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Protein

Forkhead box protein B1

Gene

FOXB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi12 – 103Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171956-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B1
Alternative name(s):
Transcription factor FKH-5
Gene namesi
Name:FOXB1
Synonyms:FKH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:3799. FOXB1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27023.
OpenTargetsiENSG00000171956.
PharmGKBiPA28216.

Polymorphism and mutation databases

BioMutaiFOXB1.
DMDMi215274160.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918031 – 325Forkhead box protein B1Add BLAST325

Proteomic databases

EPDiQ99853.
PaxDbiQ99853.
PRIDEiQ99853.

PTM databases

iPTMnetiQ99853.
PhosphoSitePlusiQ99853.

Expressioni

Gene expression databases

BgeeiENSG00000171956.
CleanExiHS_FOXB1.
GenevisibleiQ99853. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-3916225,EBI-948001
KRT40Q6A1623EBI-3916225,EBI-10171697
KRTAP10-8P604103EBI-3916225,EBI-10171774
NOTCH2NLQ7Z3S93EBI-3916225,EBI-945833
TRIM27P143733EBI-3916225,EBI-719493

Protein-protein interaction databases

BioGridi117960. 133 interactors.
IntActiQ99853. 128 interactors.
STRINGi9606.ENSP00000379369.

Structurei

3D structure databases

ProteinModelPortaliQ99853.
SMRiQ99853.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3562. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ99853.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG091G0F54.
PhylomeDBiQ99853.
TreeFamiTF350628.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY
60 70 80 90 100
RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG
110 120 130 140 150
SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM
160 170 180 190 200
PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL
210 220 230 240 250
PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA YGVPLKPLCH
260 270 280 290 300
AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
310 320
SQSSPATPSE TLTSPASALH SVAVH
Length:325
Mass (Da):34,978
Last modified:November 25, 2008 - v3
Checksum:iFAEE1B16B1997CB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65L → F in AAC09344 (Ref. 2) Curated1
Sequence conflicti106R → C in AAC62493 (Ref. 1) Curated1
Sequence conflicti106R → C in AAB47564 (Ref. 6) Curated1
Sequence conflicti126Missing in AAC62493 (Ref. 1) Curated1
Sequence conflicti126Missing in AAC09344 (Ref. 2) Curated1
Sequence conflicti126Missing in AAB47564 (Ref. 6) Curated1
Sequence conflicti171 – 173AIE → SIN in AAB47564 (Ref. 6) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071554 mRNA. Translation: AAC62493.1.
AF055080 Genomic DNA. Translation: AAC09344.1.
AK290944 mRNA. Translation: BAF83633.1.
CH471082 Genomic DNA. Translation: EAW77581.1.
BC113710 mRNA. Translation: AAI13711.1.
U87393 mRNA. Translation: AAB47564.1.
CCDSiCCDS32255.1.
RefSeqiNP_036314.2. NM_012182.2.
UniGeneiHs.734475.

Genome annotation databases

EnsembliENST00000396057; ENSP00000379369; ENSG00000171956.
GeneIDi27023.
KEGGihsa:27023.
UCSCiuc002agj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071554 mRNA. Translation: AAC62493.1.
AF055080 Genomic DNA. Translation: AAC09344.1.
AK290944 mRNA. Translation: BAF83633.1.
CH471082 Genomic DNA. Translation: EAW77581.1.
BC113710 mRNA. Translation: AAI13711.1.
U87393 mRNA. Translation: AAB47564.1.
CCDSiCCDS32255.1.
RefSeqiNP_036314.2. NM_012182.2.
UniGeneiHs.734475.

3D structure databases

ProteinModelPortaliQ99853.
SMRiQ99853.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117960. 133 interactors.
IntActiQ99853. 128 interactors.
STRINGi9606.ENSP00000379369.

PTM databases

iPTMnetiQ99853.
PhosphoSitePlusiQ99853.

Polymorphism and mutation databases

BioMutaiFOXB1.
DMDMi215274160.

Proteomic databases

EPDiQ99853.
PaxDbiQ99853.
PRIDEiQ99853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396057; ENSP00000379369; ENSG00000171956.
GeneIDi27023.
KEGGihsa:27023.
UCSCiuc002agj.2. human.

Organism-specific databases

CTDi27023.
DisGeNETi27023.
GeneCardsiFOXB1.
HGNCiHGNC:3799. FOXB1.
neXtProtiNX_Q99853.
OpenTargetsiENSG00000171956.
PharmGKBiPA28216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3562. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007545.
HOVERGENiHBG102104.
InParanoidiQ99853.
KOiK09395.
OMAiSLCHGGQ.
OrthoDBiEOG091G0F54.
PhylomeDBiQ99853.
TreeFamiTF350628.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171956-MONOMER.

Miscellaneous databases

GenomeRNAii27023.
PROiQ99853.

Gene expression databases

BgeeiENSG00000171956.
CleanExiHS_FOXB1.
GenevisibleiQ99853. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXB1_HUMAN
AccessioniPrimary (citable) accession number: Q99853
Secondary accession number(s): O60652, O75917, Q14CL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.