin-A2PRO_0000146744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei288 – 2881Phosphoserine4 Publications
Modified residuei315 – 3151PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99961.
PaxDbiQ99961.
PeptideAtlasiQ99961.
PRIDEiQ99961.

2D gel databases

OGPiQ99961.

PTM databases

PhosphoSiteiQ99961.

Expressioni

Tissue specificityi

Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

Gene expression databases

BgeeiQ99961.
CleanExiHS_SH3GL1.
ExpressionAtlasiQ99961. baseline and differential.
GenevisibleiQ99961. HS.

Organism-specific databases

HPAiHPA021485.

Interactioni

Subunit structurei

Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1. Interacts with PDCD6IP. Interacts with BIN2.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-697911,EBI-697911
DPPA4Q7L1905EBI-697911,EBI-710457
SH2D4AQ9H7883EBI-697911,EBI-747035
SH3GL2Q999623EBI-697911,EBI-77938
SH3GL3Q999634EBI-697911,EBI-473910

Protein-protein interaction databases

BioGridi112352. 63 interactions.
IntActiQ99961. 22 interactions.
MINTiMINT-128645.
STRINGi9606.ENSP00000269886.

Structurei

3D structure databases

ProteinModelPortaliQ99961.
SMRiQ99961. Positions 26-247, 305-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 249232BARPROSITE-ProRule annotationAdd
BLAST
Domaini306 – 36560SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2121Membrane-binding amphipathic helixBy similarityAdd
BLAST
Regioni60 – 8728Required for dimerization upon membrane associationBy similarityAdd
BLAST
Regioni218 – 25437Interaction with ARCBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 250106Sequence AnalysisAdd
BLAST

Domaini

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.By similarity

Sequence similaritiesi

Belongs to the endophilin family.Curated
Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG307129.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000231641.
HOVERGENiHBG052866.
InParanoidiQ99961.
KOiK11247.
OMAiPEQPSCK.
OrthoDBiEOG7G1V6H.
PhylomeDBiQ99961.
TreeFamiTF313281.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR028501. Endophilin-A.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10661:SF125. PTHR10661:SF125. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99961-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV
60 70 80 90 100
LARTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH
110 120 130 140 150
GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD
160 170 180 190 200
LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF EESKEVAETS
210 220 230 240 250
MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL KRRMREASSR
260 270 280 290 300
PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS
310 320 330 340 350
RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG
360
QSGFFPLSYV EVLVPLPQ
Length:368
Mass (Da):41,490
Last modified:May 1, 1997 - v1
Checksum:i6E5BE978BC955077
GO
Isoform 2 (identifier: Q99961-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-110: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):36,304
Checksum:i1D0826E00AC0EA31
GO
Isoform 3 (identifier: Q99961-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-143: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):34,519
Checksum:iD761B54F4160CC82
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3161D → G in BAG61213 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei63 – 11048Missing in isoform 2. 1 PublicationVSP_045837Add
BLAST
Alternative sequencei80 – 14364Missing in isoform 3. 1 PublicationVSP_047037Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99656 mRNA. Translation: CAA67970.1.
U65999 mRNA. Translation: AAB86800.1.
AF190465 Genomic DNA. Translation: AAF04290.1.
AK299166 mRNA. Translation: BAG61213.1.
AK097616 mRNA. No translation available.
AC007292 Genomic DNA. No translation available.
AC011498 Genomic DNA. No translation available.
BC001270 mRNA. Translation: AAH01270.1.
CCDSiCCDS32874.1. [Q99961-1]
CCDS56076.1. [Q99961-2]
CCDS59335.1. [Q99961-3]
RefSeqiNP_001186872.1. NM_001199943.1. [Q99961-2]
NP_001186873.1. NM_001199944.1. [Q99961-3]
NP_003016.1. NM_003025.3. [Q99961-1]
UniGeneiHs.97616.

Genome annotation databases

EnsembliENST00000269886; ENSP00000269886; ENSG00000141985. [Q99961-1]
ENST00000417295; ENSP00000404568; ENSG00000141985. [Q99961-2]
ENST00000598564; ENSP00000470792; ENSG00000141985. [Q99961-3]
GeneIDi6455.
KEGGihsa:6455.
UCSCiuc002maj.3. human. [Q99961-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99656 mRNA. Translation: CAA67970.1.
U65999 mRNA. Translation: AAB86800.1.
AF190465 Genomic DNA. Translation: AAF04290.1.
AK299166 mRNA. Translation: BAG61213.1.
AK097616 mRNA. No translation available.
AC007292 Genomic DNA. No translation available.
AC011498 Genomic DNA. No translation available.
BC001270 mRNA. Translation: AAH01270.1.
CCDSiCCDS32874.1. [Q99961-1]
CCDS56076.1. [Q99961-2]
CCDS59335.1. [Q99961-3]
RefSeqiNP_001186872.1. NM_001199943.1. [Q99961-2]
NP_001186873.1. NM_001199944.1. [Q99961-3]
NP_003016.1. NM_003025.3. [Q99961-1]
UniGeneiHs.97616.

3D structure databases

ProteinModelPortaliQ99961.
SMRiQ99961. Positions 26-247, 305-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112352. 63 interactions.
IntActiQ99961. 22 interactions.
MINTiMINT-128645.
STRINGi9606.ENSP00000269886.

PTM databases

PhosphoSiteiQ99961.

Polymorphism and mutation databases

BioMutaiSH3GL1.
DMDMi12643797.

2D gel databases

OGPiQ99961.

Proteomic databases

MaxQBiQ99961.
PaxDbiQ99961.
PeptideAtlasiQ99961.
PRIDEiQ99961.

Protocols and materials databases

DNASUi6455.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269886; ENSP00000269886; ENSG00000141985. [Q99961-1]
ENST00000417295; ENSP00000404568; ENSG00000141985. [Q99961-2]
ENST00000598564; ENSP00000470792; ENSG00000141985. [Q99961-3]
GeneIDi6455.
KEGGihsa:6455.
UCSCiuc002maj.3. human. [Q99961-1]

Organism-specific databases

CTDi6455.
GeneCardsiGC19M004360.
HGNCiHGNC:10830. SH3GL1.
HPAiHPA021485.
MIMi601768. gene.
neXtProtiNX_Q99961.
PharmGKBiPA35736.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307129.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000231641.
HOVERGENiHBG052866.
InParanoidiQ99961.
KOiK11247.
OMAiPEQPSCK.
OrthoDBiEOG7G1V6H.
PhylomeDBiQ99961.
TreeFamiTF313281.

Miscellaneous databases

ChiTaRSiSH3GL1. human.
GeneWikiiSH3GL1.
GenomeRNAii6455.
NextBioi25089.
PROiQ99961.
SOURCEiSearch...

Gene expression databases

BgeeiQ99961.
CleanExiHS_SH3GL1.
ExpressionAtlasiQ99961. baseline and differential.
GenevisibleiQ99961. HS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR028501. Endophilin-A.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10661:SF125. PTHR10661:SF125. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel SH3-containing human gene family preferentially expressed in the central nervous system."
    Giachino C., Lantelme E., Lanzetti L., Saccone S., Della Valle G., Migone N.
    Genomics 41:427-434(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia."
    So C.W., Caldas C., Liu M.-M., Chen S.-J., Huang Q.-H., Gu L.-J., Sham M.H., Wiedemann L.M., Chan L.C.
    Proc. Natl. Acad. Sci. U.S.A. 94:2563-2568(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION.
    Tissue: Fetal brain.
  3. So C.W., Caldas C., Liu M.-M., Chen S.-J., Huang Q.-H., Gu L.-J., Sham M.H., Wiedemann L.M., Chan L.C.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Homo sapiens SH3-containing protein EEN gene."
    Chen S., Xiong H., Dong H., Lin W., Zhang C., Fu G., Qi Z., Huang G.M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.
  8. "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity."
    Cestra G., Castagnoli L., Dente L., Minenkova O., Petrelli A., Migone N., Hoffmueller U., Schneider-Mergener J., Cesareni G.
    J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYNJ1.
  9. "Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding."
    Fisher R.D., Chung H.Y., Zhai Q., Robinson H., Sundquist W.I., Hill C.P.
    Cell 128:841-852(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDCD6IP.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
    Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
    PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BIN2, SUBCELLULAR LOCATION.
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSH3G1_HUMAN
AccessioniPrimary (citable) accession number: Q99961
Secondary accession number(s): B4DRA1
, E7EVZ4, M0QZV5, Q99668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: June 24, 2015
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.