Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99943

- PLCA_HUMAN

UniProt

Q99943 - PLCA_HUMAN

Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

Gene

AGPAT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.1 Publication

    Catalytic activityi

    Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. 1-acylglycerol-3-phosphate O-acyltransferase activity Source: BHF-UCL

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
    2. cellular lipid metabolic process Source: Reactome
    3. energy reserve metabolic process Source: Reactome
    4. glycerophospholipid biosynthetic process Source: Reactome
    5. phosphatidic acid biosynthetic process Source: BHF-UCL
    6. phospholipid metabolic process Source: Reactome
    7. positive regulation of cellular metabolic process Source: Reactome
    8. positive regulation of cytokine-mediated signaling pathway Source: BHF-UCL
    9. positive regulation of cytokine production Source: BHF-UCL
    10. small molecule metabolic process Source: Reactome
    11. triglyceride biosynthetic process Source: Reactome

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:HS09762-MONOMER.
    BRENDAi2.3.1.51. 2681.
    ReactomeiREACT_1190. Triglyceride Biosynthesis.
    REACT_120906. Synthesis of PA.
    REACT_2122. ChREBP activates metabolic gene expression.
    UniPathwayiUPA00557; UER00613.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC:2.3.1.51)
    Alternative name(s):
    1-acylglycerol-3-phosphate O-acyltransferase 1
    Short name:
    1-AGP acyltransferase 1
    Short name:
    1-AGPAT 1
    Lysophosphatidic acid acyltransferase alpha
    Short name:
    LPAAT-alpha
    Protein G15
    Gene namesi
    Name:AGPAT1
    Synonyms:G15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:324. AGPAT1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc
    2. endoplasmic reticulum membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24621.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 2832571-acyl-sn-glycerol-3-phosphate acyltransferase alphaPRO_0000208190Add
    BLAST

    Proteomic databases

    MaxQBiQ99943.
    PaxDbiQ99943.
    PRIDEiQ99943.

    PTM databases

    PhosphoSiteiQ99943.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ99943.
    BgeeiQ99943.
    CleanExiHS_AGPAT1.
    GenevestigatoriQ99943.

    Interactioni

    Protein-protein interaction databases

    BioGridi115805. 6 interactions.
    IntActiQ99943. 2 interactions.
    STRINGi9606.ENSP00000401287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99943.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi104 – 1096HXXXXD motif
    Motifi178 – 1814EGTR motif

    Domaini

    The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0204.
    HOGENOMiHOG000026375.
    HOVERGENiHBG000676.
    InParanoidiQ99943.
    KOiK13509.
    OMAiCALRGRN.
    PhylomeDBiQ99943.
    TreeFamiTF314867.

    Family and domain databases

    InterProiIPR004552. AGP_acyltrans.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view]
    PfamiPF01553. Acyltransferase. 1 hit.
    [Graphical view]
    SMARTiSM00563. PlsC. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00530. AGP_acyltrn. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLWPGAWML LLLLFLLLLF LLPTLWFCSP SAKYFFKMAF YNGWILFLAV    50
    LAIPVCAVRG RNVENMKILR LMLLHIKYLY GIRVEVRGAH HFPPSQPYVV 100
    VSNHQSSLDL LGMMEVLPGR CVPIAKRELL WAGSAGLACW LAGVIFIDRK 150
    RTGDAISVMS EVAQTLLTQD VRVWVFPEGT RNHNGSMLPF KRGAFHLAVQ 200
    AQVPIVPIVM SSYQDFYCKK ERRFTSGQCQ VRVLPPVPTE GLTPDDVPAL 250
    ADRVRHSMLT VFREISTDGR GGGDYLKKPG GGG 283
    Length:283
    Mass (Da):31,717
    Last modified:January 1, 1998 - v2
    Checksum:i71F3207259747C68
    GO

    Sequence cautioni

    The sequence AAB47493.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301P → S.
    Corresponds to variant rs11964847 [ dbSNP | Ensembl ].
    VAR_050593

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56417 mRNA. Translation: AAB58775.1.
    U75971 mRNA. Translation: AAB96378.1.
    Y09565 mRNA. Translation: CAA70758.1.
    U89336 Genomic DNA. Translation: AAB47493.1. Different initiation.
    AL662884 Genomic DNA. Translation: CAI18347.1.
    AL662828 Genomic DNA. Translation: CAI17430.1.
    AL845464 Genomic DNA. Translation: CAI41807.1.
    BX284686 Genomic DNA. Translation: CAM26221.1.
    BX927239 Genomic DNA. Translation: CAQ06593.1.
    CR933878 Genomic DNA. Translation: CAQ09622.1.
    CR812478 Genomic DNA. Translation: CAQ10697.1.
    CH471081 Genomic DNA. Translation: EAX03600.1.
    BC002402 mRNA. Translation: AAH02402.1.
    BC003007 mRNA. Translation: AAH03007.1.
    BC004310 mRNA. Translation: AAH04310.1.
    BC090849 mRNA. Translation: AAH90849.1.
    CCDSiCCDS4744.1.
    RefSeqiNP_006402.1. NM_006411.3.
    NP_116130.2. NM_032741.4.
    XP_005248863.1. XM_005248806.1.
    XP_005272819.1. XM_005272762.1.
    XP_005274887.1. XM_005274830.1.
    XP_005275131.1. XM_005275074.1.
    XP_005275261.1. XM_005275204.1.
    XP_005275395.1. XM_005275338.1.
    XP_005275562.1. XM_005275505.1.
    UniGeneiHs.409230.

    Genome annotation databases

    EnsembliENST00000336984; ENSP00000337463; ENSG00000204310.
    ENST00000375104; ENSP00000364245; ENSG00000204310.
    ENST00000375107; ENSP00000364248; ENSG00000204310.
    ENST00000383294; ENSP00000372782; ENSG00000206324.
    ENST00000395496; ENSP00000378874; ENSG00000204310.
    ENST00000395497; ENSP00000378875; ENSG00000204310.
    ENST00000395499; ENSP00000378877; ENSG00000204310.
    ENST00000399825; ENSP00000382721; ENSG00000206324.
    ENST00000399827; ENSP00000382723; ENSG00000206324.
    ENST00000399829; ENSP00000382725; ENSG00000206324.
    ENST00000399830; ENSP00000382726; ENSG00000206324.
    ENST00000399833; ENSP00000382728; ENSG00000206324.
    ENST00000414520; ENSP00000406615; ENSG00000227642.
    ENST00000414933; ENSP00000388870; ENSG00000227642.
    ENST00000415173; ENSP00000412805; ENSG00000228892.
    ENST00000416363; ENSP00000407189; ENSG00000236873.
    ENST00000417388; ENSP00000415015; ENSG00000228892.
    ENST00000424030; ENSP00000397765; ENSG00000236873.
    ENST00000425204; ENSP00000388253; ENSG00000226467.
    ENST00000425572; ENSP00000394919; ENSG00000235758.
    ENST00000427763; ENSP00000401410; ENSG00000226467.
    ENST00000430226; ENSP00000412304; ENSG00000235758.
    ENST00000430777; ENSP00000392820; ENSG00000236873.
    ENST00000433376; ENSP00000387810; ENSG00000228892.
    ENST00000433896; ENSP00000408842; ENSG00000236873.
    ENST00000434614; ENSP00000401287; ENSG00000235758.
    ENST00000436149; ENSP00000388090; ENSG00000235758.
    ENST00000439774; ENSP00000398016; ENSG00000236873.
    ENST00000440840; ENSP00000395863; ENSG00000236873.
    ENST00000444369; ENSP00000408032; ENSG00000227642.
    ENST00000446323; ENSP00000392083; ENSG00000226467.
    ENST00000446463; ENSP00000405864; ENSG00000226467.
    ENST00000448196; ENSP00000404106; ENSG00000235758.
    ENST00000449776; ENSP00000410831; ENSG00000226467.
    ENST00000451833; ENSP00000406582; ENSG00000228892.
    ENST00000452393; ENSP00000406614; ENSG00000228892.
    ENST00000452427; ENSP00000387738; ENSG00000235758.
    ENST00000454929; ENSP00000390988; ENSG00000227642.
    ENST00000455898; ENSP00000395613; ENSG00000228892.
    ENST00000456421; ENSP00000389516; ENSG00000227642.
    ENST00000456679; ENSP00000388815; ENSG00000227642.
    ENST00000457923; ENSP00000405565; ENSG00000226467.
    GeneIDi10554.
    KEGGihsa:10554.
    UCSCiuc003oae.3. human.

    Polymorphism databases

    DMDMi3914372.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56417 mRNA. Translation: AAB58775.1 .
    U75971 mRNA. Translation: AAB96378.1 .
    Y09565 mRNA. Translation: CAA70758.1 .
    U89336 Genomic DNA. Translation: AAB47493.1 . Different initiation.
    AL662884 Genomic DNA. Translation: CAI18347.1 .
    AL662828 Genomic DNA. Translation: CAI17430.1 .
    AL845464 Genomic DNA. Translation: CAI41807.1 .
    BX284686 Genomic DNA. Translation: CAM26221.1 .
    BX927239 Genomic DNA. Translation: CAQ06593.1 .
    CR933878 Genomic DNA. Translation: CAQ09622.1 .
    CR812478 Genomic DNA. Translation: CAQ10697.1 .
    CH471081 Genomic DNA. Translation: EAX03600.1 .
    BC002402 mRNA. Translation: AAH02402.1 .
    BC003007 mRNA. Translation: AAH03007.1 .
    BC004310 mRNA. Translation: AAH04310.1 .
    BC090849 mRNA. Translation: AAH90849.1 .
    CCDSi CCDS4744.1.
    RefSeqi NP_006402.1. NM_006411.3.
    NP_116130.2. NM_032741.4.
    XP_005248863.1. XM_005248806.1.
    XP_005272819.1. XM_005272762.1.
    XP_005274887.1. XM_005274830.1.
    XP_005275131.1. XM_005275074.1.
    XP_005275261.1. XM_005275204.1.
    XP_005275395.1. XM_005275338.1.
    XP_005275562.1. XM_005275505.1.
    UniGenei Hs.409230.

    3D structure databases

    ProteinModelPortali Q99943.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115805. 6 interactions.
    IntActi Q99943. 2 interactions.
    STRINGi 9606.ENSP00000401287.

    Chemistry

    ChEMBLi CHEMBL3583.

    PTM databases

    PhosphoSitei Q99943.

    Polymorphism databases

    DMDMi 3914372.

    Proteomic databases

    MaxQBi Q99943.
    PaxDbi Q99943.
    PRIDEi Q99943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336984 ; ENSP00000337463 ; ENSG00000204310 .
    ENST00000375104 ; ENSP00000364245 ; ENSG00000204310 .
    ENST00000375107 ; ENSP00000364248 ; ENSG00000204310 .
    ENST00000383294 ; ENSP00000372782 ; ENSG00000206324 .
    ENST00000395496 ; ENSP00000378874 ; ENSG00000204310 .
    ENST00000395497 ; ENSP00000378875 ; ENSG00000204310 .
    ENST00000395499 ; ENSP00000378877 ; ENSG00000204310 .
    ENST00000399825 ; ENSP00000382721 ; ENSG00000206324 .
    ENST00000399827 ; ENSP00000382723 ; ENSG00000206324 .
    ENST00000399829 ; ENSP00000382725 ; ENSG00000206324 .
    ENST00000399830 ; ENSP00000382726 ; ENSG00000206324 .
    ENST00000399833 ; ENSP00000382728 ; ENSG00000206324 .
    ENST00000414520 ; ENSP00000406615 ; ENSG00000227642 .
    ENST00000414933 ; ENSP00000388870 ; ENSG00000227642 .
    ENST00000415173 ; ENSP00000412805 ; ENSG00000228892 .
    ENST00000416363 ; ENSP00000407189 ; ENSG00000236873 .
    ENST00000417388 ; ENSP00000415015 ; ENSG00000228892 .
    ENST00000424030 ; ENSP00000397765 ; ENSG00000236873 .
    ENST00000425204 ; ENSP00000388253 ; ENSG00000226467 .
    ENST00000425572 ; ENSP00000394919 ; ENSG00000235758 .
    ENST00000427763 ; ENSP00000401410 ; ENSG00000226467 .
    ENST00000430226 ; ENSP00000412304 ; ENSG00000235758 .
    ENST00000430777 ; ENSP00000392820 ; ENSG00000236873 .
    ENST00000433376 ; ENSP00000387810 ; ENSG00000228892 .
    ENST00000433896 ; ENSP00000408842 ; ENSG00000236873 .
    ENST00000434614 ; ENSP00000401287 ; ENSG00000235758 .
    ENST00000436149 ; ENSP00000388090 ; ENSG00000235758 .
    ENST00000439774 ; ENSP00000398016 ; ENSG00000236873 .
    ENST00000440840 ; ENSP00000395863 ; ENSG00000236873 .
    ENST00000444369 ; ENSP00000408032 ; ENSG00000227642 .
    ENST00000446323 ; ENSP00000392083 ; ENSG00000226467 .
    ENST00000446463 ; ENSP00000405864 ; ENSG00000226467 .
    ENST00000448196 ; ENSP00000404106 ; ENSG00000235758 .
    ENST00000449776 ; ENSP00000410831 ; ENSG00000226467 .
    ENST00000451833 ; ENSP00000406582 ; ENSG00000228892 .
    ENST00000452393 ; ENSP00000406614 ; ENSG00000228892 .
    ENST00000452427 ; ENSP00000387738 ; ENSG00000235758 .
    ENST00000454929 ; ENSP00000390988 ; ENSG00000227642 .
    ENST00000455898 ; ENSP00000395613 ; ENSG00000228892 .
    ENST00000456421 ; ENSP00000389516 ; ENSG00000227642 .
    ENST00000456679 ; ENSP00000388815 ; ENSG00000227642 .
    ENST00000457923 ; ENSP00000405565 ; ENSG00000226467 .
    GeneIDi 10554.
    KEGGi hsa:10554.
    UCSCi uc003oae.3. human.

    Organism-specific databases

    CTDi 10554.
    GeneCardsi GC06M032135.
    GC06Mi32147.
    GC06Mj32084.
    GC06Ml32175.
    GC06Mm32212.
    GC06Mn32093.
    GC06Mo32142.
    HGNCi HGNC:324. AGPAT1.
    MIMi 603099. gene.
    neXtProti NX_Q99943.
    PharmGKBi PA24621.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0204.
    HOGENOMi HOG000026375.
    HOVERGENi HBG000676.
    InParanoidi Q99943.
    KOi K13509.
    OMAi CALRGRN.
    PhylomeDBi Q99943.
    TreeFami TF314867.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00613 .
    BioCyci MetaCyc:HS09762-MONOMER.
    BRENDAi 2.3.1.51. 2681.
    Reactomei REACT_1190. Triglyceride Biosynthesis.
    REACT_120906. Synthesis of PA.
    REACT_2122. ChREBP activates metabolic gene expression.

    Miscellaneous databases

    GeneWikii AGPAT1.
    GenomeRNAii 10554.
    NextBioi 40041.
    PROi Q99943.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99943.
    Bgeei Q99943.
    CleanExi HS_AGPAT1.
    Genevestigatori Q99943.

    Family and domain databases

    InterProi IPR004552. AGP_acyltrans.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view ]
    Pfami PF01553. Acyltransferase. 1 hit.
    [Graphical view ]
    SMARTi SM00563. PlsC. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00530. AGP_acyltrn. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells."
      West J., Tompkins C.K., Balantac N., Nudelman E., Meengs B., White T., Bursten S., Coleman J., Kumar A., Singer J.W., Leung D.W.
      DNA Cell Biol. 16:691-701(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases."
      Stamps A.C., Elmore M.A., Hill M.E., Kelly K., Makda A.A., Finnen M.J.
      Biochem. J. 326:455-461(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex."
      Aguado B., Campbell R.D.
      J. Biol. Chem. 273:4096-4105(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung and Skin.
    8. "Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice."
      Agarwal A.K., Sukumaran S., Cortes V.A., Tunison K., Mizrachi D., Sankella S., Gerard R.D., Horton J.D., Garg A.
      J. Biol. Chem. 286:37676-37691(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPLCA_HUMAN
    AccessioniPrimary (citable) accession number: Q99943
    Secondary accession number(s): A2BFI5, Q5BL03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3