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Reviewed, UniProtKB/Swiss-Prot Q99943 (PLCA_HUMAN)

Last modified February 9, 2010. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    EC=2.3.1.51
Alternative name(s):
    1-acylglycerol-3-phosphate O-acyltransferase 1
      Short name=1-AGP acyltransferase 1
      Short name=1-AGPAT 1
    Lysophosphatidic acid acyltransferase alpha
      Short name=LPAAT-alpha
    Protein G15
Gene names
Name: AGPAT1
Synonyms: G15
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Catalytic activity

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Domain

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.

Sequence similarities

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2832831-acyl-sn-glycerol-3-phosphate acyltransferase alpha
PRO_0000208190

Regions

Transmembrane7 – 2721 Potential
Transmembrane38 – 5821 Potential
Transmembrane128 – 14821 Potential
Motif104 – 1096HXXXXD motif

Natural variations

Natural variant301P → S: dbSNP rs11964847.
VAR_050593

Sequences

Sequence LengthMass (Da)Tools
Q99943-1 [UniParc].

Last modified January 1, 1998. Version 2.
Checksum: 71F3207259747C68

FASTA28331,717
        10         20         30         40         50         60 
MDLWPGAWML LLLLFLLLLF LLPTLWFCSP SAKYFFKMAF YNGWILFLAV LAIPVCAVRG 

        70         80         90        100        110        120 
RNVENMKILR LMLLHIKYLY GIRVEVRGAH HFPPSQPYVV VSNHQSSLDL LGMMEVLPGR 

       130        140        150        160        170        180 
CVPIAKRELL WAGSAGLACW LAGVIFIDRK RTGDAISVMS EVAQTLLTQD VRVWVFPEGT 

       190        200        210        220        230        240 
RNHNGSMLPF KRGAFHLAVQ AQVPIVPIVM SSYQDFYCKK ERRFTSGQCQ VRVLPPVPTE 

       250        260        270        280 
GLTPDDVPAL ADRVRHSMLT VFREISTDGR GGGDYLKKPG GGG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells."
West J., Tompkins C.K., Balantac N., Nudelman E., Meengs B., White T., Bursten S., Coleman J., Kumar A., Singer J.W., Leung D.W.
DNA Cell Biol. 16:691-701(1997) [PubMed: 9212163] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases."
Stamps A.C., Elmore M.A., Hill M.E., Kelly K., Makda A.A., Finnen M.J.
Biochem. J. 326:455-461(1997) [PubMed: 9291118] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex."
Aguado B., Campbell R.D.
J. Biol. Chem. 273:4096-4105(1998) [PubMed: 9461603] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lung and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U56417 mRNA. Translation: AAB58775.1.
U75971 mRNA. Translation: AAB96378.1.
Y09565 mRNA. Translation: CAA70758.1.
U89336 Genomic DNA. Translation: AAB47493.1. Different initiation.
AL662884 Genomic DNA. Translation: CAI18347.1.
AL662828 Genomic DNA. Translation: CAI17430.1.
AL845464 Genomic DNA. Translation: CAI41807.1.
BX284686 Genomic DNA. Translation: CAM26221.1.
BX927239 Genomic DNA. Translation: CAQ06593.1.
CR933878 Genomic DNA. Translation: CAQ09622.1.
CR812478 Genomic DNA. Translation: CAQ10697.1.
CH471081 Genomic DNA. Translation: EAX03600.1.
BC002402 mRNA. Translation: AAH02402.1.
BC003007 mRNA. Translation: AAH03007.1.
BC004310 mRNA. Translation: AAH04310.1.
BC090849 mRNA. Translation: AAH90849.1.
IPIIPI00019141.
RefSeqNP_006402.1.
NP_116130.2.
UniGeneHs.409230

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ99943.

PTM databases

PhosphoSiteQ99943.

Proteomic databases

PRIDEQ99943.

Genome annotation databases

EnsemblENST00000336984; ENSP00000337463; ENSG00000204310; Homo sapiens. [Genome view]
ENST00000375104; ENSP00000364245; ENSG00000204310; Homo sapiens. [Genome view]
ENST00000375107; ENSP00000364248; ENSG00000204310; Homo sapiens. [Genome view]
ENST00000383294; ENSP00000372782; ENSG00000206324; Homo sapiens. [Genome view]
ENST00000395496; ENSP00000378874; ENSG00000204310; Homo sapiens. [Genome view]
ENST00000395497; ENSP00000378875; ENSG00000204310; Homo sapiens. [Genome view]
ENST00000395499; ENSP00000378877; ENSG00000204310; Homo sapiens. [Genome view]
ENST00000399825; ENSP00000382721; ENSG00000206324; Homo sapiens. [Genome view]
ENST00000399827; ENSP00000382723; ENSG00000206324; Homo sapiens. [Genome view]
ENST00000399829; ENSP00000382725; ENSG00000206324; Homo sapiens. [Genome view]
ENST00000399830; ENSP00000382726; ENSG00000206324; Homo sapiens. [Genome view]
ENST00000399833; ENSP00000382728; ENSG00000206324; Homo sapiens. [Genome view]
ENST00000414520; ENSP00000406615; ENSG00000227642; Homo sapiens. [Genome view]
ENST00000414933; ENSP00000388870; ENSG00000227642; Homo sapiens. [Genome view]
ENST00000415173; ENSP00000412805; ENSG00000228892; Homo sapiens. [Genome view]
ENST00000416363; ENSP00000407189; ENSG00000236873; Homo sapiens. [Genome view]
ENST00000417388; ENSP00000415015; ENSG00000228892; Homo sapiens. [Genome view]
ENST00000424030; ENSP00000397765; ENSG00000236873; Homo sapiens. [Genome view]
ENST00000425204; ENSP00000388253; ENSG00000226467; Homo sapiens. [Genome view]
ENST00000425572; ENSP00000394919; ENSG00000235758; Homo sapiens. [Genome view]
ENST00000427763; ENSP00000401410; ENSG00000226467; Homo sapiens. [Genome view]
ENST00000430226; ENSP00000412304; ENSG00000235758; Homo sapiens. [Genome view]
ENST00000430777; ENSP00000392820; ENSG00000236873; Homo sapiens. [Genome view]
ENST00000433376; ENSP00000387810; ENSG00000228892; Homo sapiens. [Genome view]
ENST00000433896; ENSP00000408842; ENSG00000236873; Homo sapiens. [Genome view]
ENST00000434614; ENSP00000401287; ENSG00000235758; Homo sapiens. [Genome view]
ENST00000436149; ENSP00000388090; ENSG00000235758; Homo sapiens. [Genome view]
ENST00000439774; ENSP00000398016; ENSG00000236873; Homo sapiens. [Genome view]
ENST00000440840; ENSP00000395863; ENSG00000236873; Homo sapiens. [Genome view]
ENST00000444369; ENSP00000408032; ENSG00000227642; Homo sapiens. [Genome view]
ENST00000446323; ENSP00000392083; ENSG00000226467; Homo sapiens. [Genome view]
ENST00000446463; ENSP00000405864; ENSG00000226467; Homo sapiens. [Genome view]
ENST00000448196; ENSP00000404106; ENSG00000235758; Homo sapiens. [Genome view]
ENST00000449776; ENSP00000410831; ENSG00000226467; Homo sapiens. [Genome view]
ENST00000451833; ENSP00000406582; ENSG00000228892; Homo sapiens. [Genome view]
ENST00000452393; ENSP00000406614; ENSG00000228892; Homo sapiens. [Genome view]
ENST00000452427; ENSP00000387738; ENSG00000235758; Homo sapiens. [Genome view]
ENST00000454929; ENSP00000390988; ENSG00000227642; Homo sapiens. [Genome view]
ENST00000455898; ENSP00000395613; ENSG00000228892; Homo sapiens. [Genome view]
ENST00000456421; ENSP00000389516; ENSG00000227642; Homo sapiens. [Genome view]
ENST00000456679; ENSP00000388815; ENSG00000227642; Homo sapiens. [Genome view]
ENST00000457923; ENSP00000405565; ENSG00000226467; Homo sapiens. [Genome view]
GeneID10554.
KEGGhsa:10554.
UCSCuc003oae.1. human.

Organism-specific databases

CTD10554.
GeneCardsGC06M032243.
H-InvDBHIX0005747.
HIX0057918.
HIX0058092.
HGNCHGNC:324. AGPAT1.
MIM603099. gene.
PharmGKBPA24621.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG736534.
HOVERGENQ99943.
InParanoidQ99943.
OMAKSLVWIP.
OrthoDBEOG99GP2H.
PhylomeDBQ99943.

Enzyme and pathway databases

BioCycMetaCyc:ENSG00000168448-MONOMER.
BRENDA2.3.1.51. 247.
ReactomeREACT_1505. Integration of energy metabolism.
REACT_602. Metabolism of lipids and lipoproteins.

Gene expression databases

CleanExHS_AGPAT1.
GenevestigatorQ99943.
GermOnlineENSG00000204310. Homo sapiens.

Family and domain databases

InterProIPR002123. Acyltransferase.
IPR004552. AGP_acyltrans.
[Graphical view]
PfamPF01553. Acyltransferase. 1 hit.
[Graphical view]
SMARTSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsTIGR00530. AGP_acyltrn. 1 hit.
ProtoNetSearch...

Other Resources

NextBio40041.
SOURCESearch...

Entry information

Entry namePLCA_HUMAN
AccessionPrimary (citable) accession number: Q99943
Secondary accession number(s): A2BFI5, Q5BL03
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 9, 2010
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents