Q99853 (FOXB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein B1

Alternative name(s):
Transcription factor FKH-5

Gene names

Name:	FOXB1
Synonyms:	FKH5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon target recognition Inferred from sequence or structural similarity. Source: UniProtKB cell migration in diencephalon Inferred from sequence or structural similarity. Source: UniProtKB epithelial cell differentiation involved in mammary gland alveolus development Inferred from sequence or structural similarity. Source: UniProtKB floor plate development Inferred from sequence or structural similarity. Source: UniProtKB hypothalamus cell migration Inferred from sequence or structural similarity. Source: UniProtKB inferior colliculus development Inferred from sequence or structural similarity. Source: UniProtKB lactation Inferred from sequence or structural similarity. Source: UniProtKB mammillothalamic axonal tract development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of neuron apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome somitogenesis Inferred from sequence or structural similarity. Source: UniProtKB spinal cord development Inferred from electronic annotation. Source: Compara telencephalon cell migration Inferred from sequence or structural similarity. Source: UniProtKB thalamus development Inferred from electronic annotation. Source: Compara urogenital system development Inferred from electronic annotation. Source: Compara visual learning Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Forkhead box protein B1		PRO_0000091803
Regions
	DNA binding	12 – 103	92	Fork-head
Experimental info
	Sequence conflict	65	1	L → F in AAC09344. Ref.2
	Sequence conflict	106	1	R → C in AAC62493. Ref.1
	Sequence conflict	106	1	R → C in AAB47564. Ref.6
	Sequence conflict	126	1	Missing in AAC62493. Ref.1
	Sequence conflict	126	1	Missing in AAC09344. Ref.2
	Sequence conflict	126	1	Missing in AAB47564. Ref.6
	Sequence conflict	171 – 173	3	AIE → SIN in AAB47564. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q99853 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: FAEE1B16B1997CB0	FASTA	325	34,978
	10 20 30 40 50 60 MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY RENTQRWQNS 70 80 90 100 110 120 LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG SFLRRRKRFK VLKSDHLAPS 130 140 150 160 170 180 KPADAAQYLQ QQAKLRLSAL AASGTHLPQM PAAAYNLGGV AQPSGFKHPF AIENIIAREY 190 200 210 220 230 240 KMPGGLAFSA MQPVPAAYPL PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA 250 260 270 280 290 300 YGVPLKPLCH AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT 310 320 SQSSPATPSE TLTSPASALH SVAVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human Fkh5 from a SCLC line." Bingle C.D. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Cascio S.M., Dodd K.A., Hicks J., Chow S., Brown C. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"HNF-3/forkhead gene expression in human pulmonary cell lines: molecular cloning of a novel human HNF-3/forkhead cDNA." Bingle C.D., Gowan S. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-173. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071554 mRNA. Translation: AAC62493.1. AF055080 Genomic DNA. Translation: AAC09344.1. AK290944 mRNA. Translation: BAF83633.1. CH471082 Genomic DNA. Translation: EAW77581.1. BC113710 mRNA. Translation: AAI13711.1. U87393 mRNA. Translation: AAB47564.1.
IPI	IPI00018495.
RefSeq	NP_036314.2. NM_012182.2.
UniGene	Hs.734475.
3D structure databases
ProteinModelPortal	Q99853.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99853. 2 interactions.
STRING	9606.ENSP00000379369.
PTM databases
PhosphoSite	Q99853.
Polymorphism databases
DMDM	215274160.
Proteomic databases
PaxDb	Q99853.
PRIDE	Q99853.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396057; ENSP00000379369; ENSG00000171956.
GeneID	27023.
KEGG	hsa:27023.
UCSC	uc002agj.1. human.
Organism-specific databases
CTD	27023.
GeneCards	GC15P060296.
HGNC	HGNC:3799. FOXB1.
neXtProt	NX_Q99853.
PharmGKB	PA28216.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000007545.
HOVERGEN	HBG102104.
InParanoid	Q99853.
KO	K09395.
OMA	AREYKVP.
OrthoDB	EOG40GCRF.
PhylomeDB	Q99853.
Gene expression databases
Bgee	Q99853.
CleanEx	HS_FOXB1.
Genevestigator	Q99853.
GermOnline	ENSG00000171956. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27023.
NextBio	49554.

Entry information

Entry name

FOXB1_HUMAN

Accession

Primary (citable) accession number: Q99853
Secondary accession number(s): O60652, O75917, Q14CL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.