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Protein

Plakophilin-2

Gene

PKP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in junctional plaques.1 Publication

GO - Molecular functioni

  • alpha-catenin binding Source: BHF-UCL
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
  • intermediate filament binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL
  • protein kinase C binding Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  • adherens junction maintenance Source: BHF-UCL
  • bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
  • cardiac muscle cell action potential Source: BHF-UCL
  • cardiac muscle cell action potential involved in contraction Source: BHF-UCL
  • cell-cell signaling involved in cardiac conduction Source: BHF-UCL
  • cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • desmosome assembly Source: BHF-UCL
  • establishment of protein localization to plasma membrane Source: BHF-UCL
  • gap junction assembly Source: BHF-UCL
  • heart development Source: BHF-UCL
  • intermediate filament bundle assembly Source: BHF-UCL
  • lipid homeostasis Source: BHF-UCL
  • maintenance of organ identity Source: BHF-UCL
  • negative regulation of cell migration Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • positive regulation of sodium ion transport Source: BHF-UCL
  • regulation of bicellular tight junction assembly Source: BHF-UCL
  • regulation of heart rate by cardiac conduction Source: BHF-UCL
  • regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
  • single organismal cell-cell adhesion Source: UniProtKB
  • ventricular cardiac muscle cell action potential Source: BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

SignaLinkiQ99959.

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-2
Gene namesi
Name:PKP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9024. PKP2.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: BHF-UCL
  • cell-cell adherens junction Source: BHF-UCL
  • cell-cell junction Source: BHF-UCL
  • cell junction Source: HPA
  • desmosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • intercalated disc Source: BHF-UCL
  • intermediate filament Source: BHF-UCL
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

Pathology & Biotechi

Involvement in diseasei

Arrhythmogenic right ventricular dysplasia, familial, 9 (ARVD9)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
See also OMIM:609040
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371E → K in ARVD9. 1 Publication
Corresponds to variant rs781739949 [ dbSNP | Ensembl ].
VAR_065705
Natural varianti140 – 1401S → F in ARVD9; uncertain pathological significance. 3 Publications
Corresponds to variant rs150821281 [ dbSNP | Ensembl ].
VAR_021148
Natural varianti169 – 1691S → G in ARVD9. 1 Publication
Corresponds to variant rs139139859 [ dbSNP | Ensembl ].
VAR_065706
Natural varianti424 – 4241F → S in ARVD9. 1 Publication
Corresponds to variant rs397516990 [ dbSNP | Ensembl ].
VAR_065711
Natural varianti615 – 6151S → F in ARVD9; impairs protein stability. 2 Publications
VAR_021149
Natural varianti631 – 6311Y → C in ARVD9. 1 Publication
VAR_065716
Natural varianti654 – 6541K → Q in ARVD9; impairs protein stability. 2 Publications
VAR_021150
Natural varianti787 – 7871L → F in ARVD9. 1 Publication
VAR_065718
Natural varianti796 – 7961C → R in ARVD9; impairs protein stability. 2 Publications
Corresponds to variant rs794729098 [ dbSNP | Ensembl ].
VAR_021151

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

MalaCardsiPKP2.
MIMi609040. phenotype.
Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
PharmGKBiPA33357.

Polymorphism and mutation databases

BioMutaiPKP2.
DMDMi296452867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881Plakophilin-2PRO_0000064286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphoserineCombined sources
Modified residuei132 – 1321PhosphoserineCombined sources
Modified residuei135 – 1351PhosphoserineCombined sources
Modified residuei151 – 1511PhosphoserineCombined sources
Modified residuei154 – 1541PhosphoserineCombined sources
Modified residuei155 – 1551PhosphoserineCombined sources
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei172 – 1721PhosphoserineCombined sources
Modified residuei177 – 1771PhosphothreonineCombined sources
Modified residuei183 – 1831PhosphoserineCombined sources
Modified residuei197 – 1971PhosphoserineCombined sources
Modified residuei251 – 2511PhosphoserineCombined sources
Modified residuei294 – 2941PhosphoserineCombined sources
Modified residuei329 – 3291PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99959.
MaxQBiQ99959.
PaxDbiQ99959.
PeptideAtlasiQ99959.
PRIDEiQ99959.

PTM databases

iPTMnetiQ99959.
PhosphoSiteiQ99959.
SwissPalmiQ99959.

Expressioni

Tissue specificityi

Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.2 Publications

Gene expression databases

BgeeiENSG00000057294.
CleanExiHS_PKP2.
ExpressionAtlasiQ99959. baseline and differential.
GenevisibleiQ99959. HS.

Organism-specific databases

HPAiHPA014314.
HPA056908.

Interactioni

Subunit structurei

Interacts with DSC2. Interacts with JUP and DSP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MTUS2Q5JR594EBI-702235,EBI-742948
NDEL1Q9GZM84EBI-702235,EBI-928842

GO - Molecular functioni

  • alpha-catenin binding Source: BHF-UCL
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
  • intermediate filament binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL
  • protein kinase C binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111335. 52 interactions.
IntActiQ99959. 28 interactions.
MINTiMINT-5001916.
STRINGi9606.ENSP00000070846.

Structurei

Secondary structure

1
881
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi353 – 3586Combined sources
Helixi367 – 38115Combined sources
Helixi385 – 3939Combined sources
Helixi396 – 4027Combined sources
Helixi403 – 4053Combined sources
Helixi409 – 42315Combined sources
Helixi427 – 4359Combined sources
Helixi438 – 44811Combined sources
Helixi452 – 4598Combined sources
Helixi504 – 5107Combined sources
Helixi513 – 5153Combined sources
Helixi516 – 53015Combined sources
Helixi532 – 5365Combined sources
Helixi540 – 5423Combined sources
Helixi552 – 56514Combined sources
Helixi570 – 5778Combined sources
Helixi582 – 59514Combined sources
Helixi602 – 61413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TT9X-ray1.55A346-620[»]
ProteinModelPortaliQ99959.
SMRiQ99959. Positions 346-854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati341 – 38343ARM 1Add
BLAST
Repeati385 – 42440ARM 2Add
BLAST
Repeati427 – 46741ARM 3Add
BLAST
Repeati571 – 61646ARM 4Add
BLAST
Repeati671 – 71141ARM 5Add
BLAST
Repeati719 – 75840ARM 6Add
BLAST
Repeati763 – 80442ARM 7Add
BLAST
Repeati807 – 84943ARM 8Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 8 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000092312.
HOVERGENiHBG009157.
InParanoidiQ99959.
KOiK12642.
OMAiSWHQSSF.
OrthoDBiEOG091G01YT.
PhylomeDBiQ99959.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q99959-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGAPAEY GYIRTVLGQQ ILGQLDSSSL ALPSEAKLKL AGSSGRGGQT
60 70 80 90 100
VKSLRIQEQV QQTLARKGRS SVGNGNLHRT SSVPEYVYNL HLVENDFVGG
110 120 130 140 150
RSPVPKTYDM LKAGTTATYE GRWGRGTAQY SSQKSVEERS LRHPLRRLEI
160 170 180 190 200
SPDSSPERAH YTHSDYQYSQ RSQAGHTLHH QESRRAALLV PPRYARSEIV
210 220 230 240 250
GVSRAGTTSR QRHFDTYHRQ YQHGSVSDTV FDSIPANPAL LTYPRPGTSR
260 270 280 290 300
SMGNLLEKEN YLTAGLTVGQ VRPLVPLQPV TQNRASRSSW HQSSFHSTRT
310 320 330 340 350
LREAGPSVAV DSSGRRAHLT VGQAAAGGSG NLLTERSTFT DSQLGNADME
360 370 380 390 400
MTLERAVSML EADHMLPSRI SAAATFIQHE CFQKSEARKR VNQLRGILKL
410 420 430 440 450
LQLLKVQNED VQRAVCGALR NLVFEDNDNK LEVAELNGVP RLLQVLKQTR
460 470 480 490 500
DLETKKQITD HTVNLRSRNG WPGAVAHACN PSTLGGQGGR ITRSGVRDQP
510 520 530 540 550
DQHGLLWNLS SNDKLKNLMI TEALLTLTEN IIIPFSGWPE GDYPKANGLL
560 570 580 590 600
DFDIFYNVTG CLRNMSSAGA DGRKAMRRCD GLIDSLVHYV RGTIADYQPD
610 620 630 640 650
DKATENCVCI LHNLSYQLEA ELPEKYSQNI YIQNRNIQTD NNKSIGCFGS
660 670 680 690 700
RSRKVKEQYQ DVPMPEEKSN PKGVEWLWHS IVIRMYLSLI AKSVRNYTQE
710 720 730 740 750
ASLGALQNLT AGSGPMPTSV AQTVVQKESG LQHTRKMLHV GDPSVKKTAI
760 770 780 790 800
SLLRNLSRNL SLQNEIAKET LPDLVSIIPD TVPSTDLLIE TTASACYTLN
810 820 830 840 850
NIIQNSYQNA RDLLNTGGIQ KIMAISAGDA YASNKASKAA SVLLYSLWAH
860 870 880
TELHHAYKKA QFKKTDFVNS RTAKAYHSLK D
Note: Undetected in heart.
Length:881
Mass (Da):97,415
Last modified:May 18, 2010 - v2
Checksum:i947838B0C8275D5D
GO
Isoform 1 (identifier: Q99959-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     460-503: Missing.

Note: Major isoform in heart.
Show »
Length:837
Mass (Da):92,756
Checksum:i8E9553F9B820E8DF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261D → N Associated with increased susceptibility to arrhythmogenic right ventricular cardiomyopathy. 2 Publications
Corresponds to variant rs143004808 [ dbSNP | Ensembl ].
VAR_065701
Natural varianti58 – 581E → D.1 Publication
Corresponds to variant rs146708884 [ dbSNP | Ensembl ].
VAR_065702
Natural varianti62 – 621Q → K Found in patients with arrhythmogenic right ventricular cardiomyopathy. 1 Publication
Corresponds to variant rs199601548 [ dbSNP | Ensembl ].
VAR_065703
Natural varianti70 – 701S → I.3 Publications
Corresponds to variant rs75909145 [ dbSNP | Ensembl ].
VAR_065704
Natural varianti76 – 761N → S.1 Publication
VAR_070276
Natural varianti112 – 1121K → N.1 Publication
VAR_070277
Natural varianti137 – 1371E → K in ARVD9. 1 Publication
Corresponds to variant rs781739949 [ dbSNP | Ensembl ].
VAR_065705
Natural varianti140 – 1401S → F in ARVD9; uncertain pathological significance. 3 Publications
Corresponds to variant rs150821281 [ dbSNP | Ensembl ].
VAR_021148
Natural varianti169 – 1691S → G in ARVD9. 1 Publication
Corresponds to variant rs139139859 [ dbSNP | Ensembl ].
VAR_065706
Natural varianti195 – 1951A → V.1 Publication
VAR_065707
Natural varianti276 – 2761P → S.1 Publication
Corresponds to variant rs201944276 [ dbSNP | Ensembl ].
VAR_065708
Natural varianti338 – 3381T → A in a patient with arrhythmogenic right ventricular cardiomyopathy. 1 Publication
Corresponds to variant rs139851304 [ dbSNP | Ensembl ].
VAR_065709
Natural varianti366 – 3661L → P.5 Publications
Corresponds to variant rs1046116 [ dbSNP | Ensembl ].
VAR_063108
Natural varianti372 – 3721A → P.2 Publications
Corresponds to variant rs200586695 [ dbSNP | Ensembl ].
VAR_065710
Natural varianti424 – 4241F → S in ARVD9. 1 Publication
Corresponds to variant rs397516990 [ dbSNP | Ensembl ].
VAR_065711
Natural varianti489 – 4891G → R.1 Publication
Corresponds to variant rs111450489 [ dbSNP | Ensembl ].
VAR_065712
Natural varianti490 – 4901R → W.1 Publication
Corresponds to variant rs149930872 [ dbSNP | Ensembl ].
VAR_070037
Natural varianti526 – 5261T → M.1 Publication
Corresponds to variant rs146882581 [ dbSNP | Ensembl ].
VAR_065713
Natural varianti531 – 5311I → S.2 Publications
Corresponds to variant rs147240502 [ dbSNP | Ensembl ].
VAR_065714
Natural varianti587 – 5871V → I Associated with increased susceptibility to arrhythmogenic right ventricular cardiomyopathy. 4 Publications
Corresponds to variant rs146102241 [ dbSNP | Ensembl ].
VAR_065715
Natural varianti615 – 6151S → F in ARVD9; impairs protein stability. 2 Publications
VAR_021149
Natural varianti631 – 6311Y → C in ARVD9. 1 Publication
VAR_065716
Natural varianti654 – 6541K → Q in ARVD9; impairs protein stability. 2 Publications
VAR_021150
Natural varianti673 – 6731G → V in a patient with arrhythmogenic right ventricular cardiomyopathy. 1 Publication
VAR_065717
Natural varianti787 – 7871L → F in ARVD9. 1 Publication
VAR_065718
Natural varianti796 – 7961C → R in ARVD9; impairs protein stability. 2 Publications
Corresponds to variant rs794729098 [ dbSNP | Ensembl ].
VAR_021151

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei460 – 50344Missing in isoform 1. 2 PublicationsVSP_006736Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97675 mRNA. Translation: CAA66264.1.
X97675 mRNA. Translation: CAA66265.1.
EU492903 Genomic DNA. Translation: ACD03459.1.
EU520483 mRNA. Translation: ACD13292.1.
EU520484 mRNA. Translation: ACD13293.1.
AC087311 Genomic DNA. No translation available.
AC087588 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88511.1.
CH471116 Genomic DNA. Translation: EAW88514.1.
CH471116 Genomic DNA. Translation: EAW88515.1.
BC094762 mRNA. Translation: AAH94762.1.
BC126199 mRNA. Translation: AAI26200.1.
BC143966 mRNA. Translation: AAI43967.1.
CCDSiCCDS31771.1. [Q99959-2]
CCDS8731.1. [Q99959-1]
RefSeqiNP_001005242.2. NM_001005242.2. [Q99959-2]
NP_004563.2. NM_004572.3. [Q99959-1]
UniGeneiHs.164384.

Genome annotation databases

EnsembliENST00000070846; ENSP00000070846; ENSG00000057294. [Q99959-1]
ENST00000340811; ENSP00000342800; ENSG00000057294. [Q99959-2]
GeneIDi5318.
KEGGihsa:5318.
UCSCiuc001rlj.5. human. [Q99959-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97675 mRNA. Translation: CAA66264.1.
X97675 mRNA. Translation: CAA66265.1.
EU492903 Genomic DNA. Translation: ACD03459.1.
EU520483 mRNA. Translation: ACD13292.1.
EU520484 mRNA. Translation: ACD13293.1.
AC087311 Genomic DNA. No translation available.
AC087588 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88511.1.
CH471116 Genomic DNA. Translation: EAW88514.1.
CH471116 Genomic DNA. Translation: EAW88515.1.
BC094762 mRNA. Translation: AAH94762.1.
BC126199 mRNA. Translation: AAI26200.1.
BC143966 mRNA. Translation: AAI43967.1.
CCDSiCCDS31771.1. [Q99959-2]
CCDS8731.1. [Q99959-1]
RefSeqiNP_001005242.2. NM_001005242.2. [Q99959-2]
NP_004563.2. NM_004572.3. [Q99959-1]
UniGeneiHs.164384.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TT9X-ray1.55A346-620[»]
ProteinModelPortaliQ99959.
SMRiQ99959. Positions 346-854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111335. 52 interactions.
IntActiQ99959. 28 interactions.
MINTiMINT-5001916.
STRINGi9606.ENSP00000070846.

PTM databases

iPTMnetiQ99959.
PhosphoSiteiQ99959.
SwissPalmiQ99959.

Polymorphism and mutation databases

BioMutaiPKP2.
DMDMi296452867.

Proteomic databases

EPDiQ99959.
MaxQBiQ99959.
PaxDbiQ99959.
PeptideAtlasiQ99959.
PRIDEiQ99959.

Protocols and materials databases

DNASUi5318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000070846; ENSP00000070846; ENSG00000057294. [Q99959-1]
ENST00000340811; ENSP00000342800; ENSG00000057294. [Q99959-2]
GeneIDi5318.
KEGGihsa:5318.
UCSCiuc001rlj.5. human. [Q99959-1]

Organism-specific databases

CTDi5318.
GeneCardsiPKP2.
GeneReviewsiPKP2.
HGNCiHGNC:9024. PKP2.
HPAiHPA014314.
HPA056908.
MalaCardsiPKP2.
MIMi602861. gene.
609040. phenotype.
neXtProtiNX_Q99959.
Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
PharmGKBiPA33357.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000092312.
HOVERGENiHBG009157.
InParanoidiQ99959.
KOiK12642.
OMAiSWHQSSF.
OrthoDBiEOG091G01YT.
PhylomeDBiQ99959.
TreeFamiTF321877.

Enzyme and pathway databases

SignaLinkiQ99959.

Miscellaneous databases

ChiTaRSiPKP2. human.
GeneWikiiPKP2.
GenomeRNAii5318.
PROiQ99959.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000057294.
CleanExiHS_PKP2.
ExpressionAtlasiQ99959. baseline and differential.
GenevisibleiQ99959. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKP2_HUMAN
AccessioniPrimary (citable) accession number: Q99959
Secondary accession number(s): A0AV37
, B8QFA1, B8QGS6, B8QGS7, D3DUW9, Q4VC01, Q99960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.