Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q99853 (FOXB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein B1
Alternative name(s):
Transcription factor FKH-5
Gene names
Name:FOXB1
Synonyms:FKH5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon target recognition

Inferred from sequence or structural similarity. Source: UniProtKB

cell migration in diencephalon

Inferred from sequence or structural similarity. Source: UniProtKB

embryo development

Inferred from Biological aspect of Ancestor. Source: RefGenome

epithelial cell differentiation involved in mammary gland alveolus development

Inferred from sequence or structural similarity. Source: UniProtKB

floor plate development

Inferred from sequence or structural similarity. Source: UniProtKB

hypothalamus cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

inferior colliculus development

Inferred from sequence or structural similarity. Source: UniProtKB

lactation

Inferred from sequence or structural similarity. Source: UniProtKB

mammary gland lobule development

Inferred from sequence or structural similarity. Source: UniProtKB

mammillary body development

Inferred from sequence or structural similarity. Source: UniProtKB

mammillothalamic axonal tract development

Inferred from sequence or structural similarity. Source: UniProtKB

midbrain development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of neuron apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

organ development

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

somitogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

spinal cord development

Inferred from electronic annotation. Source: Ensembl

telencephalon cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

thalamus development

Inferred from electronic annotation. Source: Ensembl

tissue development

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

urogenital system development

Inferred from electronic annotation. Source: Ensembl

visual learning

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Forkhead box protein B1
PRO_0000091803

Regions

DNA binding12 – 10392Fork-head

Experimental info

Sequence conflict651L → F in AAC09344. Ref.2
Sequence conflict1061R → C in AAC62493. Ref.1
Sequence conflict1061R → C in AAB47564. Ref.6
Sequence conflict1261Missing in AAC62493. Ref.1
Sequence conflict1261Missing in AAC09344. Ref.2
Sequence conflict1261Missing in AAB47564. Ref.6
Sequence conflict171 – 1733AIE → SIN in AAB47564. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q99853 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: FAEE1B16B1997CB0

FASTA32534,978
        10         20         30         40         50         60 
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY RENTQRWQNS 

        70         80         90        100        110        120 
LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG SFLRRRKRFK VLKSDHLAPS 

       130        140        150        160        170        180 
KPADAAQYLQ QQAKLRLSAL AASGTHLPQM PAAAYNLGGV AQPSGFKHPF AIENIIAREY 

       190        200        210        220        230        240 
KMPGGLAFSA MQPVPAAYPL PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA 

       250        260        270        280        290        300 
YGVPLKPLCH AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT 

       310        320 
SQSSPATPSE TLTSPASALH SVAVH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of human Fkh5 from a SCLC line."
Bingle C.D.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Cascio S.M., Dodd K.A., Hicks J., Chow S., Brown C.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"HNF-3/forkhead gene expression in human pulmonary cell lines: molecular cloning of a novel human HNF-3/forkhead cDNA."
Bingle C.D., Gowan S.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-173.
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071554 mRNA. Translation: AAC62493.1.
AF055080 Genomic DNA. Translation: AAC09344.1.
AK290944 mRNA. Translation: BAF83633.1.
CH471082 Genomic DNA. Translation: EAW77581.1.
BC113710 mRNA. Translation: AAI13711.1.
U87393 mRNA. Translation: AAB47564.1.
RefSeqNP_036314.2. NM_012182.2.
UniGeneHs.734475.

3D structure databases

ProteinModelPortalQ99853.
SMRQ99853. Positions 13-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117960. 2 interactions.
IntActQ99853. 2 interactions.
STRING9606.ENSP00000379369.

PTM databases

PhosphoSiteQ99853.

Polymorphism databases

DMDM215274160.

Proteomic databases

PaxDbQ99853.
PRIDEQ99853.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000396057; ENSP00000379369; ENSG00000171956.
GeneID27023.
KEGGhsa:27023.
UCSCuc002agj.1. human.

Organism-specific databases

CTD27023.
GeneCardsGC15P060296.
HGNCHGNC:3799. FOXB1.
neXtProtNX_Q99853.
PharmGKBPA28216.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000007545.
HOVERGENHBG102104.
InParanoidQ99853.
KOK09395.
OMAFLSNSPQ.
OrthoDBEOG7C8GHD.
PhylomeDBQ99853.
TreeFamTF350628.

Gene expression databases

BgeeQ99853.
CleanExHS_FOXB1.
GenevestigatorQ99853.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi27023.
NextBio49554.
PROQ99853.

Entry information

Entry nameFOXB1_HUMAN
AccessionPrimary (citable) accession number: Q99853
Secondary accession number(s): O60652, O75917, Q14CL2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM