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Protein

Forkhead box protein B1

Gene

FOXB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi12 – 10392Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: UniProtKB
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. axon target recognition Source: UniProtKB
  2. cell migration in diencephalon Source: UniProtKB
  3. epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
  4. floor plate development Source: UniProtKB
  5. hypothalamus cell migration Source: UniProtKB
  6. inferior colliculus development Source: UniProtKB
  7. lactation Source: UniProtKB
  8. mammary gland lobule development Source: UniProtKB
  9. mammillary body development Source: UniProtKB
  10. mammillothalamic axonal tract development Source: UniProtKB
  11. midbrain development Source: UniProtKB
  12. negative regulation of neuron apoptotic process Source: UniProtKB
  13. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  14. somitogenesis Source: UniProtKB
  15. spinal cord development Source: Ensembl
  16. telencephalon cell migration Source: UniProtKB
  17. thalamus development Source: Ensembl
  18. transcription from RNA polymerase II promoter Source: GOC
  19. urogenital system development Source: Ensembl
  20. visual learning Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B1
Alternative name(s):
Transcription factor FKH-5
Gene namesi
Name:FOXB1
Synonyms:FKH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:3799. FOXB1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Forkhead box protein B1PRO_0000091803Add
BLAST

Proteomic databases

PaxDbiQ99853.
PRIDEiQ99853.

PTM databases

PhosphoSiteiQ99853.

Expressioni

Gene expression databases

BgeeiQ99853.
CleanExiHS_FOXB1.
GenevestigatoriQ99853.

Interactioni

Protein-protein interaction databases

BioGridi117960. 8 interactions.
IntActiQ99853. 2 interactions.
STRINGi9606.ENSP00000379369.

Structurei

3D structure databases

ProteinModelPortaliQ99853.
SMRiQ99853. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ99853.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ99853.
TreeFamiTF350628.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY
60 70 80 90 100
RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG
110 120 130 140 150
SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM
160 170 180 190 200
PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL
210 220 230 240 250
PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA YGVPLKPLCH
260 270 280 290 300
AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
310 320
SQSSPATPSE TLTSPASALH SVAVH
Length:325
Mass (Da):34,978
Last modified:November 25, 2008 - v3
Checksum:iFAEE1B16B1997CB0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651L → F in AAC09344 (Ref. 2) Curated
Sequence conflicti106 – 1061R → C in AAC62493 (Ref. 1) Curated
Sequence conflicti106 – 1061R → C in AAB47564 (Ref. 6) Curated
Sequence conflicti126 – 1261Missing in AAC62493 (Ref. 1) Curated
Sequence conflicti126 – 1261Missing in AAC09344 (Ref. 2) Curated
Sequence conflicti126 – 1261Missing in AAB47564 (Ref. 6) Curated
Sequence conflicti171 – 1733AIE → SIN in AAB47564 (Ref. 6) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071554 mRNA. Translation: AAC62493.1.
AF055080 Genomic DNA. Translation: AAC09344.1.
AK290944 mRNA. Translation: BAF83633.1.
CH471082 Genomic DNA. Translation: EAW77581.1.
BC113710 mRNA. Translation: AAI13711.1.
U87393 mRNA. Translation: AAB47564.1.
CCDSiCCDS32255.1.
RefSeqiNP_036314.2. NM_012182.2.
UniGeneiHs.734475.

Genome annotation databases

EnsembliENST00000396057; ENSP00000379369; ENSG00000171956.
GeneIDi27023.
KEGGihsa:27023.
UCSCiuc002agj.1. human.

Polymorphism databases

DMDMi215274160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071554 mRNA. Translation: AAC62493.1.
AF055080 Genomic DNA. Translation: AAC09344.1.
AK290944 mRNA. Translation: BAF83633.1.
CH471082 Genomic DNA. Translation: EAW77581.1.
BC113710 mRNA. Translation: AAI13711.1.
U87393 mRNA. Translation: AAB47564.1.
CCDSiCCDS32255.1.
RefSeqiNP_036314.2. NM_012182.2.
UniGeneiHs.734475.

3D structure databases

ProteinModelPortaliQ99853.
SMRiQ99853. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117960. 8 interactions.
IntActiQ99853. 2 interactions.
STRINGi9606.ENSP00000379369.

PTM databases

PhosphoSiteiQ99853.

Polymorphism databases

DMDMi215274160.

Proteomic databases

PaxDbiQ99853.
PRIDEiQ99853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396057; ENSP00000379369; ENSG00000171956.
GeneIDi27023.
KEGGihsa:27023.
UCSCiuc002agj.1. human.

Organism-specific databases

CTDi27023.
GeneCardsiGC15P060296.
HGNCiHGNC:3799. FOXB1.
neXtProtiNX_Q99853.
PharmGKBiPA28216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ99853.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ99853.
TreeFamiTF350628.

Miscellaneous databases

GenomeRNAii27023.
NextBioi49554.
PROiQ99853.

Gene expression databases

BgeeiQ99853.
CleanExiHS_FOXB1.
GenevestigatoriQ99853.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human Fkh5 from a SCLC line."
    Bingle C.D.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cascio S.M., Dodd K.A., Hicks J., Chow S., Brown C.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "HNF-3/forkhead gene expression in human pulmonary cell lines: molecular cloning of a novel human HNF-3/forkhead cDNA."
    Bingle C.D., Gowan S.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-173.
    Tissue: Lung.

Entry informationi

Entry nameiFOXB1_HUMAN
AccessioniPrimary (citable) accession number: Q99853
Secondary accession number(s): O60652, O75917, Q14CL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: February 4, 2015
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.