##gff-version 3 Q99895 UniProtKB Signal peptide 1 16 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q99895 UniProtKB Propeptide 17 29 . . . ID=PRO_0000027713;Note=Activation peptide Q99895 UniProtKB Chain 30 268 . . . ID=PRO_0000027714;Note=Chymotrypsin-C Q99895 UniProtKB Domain 30 267 . . . Note=Peptidase S1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00274 Q99895 UniProtKB Active site 74 74 . . . Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q99895 UniProtKB Active site 121 121 . . . Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q99895 UniProtKB Active site 216 216 . . . Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q99895 UniProtKB Glycosylation 25 25 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q99895 UniProtKB Glycosylation 52 52 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q99895 UniProtKB Glycosylation 226 226 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q99895 UniProtKB Disulfide bond 17 141 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:23430245;Dbxref=PMID:23430245 Q99895 UniProtKB Disulfide bond 59 75 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:23430245;Dbxref=PMID:23430245 Q99895 UniProtKB Disulfide bond 155 222 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:23430245;Dbxref=PMID:23430245 Q99895 UniProtKB Disulfide bond 186 202 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:23430245;Dbxref=PMID:23430245 Q99895 UniProtKB Disulfide bond 212 243 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00274,ECO:0000269|PubMed:23430245;Dbxref=PMID:23430245 Q99895 UniProtKB Natural variant 18 18 . . . ID=VAR_070520;Note=Found in a patient with chronic pancreatitis%3B uncertain significance%3B catalytic activity comparable to that of wild type%3B the mutant undergoes proteolytic degradation during trypsin-mediated activation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs200576965,PMID:22942235 Q99895 UniProtKB Natural variant 29 29 . . . ID=VAR_070521;Note=Found in patients with chronic pancreatitis%3B uncertain significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23135764;Dbxref=dbSNP:rs772024986,PMID:23135764 Q99895 UniProtKB Natural variant 32 32 . . . ID=VAR_070522;Note=In PCTT%3B highly reduced catalytic efficiency. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22942235;Dbxref=PMID:22942235 Q99895 UniProtKB Natural variant 35 35 . . . ID=VAR_043516;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18059268;Dbxref=dbSNP:rs184977421,PMID:18059268 Q99895 UniProtKB Natural variant 35 35 . . . ID=VAR_043517;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18059268;Dbxref=dbSNP:rs184977421,PMID:18059268 Q99895 UniProtKB Natural variant 35 35 . . . ID=VAR_070523;Note=Found in a patient with chronic pancreatitis%3B uncertain significance%3B catalytic activity comparable to that of wild type. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22942235;Dbxref=PMID:22942235 Q99895 UniProtKB Natural variant 37 37 . . . ID=VAR_043518;Note=Rare variant%3B results in normal secretion and activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18059268;Dbxref=dbSNP:rs145868278,PMID:18059268 Q99895 UniProtKB Natural variant 48 48 . . . ID=VAR_043519;Note=Rare variant that may be a risk factor for pancreatitis%3B results in markedly reduced protein secretion. Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:22580415,ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs536812916,PMID:18059268,PMID:22580415,PMID:22942235 Q99895 UniProtKB Natural variant 61 61 . . . ID=VAR_070524;Note=Found in a patient with chronic pancreatitis%3B uncertain significance%3B the mutant is not secreted. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs769482036,PMID:22942235 Q99895 UniProtKB Natural variant 73 73 . . . ID=VAR_043520;Note=In PCTT%3B results in markedly reduced protein secretion. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22580415,ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs515726209,PMID:18059268,PMID:18172691,PMID:22580415,PMID:22942235 Q99895 UniProtKB Natural variant 80 80 . . . ID=VAR_010928;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8635596;Dbxref=dbSNP:rs779643710,PMID:8635596 Q99895 UniProtKB Natural variant 151 151 . . . ID=VAR_070525;Note=Found in a patient with chronic pancreatitis%3B uncertain significance. K->N Q99895 UniProtKB Natural variant 155 155 . . . ID=VAR_070526;Note=In PCTT%3B the mutant is not secreted. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22942235;Dbxref=PMID:18172691,PMID:22942235 Q99895 UniProtKB Natural variant 162 162 . . . ID=VAR_070527;Note=Rare variant%3B found in a patient with chronic pancreatitis%3B uncertain significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18172691;Dbxref=dbSNP:rs775404479,PMID:18172691 Q99895 UniProtKB Natural variant 172 172 . . . ID=VAR_043521;Note=K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22580415;Dbxref=dbSNP:rs34949635,PMID:18059268,PMID:18172691,PMID:22580415 Q99895 UniProtKB Natural variant 178 178 . . . ID=VAR_070528;Note=In PCTT%3B impaired catalytic activity. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs200678111,PMID:22942235 Q99895 UniProtKB Natural variant 200 200 . . . ID=VAR_070529;Note=Found in a patient with chronic pancreatitis%3B uncertain significance. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18172691;Dbxref=dbSNP:rs146235499,PMID:18172691 Q99895 UniProtKB Natural variant 209 209 . . . ID=VAR_070530;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23135764;Dbxref=PMID:23135764 Q99895 UniProtKB Natural variant 217 217 . . . ID=VAR_043522;Note=In PCTT%3B results in markedly reduced protein secretion and loss of activity. G->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs202058123,PMID:18059268,PMID:18172691,PMID:22942235 Q99895 UniProtKB Natural variant 217 217 . . . ID=VAR_043523;Note=In PCTT%3B reduced protein secretion%3B impaired catalytic activity. G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs202058123,PMID:18059268,PMID:18172691,PMID:22942235 Q99895 UniProtKB Natural variant 218 218 . . . ID=VAR_043524;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18059268;Dbxref=PMID:18059268 Q99895 UniProtKB Natural variant 220 220 . . . ID=VAR_043525;Note=Rare variant%3B results in impaired protein secretion. L->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:22942235;Dbxref=PMID:18059268,PMID:22942235 Q99895 UniProtKB Natural variant 225 225 . . . ID=VAR_043526;Note=E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18059268;Dbxref=dbSNP:rs201486613,PMID:18059268 Q99895 UniProtKB Natural variant 225 225 . . . ID=VAR_070531;Note=Found in a patient with chronic pancreatitis%3B uncertain significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19407484;Dbxref=PMID:19407484 Q99895 UniProtKB Natural variant 227 227 . . . ID=VAR_070532;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs567745213,PMID:22942235 Q99895 UniProtKB Natural variant 235 235 . . . ID=VAR_043527;Note=In PCTT%3B slightly reduced activity. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22580415,ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs140993290,PMID:18059268,PMID:18172691,PMID:22580415,PMID:22942235 Q99895 UniProtKB Natural variant 239 239 . . . ID=VAR_070533;Note=Found in patients with chronic pancreatitis%3B uncertain significance. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23135764;Dbxref=PMID:23135764 Q99895 UniProtKB Natural variant 239 239 . . . ID=VAR_070534;Note=Found in patients with chronic pancreatitis%3B uncertain significance. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23135764;Dbxref=PMID:23135764 Q99895 UniProtKB Natural variant 246 246 . . . ID=VAR_070535;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22580415;Dbxref=dbSNP:rs200412314,PMID:22580415 Q99895 UniProtKB Natural variant 247 254 . . . ID=VAR_070536;Note=In PCTT%3B results in reduced protein secretion and loss of activity. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22942235;Dbxref=PMID:18172691,PMID:22942235 Q99895 UniProtKB Natural variant 247 247 . . . ID=VAR_070537;Note=Found in patients with chronic pancreatitis%3B uncertain significance. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23135764;Dbxref=PMID:23135764 Q99895 UniProtKB Natural variant 249 249 . . . ID=VAR_043528;Note=In PCTT%3B results in reduced protein secretion and loss of activity. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs142560329,PMID:18059268,PMID:22942235 Q99895 UniProtKB Natural variant 250 250 . . . ID=VAR_070538;Note=In PCTT%3B results in altered enzyme specificity and loss of activity. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22942235;Dbxref=PMID:22942235 Q99895 UniProtKB Natural variant 254 254 . . . ID=VAR_070539;Note=Found in a patient with chronic pancreatitis%3B uncertain significance%3B mutant protein secretion%2C activity and trypsin-mediated degradation are comparable to those of wild-type. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19407484,ECO:0000269|PubMed:22942235;Dbxref=dbSNP:rs755811899,PMID:19407484,PMID:22942235 Q99895 UniProtKB Natural variant 254 254 . . . ID=VAR_043529;Note=In PCTT%3B results in reduced secretion%3B normal activity%3B the mutant undergoes proteolytic degradation during trypsin-mediated activation. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18059268,ECO:0000269|PubMed:18172691,ECO:0000269|PubMed:22580415,ECO:0000269|PubMed:22942235,ECO:0000269|PubMed:23135764;Dbxref=dbSNP:rs121909293,PMID:18059268,PMID:18172691,PMID:22580415,PMID:22942235,PMID:23135764 Q99895 UniProtKB Natural variant 257 257 . . . ID=VAR_070540;Note=Found in patients with chronic pancreatitis%3B uncertain significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22580415;Dbxref=dbSNP:rs200406696,PMID:22580415 Q99895 UniProtKB Natural variant 260 260 . . . ID=VAR_043530;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18059268;Dbxref=dbSNP:rs540753875,PMID:18059268 Q99895 UniProtKB Natural variant 263 263 . . . ID=VAR_070541;Note=Found in a patient with chronic pancreatitis%3B uncertain significance. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19407484;Dbxref=dbSNP:rs769975164,PMID:19407484 Q99895 UniProtKB Sequence conflict 16 16 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q99895 UniProtKB Sequence conflict 52 52 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q99895 UniProtKB Beta strand 44 51 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 54 65 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 68 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Helix 73 75 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 82 87 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 100 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 104 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Turn 115 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 123 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 155 160 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 162 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 174 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Helix 183 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Turn 189 192 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Helix 193 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 200 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 206 210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 219 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 229 239 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 242 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Beta strand 250 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Helix 255 257 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F Q99895 UniProtKB Helix 259 265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H4F