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Protein

Sodium-dependent proline transporter

Gene

SLC6A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

GO - Biological processi

  • proline transport Source: ProtInc
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-442660. Na+/Cl- dependent neurotransmitter transporters.
R-HSA-71288. Creatine metabolism.

Protein family/group databases

TCDBi2.A.22.2.11. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent proline transporter
Alternative name(s):
Solute carrier family 6 member 7
Gene namesi
Name:SLC6A7
Synonyms:PROT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:11054. SLC6A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicSequence analysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei74 – 9320Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 21477ExtracellularSequence analysisAdd
BLAST
Transmembranei215 – 23319Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei242 – 25918Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei295 – 31218Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei324 – 34522Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei378 – 39720Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei425 – 44319Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei459 – 47921Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei500 – 51920Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei538 – 55619Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini557 – 63680CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35914.

Chemistry

ChEMBLiCHEMBL3317335.
DrugBankiDB00172. L-Proline.
GuidetoPHARMACOLOGYi938.

Polymorphism and mutation databases

BioMutaiSLC6A7.
DMDMi296452899.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Sodium-dependent proline transporterPRO_0000214770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphothreonineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Modified residuei573 – 5731PhosphoserineBy similarity
Modified residuei582 – 5821PhosphoserineBy similarity
Modified residuei588 – 5881PhosphothreonineBy similarity
Modified residuei591 – 5911PhosphotyrosineBy similarity
Modified residuei598 – 5981PhosphoserineBy similarity
Modified residuei600 – 6001PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ99884.
PRIDEiQ99884.

PTM databases

iPTMnetiQ99884.
PhosphoSiteiQ99884.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiQ99884.
CleanExiHS_SLC6A7.
ExpressionAtlasiQ99884. baseline and differential.
GenevisibleiQ99884. HS.

Organism-specific databases

HPAiHPA028907.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000230671.

Structurei

3D structure databases

ProteinModelPortaliQ99884.
SMRiQ99884. Positions 37-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ99884.
KOiK05038.
OrthoDBiEOG793B71.
PhylomeDBiQ99884.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLQGAHLR KPVTPDLLMT PSDQGDVDLD VDFAAHRGNW TGKLDFLLSC
60 70 80 90 100
IGYCVGLGNV WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF
110 120 130 140 150
SSLGPLAVWK ISPLFKGAGA AMLLIVGLVA IYYNMIIAYV LFYLFASLTS
160 170 180 190 200
DLPWEHCGNW WNTELCLEHR VSKDGNGALP LNLTCTVSPS EEYWSRYVLH
210 220 230 240 250
IQGSQGIGSP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG KVVYFTATFP
260 270 280 290 300
YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG
310 320 330 340 350
VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ
360 370 380 390 400
ELGVPVDQVA KAGPGLAFVV YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ
410 420 430 440 450
FAFLETIVTA VTDEFPYYLR PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL
460 470 480 490 500
VLLDDYSASF GLMVVVITTC LAVTRVYGIQ RFCRDIHMML GFKPGLYFRA
510 520 530 540 550
CWLFLSPATL LALMVYSIVK YQPSEYGSYR FPPWAELLGI LMGLLSCLMI
560 570 580 590 600
PAGMLVAVLR EEGSLWERLQ QASRPAMDWG PSLEENRTGM YVATLAGSQS
610 620 630
PKPLMVHMRK YGGITSFENT AIEVDREIAE EEESMM
Length:636
Mass (Da):70,911
Last modified:May 18, 2010 - v2
Checksum:i9B9D10C1F49E409B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti514 – 5141M → L in AAB47007 (PubMed:7651355).Curated
Sequence conflicti514 – 5141M → L in AAH69631 (PubMed:15489334).Curated
Sequence conflicti514 – 5141M → L in AAH93785 (PubMed:15489334).Curated
Sequence conflicti514 – 5141M → L in AAI13426 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti345 – 3451L → V.
Corresponds to variant rs1468564 [ dbSNP | Ensembl ].
VAR_011390

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80071 mRNA. Translation: AAB47007.2.
AC005895 Genomic DNA. No translation available.
BC069631 mRNA. Translation: AAH69631.1.
BC093785 mRNA. Translation: AAH93785.1.
BC113425 mRNA. Translation: AAI13426.1.
CCDSiCCDS4305.1.
RefSeqiNP_055043.2. NM_014228.3.
UniGeneiHs.241597.

Genome annotation databases

EnsembliENST00000230671; ENSP00000230671; ENSG00000011083.
GeneIDi6534.
KEGGihsa:6534.
UCSCiuc003lrr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80071 mRNA. Translation: AAB47007.2.
AC005895 Genomic DNA. No translation available.
BC069631 mRNA. Translation: AAH69631.1.
BC093785 mRNA. Translation: AAH93785.1.
BC113425 mRNA. Translation: AAI13426.1.
CCDSiCCDS4305.1.
RefSeqiNP_055043.2. NM_014228.3.
UniGeneiHs.241597.

3D structure databases

ProteinModelPortaliQ99884.
SMRiQ99884. Positions 37-578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000230671.

Chemistry

ChEMBLiCHEMBL3317335.
DrugBankiDB00172. L-Proline.
GuidetoPHARMACOLOGYi938.

Protein family/group databases

TCDBi2.A.22.2.11. the neurotransmitter:sodium symporter (nss) family.

PTM databases

iPTMnetiQ99884.
PhosphoSiteiQ99884.

Polymorphism and mutation databases

BioMutaiSLC6A7.
DMDMi296452899.

Proteomic databases

PaxDbiQ99884.
PRIDEiQ99884.

Protocols and materials databases

DNASUi6534.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230671; ENSP00000230671; ENSG00000011083.
GeneIDi6534.
KEGGihsa:6534.
UCSCiuc003lrr.3. human.

Organism-specific databases

CTDi6534.
GeneCardsiSLC6A7.
H-InvDBHIX0005311.
HGNCiHGNC:11054. SLC6A7.
HPAiHPA028907.
MIMi606205. gene.
neXtProtiNX_Q99884.
PharmGKBiPA35914.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ99884.
KOiK05038.
OrthoDBiEOG793B71.
PhylomeDBiQ99884.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-HSA-442660. Na+/Cl- dependent neurotransmitter transporters.
R-HSA-71288. Creatine metabolism.

Miscellaneous databases

GenomeRNAii6534.
PROiQ99884.
SOURCEiSearch...

Gene expression databases

BgeeiQ99884.
CleanExiHS_SLC6A7.
ExpressionAtlasiQ99884. baseline and differential.
GenevisibleiQ99884. HS.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes."
    Shafqat S., Velaz-Faircloth M., Henzi V.A., Whitney K.D., Yang-Feng T.L., Seldin M.F., Fremeau R.T. Jr.
    Mol. Pharmacol. 48:219-229(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiSC6A7_HUMAN
AccessioniPrimary (citable) accession number: Q99884
Secondary accession number(s): Q0VG81, Q52LU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.