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Q99895

- CTRC_HUMAN

UniProt

Q99895 - CTRC_HUMAN

Protein

Chymotrypsin-C

Gene

CTRC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.1 Publication

    Catalytic activityi

    Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Charge relay systemBy similarity
    Active sitei121 – 1211Charge relay systemBy similarity
    Active sitei216 – 2161Charge relay systemBy similarity

    GO - Molecular functioni

    1. peptidase activity Source: ProtInc
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. proteolysis Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.2. 2681.

    Protein family/group databases

    MEROPSiS01.157.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsin-C (EC:3.4.21.2)
    Alternative name(s):
    Caldecrin
    Gene namesi
    Name:CTRC
    Synonyms:CLCR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2523. CTRC.

    Pathology & Biotechi

    Involvement in diseasei

    Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.4 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235).2 Publications
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti32 – 321G → V in PCTT; associated with disease susceptibility; highly reduced catalytic efficiency.
    VAR_070522
    Natural varianti73 – 731A → T in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion. 3 Publications
    VAR_043520
    Natural varianti155 – 1551C → Y in PCTT; associated with susceptibility to disease; the mutant is not secreted. 1 Publication
    VAR_070526
    Natural varianti178 – 1781Q → R in PCTT; associated with disease susceptibility; impaired catalytic activity. 1 Publication
    Corresponds to variant rs200678111 [ dbSNP | Ensembl ].
    VAR_070528
    Natural varianti217 – 2171G → R in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion and loss of activity. 2 Publications
    VAR_043522
    Natural varianti217 – 2171G → S in PCTT; associated with susceptibility to disease; reduced protein secretion; impaired catalytic activity. 2 Publications
    Corresponds to variant rs202058123 [ dbSNP | Ensembl ].
    VAR_043523
    Natural varianti235 – 2351V → I in PCTT; associated with susceptibility to disease; slightly reduced activity. 3 Publications
    Corresponds to variant rs140993290 [ dbSNP | Ensembl ].
    VAR_043527
    Natural varianti247 – 2548Missing in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity.
    VAR_070536
    Natural varianti249 – 2491P → L in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity. 1 Publication
    Corresponds to variant rs142560329 [ dbSNP | Ensembl ].
    VAR_043528
    Natural varianti250 – 2501V → E in PCTT; associated with disease susceptibility; results in altered enzyme specificity and loss of activity. 1 Publication
    VAR_070538
    Natural varianti254 – 2541R → W in PCTT; associated with susceptibility to disease; results in reduced secretion; normal activity; the mutant undergoes proteolytic degradation during trypsin-mediated activation. 4 Publications
    Corresponds to variant rs121909293 [ dbSNP | Ensembl ].
    VAR_043529

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi167800. phenotype.
    Orphaneti676. Hereditary chronic pancreatitis.
    103918. Tropical pancreatitis.
    PharmGKBiPA27024.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 2913Activation peptidePRO_0000027713Add
    BLAST
    Chaini30 – 268239Chymotrypsin-CPRO_0000027714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi17 ↔ 1411 PublicationPROSITE-ProRule annotation
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi59 ↔ 751 PublicationPROSITE-ProRule annotation
    Disulfide bondi155 ↔ 2221 PublicationPROSITE-ProRule annotation
    Disulfide bondi186 ↔ 2021 PublicationPROSITE-ProRule annotation
    Disulfide bondi212 ↔ 2431 PublicationPROSITE-ProRule annotation
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ99895.
    PRIDEiQ99895.

    Expressioni

    Tissue specificityi

    Pancreas.

    Gene expression databases

    ArrayExpressiQ99895.
    BgeeiQ99895.
    CleanExiHS_CTRC.
    GenevestigatoriQ99895.

    Organism-specific databases

    HPAiHPA046920.

    Interactioni

    Protein-protein interaction databases

    BioGridi116458. 2 interactions.
    STRINGi9606.ENSP00000365116.

    Structurei

    Secondary structure

    1
    268
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi44 – 518
    Beta strandi54 – 6512
    Beta strandi68 – 714
    Helixi73 – 753
    Beta strandi82 – 876
    Beta strandi100 – 1023
    Beta strandi104 – 1096
    Turni115 – 1173
    Beta strandi123 – 1297
    Beta strandi155 – 1606
    Beta strandi162 – 1643
    Beta strandi174 – 1774
    Helixi183 – 1864
    Turni189 – 1924
    Helixi193 – 1953
    Beta strandi200 – 2034
    Beta strandi206 – 2105
    Beta strandi219 – 2235
    Beta strandi229 – 23911
    Beta strandi242 – 2454
    Beta strandi250 – 2545
    Helixi255 – 2573
    Helixi259 – 2657

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4H4FX-ray1.90A30-268[»]
    Q17-26[»]
    ProteinModelPortaliQ99895.
    SMRiQ99895. Positions 30-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 267238Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ99895.
    KOiK01311.
    OMAiGKNNLEV.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ99895.
    TreeFamiTF330455.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99895-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGITVLAAL LACASSCGVP SFPPNLSARV VGGEDARPHS WPWQISLQYL    50
    KNDTWRHTCG GTLIASNFVL TAAHCISNTR TYRVAVGKNN LEVEDEEGSL 100
    FVGVDTIHVH KRWNALLLRN DIALIKLAEH VELSDTIQVA CLPEKDSLLP 150
    KDYPCYVTGW GRLWTNGPIA DKLQQGLQPV VDHATCSRID WWGFRVKKTM 200
    VCAGGDGVIS ACNGDSGGPL NCQLENGSWE VFGIVSFGSR RGCNTRKKPV 250
    VYTRVSAYID WINEKMQL 268
    Length:268
    Mass (Da):29,484
    Last modified:June 1, 2001 - v2
    Checksum:i460BF33B4A96516F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161S → T in AAB47104. (PubMed:8635596)Curated
    Sequence conflicti52 – 521N → D in CAA74031. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181G → R Found in a patient with chronic pancreatitis; unknown pathological significance; catalytic activity comparable to that of wild type; the mutant undergoes proteolytic degradation during trypsin-mediated activation. 1 Publication
    Corresponds to variant rs200576965 [ dbSNP | Ensembl ].
    VAR_070520
    Natural varianti29 – 291R → Q Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication
    VAR_070521
    Natural varianti32 – 321G → V in PCTT; associated with disease susceptibility; highly reduced catalytic efficiency.
    VAR_070522
    Natural varianti35 – 351D → H.1 Publication
    VAR_043516
    Natural varianti35 – 351D → N.1 Publication
    Corresponds to variant rs184977421 [ dbSNP | Ensembl ].
    VAR_043517
    Natural varianti35 – 351D → Y Found in a patient with chronic pancreatitis; unknown pathological significance; catalytic activity comparable to that of wild type. 1 Publication
    VAR_070523
    Natural varianti37 – 371R → Q Rare variant resulting in normal secretion and activity. 1 Publication
    Corresponds to variant rs145868278 [ dbSNP | Ensembl ].
    VAR_043518
    Natural varianti48 – 481Q → R Rare variant that may be associated with susceptibility to pancreatitis; results in markedly reduced protein secretion. 2 Publications
    VAR_043519
    Natural varianti61 – 611G → R Found in a patient with chronic pancreatitis; unknown pathological significance; the mutant is not secreted.
    VAR_070524
    Natural varianti73 – 731A → T in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion. 3 Publications
    VAR_043520
    Natural varianti80 – 801R → W.1 Publication
    VAR_010928
    Natural varianti151 – 1511K → N Found in a patient with chronic pancreatitis; unknown pathological significance.
    VAR_070525
    Natural varianti155 – 1551C → Y in PCTT; associated with susceptibility to disease; the mutant is not secreted. 1 Publication
    VAR_070526
    Natural varianti162 – 1621R → H Rare variant; found in a patient with chronic pancreatitis; unknown pathological significance. 1 Publication
    VAR_070527
    Natural varianti172 – 1721K → E.3 Publications
    Corresponds to variant rs34949635 [ dbSNP | Ensembl ].
    VAR_043521
    Natural varianti178 – 1781Q → R in PCTT; associated with disease susceptibility; impaired catalytic activity. 1 Publication
    Corresponds to variant rs200678111 [ dbSNP | Ensembl ].
    VAR_070528
    Natural varianti200 – 2001M → V Rare variant; found in a patient with chronic pancreatitis; unknown pathological significance. 1 Publication
    Corresponds to variant rs146235499 [ dbSNP | Ensembl ].
    VAR_070529
    Natural varianti209 – 2091I → M.1 Publication
    VAR_070530
    Natural varianti217 – 2171G → R in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion and loss of activity. 2 Publications
    VAR_043522
    Natural varianti217 – 2171G → S in PCTT; associated with susceptibility to disease; reduced protein secretion; impaired catalytic activity. 2 Publications
    Corresponds to variant rs202058123 [ dbSNP | Ensembl ].
    VAR_043523
    Natural varianti218 – 2181G → S.1 Publication
    VAR_043524
    Natural varianti220 – 2201L → R Rare variant that results in impaired protein secretion. 1 Publication
    VAR_043525
    Natural varianti225 – 2251E → A.1 Publication
    VAR_043526
    Natural varianti225 – 2251E → K Found in a patient with chronic pancreatitis; unknown pathological significance. 1 Publication
    VAR_070531
    Natural varianti227 – 2271G → S.1 Publication
    VAR_070532
    Natural varianti235 – 2351V → I in PCTT; associated with susceptibility to disease; slightly reduced activity. 3 Publications
    Corresponds to variant rs140993290 [ dbSNP | Ensembl ].
    VAR_043527
    Natural varianti239 – 2391S → A Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication
    VAR_070533
    Natural varianti239 – 2391S → C Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication
    VAR_070534
    Natural varianti246 – 2461R → C.1 Publication
    Corresponds to variant rs200412314 [ dbSNP | Ensembl ].
    VAR_070535
    Natural varianti247 – 2548Missing in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity.
    VAR_070536
    Natural varianti247 – 2471K → E Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication
    VAR_070537
    Natural varianti249 – 2491P → L in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity. 1 Publication
    Corresponds to variant rs142560329 [ dbSNP | Ensembl ].
    VAR_043528
    Natural varianti250 – 2501V → E in PCTT; associated with disease susceptibility; results in altered enzyme specificity and loss of activity. 1 Publication
    VAR_070538
    Natural varianti254 – 2541R → Q Found in a patient with chronic pancreatitis; unknown pathological significance; mutant protein secretion, activity and trypsin-mediated degradation are comparable to those of wild-type. 1 Publication
    VAR_070539
    Natural varianti254 – 2541R → W in PCTT; associated with susceptibility to disease; results in reduced secretion; normal activity; the mutant undergoes proteolytic degradation during trypsin-mediated activation. 4 Publications
    Corresponds to variant rs121909293 [ dbSNP | Ensembl ].
    VAR_043529
    Natural varianti257 – 2571A → T Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication
    Corresponds to variant rs200406696 [ dbSNP | Ensembl ].
    VAR_070540
    Natural varianti260 – 2601D → N.1 Publication
    VAR_043530
    Natural varianti263 – 2631N → S Found in a patient with chronic pancreatitis; unknown pathological significance. 1 Publication
    VAR_070541

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82198 mRNA. Translation: AAB47104.2. Sequence problems.
    AK289447 mRNA. Translation: BAF82136.1.
    AL031283 Genomic DNA. Translation: CAB77355.1.
    CH471167 Genomic DNA. Translation: EAW51726.1.
    BC015118 mRNA. Translation: AAH15118.1.
    Y13697 mRNA. Translation: CAA74031.1.
    CCDSiCCDS156.1.
    PIRiS68825.
    S68826.
    RefSeqiNP_009203.2. NM_007272.2.
    UniGeneiHs.631869.

    Genome annotation databases

    EnsembliENST00000375949; ENSP00000365116; ENSG00000162438.
    GeneIDi11330.
    KEGGihsa:11330.
    UCSCiuc001awi.1. human.

    Polymorphism databases

    DMDMi14194504.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82198 mRNA. Translation: AAB47104.2 . Sequence problems.
    AK289447 mRNA. Translation: BAF82136.1 .
    AL031283 Genomic DNA. Translation: CAB77355.1 .
    CH471167 Genomic DNA. Translation: EAW51726.1 .
    BC015118 mRNA. Translation: AAH15118.1 .
    Y13697 mRNA. Translation: CAA74031.1 .
    CCDSi CCDS156.1.
    PIRi S68825.
    S68826.
    RefSeqi NP_009203.2. NM_007272.2.
    UniGenei Hs.631869.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4H4F X-ray 1.90 A 30-268 [» ]
    Q 17-26 [» ]
    ProteinModelPortali Q99895.
    SMRi Q99895. Positions 30-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116458. 2 interactions.
    STRINGi 9606.ENSP00000365116.

    Chemistry

    BindingDBi Q99895.
    ChEMBLi CHEMBL2386.

    Protein family/group databases

    MEROPSi S01.157.

    Polymorphism databases

    DMDMi 14194504.

    Proteomic databases

    PaxDbi Q99895.
    PRIDEi Q99895.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375949 ; ENSP00000365116 ; ENSG00000162438 .
    GeneIDi 11330.
    KEGGi hsa:11330.
    UCSCi uc001awi.1. human.

    Organism-specific databases

    CTDi 11330.
    GeneCardsi GC01P015764.
    HGNCi HGNC:2523. CTRC.
    HPAi HPA046920.
    MIMi 167800. phenotype.
    601405. gene.
    neXtProti NX_Q99895.
    Orphaneti 676. Hereditary chronic pancreatitis.
    103918. Tropical pancreatitis.
    PharmGKBi PA27024.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q99895.
    KOi K01311.
    OMAi GKNNLEV.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q99895.
    TreeFami TF330455.

    Enzyme and pathway databases

    BRENDAi 3.4.21.2. 2681.

    Miscellaneous databases

    GeneWikii Chymotrypsin-C.
    GenomeRNAii 11330.
    NextBioi 43039.
    PROi Q99895.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99895.
    Bgeei Q99895.
    CleanExi HS_CTRC.
    Genevestigatori Q99895.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TRP-80.
      Tissue: Pancreas.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Urinary bladder.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    6. "A human pancreatic chymotrypsin: biochemical and molecular characterization."
      Sziegoleit A.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-268.
      Tissue: Pancreas.
    7. "Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene."
      Yoshino-Yasuda I., Kobayashi K., Akiyama M., Itoh H., Tomomura A., Saheki T.
      J. Biochem. 123:546-554(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation."
      Batra J., Szabo A., Caulfield T.R., Soares A.S., Sahin-Toth M., Radisky E.S.
      J. Biol. Chem. 288:9848-9859(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 17-268 IN COMPLEX WITH INHIBITOR, FUNCTION, DISULFIDE BONDS.
    9. "Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis."
      Masson E., Chen J.M., Scotet V., Le Marechal C., Ferec C.
      Hum. Genet. 123:83-91(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PCTT THR-73; TYR-155; SER-217; ARG-217; ILE-235; 247-LYS--ARG-254 DEL AND TRP-254, VARIANTS HIS-162; GLU-172 AND VAL-200.
    10. Cited for: VARIANTS PCTT THR-73; SER-217; ARG-217; ILE-235 AND TRP-254, VARIANTS HIS-35; ASN-35; GLN-37; ARG-48; GLU-172; SER-218; ARG-220; ALA-225; LEU-249 AND ASN-260, CHARACTERIZATION OF VARIANTS PCTT THR-73; SER-217; ILE-235 AND TRP-254, CHARACTERIZATION OF VARIANTS GLN-37 AND ARG-48.
    11. "Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan."
      Chang M.C., Chang Y.T., Wei S.C., Liang P.C., Jan I.S., Su Y.N., Kuo C.H., Wong J.M.
      Pancreatology 9:287-292(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LYS-225; GLN-254 AND SER-263.
    12. "Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis."
      Masamune A., Nakano E., Kume K., Kakuta Y., Ariga H., Shimosegawa T.
      Gut 62:653-654(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLN-29; MET-209; ALA-239; CYS-239; GLU-247 AND TRP-254.
    13. "Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants."
      Paliwal S., Bhaskar S., Mani K.R., Reddy D.N., Rao G.V., Singh S.P., Thomas V., Chandak G.R.
      Gut 62:1602-1606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-48; GLU-172; CYS-246 AND THR-257, VARIANTS PCTT THR-73; ILE-235 AND TRP-254.
    14. "Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk."
      Beer S., Zhou J., Szabo A., Keiles S., Chandak G.R., Witt H., Sahin-Toth M.
      Gut 62:1616-1624(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-18; TYR-35 AND SER-227, VARIANTS PCTT ARG-178 AND GLU-250, CHARACTERIZATION OF VARIANTS ARG-18; TYR-35; ARG-48; ARG-61; ARG-220 AND GLN-254, CHARACTERIZATION OF VARIANTS PCTT VAL-32; THR-73; TYR-155; ARG-178; ARG-217; SER-217; ILE-235; 247-LYS--ARG-254 DEL; LEU-249; GLU-250 AND TRP-254.

    Entry informationi

    Entry nameiCTRC_HUMAN
    AccessioniPrimary (citable) accession number: Q99895
    Secondary accession number(s): A8K082, O00765, Q9NUH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3