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Q99856

- ARI3A_HUMAN

UniProt

Q99856 - ARI3A_HUMAN

Protein

AT-rich interactive domain-containing protein 3A

Gene

ARID3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.2 Publications

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AT-rich interactive domain-containing protein 3A
    Short name:
    ARID domain-containing protein 3A
    Alternative name(s):
    B-cell regulator of IgH transcription
    Short name:
    Bright
    Dead ringer-like protein 1
    E2F-binding protein 1
    Gene namesi
    Name:ARID3A
    Synonyms:DRIL1, DRIL3, DRX, E2FBP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3031. ARID3A.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Cytoplasm 1 Publication
    Note: Shuttles between nucleus and cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. membrane raft Source: MGI
    4. nucleolus Source: HPA
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi325 – 3251Y → A: Abolishes DNA-binding. 1 Publication
    Mutagenesisi461 – 4611K → A: Abolishes nuclear targeting. 1 Publication
    Mutagenesisi527 – 5271G → A or P: Impairs DNA-binding but not self-association. 1 Publication
    Mutagenesisi530 – 5301Y → A: Impairs DNA-binding but not self-association. 1 Publication
    Mutagenesisi530 – 5301Y → F: No effect on DNA-binding. 1 Publication
    Mutagenesisi532 – 5321G → A: Impairs DNA-binding. 1 Publication
    Mutagenesisi534 – 5341L → A: Impairs DNA-binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA27485.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593AT-rich interactive domain-containing protein 3APRO_0000200578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771Phosphoserine3 Publications
    Modified residuei81 – 811Phosphoserine2 Publications
    Modified residuei88 – 881Phosphoserine3 Publications
    Modified residuei98 – 981Phosphothreonine1 Publication
    Modified residuei101 – 1011Phosphoserine1 Publication
    Modified residuei119 – 1191Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99856.
    PaxDbiQ99856.
    PRIDEiQ99856.

    PTM databases

    PhosphoSiteiQ99856.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.

    Inductioni

    By p53/TP53 following DNA damage.1 Publication

    Gene expression databases

    ArrayExpressiQ99856.
    BgeeiQ99856.
    CleanExiHS_ARID3A.
    GenevestigatoriQ99856.

    Organism-specific databases

    HPAiHPA004793.

    Interactioni

    Subunit structurei

    Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BTKQ061873EBI-5458244,EBI-624835

    Protein-protein interaction databases

    BioGridi108154. 15 interactions.
    IntActiQ99856. 6 interactions.
    MINTiMINT-4537882.
    STRINGi9606.ENSP00000263620.

    Structurei

    Secondary structure

    1
    593
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi225 – 2284
    Helixi230 – 2334
    Helixi239 – 25517
    Helixi272 – 28110
    Helixi285 – 2917
    Helixi294 – 3007
    Helixi310 – 32112
    Helixi323 – 3297
    Helixi335 – 3439

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KK0NMR-A218-351[»]
    4LJXX-ray2.21A/B216-351[»]
    ProteinModelPortaliQ99856.
    SMRiQ99856. Positions 218-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ99856.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini238 – 33093ARIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini444 – 54198REKLESPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni119 – 15638AcidicAdd
    BLAST
    Regioni445 – 48844Important for nuclear localizationBy similarityAdd
    BLAST
    Regioni490 – 51324HomodimerizationAdd
    BLAST
    Regioni537 – 55721Important for cytoplasmic localizationBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi67 – 704Poly-Ala
    Compositional biasi89 – 15769Glu-richAdd
    BLAST
    Compositional biasi424 – 44522Ala-richAdd
    BLAST
    Compositional biasi550 – 57930Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ARID domain.PROSITE-ProRule annotation
    Contains 1 REKLES domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327790.
    HOGENOMiHOG000236281.
    HOVERGENiHBG050574.
    InParanoidiQ99856.
    OMAiLFAYSPG.
    OrthoDBiEOG77DJ6W.
    PhylomeDBiQ99856.
    TreeFamiTF320364.

    Family and domain databases

    Gene3Di1.10.150.60. 1 hit.
    InterProiIPR001606. ARID/BRIGHT_DNA-bd.
    IPR023334. REKLES_domain.
    [Graphical view]
    PfamiPF01388. ARID. 1 hit.
    [Graphical view]
    SMARTiSM00501. BRIGHT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46774. SSF46774. 1 hit.
    PROSITEiPS51011. ARID. 1 hit.
    PS51486. REKLES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99856-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLQAVMETL LQRQQRARQE LEARQQLPPD PPAAPPGRAR AAPDEDREPE    50
    SARMQRAQMA ALAAMRAAAA GLGHPASPGG SEDGPPGSEE EDAAREGTPG 100
    SPGRGREGPG EEHFEDMASD EDMKPKWEEE EMEEDLGEDE EEEEEDYEDE 150
    EEEEDEEGLG PPGPASLGTT ALFPRKAQPP QAFRGDGVPR VLGGQERPGP 200
    GPAHPGGAAH VAPQLQPPDH GDWTYEEQFK QLYELDGDPK RKEFLDDLFS 250
    FMQKRGTPVN RIPIMAKQVL DLFMLYVLVT EKGGLVEVIN KKLWREITKG 300
    LNLPTSITSA AFTLRTQYMK YLYPYECEKR GLSNPNELQA AIDSNRREGR 350
    RQSFGGSLFA YSPGGAHGML SSPKLPVSSL GLAASTNGSS ITPAPKIKKE 400
    EDSAIPITVP GRLPVSLAGH PVVAAQAAAV QAAAAQAAVA AQAAALEQLR 450
    EKLESAEPPE KKMALVADEQ QRLMQRALQQ NFLAMAAQLP MSIRINSQAS 500
    ESRQDSAVNL TGTNGSNSIS MSVEINGIMY TGVLFAQPPA PTPTSAPNKG 550
    GGGGGGSSSN AGGRGGNTGT SGGQAGPAGL STPSTSTSNN SLP 593
    Length:593
    Mass (Da):62,889
    Last modified:January 1, 1998 - v2
    Checksum:i4D09131E168A2880
    GO

    Sequence cautioni

    The sequence AAW30734.1 differs from that shown. Reason: Frameshift at position 498.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti423 – 4231V → S in AAN74028. (PubMed:9780002)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361P → H.1 Publication
    Corresponds to variant rs17857499 [ dbSNP | Ensembl ].
    VAR_033203
    Natural varianti320 – 3201K → E.1 Publication
    Corresponds to variant rs17857501 [ dbSNP | Ensembl ].
    VAR_033204
    Natural varianti556 – 5561G → S.2 Publications
    Corresponds to variant rs1051505 [ dbSNP | Ensembl ].
    VAR_033205

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88047 mRNA. Translation: AAC32888.1.
    AF039850
    , AF039844, AF039845, AF039846, AF039847, AF039848, AF039849 Genomic DNA. Translation: AAC69994.1.
    AY152547 mRNA. Translation: AAN74028.1.
    AY845638 mRNA. Translation: AAW30734.1. Frameshift.
    AC005391 Genomic DNA. Translation: AAC28918.1.
    AC005379 Genomic DNA. Translation: AAC28499.1.
    BC033163 mRNA. Translation: AAH33163.1.
    BC060828 mRNA. Translation: AAH60828.1.
    CCDSiCCDS12050.1.
    RefSeqiNP_005215.1. NM_005224.2.
    XP_005259569.1. XM_005259512.1.
    XP_005259570.1. XM_005259513.2.
    XP_005259571.1. XM_005259514.2.
    UniGeneiHs.501296.

    Genome annotation databases

    EnsembliENST00000263620; ENSP00000263620; ENSG00000116017.
    GeneIDi1820.
    KEGGihsa:1820.
    UCSCiuc002lql.3. human.

    Polymorphism databases

    DMDMi12230034.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88047 mRNA. Translation: AAC32888.1 .
    AF039850
    , AF039844 , AF039845 , AF039846 , AF039847 , AF039848 , AF039849 Genomic DNA. Translation: AAC69994.1 .
    AY152547 mRNA. Translation: AAN74028.1 .
    AY845638 mRNA. Translation: AAW30734.1 . Frameshift.
    AC005391 Genomic DNA. Translation: AAC28918.1 .
    AC005379 Genomic DNA. Translation: AAC28499.1 .
    BC033163 mRNA. Translation: AAH33163.1 .
    BC060828 mRNA. Translation: AAH60828.1 .
    CCDSi CCDS12050.1.
    RefSeqi NP_005215.1. NM_005224.2.
    XP_005259569.1. XM_005259512.1.
    XP_005259570.1. XM_005259513.2.
    XP_005259571.1. XM_005259514.2.
    UniGenei Hs.501296.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KK0 NMR - A 218-351 [» ]
    4LJX X-ray 2.21 A/B 216-351 [» ]
    ProteinModelPortali Q99856.
    SMRi Q99856. Positions 218-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108154. 15 interactions.
    IntActi Q99856. 6 interactions.
    MINTi MINT-4537882.
    STRINGi 9606.ENSP00000263620.

    PTM databases

    PhosphoSitei Q99856.

    Polymorphism databases

    DMDMi 12230034.

    Proteomic databases

    MaxQBi Q99856.
    PaxDbi Q99856.
    PRIDEi Q99856.

    Protocols and materials databases

    DNASUi 1820.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263620 ; ENSP00000263620 ; ENSG00000116017 .
    GeneIDi 1820.
    KEGGi hsa:1820.
    UCSCi uc002lql.3. human.

    Organism-specific databases

    CTDi 1820.
    GeneCardsi GC19P000926.
    HGNCi HGNC:3031. ARID3A.
    HPAi HPA004793.
    MIMi 603265. gene.
    neXtProti NX_Q99856.
    PharmGKBi PA27485.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327790.
    HOGENOMi HOG000236281.
    HOVERGENi HBG050574.
    InParanoidi Q99856.
    OMAi LFAYSPG.
    OrthoDBi EOG77DJ6W.
    PhylomeDBi Q99856.
    TreeFami TF320364.

    Miscellaneous databases

    EvolutionaryTracei Q99856.
    GeneWikii ARID3A.
    GenomeRNAii 1820.
    NextBioi 7417.
    PROi Q99856.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99856.
    Bgeei Q99856.
    CleanExi HS_ARID3A.
    Genevestigatori Q99856.

    Family and domain databases

    Gene3Di 1.10.150.60. 1 hit.
    InterProi IPR001606. ARID/BRIGHT_DNA-bd.
    IPR023334. REKLES_domain.
    [Graphical view ]
    Pfami PF01388. ARID. 1 hit.
    [Graphical view ]
    SMARTi SM00501. BRIGHT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46774. SSF46774. 1 hit.
    PROSITEi PS51011. ARID. 1 hit.
    PS51486. REKLES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome."
      Kortschak R.D., Reimann H., Zimmer M., Eyre H.J., Saint R., Jenne D.E.
      Genomics 51:288-292(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer."
      Suzuki M., Okuyama S., Okamoto S., Shirasuna K., Nakajima T., Hachiya T., Nojima H., Sekiya S., Oda K.
      Oncogene 17:853-865(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH E2F1, VARIANT SER-556.
    3. "Molecular cloning and immunologic characterization of DRIL3, a new bright-like ARID protein expressed in both myeloid and lymphoid cells, shares homology to E2FBP1/pRB family complexes."
      Paulin Y.G., Frank R.T., Davy E.J.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-36; GLU-320 AND SER-556.
      Tissue: Placenta.
    6. "A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence."
      Peeper D.S., Shvarts A., Brummelkamp T., Douma S., Koh E.Y., Daley G.Q., Bernards R.
      Nat. Cell Biol. 4:148-153(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53."
      Ma K., Araki K., Ichwan S.J.A., Suganuma T., Tamamori-Adachi M., Ikeda M.-A.
      Mol. Cancer Res. 1:438-444(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-81 AND SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I."
      Rajaiya J., Nixon J.C., Ayers N., Desgranges Z.P., Roy A.L., Webb C.F.
      Mol. Cell. Biol. 26:4758-4768(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GTF2I AND BTK, SUBUNIT, DNA-BINDING, MUTAGENESIS OF TYR-325.
    10. "REKLES is an ARID3-restricted multifunctional domain."
      Kim D., Probst L., Das C., Tucker P.W.
      J. Biol. Chem. 282:15768-15777(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARID3B, DNA-BINDING, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-461; GLY-527; TYR-530; GLY-532 AND LEU-534.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-81 AND SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-88; THR-98; SER-101 AND SER-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target."
      Liu G., Huang Y.J., Xiao R., Wang D., Acton T.B., Montelione G.T.
      Proteins 78:2170-2175(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 218-351.

    Entry informationi

    Entry nameiARI3A_HUMAN
    AccessioniPrimary (citable) accession number: Q99856
    Secondary accession number(s): Q5I858
    , Q6P9C6, Q8IZA7, Q8N4Z3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3