ID   FOXB1_HUMAN             Reviewed;         325 AA.
AC   Q99853; O60652; O75917; Q14CL2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   27-MAR-2024, entry version 174.
DE   RecName: Full=Forkhead box protein B1;
DE   AltName: Full=Transcription factor FKH-5;
GN   Name=FOXB1; Synonyms=FKH5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bingle C.D.;
RT   "Molecular cloning of human Fkh5 from a SCLC line.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Placenta;
RA   Cascio S.M., Dodd K.A., Hicks J., Chow S., Brown C.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8-173.
RC   TISSUE=Lung;
RA   Bingle C.D., Gowan S.;
RT   "HNF-3/forkhead gene expression in human pulmonary cell lines: molecular
RT   cloning of a novel human HNF-3/forkhead cDNA.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor expressed by neural progenitor cells in
CC       specific regions of the embryonic neuroepithelium. Essential for the
CC       mammillary nuclei maintenance. Negatively regulates the proliferation
CC       of oligodendrocyte progenitors and promotes oligodendrocyte maturation.
CC       Also expressed in mammary glands, plays a role in lactation, controls
CC       development of mammary glands and the inferior colliculi of the
CC       midbrain in the central nervous system that regulates the milk-ejection
CC       reflex. {ECO:0000250|UniProtKB:Q64732}.
CC   -!- INTERACTION:
CC       Q99853; Q15323: KRT31; NbExp=3; IntAct=EBI-3916225, EBI-948001;
CC       Q99853; Q6A162: KRT40; NbExp=3; IntAct=EBI-3916225, EBI-10171697;
CC       Q99853; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-3916225, EBI-10171774;
CC       Q99853; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-3916225, EBI-945833;
CC       Q99853; P14373: TRIM27; NbExp=3; IntAct=EBI-3916225, EBI-719493;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64732}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF071554; AAC62493.1; -; mRNA.
DR   EMBL; AF055080; AAC09344.1; -; Genomic_DNA.
DR   EMBL; AK290944; BAF83633.1; -; mRNA.
DR   EMBL; CH471082; EAW77581.1; -; Genomic_DNA.
DR   EMBL; BC113710; AAI13711.1; -; mRNA.
DR   EMBL; U87393; AAB47564.1; -; mRNA.
DR   CCDS; CCDS32255.1; -.
DR   RefSeq; NP_036314.2; NM_012182.2.
DR   AlphaFoldDB; Q99853; -.
DR   SMR; Q99853; -.
DR   BioGRID; 117960; 133.
DR   IntAct; Q99853; 128.
DR   MINT; Q99853; -.
DR   STRING; 9606.ENSP00000379369; -.
DR   iPTMnet; Q99853; -.
DR   PhosphoSitePlus; Q99853; -.
DR   BioMuta; FOXB1; -.
DR   DMDM; 215274160; -.
DR   MassIVE; Q99853; -.
DR   PaxDb; 9606-ENSP00000379369; -.
DR   PeptideAtlas; Q99853; -.
DR   ProteomicsDB; 78505; -.
DR   Antibodypedia; 12956; 180 antibodies from 33 providers.
DR   DNASU; 27023; -.
DR   Ensembl; ENST00000396057.6; ENSP00000379369.4; ENSG00000171956.7.
DR   GeneID; 27023; -.
DR   KEGG; hsa:27023; -.
DR   MANE-Select; ENST00000396057.6; ENSP00000379369.4; NM_012182.3; NP_036314.2.
DR   UCSC; uc002agj.2; human.
DR   AGR; HGNC:3799; -.
DR   CTD; 27023; -.
DR   DisGeNET; 27023; -.
DR   GeneCards; FOXB1; -.
DR   HGNC; HGNC:3799; FOXB1.
DR   HPA; ENSG00000171956; Tissue enriched (brain).
DR   MIM; 619961; gene.
DR   neXtProt; NX_Q99853; -.
DR   OpenTargets; ENSG00000171956; -.
DR   PharmGKB; PA28216; -.
DR   VEuPathDB; HostDB:ENSG00000171956; -.
DR   eggNOG; KOG3562; Eukaryota.
DR   GeneTree; ENSGT00940000160522; -.
DR   HOGENOM; CLU_040357_2_0_1; -.
DR   InParanoid; Q99853; -.
DR   OMA; MYSTSVI; -.
DR   OrthoDB; 5385885at2759; -.
DR   PhylomeDB; Q99853; -.
DR   TreeFam; TF350628; -.
DR   PathwayCommons; Q99853; -.
DR   SignaLink; Q99853; -.
DR   BioGRID-ORCS; 27023; 10 hits in 1166 CRISPR screens.
DR   ChiTaRS; FOXB1; human.
DR   GenomeRNAi; 27023; -.
DR   Pharos; Q99853; Tbio.
DR   PRO; PR:Q99853; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q99853; Protein.
DR   Bgee; ENSG00000171956; Expressed in hypothalamus and 52 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0007412; P:axon target recognition; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0061381; P:cell migration in diencephalon; ISS:UniProtKB.
DR   GO; GO:0061030; P:epithelial cell differentiation involved in mammary gland alveolus development; ISS:UniProtKB.
DR   GO; GO:0033504; P:floor plate development; ISS:UniProtKB.
DR   GO; GO:0021855; P:hypothalamus cell migration; ISS:UniProtKB.
DR   GO; GO:0061379; P:inferior colliculus development; ISS:UniProtKB.
DR   GO; GO:0007595; P:lactation; ISS:UniProtKB.
DR   GO; GO:0061377; P:mammary gland lobule development; ISS:UniProtKB.
DR   GO; GO:0021767; P:mammillary body development; ISS:UniProtKB.
DR   GO; GO:0061374; P:mammillothalamic axonal tract development; ISS:UniProtKB.
DR   GO; GO:0030901; P:midbrain development; ISS:UniProtKB.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001756; P:somitogenesis; ISS:UniProtKB.
DR   GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
DR   GO; GO:0022029; P:telencephalon cell migration; ISS:UniProtKB.
DR   GO; GO:0021794; P:thalamus development; IEA:Ensembl.
DR   GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
DR   GO; GO:0008542; P:visual learning; ISS:UniProtKB.
DR   CDD; cd20043; FH_FOXB2; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR047389; FOXB1_B2_FH.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR   PANTHER; PTHR11829:SF209; FORKHEAD BOX PROTEIN B1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   Genevisible; Q99853; HS.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Forkhead box protein B1"
FT                   /id="PRO_0000091803"
FT   DNA_BIND        12..103
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          284..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        65
FT                   /note="L -> F (in Ref. 2; AAC09344)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        106
FT                   /note="R -> C (in Ref. 1; AAC62493 and 6; AAB47564)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        126
FT                   /note="Missing (in Ref. 1; AAC62493, 2; AAC09344 and 6;
FT                   AAB47564)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        171..173
FT                   /note="AIE -> SIN (in Ref. 6; AAB47564)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  34978 MW;  FAEE1B16B1997CB0 CRC64;
     MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY RENTQRWQNS
     LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG SFLRRRKRFK VLKSDHLAPS
     KPADAAQYLQ QQAKLRLSAL AASGTHLPQM PAAAYNLGGV AQPSGFKHPF AIENIIAREY
     KMPGGLAFSA MQPVPAAYPL PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA
     YGVPLKPLCH AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
     SQSSPATPSE TLTSPASALH SVAVH
//