Gamma-aminobutyric acid receptor subunit gamma-3 precursor

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Q99928 (GBRG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-3

Alternative name(s):
GABA(A) receptor subunit gamma-3

Gene names

Name:

GABRG3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Post-translational modification	May be palmitoylated By similarity.
Miscellaneous	This subunit carries the benzodiazepine binding site.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ion channel
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid signaling pathway Inferred from electronic annotation. Source: InterPro response to drug Inferred from electronic annotation. Source: Compara synaptic transmission Non-traceable author statement. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GABA-A receptor activity Inferred from electronic annotation. Source: Compara chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW extracellular ligand-gated ion channel activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

Potential

Chain

18 – 467

450

Gamma-aminobutyric acid receptor subunit gamma-3

PRO_0000000481

Regions

Topological domain

18 – 254

237

Extracellular Probable

Transmembrane

255 – 277

Helical; Probable

Transmembrane

281 – 303

Helical; Probable

Transmembrane

315 – 337

Helical; Probable

Topological domain

338 – 443

106

Cytoplasmic Probable

Transmembrane

444 – 467

Helical; Probable

Amino acid modifications

Glycosylation

110

N-linked (GlcNAc...) Potential

Glycosylation

228

N-linked (GlcNAc...) Potential

Disulfide bond

171 ↔ 185

By similarity

Natural variations

Natural variant

352

T → A.
Corresponds to variant rs2066712 [ dbSNP | Ensembl ].

VAR_033957

Experimental info

Sequence conflict

386

T → P in AAB39369. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q99928 [UniParc].

Last modified May 4, 2001. Version 2.
Checksum: 1B22D145166438D6
Show »

FASTA

467

54,289

        10         20         30         40         50         60 
MAPKLLLLLC LFSGLHARSR KVEEDEYEDS SSNQKWVLAP KSQDTDVTLI LNKLLREYDK 

        70         80         90        100        110        120 
KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ TWTDSRLRFN STMKILTLNS 

       130        140        150        160        170        180 
NMVGLIWIPD TIFRNSKTAE AHWITTPNQL LRIWNDGKIL YTLRLTINAE CQLQLHNFPM 

       190        200        210        220        230        240 
DEHSCPLIFS SYGYPKEEMI YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY 

       250        260        270        280        290        300 
VVMTIYFELS RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTALGI TTVLTMTTLS 

       310        320        330        340        350        360 
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTTTK KTTSLLHPDS 

       370        380        390        400        410        420 
SRWIPERISL QAPSNYSLLD MRPPPTAMIT LNNSVYWQEF EDTCVYECLD GKDCQSFFCC 

       430        440        450        460 
YEECKSGSWR KGRIHIDILE LDSYSRVFFP TSFLLFNLVY WVGYLYL

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References

[1]	"Expression and pharmacology of human GABAA receptors containing gamma 3 subunits." Hadingham K.L., Wafford K.A., Thompson S.A., Palmer K.J., Whiting P.J. Eur. J. Pharmacol. 291:301-309(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Gene structure and organization of the GABAA receptor gamma 3 subunit (GABRG3) gene." Han M.K., Chen Y.-H., Nurmi E.L., Sutcliffe J.S. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genomic organization of GABAA receptor gamma 3 subunit gene (GABRG3)." Kim S.-J., Gonen D., Yang Z.-Y., Reliford A., Dy A., Leventhal B.L., Cook E.H. Jr. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-467.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	S82769 mRNA. Translation: AAB39369.1. AF269144 AF269143 Genomic DNA. Translation: AAF99698.1. AH009226 Genomic DNA. Translation: AAF63215.1.
IPI	IPI00294459.
RefSeq	NP_150092.2. NM_033223.4.
UniGene	Hs.569475.
3D structure databases
ProteinModelPortal	Q99928.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000331912.
PTM databases
PhosphoSite	Q99928.
Polymorphism databases
DMDM	13959689.
Proteomic databases
PaxDb	Q99928.
PRIDE	Q99928.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333743; ENSP00000331912; ENSG00000182256.
GeneID	2567.
KEGG	hsa:2567.
UCSC	uc001zbf.3. human.
Organism-specific databases
CTD	2567.
GeneCards	GC15P027216.
H-InvDB	HIX0026811.
HGNC	HGNC:4088. GABRG3.
HPA	HPA054010.
MIM	600233. gene.
neXtProt	NX_Q99928.
PharmGKB	PA28502.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300758.
HOGENOM	HOG000231337.
HOVERGEN	HBG051707.
InParanoid	Q99928.
KO	K05186.
OMA	RGRIHID.
PhylomeDB	Q99928.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q99928.
Bgee	Q99928.
CleanEx	HS_GABRG3.
Genevestigator	Q99928.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006028. GABAA_rcpt. IPR005440. GABBAg3_rcpt. IPR005437. GABBAg_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00253. GABAARECEPTR. PR01620. GABAARGAMMA. PR01623. GABAARGAMMA3. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q99928.
ChEMBL	CHEMBL2739.
GenomeRNAi	2567.
NextBio	10153.
SOURCE	Search...

Entry information

Entry name

GBRG3_HUMAN

Accession

Primary (citable) accession number: Q99928
Secondary accession number(s): Q9HD46, Q9NYT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 4, 2001
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents