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Protein

Forkhead box protein B1

Gene

FOXB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi12 – 103Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B1
Alternative name(s):
Transcription factor FKH-5
Gene namesi
Name:FOXB1
Synonyms:FKH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:3799. FOXB1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27023.
OpenTargetsiENSG00000171956.
PharmGKBiPA28216.

Polymorphism and mutation databases

BioMutaiFOXB1.
DMDMi215274160.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918031 – 325Forkhead box protein B1Add BLAST325

Proteomic databases

EPDiQ99853.
PaxDbiQ99853.
PeptideAtlasiQ99853.
PRIDEiQ99853.

PTM databases

iPTMnetiQ99853.
PhosphoSitePlusiQ99853.

Expressioni

Gene expression databases

BgeeiENSG00000171956.
CleanExiHS_FOXB1.
GenevisibleiQ99853. HS.

Organism-specific databases

HPAiHPA073369.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117960. 133 interactors.
IntActiQ99853. 128 interactors.
STRINGi9606.ENSP00000379369.

Structurei

3D structure databases

ProteinModelPortaliQ99853.
SMRiQ99853.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3562. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ99853.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG091G0F54.
PhylomeDBiQ99853.
TreeFamiTF350628.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY
60 70 80 90 100
RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG
110 120 130 140 150
SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM
160 170 180 190 200
PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL
210 220 230 240 250
PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA YGVPLKPLCH
260 270 280 290 300
AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
310 320
SQSSPATPSE TLTSPASALH SVAVH
Length:325
Mass (Da):34,978
Last modified:November 25, 2008 - v3
Checksum:iFAEE1B16B1997CB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65L → F in AAC09344 (Ref. 2) Curated1
Sequence conflicti106R → C in AAC62493 (Ref. 1) Curated1
Sequence conflicti106R → C in AAB47564 (Ref. 6) Curated1
Sequence conflicti126Missing in AAC62493 (Ref. 1) Curated1
Sequence conflicti126Missing in AAC09344 (Ref. 2) Curated1
Sequence conflicti126Missing in AAB47564 (Ref. 6) Curated1
Sequence conflicti171 – 173AIE → SIN in AAB47564 (Ref. 6) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071554 mRNA. Translation: AAC62493.1.
AF055080 Genomic DNA. Translation: AAC09344.1.
AK290944 mRNA. Translation: BAF83633.1.
CH471082 Genomic DNA. Translation: EAW77581.1.
BC113710 mRNA. Translation: AAI13711.1.
U87393 mRNA. Translation: AAB47564.1.
CCDSiCCDS32255.1.
RefSeqiNP_036314.2. NM_012182.2.
UniGeneiHs.734475.

Genome annotation databases

EnsembliENST00000396057; ENSP00000379369; ENSG00000171956.
GeneIDi27023.
KEGGihsa:27023.
UCSCiuc002agj.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFOXB1_HUMAN
AccessioniPrimary (citable) accession number: Q99853
Secondary accession number(s): O60652, O75917, Q14CL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: July 5, 2017
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM