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Protein

Forkhead box protein C2

Gene

FOXC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi71 – 162Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176692-MONOMER.
SignaLinkiQ99958.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein C2
Alternative name(s):
Forkhead-related protein FKHL14
Mesenchyme fork head protein 1
Short name:
MFH-1 protein
Transcription factor FKH-14
Gene namesi
Name:FOXC2
Synonyms:FKHL14, MFH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:3801. FOXC2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Lymphedema-distichiasis (LYD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by primary limb lymphedema associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices). Swelling of the extremities, due to altered lymphatic flow, usually appears in late childhood or puberty. Most affected individuals have ocular findings including corneal irritation, recurrent conjunctivitis, and photophobia. Drooping of the upper eyelid (ptosis) is a variable feature of the lymphedema-distichiasis syndrome, occurring in about 30% of patients.
See also OMIM:153400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018418125S → L in LYD. 1 PublicationCorresponds to variant rs121909106dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi2303.
MalaCardsiFOXC2.
MIMi153400. phenotype.
OpenTargetsiENSG00000176692.
Orphaneti33001. Lymphedema - distichiasis.
PharmGKBiPA28218.

Polymorphism and mutation databases

BioMutaiFOXC2.
DMDMi3024149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918081 – 501Forkhead box protein C2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei215PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1 Publication1
Modified residuei232PhosphoserineCombined sources1 Publication1
Modified residuei235PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1 Publication1
Modified residuei247Phosphothreonine1 Publication1
Modified residuei251Phosphoserine1 Publication1
Modified residuei279Omega-N-methylarginineBy similarity1
Modified residuei281Phosphoserine1 Publication1
Modified residuei288PhosphoserineCombined sources1 Publication1
Modified residuei293Omega-N-methylarginineBy similarity1
Modified residuei367Phosphoserine1 Publication1
Modified residuei458Asymmetric dimethylarginineBy similarity1

Post-translational modificationi

Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ99958.
PaxDbiQ99958.
PeptideAtlasiQ99958.
PRIDEiQ99958.

PTM databases

iPTMnetiQ99958.
PhosphoSitePlusiQ99958.

Expressioni

Gene expression databases

BgeeiENSG00000176692.
CleanExiHS_FOXC2.
GenevisibleiQ99958. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-3956892,EBI-3956892
Q96IQ63EBI-3956892,EBI-10295632
RBPMSQ930623EBI-3956892,EBI-740322
TAX1BP1Q86VP13EBI-3956892,EBI-529518
TRIM27P143733EBI-3956892,EBI-719493

Protein-protein interaction databases

BioGridi108592. 35 interactors.
IntActiQ99958. 34 interactors.
STRINGi9606.ENSP00000326371.

Structurei

Secondary structure

1501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi77 – 86Combined sources10
Beta strandi89 – 93Combined sources5
Helixi95 – 105Combined sources11
Helixi108 – 111Combined sources4
Helixi116 – 126Combined sources11
Beta strandi128 – 132Combined sources5
Beta strandi146 – 148Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D5VNMR-A70-162[»]
ProteinModelPortaliQ99958.
SMRiQ99958.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99958.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi163 – 167Poly-Arg5
Compositional biasi387 – 396His-rich10
Compositional biasi397 – 414Pro-richAdd BLAST18

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ99958.
KOiK09396.
OMAiLNHLPGH.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ99958.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYSA
60 70 80 90 100
GMGRSYAPYH HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ
110 120 130 140 150
FIMDRFPFYR ENKQGWQNSI RHNLSLNECF VKVPRDDKKP GKGSYWTLDP
160 170 180 190 200
DSYNMFENGS FLRRRRRFKK KDVSKEKEER AHLKEPPPAA SKGAPATPHL
210 220 230 240 250
ADAPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS PRSAASTPAG
260 270 280 290 300
SPDGSLPEHH AAAPNGLPGF SVENIMTLRT SPPGGELSPG AGRAGLVVPP
310 320 330 340 350
LALPYAAAPP AAYGQPCAQG LEAGAAGGYQ CSMRAMSLYT GAERPAHMCV
360 370 380 390 400
PPALDEALSD HPSGPTSPLS ALNLAAGQEG ALAATGHHHQ HHGHHHPQAP
410 420 430 440 450
PPPPAPQPQP TPQPGAAAAQ AASWYLNHSG DLNHLPGHTF AAQQQTFPNV
460 470 480 490 500
REMFNSHRLG IENSTLGESQ VSGNASCQLP YRSTPPLYRH AAPYSYDCTK

Y
Length:501
Mass (Da):53,719
Last modified:May 1, 1997 - v1
Checksum:iF66513878EDC3A87
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018418125S → L in LYD. 1 PublicationCorresponds to variant rs121909106dbSNPEnsembl.1
Natural variantiVAR_060950191S → F.1 PublicationCorresponds to variant rs78018668dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08223 Genomic DNA. Translation: CAA69400.1.
GQ282998 Genomic DNA. Translation: ACS83751.1.
BC113437 mRNA. Translation: AAI13438.1.
BC113439 mRNA. Translation: AAI13440.1.
CCDSiCCDS10958.1.
RefSeqiNP_005242.1. NM_005251.2.
UniGeneiHs.436448.

Genome annotation databases

EnsembliENST00000320354; ENSP00000326371; ENSG00000176692.
GeneIDi2303.
KEGGihsa:2303.
UCSCiuc002fjq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08223 Genomic DNA. Translation: CAA69400.1.
GQ282998 Genomic DNA. Translation: ACS83751.1.
BC113437 mRNA. Translation: AAI13438.1.
BC113439 mRNA. Translation: AAI13440.1.
CCDSiCCDS10958.1.
RefSeqiNP_005242.1. NM_005251.2.
UniGeneiHs.436448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D5VNMR-A70-162[»]
ProteinModelPortaliQ99958.
SMRiQ99958.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108592. 35 interactors.
IntActiQ99958. 34 interactors.
STRINGi9606.ENSP00000326371.

PTM databases

iPTMnetiQ99958.
PhosphoSitePlusiQ99958.

Polymorphism and mutation databases

BioMutaiFOXC2.
DMDMi3024149.

Proteomic databases

MaxQBiQ99958.
PaxDbiQ99958.
PeptideAtlasiQ99958.
PRIDEiQ99958.

Protocols and materials databases

DNASUi2303.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320354; ENSP00000326371; ENSG00000176692.
GeneIDi2303.
KEGGihsa:2303.
UCSCiuc002fjq.4. human.

Organism-specific databases

CTDi2303.
DisGeNETi2303.
GeneCardsiFOXC2.
GeneReviewsiFOXC2.
HGNCiHGNC:3801. FOXC2.
MalaCardsiFOXC2.
MIMi153400. phenotype.
602402. gene.
neXtProtiNX_Q99958.
OpenTargetsiENSG00000176692.
Orphaneti33001. Lymphedema - distichiasis.
PharmGKBiPA28218.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ99958.
KOiK09396.
OMAiLNHLPGH.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ99958.
TreeFamiTF316127.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176692-MONOMER.
SignaLinkiQ99958.

Miscellaneous databases

EvolutionaryTraceiQ99958.
GeneWikiiFOXC2.
GenomeRNAii2303.
PROiQ99958.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176692.
CleanExiHS_FOXC2.
GenevisibleiQ99958. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXC2_HUMAN
AccessioniPrimary (citable) accession number: Q99958
Secondary accession number(s): C6KMR9, Q14DA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.