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Protein

Tyrosine-protein phosphatase non-receptor type 18

Gene

PTPN18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197SubstrateBy similarity1
Active sitei229Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei276SubstrateBy similarity1

GO - Molecular functioni

  • non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS01057-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)
Alternative name(s):
Brain-derived phosphatase
Gene namesi
Name:PTPN18
Synonyms:BDP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9649. PTPN18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26469.
OpenTargetsiENSG00000072135.
PharmGKBiPA33991.

Chemistry databases

ChEMBLiCHEMBL3351197.

Polymorphism and mutation databases

BioMutaiPTPN18.
DMDMi215273871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947731 – 460Tyrosine-protein phosphatase non-receptor type 18Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei393PhosphothreonineCombined sources1
Modified residuei426PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99952.
MaxQBiQ99952.
PaxDbiQ99952.
PeptideAtlasiQ99952.
PRIDEiQ99952.

PTM databases

DEPODiQ99952.
iPTMnetiQ99952.
PhosphoSitePlusiQ99952.

Expressioni

Tissue specificityi

Expressed in brain, colon and several tumor-derived cell lines.1 Publication

Gene expression databases

BgeeiENSG00000072135.
CleanExiHS_BDP1.
HS_PTPN18.
ExpressionAtlasiQ99952. baseline and differential.
GenevisibleiQ99952. HS.

Organism-specific databases

HPAiCAB012174.
HPA053367.

Interactioni

Subunit structurei

Interacts with PSTPIP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PSTPIP1O435864EBI-1384210,EBI-1050964

Protein-protein interaction databases

BioGridi117693. 5 interactors.
IntActiQ99952. 5 interactors.
MINTiMINT-2815851.
STRINGi9606.ENSP00000175756.

Chemistry databases

BindingDBiQ99952.

Structurei

Secondary structure

1460
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Helixi20 – 22Combined sources3
Helixi25 – 43Combined sources19
Helixi49 – 52Combined sources4
Turni54 – 56Combined sources3
Helixi57 – 59Combined sources3
Helixi69 – 71Combined sources3
Beta strandi72 – 74Combined sources3
Helixi79 – 81Combined sources3
Beta strandi85 – 93Combined sources9
Beta strandi97 – 104Combined sources8
Helixi109 – 111Combined sources3
Helixi112 – 121Combined sources10
Beta strandi126 – 129Combined sources4
Beta strandi133 – 135Combined sources3
Beta strandi152 – 154Combined sources3
Beta strandi157 – 168Combined sources12
Beta strandi171 – 180Combined sources10
Beta strandi183 – 192Combined sources10
Beta strandi197 – 199Combined sources3
Helixi205 – 218Combined sources14
Beta strandi220 – 222Combined sources3
Beta strandi225 – 228Combined sources4
Beta strandi230 – 233Combined sources4
Helixi234 – 250Combined sources17
Helixi260 – 268Combined sources9
Helixi278 – 292Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OC3X-ray1.50A6-299[»]
4GFUX-ray2.00A6-300[»]
4GFVX-ray2.10A/B6-300[»]
4NNDX-ray2.50A/B/D/G6-295[»]
ProteinModelPortaliQ99952.
SMRiQ99952.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99952.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 291Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 235Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
InParanoidiQ99952.
KOiK18024.
OMAiNCAPLYD.
OrthoDBiEOG091G0B5O.
PhylomeDBiQ99952.
TreeFamiTF351977.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA
60 70 80 90 100
GSRPENVRKN RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGVKVILMA CREIENGRKR CERYWAQEQE
160 170 180 190 200
PLQTGLFCIT LIKEKWLNED IMLRTLKVTF QKESRSVYQL QYMSWPDRGV
210 220 230 240 250
PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC TVDYVRQLLL
260 270 280 290 300
TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS
310 320 330 340 350
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM
360 370 380 390 400
ADTYAVVQKR GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG
410 420 430 440 450
AHAEDARGTL PGRVPADQSP AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP
460
RDPPAEWTRV
Length:460
Mass (Da):50,482
Last modified:November 25, 2008 - v2
Checksum:i67ED24A0504D1883
GO
Isoform 2 (identifier: Q99952-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-138: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):38,476
Checksum:i12B3D38CA2A8A7DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356 – 357VV → EE in CAA56105 (PubMed:8950995).Curated2
Sequence conflicti378 – 379Missing in CAA56105 (PubMed:8950995).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047651193M → V.Corresponds to variant rs3739124dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04307332 – 138Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79568 mRNA. Translation: CAA56105.1.
AK303804 mRNA. Translation: BAG64758.1.
AC132479 Genomic DNA. Translation: AAY24077.1.
CH471263 Genomic DNA. Translation: EAW55618.1.
CH471263 Genomic DNA. Translation: EAW55619.1.
CCDSiCCDS2161.1. [Q99952-1]
CCDS46410.1. [Q99952-2]
RefSeqiNP_001135842.1. NM_001142370.1. [Q99952-2]
NP_055184.2. NM_014369.3. [Q99952-1]
UniGeneiHs.516390.
Hs.744861.

Genome annotation databases

EnsembliENST00000175756; ENSP00000175756; ENSG00000072135. [Q99952-1]
ENST00000347849; ENSP00000310092; ENSG00000072135. [Q99952-2]
GeneIDi26469.
KEGGihsa:26469.
UCSCiuc002trb.4. human. [Q99952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79568 mRNA. Translation: CAA56105.1.
AK303804 mRNA. Translation: BAG64758.1.
AC132479 Genomic DNA. Translation: AAY24077.1.
CH471263 Genomic DNA. Translation: EAW55618.1.
CH471263 Genomic DNA. Translation: EAW55619.1.
CCDSiCCDS2161.1. [Q99952-1]
CCDS46410.1. [Q99952-2]
RefSeqiNP_001135842.1. NM_001142370.1. [Q99952-2]
NP_055184.2. NM_014369.3. [Q99952-1]
UniGeneiHs.516390.
Hs.744861.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OC3X-ray1.50A6-299[»]
4GFUX-ray2.00A6-300[»]
4GFVX-ray2.10A/B6-300[»]
4NNDX-ray2.50A/B/D/G6-295[»]
ProteinModelPortaliQ99952.
SMRiQ99952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117693. 5 interactors.
IntActiQ99952. 5 interactors.
MINTiMINT-2815851.
STRINGi9606.ENSP00000175756.

Chemistry databases

BindingDBiQ99952.
ChEMBLiCHEMBL3351197.

PTM databases

DEPODiQ99952.
iPTMnetiQ99952.
PhosphoSitePlusiQ99952.

Polymorphism and mutation databases

BioMutaiPTPN18.
DMDMi215273871.

Proteomic databases

EPDiQ99952.
MaxQBiQ99952.
PaxDbiQ99952.
PeptideAtlasiQ99952.
PRIDEiQ99952.

Protocols and materials databases

DNASUi26469.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000175756; ENSP00000175756; ENSG00000072135. [Q99952-1]
ENST00000347849; ENSP00000310092; ENSG00000072135. [Q99952-2]
GeneIDi26469.
KEGGihsa:26469.
UCSCiuc002trb.4. human. [Q99952-1]

Organism-specific databases

CTDi26469.
DisGeNETi26469.
GeneCardsiPTPN18.
HGNCiHGNC:9649. PTPN18.
HPAiCAB012174.
HPA053367.
MIMi606587. gene.
neXtProtiNX_Q99952.
OpenTargetsiENSG00000072135.
PharmGKBiPA33991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
InParanoidiQ99952.
KOiK18024.
OMAiNCAPLYD.
OrthoDBiEOG091G0B5O.
PhylomeDBiQ99952.
TreeFamiTF351977.

Enzyme and pathway databases

BioCyciZFISH:HS01057-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-8863795. Downregulation of ERBB2 signaling.

Miscellaneous databases

ChiTaRSiPTPN18. human.
EvolutionaryTraceiQ99952.
GeneWikiiPTPN18.
GenomeRNAii26469.
PROiQ99952.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072135.
CleanExiHS_BDP1.
HS_PTPN18.
ExpressionAtlasiQ99952. baseline and differential.
GenevisibleiQ99952. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN18_HUMAN
AccessioniPrimary (citable) accession number: Q99952
Secondary accession number(s): B4E1E6, Q53P42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.