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Q99853

- FOXB1_HUMAN

UniProt

Q99853 - FOXB1_HUMAN

Protein

Forkhead box protein B1

Gene

FOXB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi12 – 10392Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. axon target recognition Source: UniProtKB
    2. cell migration in diencephalon Source: UniProtKB
    3. epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
    4. floor plate development Source: UniProtKB
    5. hypothalamus cell migration Source: UniProtKB
    6. inferior colliculus development Source: UniProtKB
    7. lactation Source: UniProtKB
    8. mammary gland lobule development Source: UniProtKB
    9. mammillary body development Source: UniProtKB
    10. mammillothalamic axonal tract development Source: UniProtKB
    11. midbrain development Source: UniProtKB
    12. negative regulation of neuron apoptotic process Source: UniProtKB
    13. somitogenesis Source: UniProtKB
    14. spinal cord development Source: Ensembl
    15. telencephalon cell migration Source: UniProtKB
    16. thalamus development Source: Ensembl
    17. transcription, DNA-templated Source: UniProtKB-KW
    18. urogenital system development Source: Ensembl
    19. visual learning Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein B1
    Alternative name(s):
    Transcription factor FKH-5
    Gene namesi
    Name:FOXB1
    Synonyms:FKH5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:3799. FOXB1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28216.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Forkhead box protein B1PRO_0000091803Add
    BLAST

    Proteomic databases

    PaxDbiQ99853.
    PRIDEiQ99853.

    PTM databases

    PhosphoSiteiQ99853.

    Expressioni

    Gene expression databases

    BgeeiQ99853.
    CleanExiHS_FOXB1.
    GenevestigatoriQ99853.

    Interactioni

    Protein-protein interaction databases

    BioGridi117960. 2 interactions.
    IntActiQ99853. 2 interactions.
    STRINGi9606.ENSP00000379369.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99853.
    SMRiQ99853. Positions 13-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000007545.
    HOVERGENiHBG102104.
    InParanoidiQ99853.
    KOiK09395.
    OMAiSLCHGGQ.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiQ99853.
    TreeFamiTF350628.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99853-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY    50
    RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG 100
    SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM 150
    PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL 200
    PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA YGVPLKPLCH 250
    AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT 300
    SQSSPATPSE TLTSPASALH SVAVH 325
    Length:325
    Mass (Da):34,978
    Last modified:November 25, 2008 - v3
    Checksum:iFAEE1B16B1997CB0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651L → F in AAC09344. 1 PublicationCurated
    Sequence conflicti106 – 1061R → C in AAC62493. 1 PublicationCurated
    Sequence conflicti106 – 1061R → C in AAB47564. 1 PublicationCurated
    Sequence conflicti126 – 1261Missing in AAC62493. 1 PublicationCurated
    Sequence conflicti126 – 1261Missing in AAC09344. 1 PublicationCurated
    Sequence conflicti126 – 1261Missing in AAB47564. 1 PublicationCurated
    Sequence conflicti171 – 1733AIE → SIN in AAB47564. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071554 mRNA. Translation: AAC62493.1.
    AF055080 Genomic DNA. Translation: AAC09344.1.
    AK290944 mRNA. Translation: BAF83633.1.
    CH471082 Genomic DNA. Translation: EAW77581.1.
    BC113710 mRNA. Translation: AAI13711.1.
    U87393 mRNA. Translation: AAB47564.1.
    CCDSiCCDS32255.1.
    RefSeqiNP_036314.2. NM_012182.2.
    UniGeneiHs.734475.

    Genome annotation databases

    EnsembliENST00000396057; ENSP00000379369; ENSG00000171956.
    GeneIDi27023.
    KEGGihsa:27023.
    UCSCiuc002agj.1. human.

    Polymorphism databases

    DMDMi215274160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071554 mRNA. Translation: AAC62493.1 .
    AF055080 Genomic DNA. Translation: AAC09344.1 .
    AK290944 mRNA. Translation: BAF83633.1 .
    CH471082 Genomic DNA. Translation: EAW77581.1 .
    BC113710 mRNA. Translation: AAI13711.1 .
    U87393 mRNA. Translation: AAB47564.1 .
    CCDSi CCDS32255.1.
    RefSeqi NP_036314.2. NM_012182.2.
    UniGenei Hs.734475.

    3D structure databases

    ProteinModelPortali Q99853.
    SMRi Q99853. Positions 13-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117960. 2 interactions.
    IntActi Q99853. 2 interactions.
    STRINGi 9606.ENSP00000379369.

    PTM databases

    PhosphoSitei Q99853.

    Polymorphism databases

    DMDMi 215274160.

    Proteomic databases

    PaxDbi Q99853.
    PRIDEi Q99853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396057 ; ENSP00000379369 ; ENSG00000171956 .
    GeneIDi 27023.
    KEGGi hsa:27023.
    UCSCi uc002agj.1. human.

    Organism-specific databases

    CTDi 27023.
    GeneCardsi GC15P060296.
    HGNCi HGNC:3799. FOXB1.
    neXtProti NX_Q99853.
    PharmGKBi PA28216.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000007545.
    HOVERGENi HBG102104.
    InParanoidi Q99853.
    KOi K09395.
    OMAi SLCHGGQ.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi Q99853.
    TreeFami TF350628.

    Miscellaneous databases

    GenomeRNAii 27023.
    NextBioi 49554.
    PROi Q99853.

    Gene expression databases

    Bgeei Q99853.
    CleanExi HS_FOXB1.
    Genevestigatori Q99853.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human Fkh5 from a SCLC line."
      Bingle C.D.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cascio S.M., Dodd K.A., Hicks J., Chow S., Brown C.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "HNF-3/forkhead gene expression in human pulmonary cell lines: molecular cloning of a novel human HNF-3/forkhead cDNA."
      Bingle C.D., Gowan S.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-173.
      Tissue: Lung.

    Entry informationi

    Entry nameiFOXB1_HUMAN
    AccessioniPrimary (citable) accession number: Q99853
    Secondary accession number(s): O60652, O75917, Q14CL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3