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Protein

Epidermal growth factor-like protein 8

Gene

EGFL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 8
Short name:
EGF-like protein 8
Alternative name(s):
Vascular endothelial statin-2
Short name:
VE-statin-2
Gene namesi
Name:EGFL8
Synonyms:C6orf8, NG3
ORF Names:UNQ8752/PRO29920
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000241404.6.
HGNCiHGNC:13944. EGFL8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80864.
OpenTargetsiENSG00000241404.
PharmGKBiPA38372.

Polymorphism and mutation databases

BioMutaiEGFL8.
DMDMi55584040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000000753126 – 293Epidermal growth factor-like protein 8Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 97By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi65 ↔ 71By similarity
Disulfide bondi96 ↔ 110By similarity
Disulfide bondi114 ↔ 124By similarity
Disulfide bondi118 ↔ 130By similarity
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi148 ↔ 159By similarity
Disulfide bondi155 ↔ 168By similarity
Disulfide bondi170 ↔ 183By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99944.
PeptideAtlasiQ99944.
PRIDEiQ99944.

PTM databases

iPTMnetiQ99944.
PhosphoSitePlusiQ99944.

Expressioni

Gene expression databases

BgeeiENSG00000241404.
CleanExiHS_EGFL8.
ExpressionAtlasiQ99944. baseline and differential.
GenevisibleiQ99944. HS.

Organism-specific databases

HPAiHPA061173.

Interactioni

Protein-protein interaction databases

BioGridi123336. 9 interactors.
IntActiQ99944. 2 interactors.
STRINGi9606.ENSP00000463517.

Structurei

3D structure databases

ProteinModelPortaliQ99944.
SMRiQ99944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 112EMIPROSITE-ProRule annotationAdd BLAST79
Domaini111 – 142EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini144 – 184EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili195 – 232Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR79. Eukaryota.
ENOG41129FY. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ99944.
OMAiTCSCEDN.
OrthoDBiEOG09370D4F.
TreeFamiTF331360.

Family and domain databases

InterProiView protein in InterPro
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011489. EMI_domain.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRAELCTL LGGFSFLLLL IPGEGAKGGS LRESQGVCSK QTLVVPLHYN
60 70 80 90 100
ESYSQPVYKP YLTLCAGRRI CSTYRTMYRV MWREVRREVQ QTHAVCCQGW
110 120 130 140 150
KKRHPGALTC EAICAKPCLN GGVCVRPDQC ECAPGWGGKH CHVDVDECRT
160 170 180 190 200
SITLCSHHCF NTAGSFTCGC PHDLVLGVDG RTCMEGSPEP PTSASILSVA
210 220 230 240 250
VREAEKDERA LKQEIHELRG RLERLEQWAG QAGAWVRAVL PVPPEELQPE
260 270 280 290
QVAELWGRGD RIESLSDQVL LLEERLGACS CEDNSLGLGV NHR
Length:293
Mass (Da):32,262
Last modified:May 1, 1997 - v1
Checksum:i6519CA254FB23FD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273E → Q in AAH35574 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01979286R → K1 PublicationCorresponds to variant dbSNP:rs3096697Ensembl.1
Natural variantiVAR_019793204A → E. Corresponds to variant dbSNP:rs2071289Ensembl.1
Natural variantiVAR_048983277G → C. Corresponds to variant dbSNP:rs35587174Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190520 mRNA. Translation: BAD51398.1.
AY358139 mRNA. Translation: AAQ88506.1.
U89336 Genomic DNA. Translation: AAB47494.1.
AL662828 Genomic DNA. No translation available.
AL662884 Genomic DNA. No translation available.
AL845464 Genomic DNA. No translation available.
BX284686 Genomic DNA. No translation available.
BX927239 Genomic DNA. No translation available.
CR933878 Genomic DNA. No translation available.
CR812478 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03598.1.
BC035574 mRNA. Translation: AAH35574.1.
BC052591 mRNA. Translation: AAH52591.1.
CCDSiCCDS4743.1.
RefSeqiNP_085155.1. NM_030652.3.
UniGeneiHs.731888.

Genome annotation databases

EnsembliENST00000333845; ENSP00000333380; ENSG00000241404.
ENST00000395512; ENSP00000378888; ENSG00000241404.
ENST00000399648; ENSP00000382556; ENSG00000242038.
ENST00000413733; ENSP00000390866; ENSG00000239974.
ENST00000414111; ENSP00000415577; ENSG00000240389.
ENST00000418252; ENSP00000414996; ENSG00000244444.
ENST00000433364; ENSP00000388000; ENSG00000240389.
ENST00000436155; ENSP00000405502; ENSG00000243897.
ENST00000443511; ENSP00000394193; ENSG00000244444.
ENST00000447331; ENSP00000407236; ENSG00000242038.
ENST00000450526; ENSP00000398893; ENSG00000243897.
ENST00000452189; ENSP00000397426; ENSG00000239974.
ENST00000452290; ENSP00000416366; ENSG00000240592.
ENST00000455889; ENSP00000411023; ENSG00000240592.
GeneIDi80864.
KEGGihsa:80864.
UCSCiuc003oab.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEGFL8_HUMAN
AccessioniPrimary (citable) accession number: Q99944
Secondary accession number(s): B0S884
, G5E9Q0, Q5JP23, Q5SSX3, Q8IV30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: May 1, 1997
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot