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Protein

Epidermal growth factor-like protein 8

Gene

EGFL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-33101-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 8
Short name:
EGF-like protein 8
Alternative name(s):
Vascular endothelial statin-2
Short name:
VE-statin-2
Gene namesi
Name:EGFL8
Synonyms:C6orf8, NG3
ORF Names:UNQ8752/PRO29920
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13944. EGFL8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80864.
OpenTargetsiENSG00000239974.
ENSG00000240389.
ENSG00000240592.
ENSG00000241404.
ENSG00000243897.
ENSG00000244444.
PharmGKBiPA38372.

Polymorphism and mutation databases

BioMutaiEGFL8.
DMDMi55584040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000000753126 – 293Epidermal growth factor-like protein 8Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 97By similarity
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi65 ↔ 71By similarity
Disulfide bondi96 ↔ 110By similarity
Disulfide bondi114 ↔ 124By similarity
Disulfide bondi118 ↔ 130By similarity
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi148 ↔ 159By similarity
Disulfide bondi155 ↔ 168By similarity
Disulfide bondi170 ↔ 183By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99944.
PeptideAtlasiQ99944.
PRIDEiQ99944.

PTM databases

iPTMnetiQ99944.
PhosphoSitePlusiQ99944.

Expressioni

Gene expression databases

BgeeiENSG00000239974.
CleanExiHS_EGFL8.
ExpressionAtlasiQ99944. baseline and differential.
GenevisibleiQ99944. HS.

Organism-specific databases

HPAiHPA061173.

Interactioni

Protein-protein interaction databases

BioGridi123336. 9 interactors.
IntActiQ99944. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ99944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 112EMIPROSITE-ProRule annotationAdd BLAST79
Domaini111 – 142EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini144 – 184EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili195 – 232Sequence analysisAdd BLAST38

Sequence similaritiesi

Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR79. Eukaryota.
ENOG41129FY. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ99944.
OMAiTCSCEDN.
OrthoDBiEOG091G0I7L.
TreeFamiTF331360.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRAELCTL LGGFSFLLLL IPGEGAKGGS LRESQGVCSK QTLVVPLHYN
60 70 80 90 100
ESYSQPVYKP YLTLCAGRRI CSTYRTMYRV MWREVRREVQ QTHAVCCQGW
110 120 130 140 150
KKRHPGALTC EAICAKPCLN GGVCVRPDQC ECAPGWGGKH CHVDVDECRT
160 170 180 190 200
SITLCSHHCF NTAGSFTCGC PHDLVLGVDG RTCMEGSPEP PTSASILSVA
210 220 230 240 250
VREAEKDERA LKQEIHELRG RLERLEQWAG QAGAWVRAVL PVPPEELQPE
260 270 280 290
QVAELWGRGD RIESLSDQVL LLEERLGACS CEDNSLGLGV NHR
Length:293
Mass (Da):32,262
Last modified:May 1, 1997 - v1
Checksum:i6519CA254FB23FD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273E → Q in AAH35574 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01979286R → K.1 PublicationCorresponds to variant rs3096697dbSNPEnsembl.1
Natural variantiVAR_019793204A → E.Corresponds to variant rs2071289dbSNPEnsembl.1
Natural variantiVAR_048983277G → C.Corresponds to variant rs35587174dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190520 mRNA. Translation: BAD51398.1.
AY358139 mRNA. Translation: AAQ88506.1.
U89336 Genomic DNA. Translation: AAB47494.1.
AL662828 Genomic DNA. Translation: CAI17428.1.
AL662884 Genomic DNA. Translation: CAI18345.2.
AL845464 Genomic DNA. Translation: CAI41800.2.
BX284686 Genomic DNA. Translation: CAM26220.1.
BX927239 Genomic DNA. Translation: CAQ06592.1.
CR933878 Genomic DNA. Translation: CAQ09621.1.
CR812478 Genomic DNA. Translation: CAQ10696.1.
CH471081 Genomic DNA. Translation: EAX03598.1.
BC035574 mRNA. Translation: AAH35574.1.
BC052591 mRNA. Translation: AAH52591.1.
CCDSiCCDS4743.1.
RefSeqiNP_085155.1. NM_030652.3.
UniGeneiHs.731888.

Genome annotation databases

EnsembliENST00000333845; ENSP00000333380; ENSG00000241404.
ENST00000395512; ENSP00000378888; ENSG00000241404.
ENST00000399648; ENSP00000382556; ENSG00000242038.
ENST00000413733; ENSP00000390866; ENSG00000239974.
ENST00000414111; ENSP00000415577; ENSG00000240389.
ENST00000418252; ENSP00000414996; ENSG00000244444.
ENST00000433364; ENSP00000388000; ENSG00000240389.
ENST00000436155; ENSP00000405502; ENSG00000243897.
ENST00000443511; ENSP00000394193; ENSG00000244444.
ENST00000447331; ENSP00000407236; ENSG00000242038.
ENST00000450526; ENSP00000398893; ENSG00000243897.
ENST00000452189; ENSP00000397426; ENSG00000239974.
ENST00000452290; ENSP00000416366; ENSG00000240592.
ENST00000455889; ENSP00000411023; ENSG00000240592.
GeneIDi80864.
KEGGihsa:80864.
UCSCiuc003oab.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190520 mRNA. Translation: BAD51398.1.
AY358139 mRNA. Translation: AAQ88506.1.
U89336 Genomic DNA. Translation: AAB47494.1.
AL662828 Genomic DNA. Translation: CAI17428.1.
AL662884 Genomic DNA. Translation: CAI18345.2.
AL845464 Genomic DNA. Translation: CAI41800.2.
BX284686 Genomic DNA. Translation: CAM26220.1.
BX927239 Genomic DNA. Translation: CAQ06592.1.
CR933878 Genomic DNA. Translation: CAQ09621.1.
CR812478 Genomic DNA. Translation: CAQ10696.1.
CH471081 Genomic DNA. Translation: EAX03598.1.
BC035574 mRNA. Translation: AAH35574.1.
BC052591 mRNA. Translation: AAH52591.1.
CCDSiCCDS4743.1.
RefSeqiNP_085155.1. NM_030652.3.
UniGeneiHs.731888.

3D structure databases

ProteinModelPortaliQ99944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123336. 9 interactors.
IntActiQ99944. 2 interactors.

PTM databases

iPTMnetiQ99944.
PhosphoSitePlusiQ99944.

Polymorphism and mutation databases

BioMutaiEGFL8.
DMDMi55584040.

Proteomic databases

PaxDbiQ99944.
PeptideAtlasiQ99944.
PRIDEiQ99944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333845; ENSP00000333380; ENSG00000241404.
ENST00000395512; ENSP00000378888; ENSG00000241404.
ENST00000399648; ENSP00000382556; ENSG00000242038.
ENST00000413733; ENSP00000390866; ENSG00000239974.
ENST00000414111; ENSP00000415577; ENSG00000240389.
ENST00000418252; ENSP00000414996; ENSG00000244444.
ENST00000433364; ENSP00000388000; ENSG00000240389.
ENST00000436155; ENSP00000405502; ENSG00000243897.
ENST00000443511; ENSP00000394193; ENSG00000244444.
ENST00000447331; ENSP00000407236; ENSG00000242038.
ENST00000450526; ENSP00000398893; ENSG00000243897.
ENST00000452189; ENSP00000397426; ENSG00000239974.
ENST00000452290; ENSP00000416366; ENSG00000240592.
ENST00000455889; ENSP00000411023; ENSG00000240592.
GeneIDi80864.
KEGGihsa:80864.
UCSCiuc003oab.2. human.

Organism-specific databases

CTDi80864.
DisGeNETi80864.
GeneCardsiEGFL8.
HGNCiHGNC:13944. EGFL8.
HPAiHPA061173.
MIMi609897. gene.
neXtProtiNX_Q99944.
OpenTargetsiENSG00000239974.
ENSG00000240389.
ENSG00000240592.
ENSG00000241404.
ENSG00000243897.
ENSG00000244444.
PharmGKBiPA38372.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR79. Eukaryota.
ENOG41129FY. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ99944.
OMAiTCSCEDN.
OrthoDBiEOG091G0I7L.
TreeFamiTF331360.

Enzyme and pathway databases

BioCyciZFISH:G66-33101-MONOMER.

Miscellaneous databases

GenomeRNAii80864.
PROiQ99944.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239974.
CleanExiHS_EGFL8.
ExpressionAtlasiQ99944. baseline and differential.
GenevisibleiQ99944. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGFL8_HUMAN
AccessioniPrimary (citable) accession number: Q99944
Secondary accession number(s): B0S884
, G5E9Q0, Q5JP23, Q5SSX3, Q8IV30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.