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Q99884 (SC6A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent proline transporter
Alternative name(s):
Solute carrier family 6 member 7
Gene names
Name:SLC6A7
Synonyms:PROT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Brain.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily. [View classification]

Ontologies

Keywords
   Biological processAmino-acid transport
Neurotransmitter transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproline transport

Traceable author statement Ref.1. Source: ProtInc

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral to plasma membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionneurotransmitter:sodium symporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 636636Sodium-dependent proline transporter
PRO_0000214770

Regions

Topological domain1 – 4545Cytoplasmic Potential
Transmembrane46 – 6621Helical; Name=1; Potential
Transmembrane74 – 9320Helical; Name=2; Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 21477Extracellular Potential
Transmembrane215 – 23319Helical; Name=4; Potential
Transmembrane242 – 25918Helical; Name=5; Potential
Transmembrane295 – 31218Helical; Name=6; Potential
Transmembrane324 – 34522Helical; Name=7; Potential
Transmembrane378 – 39720Helical; Name=8; Potential
Transmembrane425 – 44319Helical; Name=9; Potential
Transmembrane459 – 47921Helical; Name=10; Potential
Transmembrane500 – 51920Helical; Name=11; Potential
Transmembrane538 – 55619Helical; Name=12; Potential
Topological domain557 – 63680Cytoplasmic Potential

Amino acid modifications

Glycosylation1821N-linked (GlcNAc...) Potential

Natural variations

Natural variant3451L → V.
Corresponds to variant rs1468564 [ dbSNP | Ensembl ].
VAR_011390

Experimental info

Sequence conflict5141M → L in AAB47007. Ref.1
Sequence conflict5141M → L in AAH69631. Ref.3
Sequence conflict5141M → L in AAH93785. Ref.3
Sequence conflict5141M → L in AAI13426. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q99884 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 9B9D10C1F49E409B

FASTA63670,911
        10         20         30         40         50         60 
MKKLQGAHLR KPVTPDLLMT PSDQGDVDLD VDFAAHRGNW TGKLDFLLSC IGYCVGLGNV 

        70         80         90        100        110        120 
WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF SSLGPLAVWK ISPLFKGAGA 

       130        140        150        160        170        180 
AMLLIVGLVA IYYNMIIAYV LFYLFASLTS DLPWEHCGNW WNTELCLEHR VSKDGNGALP 

       190        200        210        220        230        240 
LNLTCTVSPS EEYWSRYVLH IQGSQGIGSP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG 

       250        260        270        280        290        300 
KVVYFTATFP YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG 

       310        320        330        340        350        360 
VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ ELGVPVDQVA 

       370        380        390        400        410        420 
KAGPGLAFVV YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ FAFLETIVTA VTDEFPYYLR 

       430        440        450        460        470        480 
PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL VLLDDYSASF GLMVVVITTC LAVTRVYGIQ 

       490        500        510        520        530        540 
RFCRDIHMML GFKPGLYFRA CWLFLSPATL LALMVYSIVK YQPSEYGSYR FPPWAELLGI 

       550        560        570        580        590        600 
LMGLLSCLMI PAGMLVAVLR EEGSLWERLQ QASRPAMDWG PSLEENRTGM YVATLAGSQS 

       610        620        630 
PKPLMVHMRK YGGITSFENT AIEVDREIAE EEESMM

« Hide

References

« Hide 'large scale' references
[1]"Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes."
Shafqat S., Velaz-Faircloth M., Henzi V.A., Whitney K.D., Yang-Feng T.L., Seldin M.F., Fremeau R.T. Jr.
Mol. Pharmacol. 48:219-229(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S80071 mRNA. Translation: AAB47007.2.
AC005895 Genomic DNA. No translation available.
BC069631 mRNA. Translation: AAH69631.1.
BC093785 mRNA. Translation: AAH93785.1.
BC113425 mRNA. Translation: AAI13426.1.
IPIIPI00018537.
RefSeqNP_055043.2. NM_014228.3.
UniGeneHs.241597.

3D structure databases

ProteinModelPortalQ99884.
SMRQ99884. Positions 37-523.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000230671.

PTM databases

PhosphoSiteQ99884.

Polymorphism databases

DMDM296452899.

Proteomic databases

PaxDbQ99884.
PRIDEQ99884.

Protocols and materials databases

DNASU6534.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000230671; ENSP00000230671; ENSG00000011083.
GeneID6534.
KEGGhsa:6534.
UCSCuc003lrr.3. human.

Organism-specific databases

CTD6534.
GeneCardsGC05P149569.
H-InvDBHIX0005311.
HGNCHGNC:11054. SLC6A7.
HPAHPA028907.
MIM606205. gene.
neXtProtNX_Q99884.
PharmGKBPA35914.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ99884.
KOK05038.
OrthoDBEOG46HG99.
PhylomeDBQ99884.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressQ99884.
BgeeQ99884.
CleanExHS_SLC6A7.
GenevestigatorQ99884.
GermOnlineENSG00000011083. Homo sapiens.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

DrugBankDB00172. L-Proline.
GenomeRNAi6534.
NextBio25423.
SOURCESearch...

Entry information

Entry nameSC6A7_HUMAN
AccessionPrimary (citable) accession number: Q99884
Secondary accession number(s): Q0VG81, Q52LU6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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