ID GBRG3_HUMAN Reviewed; 467 AA. AC Q99928; Q9HD46; Q9NYT2; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 04-MAY-2001, sequence version 2. DT 16-JUN-2009, entry version 81. DE RecName: Full=Gamma-aminobutyric acid receptor subunit gamma-3; DE AltName: Full=GABA(A) receptor subunit gamma-3; DE Flags: Precursor; GN Name=GABRG3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Fetal brain; RX MEDLINE=96360042; PubMed=8719414; DOI=10.1016/0922-4106(95)90070-5; RA Hadingham K.L., Wafford K.A., Thompson S.A., Palmer K.J., RA Whiting P.J.; RT "Expression and pharmacology of human GABAA receptors containing gamma RT 3 subunits."; RL Eur. J. Pharmacol. 291:301-309(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Han M.K., Chen Y.-H., Nurmi E.L., Sutcliffe J.S.; RT "Gene structure and organization of the GABAA receptor gamma 3 subunit RT (GABRG3) gene."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-467. RA Kim S.-J., Gonen D., Yang Z.-Y., Reliford A., Dy A., Leventhal B.L., RA Cook E.H. Jr.; RT "Genomic organization of GABAA receptor gamma 3 subunit gene RT (GABRG3)."; RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the CC vertebrate brain, mediates neuronal inhibition by binding to the CC GABA/benzodiazepine receptor and opening an integral chloride CC channel. CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A) CC receptor chains: alpha, beta, gamma, delta, and rho. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane; Multi-pass membrane protein. Cell membrane; Multi-pass CC membrane protein. CC -!- PTM: May be palmitoylated (By similarity). CC -!- MISCELLANEOUS: This subunit carries the benzodiazepine binding CC site. CC -!- SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) CC family. CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Forbidden fruit - Issue CC 56 of March 2005; CC URL="http://www.expasy.org/spotlight/back_issues/sptlt056.shtml"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S82769; AAB39369.1; -; mRNA. DR EMBL; AF269144; AAF99698.1; -; Genomic_DNA. DR EMBL; AF269135; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269136; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269137; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269138; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269139; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269140; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269141; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269142; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF269143; AAF99698.1; JOINED; Genomic_DNA. DR EMBL; AF228458; AAF63215.1; -; Genomic_DNA. DR EMBL; AF228450; AAF63215.1; JOINED; Genomic_DNA. DR EMBL; AF228451; AAF63215.1; JOINED; Genomic_DNA. DR EMBL; AF228452; AAF63215.1; JOINED; Genomic_DNA. DR EMBL; AF228453; AAF63215.1; JOINED; Genomic_DNA. DR EMBL; AF228454; AAF63215.1; JOINED; Genomic_DNA. DR EMBL; AF228455; AAF63215.1; JOINED; Genomic_DNA. DR EMBL; AF228456; AAF63215.1; JOINED; Genomic_DNA. DR EMBL; AF228457; AAF63215.1; JOINED; Genomic_DNA. DR IPI; IPI00294459; -. DR RefSeq; NP_150092.2; -. DR UniGene; Hs.569475; -. DR UniGene; Hs.592027; -. DR PhosphoSite; Q99928; -. DR PRIDE; Q99928; -. DR Ensembl; ENSG00000182256; Homo sapiens. DR GeneID; 2567; -. DR KEGG; hsa:2567; -. DR GeneCards; GC15P024800; -. DR HGNC; HGNC:4088; GABRG3. DR MIM; 600233; gene. DR PharmGKB; PA28502; -. DR HOGENOM; Q99928; -. DR HOVERGEN; Q99928; -. DR OMA; Q99928; LNNSMYW. DR NextBio; 10153; -. DR ArrayExpress; Q99928; -. DR Bgee; Q99928; -. DR CleanEx; HS_GABRG3; -. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; NAS:UniProtKB. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW. DR GO; GO:0031404; F:chloride ion binding; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel acti...; NAS:UniProtKB. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR GO; GO:0030594; F:neurotransmitter receptor activity; IEA:InterPro. DR GO; GO:0006821; P:chloride transport; IEA:InterPro. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. DR GO; GO:0007268; P:synaptic transmission; NAS:UniProtKB. DR InterPro; IPR006028; GABAA_rcpt. DR InterPro; IPR005440; GABBAg3_rcpt. DR InterPro; IPR005437; GABBAg_rcpt. DR InterPro; IPR006029; Neu_channel_TM. DR InterPro; IPR006202; Neur_chan_lig_bd. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR Gene3D; G3DSA:2.70.170.10; Neur_chan_lig_bd; 1. DR PANTHER; PTHR18945; Neur_channel; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01620; GABAARGAMMA. DR PRINTS; PR01623; GABAARGAMMA3. DR PRINTS; PR00252; NRIONCHANNEL. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 2: Evidence at transcript level; KW Cell junction; Cell membrane; Chloride; Chloride channel; KW Disulfide bond; Glycoprotein; Ion transport; Ionic channel; KW Lipoprotein; Membrane; Palmitate; Polymorphism; KW Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport. FT SIGNAL 1 17 Potential. FT CHAIN 18 467 Gamma-aminobutyric acid receptor subunit FT gamma-3. FT /FTId=PRO_0000000481. FT TOPO_DOM 18 254 Extracellular (Probable). FT TRANSMEM 255 277 Probable. FT TRANSMEM 281 303 Probable. FT TRANSMEM 315 337 Probable. FT TOPO_DOM 338 443 Cytoplasmic (Probable). FT TRANSMEM 444 467 Probable. FT CARBOHYD 110 110 N-linked (GlcNAc...) (Potential). FT CARBOHYD 228 228 N-linked (GlcNAc...) (Potential). FT DISULFID 171 185 By similarity. FT VARIANT 352 352 T -> A (in dbSNP:rs2066712). FT /FTId=VAR_033957. FT CONFLICT 386 386 T -> P (in Ref. 1; AAB39369). SQ SEQUENCE 467 AA; 54289 MW; 1B22D145166438D6 CRC64; MAPKLLLLLC LFSGLHARSR KVEEDEYEDS SSNQKWVLAP KSQDTDVTLI LNKLLREYDK KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ TWTDSRLRFN STMKILTLNS NMVGLIWIPD TIFRNSKTAE AHWITTPNQL LRIWNDGKIL YTLRLTINAE CQLQLHNFPM DEHSCPLIFS SYGYPKEEMI YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY VVMTIYFELS RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTALGI TTVLTMTTLS TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTTTK KTTSLLHPDS SRWIPERISL QAPSNYSLLD MRPPPTAMIT LNNSVYWQEF EDTCVYECLD GKDCQSFFCC YEECKSGSWR KGRIHIDILE LDSYSRVFFP TSFLLFNLVY WVGYLYL //