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Protein

Forkhead box protein B1

Gene

FOXB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi12 – 103Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B1
Alternative name(s):
Transcription factor FKH-5
Gene namesi
Name:FOXB1
Synonyms:FKH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000171956.6
HGNCiHGNC:3799 FOXB1
neXtProtiNX_Q99853

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27023
OpenTargetsiENSG00000171956
PharmGKBiPA28216

Polymorphism and mutation databases

BioMutaiFOXB1
DMDMi215274160

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918031 – 325Forkhead box protein B1Add BLAST325

Proteomic databases

PaxDbiQ99853
PRIDEiQ99853

PTM databases

iPTMnetiQ99853
PhosphoSitePlusiQ99853

Expressioni

Gene expression databases

BgeeiENSG00000171956
CleanExiHS_FOXB1
GenevisibleiQ99853 HS

Organism-specific databases

HPAiHPA073369

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117960, 133 interactors
IntActiQ99853, 128 interactors
MINTiQ99853
STRINGi9606.ENSP00000379369

Structurei

3D structure databases

ProteinModelPortaliQ99853
SMRiQ99853
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3562 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000007545
HOVERGENiHBG102104
InParanoidiQ99853
KOiK09395
OMAiSLCHGGQ
OrthoDBiEOG091G0F54
PhylomeDBiQ99853
TreeFamiTF350628

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q99853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY
60 70 80 90 100
RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG
110 120 130 140 150
SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM
160 170 180 190 200
PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL
210 220 230 240 250
PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA YGVPLKPLCH
260 270 280 290 300
AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
310 320
SQSSPATPSE TLTSPASALH SVAVH
Length:325
Mass (Da):34,978
Last modified:November 25, 2008 - v3
Checksum:iFAEE1B16B1997CB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65L → F in AAC09344 (Ref. 2) Curated1
Sequence conflicti106R → C in AAC62493 (Ref. 1) Curated1
Sequence conflicti106R → C in AAB47564 (Ref. 6) Curated1
Sequence conflicti126Missing in AAC62493 (Ref. 1) Curated1
Sequence conflicti126Missing in AAC09344 (Ref. 2) Curated1
Sequence conflicti126Missing in AAB47564 (Ref. 6) Curated1
Sequence conflicti171 – 173AIE → SIN in AAB47564 (Ref. 6) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071554 mRNA Translation: AAC62493.1
AF055080 Genomic DNA Translation: AAC09344.1
AK290944 mRNA Translation: BAF83633.1
CH471082 Genomic DNA Translation: EAW77581.1
BC113710 mRNA Translation: AAI13711.1
U87393 mRNA Translation: AAB47564.1
CCDSiCCDS32255.1
RefSeqiNP_036314.2, NM_012182.2
UniGeneiHs.734475

Genome annotation databases

EnsembliENST00000396057; ENSP00000379369; ENSG00000171956
GeneIDi27023
KEGGihsa:27023
UCSCiuc002agj.2 human

Similar proteinsi

Entry informationi

Entry nameiFOXB1_HUMAN
AccessioniPrimary (citable) accession number: Q99853
Secondary accession number(s): O60652, O75917, Q14CL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health