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Protein

Submaxillary gland androgen-regulated protein 3A

Gene

SMR3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a role in protection or detoxification.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Submaxillary gland androgen-regulated protein 3A
Alternative name(s):
Proline-rich protein 5
Proline-rich protein PBI
Gene namesi
Name:SMR3A
Synonyms:PBI, PROL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19216. SMR3A.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38824.

Polymorphism and mutation databases

BioMutaiSMR3A.
DMDMi296452907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 134112Submaxillary gland androgen-regulated protein 3APRO_0000022116Add
BLAST

Proteomic databases

PaxDbiQ99954.
PRIDEiQ99954.

Expressioni

Gene expression databases

BgeeiQ99954.
CleanExiHS_SMR3A.
GenevisibleiQ99954. HS.

Organism-specific databases

HPAiHPA044567.

Interactioni

Protein-protein interaction databases

BioGridi117923. 2 interactions.
STRINGi9606.ENSP00000226460.

Structurei

3D structure databases

ProteinModelPortaliQ99954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 134109Pro-richAdd
BLAST
Compositional biasi37 – 415Poly-Pro
Compositional biasi77 – 837Poly-Pro

Sequence similaritiesi

Belongs to the PROL1/PROL3 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KIJT. Eukaryota.
ENOG4110Q5Y. LUCA.
GeneTreeiENSGT00770000121019.
HOGENOMiHOG000170907.
HOVERGENiHBG093968.
InParanoidiQ99954.
OMAiGPPFFPV.
TreeFamiTF338396.

Family and domain databases

InterProiIPR026288. SMR-like.
[Graphical view]
PANTHERiPTHR14179. PTHR14179. 1 hit.
PfamiPF15621. PROL5-SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPPP PCFPFGTGFV
60 70 80 90 100
PPPHPPPYGP GRFPPPLSPP YGPGRIPPSP PPPYGPGRIQ SHSLPPPYGP
110 120 130
GYPQPPSQPR PYPPGPPFFP VNSPTDPALP TPAP
Length:134
Mass (Da):14,048
Last modified:May 18, 2010 - v2
Checksum:iBF0192C0D09C4A63
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281G → R.
Corresponds to variant rs10031844 [ dbSNP | Ensembl ].
VAR_056989
Natural varianti42 – 421C → R.1 Publication
Corresponds to variant rs10024123 [ dbSNP | Ensembl ].
VAR_060392
Natural varianti132 – 1321P → L.1 Publication
Corresponds to variant rs6853742 [ dbSNP | Ensembl ].
VAR_060393

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89501 Genomic DNA. Translation: BAA13971.1.
AC106884 Genomic DNA. No translation available.
CCDSiCCDS34000.1.
PIRiJC5572.
RefSeqiNP_036522.3. NM_012390.3.
UniGeneiHs.701334.

Genome annotation databases

EnsembliENST00000226460; ENSP00000226460; ENSG00000109208.
GeneIDi26952.
KEGGihsa:26952.
UCSCiuc003hfg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89501 Genomic DNA. Translation: BAA13971.1.
AC106884 Genomic DNA. No translation available.
CCDSiCCDS34000.1.
PIRiJC5572.
RefSeqiNP_036522.3. NM_012390.3.
UniGeneiHs.701334.

3D structure databases

ProteinModelPortaliQ99954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117923. 2 interactions.
STRINGi9606.ENSP00000226460.

Polymorphism and mutation databases

BioMutaiSMR3A.
DMDMi296452907.

Proteomic databases

PaxDbiQ99954.
PRIDEiQ99954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226460; ENSP00000226460; ENSG00000109208.
GeneIDi26952.
KEGGihsa:26952.
UCSCiuc003hfg.2. human.

Organism-specific databases

CTDi26952.
GeneCardsiSMR3A.
HGNCiHGNC:19216. SMR3A.
HPAiHPA044567.
neXtProtiNX_Q99954.
PharmGKBiPA38824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIJT. Eukaryota.
ENOG4110Q5Y. LUCA.
GeneTreeiENSGT00770000121019.
HOGENOMiHOG000170907.
HOVERGENiHBG093968.
InParanoidiQ99954.
OMAiGPPFFPV.
TreeFamiTF338396.

Miscellaneous databases

GenomeRNAii26952.
NextBioi49402.
PROiQ99954.

Gene expression databases

BgeeiQ99954.
CleanExiHS_SMR3A.
GenevisibleiQ99954. HS.

Family and domain databases

InterProiIPR026288. SMR-like.
[Graphical view]
PANTHERiPTHR14179. PTHR14179. 1 hit.
PfamiPF15621. PROL5-SMR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of gene PBI encoding a protein homologous to salivary proline-rich protein P-B."
    Isemura S., Saitoh E.
    J. Biochem. 121:1025-1030(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-42 AND LEU-132.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSMR3A_HUMAN
AccessioniPrimary (citable) accession number: Q99954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.