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Protein

Sodium-dependent proline transporter

Gene

SLC6A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

GO - Biological processi

  • proline transport Source: ProtInc

Keywordsi

Biological processAmino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-71288 Creatine metabolism

Protein family/group databases

TCDBi2.A.22.2.11 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent proline transporter
Alternative name(s):
Solute carrier family 6 member 7
Gene namesi
Name:SLC6A7
Synonyms:PROT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000011083.8
HGNCiHGNC:11054 SLC6A7
MIMi606205 gene
neXtProtiNX_Q99884

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 214ExtracellularSequence analysisAdd BLAST77
Transmembranei215 – 233Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei242 – 259Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei295 – 312Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei324 – 345Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei378 – 397Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei425 – 443Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei459 – 479Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei500 – 519Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei538 – 556Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini557 – 636CytoplasmicSequence analysisAdd BLAST80

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6534
OpenTargetsiENSG00000011083
PharmGKBiPA35914

Chemistry databases

ChEMBLiCHEMBL3317335
DrugBankiDB00172 L-Proline
GuidetoPHARMACOLOGYi938

Polymorphism and mutation databases

BioMutaiSLC6A7
DMDMi296452899

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147701 – 636Sodium-dependent proline transporterAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphothreonineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei573PhosphoserineBy similarity1
Modified residuei582PhosphoserineBy similarity1
Modified residuei588PhosphothreonineBy similarity1
Modified residuei591PhosphotyrosineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei600PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ99884
PeptideAtlasiQ99884
PRIDEiQ99884

PTM databases

iPTMnetiQ99884
PhosphoSitePlusiQ99884

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000011083
CleanExiHS_SLC6A7
ExpressionAtlasiQ99884 baseline and differential
GenevisibleiQ99884 HS

Organism-specific databases

HPAiHPA028907

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000230671

Chemistry databases

BindingDBiQ99884

Structurei

3D structure databases

ProteinModelPortaliQ99884
SMRiQ99884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ99884
KOiK05038
PhylomeDBiQ99884
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q99884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLQGAHLR KPVTPDLLMT PSDQGDVDLD VDFAAHRGNW TGKLDFLLSC
60 70 80 90 100
IGYCVGLGNV WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF
110 120 130 140 150
SSLGPLAVWK ISPLFKGAGA AMLLIVGLVA IYYNMIIAYV LFYLFASLTS
160 170 180 190 200
DLPWEHCGNW WNTELCLEHR VSKDGNGALP LNLTCTVSPS EEYWSRYVLH
210 220 230 240 250
IQGSQGIGSP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG KVVYFTATFP
260 270 280 290 300
YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG
310 320 330 340 350
VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ
360 370 380 390 400
ELGVPVDQVA KAGPGLAFVV YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ
410 420 430 440 450
FAFLETIVTA VTDEFPYYLR PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL
460 470 480 490 500
VLLDDYSASF GLMVVVITTC LAVTRVYGIQ RFCRDIHMML GFKPGLYFRA
510 520 530 540 550
CWLFLSPATL LALMVYSIVK YQPSEYGSYR FPPWAELLGI LMGLLSCLMI
560 570 580 590 600
PAGMLVAVLR EEGSLWERLQ QASRPAMDWG PSLEENRTGM YVATLAGSQS
610 620 630
PKPLMVHMRK YGGITSFENT AIEVDREIAE EEESMM
Length:636
Mass (Da):70,911
Last modified:May 18, 2010 - v2
Checksum:i9B9D10C1F49E409B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti514M → L in AAB47007 (PubMed:7651355).Curated1
Sequence conflicti514M → L in AAH69631 (PubMed:15489334).Curated1
Sequence conflicti514M → L in AAH93785 (PubMed:15489334).Curated1
Sequence conflicti514M → L in AAI13426 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011390345L → V. Corresponds to variant dbSNP:rs1468564Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80071 mRNA Translation: AAB47007.2
AC005895 Genomic DNA No translation available.
BC069631 mRNA Translation: AAH69631.1
BC093785 mRNA Translation: AAH93785.1
BC113425 mRNA Translation: AAI13426.1
CCDSiCCDS4305.1
RefSeqiNP_055043.2, NM_014228.4
UniGeneiHs.241597

Genome annotation databases

EnsembliENST00000230671; ENSP00000230671; ENSG00000011083
GeneIDi6534
KEGGihsa:6534
UCSCiuc003lrr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSC6A7_HUMAN
AccessioniPrimary (citable) accession number: Q99884
Secondary accession number(s): Q0VG81, Q52LU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health