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Q99961

- SH3G1_HUMAN

UniProt

Q99961 - SH3G1_HUMAN

Protein

Endophilin-A2

Gene

SH3GL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Implicated in endocytosis. May recruit other proteins to membranes with high curvature By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei15 – 162Breakpoint for translocation to form KMT2A/MLL1-EEN oncogene

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. lipid binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. central nervous system development Source: ProtInc
    2. endocytosis Source: UniProtKB-KW
    3. signal transduction Source: ProtInc

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endophilin-A2
    Alternative name(s):
    EEN fusion partner of MLL
    Endophilin-2
    Extra eleven-nineteen leukemia fusion gene protein
    Short name:
    EEN
    SH3 domain protein 2B
    SH3 domain-containing GRB2-like protein 1
    Gene namesi
    Name:SH3GL1
    Synonyms:CNSA1, SH3D2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10830. SH3GL1.

    Subcellular locationi

    Cytoplasm By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity. Cell projectionpodosome 1 Publication
    Note: Associated with postsynaptic endosomes in hippocampal neurons.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell projection Source: UniProtKB-KW
    3. cytoplasm Source: HPA
    4. early endosome membrane Source: UniProtKB-SubCell
    5. podosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell projection, Cytoplasm, Endosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA35736.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Endophilin-A2PRO_0000146744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei288 – 2881Phosphoserine3 Publications
    Modified residuei315 – 3151PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99961.
    PaxDbiQ99961.
    PeptideAtlasiQ99961.
    PRIDEiQ99961.

    2D gel databases

    OGPiQ99961.

    PTM databases

    PhosphoSiteiQ99961.

    Expressioni

    Tissue specificityi

    Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

    Gene expression databases

    ArrayExpressiQ99961.
    BgeeiQ99961.
    CleanExiHS_SH3GL1.
    GenevestigatoriQ99961.

    Organism-specific databases

    HPAiHPA021485.

    Interactioni

    Subunit structurei

    Interacts with ARC By similarity. Interacts with SYNJ1 and DNM1. Interacts with PDCD6IP. Interacts with BIN2.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-697911,EBI-697911
    DPPA4Q7L1905EBI-697911,EBI-710457
    SH2D4AQ9H7883EBI-697911,EBI-747035
    SH3GL2Q999623EBI-697911,EBI-77938
    SH3GL3Q999634EBI-697911,EBI-473910

    Protein-protein interaction databases

    BioGridi112352. 52 interactions.
    IntActiQ99961. 22 interactions.
    MINTiMINT-128645.
    STRINGi9606.ENSP00000269886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99961.
    SMRiQ99961. Positions 26-247, 305-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 249232BARPROSITE-ProRule annotationAdd
    BLAST
    Domaini306 – 36560SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2121Membrane-binding amphipathic helixBy similarityAdd
    BLAST
    Regioni60 – 8728Required for dimerization upon membrane associationBy similarityAdd
    BLAST
    Regioni218 – 25437Interaction with ARCBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili145 – 250106Sequence AnalysisAdd
    BLAST

    Domaini

    An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.By similarity

    Sequence similaritiesi

    Belongs to the endophilin family.Curated
    Contains 1 BAR domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG307129.
    HOGENOMiHOG000231641.
    HOVERGENiHBG052866.
    InParanoidiQ99961.
    KOiK11247.
    OMAiPEQPSCK.
    OrthoDBiEOG7G1V6H.
    PhylomeDBiQ99961.
    TreeFamiTF313281.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR028501. Endophilin-A.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10661:SF125. PTHR10661:SF125. 1 hit.
    PfamiPF03114. BAR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99961-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV    50
    LARTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH 100
    GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD 150
    LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF EESKEVAETS 200
    MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL KRRMREASSR 250
    PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS 300
    RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG 350
    QSGFFPLSYV EVLVPLPQ 368
    Length:368
    Mass (Da):41,490
    Last modified:May 1, 1997 - v1
    Checksum:i6E5BE978BC955077
    GO
    Isoform 2 (identifier: Q99961-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         63-110: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:320
    Mass (Da):36,304
    Checksum:i1D0826E00AC0EA31
    GO
    Isoform 3 (identifier: Q99961-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         80-143: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:304
    Mass (Da):34,519
    Checksum:iD761B54F4160CC82
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti316 – 3161D → G in BAG61213. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei63 – 11048Missing in isoform 2. 1 PublicationVSP_045837Add
    BLAST
    Alternative sequencei80 – 14364Missing in isoform 3. 1 PublicationVSP_047037Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99656 mRNA. Translation: CAA67970.1.
    U65999 mRNA. Translation: AAB86800.1.
    AF190465 Genomic DNA. Translation: AAF04290.1.
    AK299166 mRNA. Translation: BAG61213.1.
    AK097616 mRNA. No translation available.
    AC007292 Genomic DNA. No translation available.
    AC011498 Genomic DNA. No translation available.
    BC001270 mRNA. Translation: AAH01270.1.
    CCDSiCCDS32874.1. [Q99961-1]
    CCDS56076.1. [Q99961-2]
    CCDS59335.1. [Q99961-3]
    RefSeqiNP_001186872.1. NM_001199943.1. [Q99961-2]
    NP_001186873.1. NM_001199944.1. [Q99961-3]
    NP_003016.1. NM_003025.3. [Q99961-1]
    UniGeneiHs.97616.

    Genome annotation databases

    EnsembliENST00000269886; ENSP00000269886; ENSG00000141985. [Q99961-1]
    ENST00000417295; ENSP00000404568; ENSG00000141985. [Q99961-2]
    ENST00000598564; ENSP00000470792; ENSG00000141985. [Q99961-3]
    GeneIDi6455.
    KEGGihsa:6455.
    UCSCiuc002maj.3. human. [Q99961-1]

    Polymorphism databases

    DMDMi12643797.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99656 mRNA. Translation: CAA67970.1 .
    U65999 mRNA. Translation: AAB86800.1 .
    AF190465 Genomic DNA. Translation: AAF04290.1 .
    AK299166 mRNA. Translation: BAG61213.1 .
    AK097616 mRNA. No translation available.
    AC007292 Genomic DNA. No translation available.
    AC011498 Genomic DNA. No translation available.
    BC001270 mRNA. Translation: AAH01270.1 .
    CCDSi CCDS32874.1. [Q99961-1 ]
    CCDS56076.1. [Q99961-2 ]
    CCDS59335.1. [Q99961-3 ]
    RefSeqi NP_001186872.1. NM_001199943.1. [Q99961-2 ]
    NP_001186873.1. NM_001199944.1. [Q99961-3 ]
    NP_003016.1. NM_003025.3. [Q99961-1 ]
    UniGenei Hs.97616.

    3D structure databases

    ProteinModelPortali Q99961.
    SMRi Q99961. Positions 26-247, 305-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112352. 52 interactions.
    IntActi Q99961. 22 interactions.
    MINTi MINT-128645.
    STRINGi 9606.ENSP00000269886.

    PTM databases

    PhosphoSitei Q99961.

    Polymorphism databases

    DMDMi 12643797.

    2D gel databases

    OGPi Q99961.

    Proteomic databases

    MaxQBi Q99961.
    PaxDbi Q99961.
    PeptideAtlasi Q99961.
    PRIDEi Q99961.

    Protocols and materials databases

    DNASUi 6455.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269886 ; ENSP00000269886 ; ENSG00000141985 . [Q99961-1 ]
    ENST00000417295 ; ENSP00000404568 ; ENSG00000141985 . [Q99961-2 ]
    ENST00000598564 ; ENSP00000470792 ; ENSG00000141985 . [Q99961-3 ]
    GeneIDi 6455.
    KEGGi hsa:6455.
    UCSCi uc002maj.3. human. [Q99961-1 ]

    Organism-specific databases

    CTDi 6455.
    GeneCardsi GC19M004360.
    HGNCi HGNC:10830. SH3GL1.
    HPAi HPA021485.
    MIMi 601768. gene.
    neXtProti NX_Q99961.
    PharmGKBi PA35736.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307129.
    HOGENOMi HOG000231641.
    HOVERGENi HBG052866.
    InParanoidi Q99961.
    KOi K11247.
    OMAi PEQPSCK.
    OrthoDBi EOG7G1V6H.
    PhylomeDBi Q99961.
    TreeFami TF313281.

    Miscellaneous databases

    GeneWikii SH3GL1.
    GenomeRNAii 6455.
    NextBioi 25089.
    PROi Q99961.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99961.
    Bgeei Q99961.
    CleanExi HS_SH3GL1.
    Genevestigatori Q99961.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR028501. Endophilin-A.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10661:SF125. PTHR10661:SF125. 1 hit.
    Pfami PF03114. BAR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel SH3-containing human gene family preferentially expressed in the central nervous system."
      Giachino C., Lantelme E., Lanzetti L., Saccone S., Della Valle G., Migone N.
      Genomics 41:427-434(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia."
      So C.W., Caldas C., Liu M.-M., Chen S.-J., Huang Q.-H., Gu L.-J., Sham M.H., Wiedemann L.M., Chan L.C.
      Proc. Natl. Acad. Sci. U.S.A. 94:2563-2568(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION.
      Tissue: Fetal brain.
    3. So C.W., Caldas C., Liu M.-M., Chen S.-J., Huang Q.-H., Gu L.-J., Sham M.H., Wiedemann L.M., Chan L.C.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Homo sapiens SH3-containing protein EEN gene."
      Chen S., Xiong H., Dong H., Lin W., Zhang C., Fu G., Qi Z., Huang G.M.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix.
    8. "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity."
      Cestra G., Castagnoli L., Dente L., Minenkova O., Petrelli A., Migone N., Hoffmueller U., Schneider-Mergener J., Cesareni G.
      J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYNJ1.
    9. "Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding."
      Fisher R.D., Chung H.Y., Zhai Q., Robinson H., Sundquist W.I., Hill C.P.
      Cell 128:841-852(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDCD6IP.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
      Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
      PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BIN2, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSH3G1_HUMAN
    AccessioniPrimary (citable) accession number: Q99961
    Secondary accession number(s): B4DRA1
    , E7EVZ4, M0QZV5, Q99668
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3