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Q99865

- SPI2A_HUMAN

UniProt

Q99865 - SPI2A_HUMAN

Protein

Spindlin-2A

Gene

SPIN2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of cell cycle progression.By similarity

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. gamete generation Source: InterPro

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spindlin-2A
    Alternative name(s):
    Protein DXF34
    Spindlin-like protein 2A
    Short name:
    SPIN-2
    Short name:
    SPIN-2A
    Gene namesi
    Name:SPIN2A
    Synonyms:DXF34, SPIN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:20694. SPIN2A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596490.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Spindlin-2APRO_0000181371Add
    BLAST

    Proteomic databases

    MaxQBiQ99865.
    PaxDbiQ99865.
    PRIDEiQ99865.

    PTM databases

    PhosphoSiteiQ99865.

    Expressioni

    Gene expression databases

    BgeeiQ99865.
    CleanExiHS_SPIN2A.
    GenevestigatoriQ99865.

    Interactioni

    Protein-protein interaction databases

    BioGridi119972. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99865.
    SMRiQ99865. Positions 46-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SPIN/STSY family.Curated

    Phylogenomic databases

    eggNOGiNOG40069.
    HOGENOMiHOG000293367.
    HOVERGENiHBG000686.
    InParanoidiQ99865.
    OMAiMNESELH.
    OrthoDBiEOG7CK37K.
    PhylomeDBiQ99865.
    TreeFamiTF332665.

    Family and domain databases

    InterProiIPR029564. SPIN-2.
    IPR003671. SPIN/Ssty.
    [Graphical view]
    PANTHERiPTHR10405. PTHR10405. 1 hit.
    PTHR10405:SF17. PTHR10405:SF17. 1 hit.
    PfamiPF02513. Spin-Ssty. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99865-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV    50
    GCRISHGWKE GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR 100
    DERVLSLKIL SDRVASSHIS DANLANTIIG KAVEHMFEGE HGSKDEWRGM 150
    VLAQAPIMKA WFYITYEKDP VLYMYQLLDD YKEGDLRIMP ESSESPPTER 200
    EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVETKPSVYF IKFDDDFHIY 250
    VYDLVKKS 258
    Length:258
    Mass (Da):29,188
    Last modified:October 17, 2006 - v3
    Checksum:iDE860789970B4BCD
    GO

    Sequence cautioni

    The sequence CAA70988.1 differs from that shown. Reason: Frameshift at position 10.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461R → C in CAA70988. (PubMed:9271673)Curated
    Sequence conflicti46 – 461R → C in AAH71694. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09858 mRNA. Translation: CAA70988.1. Frameshift.
    AL022157 Genomic DNA. Translation: CAI42597.1.
    BC071694 mRNA. Translation: AAH71694.1.
    CCDSiCCDS35312.1.
    RefSeqiNP_061876.3. NM_019003.3.
    XP_005262076.1. XM_005262019.1.
    XP_006724651.1. XM_006724588.1.
    UniGeneiHs.460725.

    Genome annotation databases

    EnsembliENST00000374906; ENSP00000364041; ENSG00000147059.
    ENST00000374908; ENSP00000364043; ENSG00000147059.
    GeneIDi54466.
    KEGGihsa:54466.
    UCSCiuc004dvb.3. human.

    Polymorphism databases

    DMDMi116242797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09858 mRNA. Translation: CAA70988.1 . Frameshift.
    AL022157 Genomic DNA. Translation: CAI42597.1 .
    BC071694 mRNA. Translation: AAH71694.1 .
    CCDSi CCDS35312.1.
    RefSeqi NP_061876.3. NM_019003.3.
    XP_005262076.1. XM_005262019.1.
    XP_006724651.1. XM_006724588.1.
    UniGenei Hs.460725.

    3D structure databases

    ProteinModelPortali Q99865.
    SMRi Q99865. Positions 46-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119972. 3 interactions.

    PTM databases

    PhosphoSitei Q99865.

    Polymorphism databases

    DMDMi 116242797.

    Proteomic databases

    MaxQBi Q99865.
    PaxDbi Q99865.
    PRIDEi Q99865.

    Protocols and materials databases

    DNASUi 54466.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374906 ; ENSP00000364041 ; ENSG00000147059 .
    ENST00000374908 ; ENSP00000364043 ; ENSG00000147059 .
    GeneIDi 54466.
    KEGGi hsa:54466.
    UCSCi uc004dvb.3. human.

    Organism-specific databases

    CTDi 54466.
    GeneCardsi GC0XM057178.
    H-InvDB HIX0056252.
    HGNCi HGNC:20694. SPIN2A.
    MIMi 300621. gene.
    neXtProti NX_Q99865.
    PharmGKBi PA144596490.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40069.
    HOGENOMi HOG000293367.
    HOVERGENi HBG000686.
    InParanoidi Q99865.
    OMAi MNESELH.
    OrthoDBi EOG7CK37K.
    PhylomeDBi Q99865.
    TreeFami TF332665.

    Miscellaneous databases

    GenomeRNAii 54466.
    NextBioi 56741.
    PROi Q99865.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99865.
    CleanExi HS_SPIN2A.
    Genevestigatori Q99865.

    Family and domain databases

    InterProi IPR029564. SPIN-2.
    IPR003671. SPIN/Ssty.
    [Graphical view ]
    PANTHERi PTHR10405. PTHR10405. 1 hit.
    PTHR10405:SF17. PTHR10405:SF17. 1 hit.
    Pfami PF02513. Spin-Ssty. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure of DXF34, a human X-linked sequence family with homology to a transcribed mouse Y-linked repeat."
      Laval S.H., Reed V., Blair H.J., Boyd Y.
      Mamm. Genome 8:689-691(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. Bienvenut W.V., Calvo F., Kolch W.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 70-86 AND 114-131, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiSPI2A_HUMAN
    AccessioniPrimary (citable) accession number: Q99865
    Secondary accession number(s): O75650, Q6IPW2, Q9UJJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3