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Q99853

- FOXB1_HUMAN

UniProt

Q99853 - FOXB1_HUMAN

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Protein

Forkhead box protein B1

Gene
FOXB1, FKH5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi12 – 10392Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. double-stranded DNA binding Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding Source: UniProtKB
  5. transcription factor binding Source: RefGenome

GO - Biological processi

  1. axon target recognition Source: UniProtKB
  2. cell migration in diencephalon Source: UniProtKB
  3. epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
  4. floor plate development Source: UniProtKB
  5. hypothalamus cell migration Source: UniProtKB
  6. inferior colliculus development Source: UniProtKB
  7. lactation Source: UniProtKB
  8. mammary gland lobule development Source: UniProtKB
  9. mammillary body development Source: UniProtKB
  10. mammillothalamic axonal tract development Source: UniProtKB
  11. midbrain development Source: UniProtKB
  12. negative regulation of neuron apoptotic process Source: UniProtKB
  13. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  14. organ development Source: RefGenome
  15. pattern specification process Source: RefGenome
  16. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  17. somitogenesis Source: UniProtKB
  18. spinal cord development Source: Ensembl
  19. telencephalon cell migration Source: UniProtKB
  20. thalamus development Source: Ensembl
  21. tissue development Source: RefGenome
  22. transcription from RNA polymerase II promoter Source: GOC
  23. urogenital system development Source: Ensembl
  24. visual learning Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B1
Alternative name(s):
Transcription factor FKH-5
Gene namesi
Name:FOXB1
Synonyms:FKH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:3799. FOXB1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Forkhead box protein B1PRO_0000091803Add
BLAST

Proteomic databases

PaxDbiQ99853.
PRIDEiQ99853.

PTM databases

PhosphoSiteiQ99853.

Expressioni

Gene expression databases

BgeeiQ99853.
CleanExiHS_FOXB1.
GenevestigatoriQ99853.

Interactioni

Protein-protein interaction databases

BioGridi117960. 2 interactions.
IntActiQ99853. 2 interactions.
STRINGi9606.ENSP00000379369.

Structurei

3D structure databases

ProteinModelPortaliQ99853.
SMRiQ99853. Positions 13-111.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ99853.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ99853.
TreeFamiTF350628.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99853-1 [UniParc]FASTAAdd to Basket

« Hide

MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY    50
RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG 100
SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM 150
PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL 200
PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA YGVPLKPLCH 250
AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT 300
SQSSPATPSE TLTSPASALH SVAVH 325
Length:325
Mass (Da):34,978
Last modified:November 25, 2008 - v3
Checksum:iFAEE1B16B1997CB0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651L → F in AAC09344. 1 Publication
Sequence conflicti106 – 1061R → C in AAC62493. 1 Publication
Sequence conflicti106 – 1061R → C in AAB47564. 1 Publication
Sequence conflicti126 – 1261Missing in AAC62493. 1 Publication
Sequence conflicti126 – 1261Missing in AAC09344. 1 Publication
Sequence conflicti126 – 1261Missing in AAB47564. 1 Publication
Sequence conflicti171 – 1733AIE → SIN in AAB47564. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071554 mRNA. Translation: AAC62493.1.
AF055080 Genomic DNA. Translation: AAC09344.1.
AK290944 mRNA. Translation: BAF83633.1.
CH471082 Genomic DNA. Translation: EAW77581.1.
BC113710 mRNA. Translation: AAI13711.1.
U87393 mRNA. Translation: AAB47564.1.
CCDSiCCDS32255.1.
RefSeqiNP_036314.2. NM_012182.2.
UniGeneiHs.734475.

Genome annotation databases

EnsembliENST00000396057; ENSP00000379369; ENSG00000171956.
GeneIDi27023.
KEGGihsa:27023.
UCSCiuc002agj.1. human.

Polymorphism databases

DMDMi215274160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071554 mRNA. Translation: AAC62493.1 .
AF055080 Genomic DNA. Translation: AAC09344.1 .
AK290944 mRNA. Translation: BAF83633.1 .
CH471082 Genomic DNA. Translation: EAW77581.1 .
BC113710 mRNA. Translation: AAI13711.1 .
U87393 mRNA. Translation: AAB47564.1 .
CCDSi CCDS32255.1.
RefSeqi NP_036314.2. NM_012182.2.
UniGenei Hs.734475.

3D structure databases

ProteinModelPortali Q99853.
SMRi Q99853. Positions 13-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117960. 2 interactions.
IntActi Q99853. 2 interactions.
STRINGi 9606.ENSP00000379369.

PTM databases

PhosphoSitei Q99853.

Polymorphism databases

DMDMi 215274160.

Proteomic databases

PaxDbi Q99853.
PRIDEi Q99853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396057 ; ENSP00000379369 ; ENSG00000171956 .
GeneIDi 27023.
KEGGi hsa:27023.
UCSCi uc002agj.1. human.

Organism-specific databases

CTDi 27023.
GeneCardsi GC15P060296.
HGNCi HGNC:3799. FOXB1.
neXtProti NX_Q99853.
PharmGKBi PA28216.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000007545.
HOVERGENi HBG102104.
InParanoidi Q99853.
KOi K09395.
OMAi SLCHGGQ.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q99853.
TreeFami TF350628.

Miscellaneous databases

GenomeRNAii 27023.
NextBioi 49554.
PROi Q99853.

Gene expression databases

Bgeei Q99853.
CleanExi HS_FOXB1.
Genevestigatori Q99853.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human Fkh5 from a SCLC line."
    Bingle C.D.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cascio S.M., Dodd K.A., Hicks J., Chow S., Brown C.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "HNF-3/forkhead gene expression in human pulmonary cell lines: molecular cloning of a novel human HNF-3/forkhead cDNA."
    Bingle C.D., Gowan S.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-173.
    Tissue: Lung.

Entry informationi

Entry nameiFOXB1_HUMAN
AccessioniPrimary (citable) accession number: Q99853
Secondary accession number(s): O60652, O75917, Q14CL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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