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Protein

Plakophilin-2

Gene

PKP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in junctional plaques.1 Publication

GO - Molecular functioni

  • alpha-catenin binding Source: BHF-UCL
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
  • intermediate filament binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL
  • protein kinase C binding Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  • adherens junction maintenance Source: BHF-UCL
  • bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
  • cardiac muscle cell action potential Source: BHF-UCL
  • cardiac muscle cell action potential involved in contraction Source: BHF-UCL
  • cell-cell signaling involved in cardiac conduction Source: BHF-UCL
  • cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • desmosome assembly Source: BHF-UCL
  • establishment of protein localization to plasma membrane Source: BHF-UCL
  • gap junction assembly Source: BHF-UCL
  • heart development Source: BHF-UCL
  • intermediate filament bundle assembly Source: BHF-UCL
  • lipid homeostasis Source: BHF-UCL
  • maintenance of animal organ identity Source: BHF-UCL
  • negative regulation of cell migration Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • positive regulation of sodium ion transport Source: BHF-UCL
  • regulation of bicellular tight junction assembly Source: BHF-UCL
  • regulation of heart rate by cardiac conduction Source: BHF-UCL
  • regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
  • single organismal cell-cell adhesion Source: UniProtKB
  • ventricular cardiac muscle cell action potential Source: BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000057294-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.
SignaLinkiQ99959.

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-2
Gene namesi
Name:PKP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9024. PKP2.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: BHF-UCL
  • cell-cell adherens junction Source: BHF-UCL
  • cell-cell junction Source: BHF-UCL
  • cell junction Source: HPA
  • desmosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • intercalated disc Source: BHF-UCL
  • intermediate filament Source: BHF-UCL
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

Pathology & Biotechi

Involvement in diseasei

Arrhythmogenic right ventricular dysplasia, familial, 9 (ARVD9)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
See also OMIM:609040
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065705137E → K in ARVD9. 1 PublicationCorresponds to variant rs781739949dbSNPEnsembl.1
Natural variantiVAR_021148140S → F in ARVD9; uncertain pathological significance. 3 PublicationsCorresponds to variant rs150821281dbSNPEnsembl.1
Natural variantiVAR_065706169S → G in ARVD9. 1 PublicationCorresponds to variant rs139139859dbSNPEnsembl.1
Natural variantiVAR_065711424F → S in ARVD9. 1 PublicationCorresponds to variant rs397516990dbSNPEnsembl.1
Natural variantiVAR_021149615S → F in ARVD9; impairs protein stability. 2 Publications1
Natural variantiVAR_065716631Y → C in ARVD9. 1 Publication1
Natural variantiVAR_021150654K → Q in ARVD9; impairs protein stability. 2 Publications1
Natural variantiVAR_065718787L → F in ARVD9. 1 Publication1
Natural variantiVAR_021151796C → R in ARVD9; impairs protein stability. 2 PublicationsCorresponds to variant rs794729098dbSNPEnsembl.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi5318.
MalaCardsiPKP2.
MIMi609040. phenotype.
OpenTargetsiENSG00000057294.
Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
PharmGKBiPA33357.

Polymorphism and mutation databases

BioMutaiPKP2.
DMDMi296452867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642861 – 881Plakophilin-2Add BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei46Omega-N-methylarginineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei177PhosphothreonineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ99959.
MaxQBiQ99959.
PaxDbiQ99959.
PeptideAtlasiQ99959.
PRIDEiQ99959.

PTM databases

iPTMnetiQ99959.
PhosphoSitePlusiQ99959.
SwissPalmiQ99959.

Expressioni

Tissue specificityi

Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.2 Publications

Gene expression databases

BgeeiENSG00000057294.
CleanExiHS_PKP2.
ExpressionAtlasiQ99959. baseline and differential.
GenevisibleiQ99959. HS.

Organism-specific databases

HPAiHPA014314.
HPA056908.

Interactioni

Subunit structurei

Interacts with DSC2. Interacts with JUP and DSP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MTUS2Q5JR594EBI-702235,EBI-742948
NDEL1Q9GZM84EBI-702235,EBI-928842

GO - Molecular functioni

  • alpha-catenin binding Source: BHF-UCL
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
  • intermediate filament binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL
  • protein kinase C binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111335. 52 interactors.
IntActiQ99959. 37 interactors.
MINTiMINT-5001916.
STRINGi9606.ENSP00000070846.

Structurei

Secondary structure

1881
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi353 – 358Combined sources6
Helixi367 – 381Combined sources15
Helixi385 – 393Combined sources9
Helixi396 – 402Combined sources7
Helixi403 – 405Combined sources3
Helixi409 – 423Combined sources15
Helixi427 – 435Combined sources9
Helixi438 – 448Combined sources11
Helixi452 – 459Combined sources8
Helixi504 – 510Combined sources7
Helixi513 – 515Combined sources3
Helixi516 – 530Combined sources15
Helixi532 – 536Combined sources5
Helixi540 – 542Combined sources3
Helixi552 – 565Combined sources14
Helixi570 – 577Combined sources8
Helixi582 – 595Combined sources14
Helixi602 – 614Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TT9X-ray1.55A346-620[»]
ProteinModelPortaliQ99959.
SMRiQ99959.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati341 – 383ARM 1Add BLAST43
Repeati385 – 424ARM 2Add BLAST40
Repeati427 – 467ARM 3Add BLAST41
Repeati571 – 616ARM 4Add BLAST46
Repeati671 – 711ARM 5Add BLAST41
Repeati719 – 758ARM 6Add BLAST40
Repeati763 – 804ARM 7Add BLAST42
Repeati807 – 849ARM 8Add BLAST43

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 8 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000092312.
HOVERGENiHBG009157.
InParanoidiQ99959.
KOiK12642.
OMAiSWHQSSF.
OrthoDBiEOG091G01YT.
PhylomeDBiQ99959.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q99959-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGAPAEY GYIRTVLGQQ ILGQLDSSSL ALPSEAKLKL AGSSGRGGQT
60 70 80 90 100
VKSLRIQEQV QQTLARKGRS SVGNGNLHRT SSVPEYVYNL HLVENDFVGG
110 120 130 140 150
RSPVPKTYDM LKAGTTATYE GRWGRGTAQY SSQKSVEERS LRHPLRRLEI
160 170 180 190 200
SPDSSPERAH YTHSDYQYSQ RSQAGHTLHH QESRRAALLV PPRYARSEIV
210 220 230 240 250
GVSRAGTTSR QRHFDTYHRQ YQHGSVSDTV FDSIPANPAL LTYPRPGTSR
260 270 280 290 300
SMGNLLEKEN YLTAGLTVGQ VRPLVPLQPV TQNRASRSSW HQSSFHSTRT
310 320 330 340 350
LREAGPSVAV DSSGRRAHLT VGQAAAGGSG NLLTERSTFT DSQLGNADME
360 370 380 390 400
MTLERAVSML EADHMLPSRI SAAATFIQHE CFQKSEARKR VNQLRGILKL
410 420 430 440 450
LQLLKVQNED VQRAVCGALR NLVFEDNDNK LEVAELNGVP RLLQVLKQTR
460 470 480 490 500
DLETKKQITD HTVNLRSRNG WPGAVAHACN PSTLGGQGGR ITRSGVRDQP
510 520 530 540 550
DQHGLLWNLS SNDKLKNLMI TEALLTLTEN IIIPFSGWPE GDYPKANGLL
560 570 580 590 600
DFDIFYNVTG CLRNMSSAGA DGRKAMRRCD GLIDSLVHYV RGTIADYQPD
610 620 630 640 650
DKATENCVCI LHNLSYQLEA ELPEKYSQNI YIQNRNIQTD NNKSIGCFGS
660 670 680 690 700
RSRKVKEQYQ DVPMPEEKSN PKGVEWLWHS IVIRMYLSLI AKSVRNYTQE
710 720 730 740 750
ASLGALQNLT AGSGPMPTSV AQTVVQKESG LQHTRKMLHV GDPSVKKTAI
760 770 780 790 800
SLLRNLSRNL SLQNEIAKET LPDLVSIIPD TVPSTDLLIE TTASACYTLN
810 820 830 840 850
NIIQNSYQNA RDLLNTGGIQ KIMAISAGDA YASNKASKAA SVLLYSLWAH
860 870 880
TELHHAYKKA QFKKTDFVNS RTAKAYHSLK D
Note: Undetected in heart.
Length:881
Mass (Da):97,415
Last modified:May 18, 2010 - v2
Checksum:i947838B0C8275D5D
GO
Isoform 1 (identifier: Q99959-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     460-503: Missing.

Note: Major isoform in heart.
Show »
Length:837
Mass (Da):92,756
Checksum:i8E9553F9B820E8DF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06570126D → N Associated with increased susceptibility to arrhythmogenic right ventricular cardiomyopathy. 2 PublicationsCorresponds to variant rs143004808dbSNPEnsembl.1
Natural variantiVAR_06570258E → D.1 PublicationCorresponds to variant rs146708884dbSNPEnsembl.1
Natural variantiVAR_06570362Q → K Found in patients with arrhythmogenic right ventricular cardiomyopathy. 1 PublicationCorresponds to variant rs199601548dbSNPEnsembl.1
Natural variantiVAR_06570470S → I.3 PublicationsCorresponds to variant rs75909145dbSNPEnsembl.1
Natural variantiVAR_07027676N → S.1 Publication1
Natural variantiVAR_070277112K → N.1 Publication1
Natural variantiVAR_065705137E → K in ARVD9. 1 PublicationCorresponds to variant rs781739949dbSNPEnsembl.1
Natural variantiVAR_021148140S → F in ARVD9; uncertain pathological significance. 3 PublicationsCorresponds to variant rs150821281dbSNPEnsembl.1
Natural variantiVAR_065706169S → G in ARVD9. 1 PublicationCorresponds to variant rs139139859dbSNPEnsembl.1
Natural variantiVAR_065707195A → V.1 Publication1
Natural variantiVAR_065708276P → S.1 PublicationCorresponds to variant rs201944276dbSNPEnsembl.1
Natural variantiVAR_065709338T → A in a patient with arrhythmogenic right ventricular cardiomyopathy. 1 PublicationCorresponds to variant rs139851304dbSNPEnsembl.1
Natural variantiVAR_063108366L → P.5 PublicationsCorresponds to variant rs1046116dbSNPEnsembl.1
Natural variantiVAR_065710372A → P.2 PublicationsCorresponds to variant rs200586695dbSNPEnsembl.1
Natural variantiVAR_065711424F → S in ARVD9. 1 PublicationCorresponds to variant rs397516990dbSNPEnsembl.1
Natural variantiVAR_065712489G → R.1 PublicationCorresponds to variant rs111450489dbSNPEnsembl.1
Natural variantiVAR_070037490R → W.1 PublicationCorresponds to variant rs149930872dbSNPEnsembl.1
Natural variantiVAR_065713526T → M.1 PublicationCorresponds to variant rs146882581dbSNPEnsembl.1
Natural variantiVAR_065714531I → S.2 PublicationsCorresponds to variant rs147240502dbSNPEnsembl.1
Natural variantiVAR_065715587V → I Associated with increased susceptibility to arrhythmogenic right ventricular cardiomyopathy. 4 PublicationsCorresponds to variant rs146102241dbSNPEnsembl.1
Natural variantiVAR_021149615S → F in ARVD9; impairs protein stability. 2 Publications1
Natural variantiVAR_065716631Y → C in ARVD9. 1 Publication1
Natural variantiVAR_021150654K → Q in ARVD9; impairs protein stability. 2 Publications1
Natural variantiVAR_065717673G → V in a patient with arrhythmogenic right ventricular cardiomyopathy. 1 Publication1
Natural variantiVAR_065718787L → F in ARVD9. 1 Publication1
Natural variantiVAR_021151796C → R in ARVD9; impairs protein stability. 2 PublicationsCorresponds to variant rs794729098dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006736460 – 503Missing in isoform 1. 2 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97675 mRNA. Translation: CAA66264.1.
X97675 mRNA. Translation: CAA66265.1.
EU492903 Genomic DNA. Translation: ACD03459.1.
EU520483 mRNA. Translation: ACD13292.1.
EU520484 mRNA. Translation: ACD13293.1.
AC087311 Genomic DNA. No translation available.
AC087588 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88511.1.
CH471116 Genomic DNA. Translation: EAW88514.1.
CH471116 Genomic DNA. Translation: EAW88515.1.
BC094762 mRNA. Translation: AAH94762.1.
BC126199 mRNA. Translation: AAI26200.1.
BC143966 mRNA. Translation: AAI43967.1.
CCDSiCCDS31771.1. [Q99959-2]
CCDS8731.1. [Q99959-1]
RefSeqiNP_001005242.2. NM_001005242.2. [Q99959-2]
NP_004563.2. NM_004572.3. [Q99959-1]
UniGeneiHs.164384.

Genome annotation databases

EnsembliENST00000070846; ENSP00000070846; ENSG00000057294. [Q99959-1]
ENST00000340811; ENSP00000342800; ENSG00000057294. [Q99959-2]
GeneIDi5318.
KEGGihsa:5318.
UCSCiuc001rlj.5. human. [Q99959-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97675 mRNA. Translation: CAA66264.1.
X97675 mRNA. Translation: CAA66265.1.
EU492903 Genomic DNA. Translation: ACD03459.1.
EU520483 mRNA. Translation: ACD13292.1.
EU520484 mRNA. Translation: ACD13293.1.
AC087311 Genomic DNA. No translation available.
AC087588 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88511.1.
CH471116 Genomic DNA. Translation: EAW88514.1.
CH471116 Genomic DNA. Translation: EAW88515.1.
BC094762 mRNA. Translation: AAH94762.1.
BC126199 mRNA. Translation: AAI26200.1.
BC143966 mRNA. Translation: AAI43967.1.
CCDSiCCDS31771.1. [Q99959-2]
CCDS8731.1. [Q99959-1]
RefSeqiNP_001005242.2. NM_001005242.2. [Q99959-2]
NP_004563.2. NM_004572.3. [Q99959-1]
UniGeneiHs.164384.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TT9X-ray1.55A346-620[»]
ProteinModelPortaliQ99959.
SMRiQ99959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111335. 52 interactors.
IntActiQ99959. 37 interactors.
MINTiMINT-5001916.
STRINGi9606.ENSP00000070846.

PTM databases

iPTMnetiQ99959.
PhosphoSitePlusiQ99959.
SwissPalmiQ99959.

Polymorphism and mutation databases

BioMutaiPKP2.
DMDMi296452867.

Proteomic databases

EPDiQ99959.
MaxQBiQ99959.
PaxDbiQ99959.
PeptideAtlasiQ99959.
PRIDEiQ99959.

Protocols and materials databases

DNASUi5318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000070846; ENSP00000070846; ENSG00000057294. [Q99959-1]
ENST00000340811; ENSP00000342800; ENSG00000057294. [Q99959-2]
GeneIDi5318.
KEGGihsa:5318.
UCSCiuc001rlj.5. human. [Q99959-1]

Organism-specific databases

CTDi5318.
DisGeNETi5318.
GeneCardsiPKP2.
GeneReviewsiPKP2.
HGNCiHGNC:9024. PKP2.
HPAiHPA014314.
HPA056908.
MalaCardsiPKP2.
MIMi602861. gene.
609040. phenotype.
neXtProtiNX_Q99959.
OpenTargetsiENSG00000057294.
Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
PharmGKBiPA33357.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000092312.
HOVERGENiHBG009157.
InParanoidiQ99959.
KOiK12642.
OMAiSWHQSSF.
OrthoDBiEOG091G01YT.
PhylomeDBiQ99959.
TreeFamiTF321877.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000057294-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.
SignaLinkiQ99959.

Miscellaneous databases

ChiTaRSiPKP2. human.
GeneWikiiPKP2.
GenomeRNAii5318.
PROiQ99959.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000057294.
CleanExiHS_PKP2.
ExpressionAtlasiQ99959. baseline and differential.
GenevisibleiQ99959. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKP2_HUMAN
AccessioniPrimary (citable) accession number: Q99959
Secondary accession number(s): A0AV37
, B8QFA1, B8QGS6, B8QGS7, D3DUW9, Q4VC01, Q99960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.