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Q99865

- SPI2A_HUMAN

UniProt

Q99865 - SPI2A_HUMAN

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Protein

Spindlin-2A

Gene

SPIN2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cell cycle progression.By similarity

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. gamete generation Source: InterPro
  3. regulation of cell cycle Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-2A
Alternative name(s):
Protein DXF34
Spindlin-like protein 2A
Short name:
SPIN-2
Short name:
SPIN-2A
Gene namesi
Name:SPIN2A
Synonyms:DXF34, SPIN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:20694. SPIN2A.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Spindlin-2APRO_0000181371Add
BLAST

Proteomic databases

MaxQBiQ99865.
PaxDbiQ99865.
PRIDEiQ99865.

PTM databases

PhosphoSiteiQ99865.

Expressioni

Gene expression databases

BgeeiQ99865.
CleanExiHS_SPIN2A.
GenevestigatoriQ99865.

Interactioni

Protein-protein interaction databases

BioGridi119972. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ99865.
SMRiQ99865. Positions 46-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiNOG40069.
GeneTreeiENSGT00760000119261.
HOGENOMiHOG000293367.
HOVERGENiHBG000686.
InParanoidiQ99865.
OMAiMNESELH.
OrthoDBiEOG7CK37K.
PhylomeDBiQ99865.
TreeFamiTF332665.

Family and domain databases

InterProiIPR029564. SPIN-2.
IPR003671. SPIN/Ssty.
[Graphical view]
PANTHERiPTHR10405. PTHR10405. 1 hit.
PTHR10405:SF17. PTHR10405:SF17. 1 hit.
PfamiPF02513. Spin-Ssty. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99865-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV
60 70 80 90 100
GCRISHGWKE GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR
110 120 130 140 150
DERVLSLKIL SDRVASSHIS DANLANTIIG KAVEHMFEGE HGSKDEWRGM
160 170 180 190 200
VLAQAPIMKA WFYITYEKDP VLYMYQLLDD YKEGDLRIMP ESSESPPTER
210 220 230 240 250
EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVETKPSVYF IKFDDDFHIY

VYDLVKKS
Length:258
Mass (Da):29,188
Last modified:October 17, 2006 - v3
Checksum:iDE860789970B4BCD
GO

Sequence cautioni

The sequence CAA70988.1 differs from that shown. Reason: Frameshift at position 10.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461R → C in CAA70988. (PubMed:9271673)Curated
Sequence conflicti46 – 461R → C in AAH71694. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09858 mRNA. Translation: CAA70988.1. Frameshift.
AL022157 Genomic DNA. Translation: CAI42597.1.
BC071694 mRNA. Translation: AAH71694.1.
CCDSiCCDS35312.1.
RefSeqiNP_061876.3. NM_019003.3.
XP_005262076.1. XM_005262019.1.
XP_006724651.1. XM_006724588.1.
UniGeneiHs.460725.

Genome annotation databases

EnsembliENST00000374906; ENSP00000364041; ENSG00000147059.
ENST00000374908; ENSP00000364043; ENSG00000147059.
GeneIDi54466.
KEGGihsa:54466.
UCSCiuc004dvb.3. human.

Polymorphism databases

DMDMi116242797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09858 mRNA. Translation: CAA70988.1 . Frameshift.
AL022157 Genomic DNA. Translation: CAI42597.1 .
BC071694 mRNA. Translation: AAH71694.1 .
CCDSi CCDS35312.1.
RefSeqi NP_061876.3. NM_019003.3.
XP_005262076.1. XM_005262019.1.
XP_006724651.1. XM_006724588.1.
UniGenei Hs.460725.

3D structure databases

ProteinModelPortali Q99865.
SMRi Q99865. Positions 46-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119972. 4 interactions.

PTM databases

PhosphoSitei Q99865.

Polymorphism databases

DMDMi 116242797.

Proteomic databases

MaxQBi Q99865.
PaxDbi Q99865.
PRIDEi Q99865.

Protocols and materials databases

DNASUi 54466.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374906 ; ENSP00000364041 ; ENSG00000147059 .
ENST00000374908 ; ENSP00000364043 ; ENSG00000147059 .
GeneIDi 54466.
KEGGi hsa:54466.
UCSCi uc004dvb.3. human.

Organism-specific databases

CTDi 54466.
GeneCardsi GC0XM057178.
H-InvDB HIX0056252.
HGNCi HGNC:20694. SPIN2A.
MIMi 300621. gene.
neXtProti NX_Q99865.
PharmGKBi PA144596490.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40069.
GeneTreei ENSGT00760000119261.
HOGENOMi HOG000293367.
HOVERGENi HBG000686.
InParanoidi Q99865.
OMAi MNESELH.
OrthoDBi EOG7CK37K.
PhylomeDBi Q99865.
TreeFami TF332665.

Miscellaneous databases

GenomeRNAii 54466.
NextBioi 56741.
PROi Q99865.
SOURCEi Search...

Gene expression databases

Bgeei Q99865.
CleanExi HS_SPIN2A.
Genevestigatori Q99865.

Family and domain databases

InterProi IPR029564. SPIN-2.
IPR003671. SPIN/Ssty.
[Graphical view ]
PANTHERi PTHR10405. PTHR10405. 1 hit.
PTHR10405:SF17. PTHR10405:SF17. 1 hit.
Pfami PF02513. Spin-Ssty. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of DXF34, a human X-linked sequence family with homology to a transcribed mouse Y-linked repeat."
    Laval S.H., Reed V., Blair H.J., Boyd Y.
    Mamm. Genome 8:689-691(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. Bienvenut W.V., Calvo F., Kolch W.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 70-86 AND 114-131, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSPI2A_HUMAN
AccessioniPrimary (citable) accession number: Q99865
Secondary accession number(s): O75650, Q6IPW2, Q9UJJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3