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Protein

Epidermal growth factor-like protein 8

Gene

EGFL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 8
Short name:
EGF-like protein 8
Alternative name(s):
Vascular endothelial statin-2
Short name:
VE-statin-2
Gene namesi
Name:EGFL8
Synonyms:C6orf8, NG3
ORF Names:UNQ8752/PRO29920
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13944. EGFL8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38372.

Polymorphism and mutation databases

BioMutaiEGFL8.
DMDMi55584040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 293268Epidermal growth factor-like protein 8PRO_0000007531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 97By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi65 ↔ 71By similarity
Disulfide bondi96 ↔ 110By similarity
Disulfide bondi114 ↔ 124By similarity
Disulfide bondi118 ↔ 130By similarity
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi148 ↔ 159By similarity
Disulfide bondi155 ↔ 168By similarity
Disulfide bondi170 ↔ 183By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99944.
PeptideAtlasiQ99944.
PRIDEiQ99944.

PTM databases

iPTMnetiQ99944.

Expressioni

Gene expression databases

BgeeiQ99944.
CleanExiHS_EGFL8.
ExpressionAtlasiQ99944. baseline and differential.
GenevisibleiQ99944. HS.

Interactioni

Protein-protein interaction databases

BioGridi123336. 9 interactions.
IntActiQ99944. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ99944.
SMRiQ99944. Positions 115-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11279EMIPROSITE-ProRule annotationAdd
BLAST
Domaini111 – 14232EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 18441EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili195 – 23238Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR79. Eukaryota.
ENOG41129FY. LUCA.
GeneTreeiENSGT00840000129786.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ99944.
OMAiTCSCEDN.
TreeFamiTF331360.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRAELCTL LGGFSFLLLL IPGEGAKGGS LRESQGVCSK QTLVVPLHYN
60 70 80 90 100
ESYSQPVYKP YLTLCAGRRI CSTYRTMYRV MWREVRREVQ QTHAVCCQGW
110 120 130 140 150
KKRHPGALTC EAICAKPCLN GGVCVRPDQC ECAPGWGGKH CHVDVDECRT
160 170 180 190 200
SITLCSHHCF NTAGSFTCGC PHDLVLGVDG RTCMEGSPEP PTSASILSVA
210 220 230 240 250
VREAEKDERA LKQEIHELRG RLERLEQWAG QAGAWVRAVL PVPPEELQPE
260 270 280 290
QVAELWGRGD RIESLSDQVL LLEERLGACS CEDNSLGLGV NHR
Length:293
Mass (Da):32,262
Last modified:May 1, 1997 - v1
Checksum:i6519CA254FB23FD0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731E → Q in AAH35574 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861R → K.1 Publication
Corresponds to variant rs3096697 [ dbSNP | Ensembl ].
VAR_019792
Natural varianti204 – 2041A → E.
Corresponds to variant rs2071289 [ dbSNP | Ensembl ].
VAR_019793
Natural varianti277 – 2771G → C.
Corresponds to variant rs35587174 [ dbSNP | Ensembl ].
VAR_048983

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190520 mRNA. Translation: BAD51398.1.
AY358139 mRNA. Translation: AAQ88506.1.
U89336 Genomic DNA. Translation: AAB47494.1.
AL662828 Genomic DNA. Translation: CAI17428.1.
AL662884 Genomic DNA. Translation: CAI18345.2.
AL845464 Genomic DNA. Translation: CAI41800.2.
BX284686 Genomic DNA. Translation: CAM26220.1.
BX927239 Genomic DNA. Translation: CAQ06592.1.
CR933878 Genomic DNA. Translation: CAQ09621.1.
CR812478 Genomic DNA. Translation: CAQ10696.1.
CH471081 Genomic DNA. Translation: EAX03598.1.
BC035574 mRNA. Translation: AAH35574.1.
BC052591 mRNA. Translation: AAH52591.1.
CCDSiCCDS4743.1.
RefSeqiNP_085155.1. NM_030652.3.
UniGeneiHs.731888.

Genome annotation databases

EnsembliENST00000333845; ENSP00000333380; ENSG00000241404.
ENST00000395512; ENSP00000378888; ENSG00000241404.
ENST00000399648; ENSP00000382556; ENSG00000242038.
ENST00000413733; ENSP00000390866; ENSG00000239974.
ENST00000414111; ENSP00000415577; ENSG00000240389.
ENST00000418252; ENSP00000414996; ENSG00000244444.
ENST00000433364; ENSP00000388000; ENSG00000240389.
ENST00000436155; ENSP00000405502; ENSG00000243897.
ENST00000443511; ENSP00000394193; ENSG00000244444.
ENST00000447331; ENSP00000407236; ENSG00000242038.
ENST00000450526; ENSP00000398893; ENSG00000243897.
ENST00000452189; ENSP00000397426; ENSG00000239974.
ENST00000452290; ENSP00000416366; ENSG00000240592.
ENST00000455889; ENSP00000411023; ENSG00000240592.
GeneIDi80864.
KEGGihsa:80864.
UCSCiuc003oab.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190520 mRNA. Translation: BAD51398.1.
AY358139 mRNA. Translation: AAQ88506.1.
U89336 Genomic DNA. Translation: AAB47494.1.
AL662828 Genomic DNA. Translation: CAI17428.1.
AL662884 Genomic DNA. Translation: CAI18345.2.
AL845464 Genomic DNA. Translation: CAI41800.2.
BX284686 Genomic DNA. Translation: CAM26220.1.
BX927239 Genomic DNA. Translation: CAQ06592.1.
CR933878 Genomic DNA. Translation: CAQ09621.1.
CR812478 Genomic DNA. Translation: CAQ10696.1.
CH471081 Genomic DNA. Translation: EAX03598.1.
BC035574 mRNA. Translation: AAH35574.1.
BC052591 mRNA. Translation: AAH52591.1.
CCDSiCCDS4743.1.
RefSeqiNP_085155.1. NM_030652.3.
UniGeneiHs.731888.

3D structure databases

ProteinModelPortaliQ99944.
SMRiQ99944. Positions 115-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123336. 9 interactions.
IntActiQ99944. 2 interactions.

PTM databases

iPTMnetiQ99944.

Polymorphism and mutation databases

BioMutaiEGFL8.
DMDMi55584040.

Proteomic databases

PaxDbiQ99944.
PeptideAtlasiQ99944.
PRIDEiQ99944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333845; ENSP00000333380; ENSG00000241404.
ENST00000395512; ENSP00000378888; ENSG00000241404.
ENST00000399648; ENSP00000382556; ENSG00000242038.
ENST00000413733; ENSP00000390866; ENSG00000239974.
ENST00000414111; ENSP00000415577; ENSG00000240389.
ENST00000418252; ENSP00000414996; ENSG00000244444.
ENST00000433364; ENSP00000388000; ENSG00000240389.
ENST00000436155; ENSP00000405502; ENSG00000243897.
ENST00000443511; ENSP00000394193; ENSG00000244444.
ENST00000447331; ENSP00000407236; ENSG00000242038.
ENST00000450526; ENSP00000398893; ENSG00000243897.
ENST00000452189; ENSP00000397426; ENSG00000239974.
ENST00000452290; ENSP00000416366; ENSG00000240592.
ENST00000455889; ENSP00000411023; ENSG00000240592.
GeneIDi80864.
KEGGihsa:80864.
UCSCiuc003oab.2. human.

Organism-specific databases

CTDi80864.
GeneCardsiEGFL8.
HGNCiHGNC:13944. EGFL8.
MIMi609897. gene.
neXtProtiNX_Q99944.
PharmGKBiPA38372.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR79. Eukaryota.
ENOG41129FY. LUCA.
GeneTreeiENSGT00840000129786.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ99944.
OMAiTCSCEDN.
TreeFamiTF331360.

Miscellaneous databases

GenomeRNAii80864.
PROiQ99944.
SOURCEiSearch...

Gene expression databases

BgeeiQ99944.
CleanExiHS_EGFL8.
ExpressionAtlasiQ99944. baseline and differential.
GenevisibleiQ99944. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene regulating tumor angiogenesis."
    Tanaka S.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-86.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40.

Entry informationi

Entry nameiEGFL8_HUMAN
AccessioniPrimary (citable) accession number: Q99944
Secondary accession number(s): B0S884
, G5E9Q0, Q5JP23, Q5SSX3, Q8IV30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.