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Q99952

- PTN18_HUMAN

UniProt

Q99952 - PTN18_HUMAN

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Protein

Tyrosine-protein phosphatase non-receptor type 18

Gene

PTPN18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei197 – 1971SubstrateBy similarity
Active sitei229 – 2291Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei276 – 2761SubstrateBy similarity

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
  2. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)
Alternative name(s):
Brain-derived phosphatase
Gene namesi
Name:PTPN18
Synonyms:BDP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:9649. PTPN18.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Tyrosine-protein phosphatase non-receptor type 18PRO_0000094773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei389 – 3891PhosphotyrosineBy similarity
Modified residuei426 – 4261PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99952.
PaxDbiQ99952.
PRIDEiQ99952.

PTM databases

PhosphoSiteiQ99952.

Expressioni

Tissue specificityi

Expressed in brain, colon and several tumor-derived cell lines.1 Publication

Gene expression databases

BgeeiQ99952.
CleanExiHS_BDP1.
HS_PTPN18.
ExpressionAtlasiQ99952. baseline and differential.
GenevestigatoriQ99952.

Organism-specific databases

HPAiCAB012174.
HPA053367.

Interactioni

Subunit structurei

Interacts with PSTPIP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PSTPIP1O435864EBI-1384210,EBI-1050964

Protein-protein interaction databases

BioGridi117693. 2 interactions.
IntActiQ99952. 5 interactions.
MINTiMINT-2815851.
STRINGi9606.ENSP00000175756.

Structurei

Secondary structure

1
460
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 144Combined sources
Helixi20 – 223Combined sources
Helixi25 – 4319Combined sources
Helixi49 – 524Combined sources
Turni54 – 563Combined sources
Helixi57 – 593Combined sources
Helixi69 – 713Combined sources
Beta strandi72 – 743Combined sources
Helixi79 – 813Combined sources
Beta strandi85 – 939Combined sources
Beta strandi97 – 1048Combined sources
Helixi109 – 1113Combined sources
Helixi112 – 12110Combined sources
Beta strandi126 – 1294Combined sources
Beta strandi133 – 1353Combined sources
Beta strandi152 – 1543Combined sources
Beta strandi157 – 16812Combined sources
Beta strandi171 – 18010Combined sources
Beta strandi183 – 19210Combined sources
Beta strandi197 – 1993Combined sources
Helixi205 – 21814Combined sources
Beta strandi225 – 2284Combined sources
Beta strandi230 – 2334Combined sources
Helixi234 – 25017Combined sources
Helixi260 – 2689Combined sources
Helixi278 – 29215Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OC3X-ray1.50A6-299[»]
4GFUX-ray2.00A6-300[»]
4GFVX-ray2.10A/B6-300[»]
ProteinModelPortaliQ99952.
SMRiQ99952. Positions 7-295.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99952.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 291266Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 2357Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
InParanoidiQ99952.
KOiK18024.
OMAiNCAPLYD.
OrthoDBiEOG744T8Z.
PhylomeDBiQ99952.
TreeFamiTF351977.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99952-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA
60 70 80 90 100
GSRPENVRKN RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGVKVILMA CREIENGRKR CERYWAQEQE
160 170 180 190 200
PLQTGLFCIT LIKEKWLNED IMLRTLKVTF QKESRSVYQL QYMSWPDRGV
210 220 230 240 250
PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC TVDYVRQLLL
260 270 280 290 300
TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS
310 320 330 340 350
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM
360 370 380 390 400
ADTYAVVQKR GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG
410 420 430 440 450
AHAEDARGTL PGRVPADQSP AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP
460
RDPPAEWTRV
Length:460
Mass (Da):50,482
Last modified:November 25, 2008 - v2
Checksum:i67ED24A0504D1883
GO
Isoform 2 (identifier: Q99952-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-138: Missing.

Note: No experimental confirmation available.

Show »
Length:353
Mass (Da):38,476
Checksum:i12B3D38CA2A8A7DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti356 – 3572VV → EE in CAA56105. (PubMed:8950995)Curated
Sequence conflicti378 – 3792Missing in CAA56105. (PubMed:8950995)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931M → V.
Corresponds to variant rs3739124 [ dbSNP | Ensembl ].
VAR_047651

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 138107Missing in isoform 2. 1 PublicationVSP_043073Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79568 mRNA. Translation: CAA56105.1.
AK303804 mRNA. Translation: BAG64758.1.
AC132479 Genomic DNA. Translation: AAY24077.1.
CH471263 Genomic DNA. Translation: EAW55618.1.
CH471263 Genomic DNA. Translation: EAW55619.1.
CCDSiCCDS2161.1. [Q99952-1]
CCDS46410.1. [Q99952-2]
RefSeqiNP_001135842.1. NM_001142370.1. [Q99952-2]
NP_055184.2. NM_014369.3. [Q99952-1]
UniGeneiHs.516390.
Hs.744861.

Genome annotation databases

EnsembliENST00000175756; ENSP00000175756; ENSG00000072135. [Q99952-1]
ENST00000347849; ENSP00000310092; ENSG00000072135. [Q99952-2]
GeneIDi26469.
KEGGihsa:26469.
UCSCiuc002trb.3. human. [Q99952-2]
uc002trc.3. human. [Q99952-1]

Polymorphism databases

DMDMi215273871.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79568 mRNA. Translation: CAA56105.1 .
AK303804 mRNA. Translation: BAG64758.1 .
AC132479 Genomic DNA. Translation: AAY24077.1 .
CH471263 Genomic DNA. Translation: EAW55618.1 .
CH471263 Genomic DNA. Translation: EAW55619.1 .
CCDSi CCDS2161.1. [Q99952-1 ]
CCDS46410.1. [Q99952-2 ]
RefSeqi NP_001135842.1. NM_001142370.1. [Q99952-2 ]
NP_055184.2. NM_014369.3. [Q99952-1 ]
UniGenei Hs.516390.
Hs.744861.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OC3 X-ray 1.50 A 6-299 [» ]
4GFU X-ray 2.00 A 6-300 [» ]
4GFV X-ray 2.10 A/B 6-300 [» ]
ProteinModelPortali Q99952.
SMRi Q99952. Positions 7-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117693. 2 interactions.
IntActi Q99952. 5 interactions.
MINTi MINT-2815851.
STRINGi 9606.ENSP00000175756.

PTM databases

PhosphoSitei Q99952.

Polymorphism databases

DMDMi 215273871.

Proteomic databases

MaxQBi Q99952.
PaxDbi Q99952.
PRIDEi Q99952.

Protocols and materials databases

DNASUi 26469.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000175756 ; ENSP00000175756 ; ENSG00000072135 . [Q99952-1 ]
ENST00000347849 ; ENSP00000310092 ; ENSG00000072135 . [Q99952-2 ]
GeneIDi 26469.
KEGGi hsa:26469.
UCSCi uc002trb.3. human. [Q99952-2 ]
uc002trc.3. human. [Q99952-1 ]

Organism-specific databases

CTDi 26469.
GeneCardsi GC02P131113.
HGNCi HGNC:9649. PTPN18.
HPAi CAB012174.
HPA053367.
MIMi 606587. gene.
neXtProti NX_Q99952.
PharmGKBi PA33991.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00770000120452.
HOGENOMi HOG000115776.
HOVERGENi HBG053419.
InParanoidi Q99952.
KOi K18024.
OMAi NCAPLYD.
OrthoDBi EOG744T8Z.
PhylomeDBi Q99952.
TreeFami TF351977.

Miscellaneous databases

ChiTaRSi PTPN18. human.
EvolutionaryTracei Q99952.
GeneWikii PTPN18.
GenomeRNAii 26469.
NextBioi 48711.
PROi Q99952.
SOURCEi Search...

Gene expression databases

Bgeei Q99952.
CleanExi HS_BDP1.
HS_PTPN18.
ExpressionAtlasi Q99952. baseline and differential.
Genevestigatori Q99952.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the PEST family protein tyrosine phosphatase BDP1."
    Kim Y.W., Wang H.-Y., Sures I., Lammers R., Martell K.J., Ullrich A.
    Oncogene 13:2275-2279(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHARACTERIZATION.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 6-299.

Entry informationi

Entry nameiPTN18_HUMAN
AccessioniPrimary (citable) accession number: Q99952
Secondary accession number(s): B4E1E6, Q53P42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3