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Protein

Spindlin-2A

Gene

SPIN2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169Histone H3K4me3 and H3R8me2aBy similarity1
Binding sitei176Histone H3K4me3 and H3R8me2aBy similarity1
Binding sitei180Histone H3K4me3 and H3R8me2aBy similarity1

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-2A
Alternative name(s):
Protein DXF34
Spindlin-like protein 2A
Short name:
SPIN-2
Short name:
SPIN-2A
Gene namesi
Name:SPIN2A
Synonyms:DXF34, SPIN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147059.8
HGNCiHGNC:20694 SPIN2A
MIMi300621 gene
neXtProtiNX_Q99865

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54466
OpenTargetsiENSG00000147059
PharmGKBiPA144596490

Polymorphism and mutation databases

BioMutaiSPIN2A
DMDMi116242797

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813711 – 258Spindlin-2AAdd BLAST258

Proteomic databases

EPDiQ99865
MaxQBiQ99865
PaxDbiQ99865
PeptideAtlasiQ99865
PRIDEiQ99865
ProteomicsDBi78507

PTM databases

iPTMnetiQ99865
PhosphoSitePlusiQ99865

Expressioni

Gene expression databases

BgeeiENSG00000147059
CleanExiHS_SPIN2A
ExpressionAtlasiQ99865 baseline and differential
GenevisibleiQ99865 HS

Organism-specific databases

HPAiHPA000162
HPA069835

Interactioni

Subunit structurei

Interacts with C11orf84/SPINDOC (PubMed:29061846).1 Publication

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119972, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ99865
SMRiQ99865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 99Tudor-like domain 1Sequence analysisAdd BLAST50
Regioni129 – 178Tudor-like domain 2Sequence analysisAdd BLAST50
Regioni138Histone H3K4me3 and H3R8me2a bindingBy similarity1
Regioni210 – 255Tudor-like domain 3Sequence analysisAdd BLAST46
Regioni246 – 248Histone H3K4me3 and H3R8me2a bindingBy similarity3

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiENOG410IGUH Eukaryota
ENOG410XQI2 LUCA
GeneTreeiENSGT00760000119261
HOGENOMiHOG000293367
HOVERGENiHBG000686
InParanoidiQ99865
OMAiLRIMSEP
OrthoDBiEOG091G0EE3
PhylomeDBiQ99865
TreeFamiTF332665

Family and domain databases

InterProiView protein in InterPro
IPR029564 SPIN-2
IPR003671 SPIN/Ssty
PANTHERiPTHR10405 PTHR10405, 1 hit
PTHR10405:SF28 PTHR10405:SF28, 1 hit
PfamiView protein in Pfam
PF02513 Spin-Ssty, 3 hits

Sequencei

Sequence statusi: Complete.

Q99865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV
60 70 80 90 100
GCRISHGWKE GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR
110 120 130 140 150
DERVLSLKIL SDRVASSHIS DANLANTIIG KAVEHMFEGE HGSKDEWRGM
160 170 180 190 200
VLAQAPIMKA WFYITYEKDP VLYMYQLLDD YKEGDLRIMP ESSESPPTER
210 220 230 240 250
EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVETKPSVYF IKFDDDFHIY

VYDLVKKS
Length:258
Mass (Da):29,188
Last modified:October 17, 2006 - v3
Checksum:iDE860789970B4BCD
GO

Sequence cautioni

The sequence CAA70988 differs from that shown. Reason: Frameshift at position 10.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46R → C in CAA70988 (PubMed:9271673).Curated1
Sequence conflicti46R → C in AAH71694 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09858 mRNA Translation: CAA70988.1 Frameshift.
AL022157 Genomic DNA No translation available.
BC071694 mRNA Translation: AAH71694.1
CCDSiCCDS35312.1
RefSeqiNP_061876.3, NM_019003.3
XP_005262073.3, XM_005262016.4
XP_005262074.3, XM_005262017.4
XP_005262076.1, XM_005262019.3
XP_016885087.1, XM_017029598.1
UniGeneiHs.460725

Genome annotation databases

EnsembliENST00000374906; ENSP00000364041; ENSG00000147059
ENST00000374908; ENSP00000364043; ENSG00000147059
GeneIDi54466
KEGGihsa:54466
UCSCiuc004dvb.3 human

Similar proteinsi

Entry informationi

Entry nameiSPI2A_HUMAN
AccessioniPrimary (citable) accession number: Q99865
Secondary accession number(s): O75650, Q6IPW2, Q9UJJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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