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Protein

Probable rRNA-processing protein EBP2

Gene

EBNA1BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the processing of the 27S pre-rRNA.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117395-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable rRNA-processing protein EBP2
Alternative name(s):
EBNA1-binding protein 2
Nucleolar protein p40
Gene namesi
Name:EBNA1BP2
Synonyms:EBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15531. EBNA1BP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10969.
OpenTargetsiENSG00000117395.
PharmGKBiPA27586.

Polymorphism and mutation databases

BioMutaiEBNA1BP2.
DMDMi116241344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199931 – 306Probable rRNA-processing protein EBP2Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphothreonineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99848.
MaxQBiQ99848.
PaxDbiQ99848.
PeptideAtlasiQ99848.
PRIDEiQ99848.

2D gel databases

SWISS-2DPAGEQ99848.

PTM databases

iPTMnetiQ99848.
PhosphoSitePlusiQ99848.
SwissPalmiQ99848.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000117395.
CleanExiHS_EBNA1BP2.
ExpressionAtlasiQ99848. baseline and differential.
GenevisibleiQ99848. HS.

Organism-specific databases

HPAiHPA026512.
HPA028277.

Interactioni

Subunit structurei

Specifically interacts with EBV EBNA1. The EBNA1-EBP2 interaction is important for the stable segregation of EBV episomes during cell division (PubMed:10074103). Interacts with WDR46.2 Publications

Protein-protein interaction databases

BioGridi116166. 124 interactors.
IntActiQ99848. 32 interactors.
MINTiMINT-86910.
STRINGi9606.ENSP00000407323.

Structurei

3D structure databases

ProteinModelPortaliQ99848.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 169Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the EBP2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3080. Eukaryota.
ENOG410YYHN. LUCA.
GeneTreeiENSGT00390000014984.
HOGENOMiHOG000231281.
HOVERGENiHBG031528.
InParanoidiQ99848.
KOiK14823.
PhylomeDBiQ99848.

Family and domain databases

InterProiIPR008610. Ebp2.
[Graphical view]
PANTHERiPTHR13028. PTHR13028. 1 hit.
PfamiPF05890. Ebp2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPPLSDSE SESDESLVTD RELQDAFSRG LLKPGLNVVL EGPKKAVNDV
60 70 80 90 100
NGLKQCLAEF KRDLEWVERL DVTLGPVPEI GGSEAPAPQN KDQKAVDPED
110 120 130 140 150
DFQREMSFYR QAQAAVLAVL PRLHQLKVPT KRPTDYFAEM AKSDLQMQKI
160 170 180 190 200
RQKLQTKQAA MERSEKAKQL RALRKYGKKV QTEVLQKRQQ EKAHMMNAIK
210 220 230 240 250
KYQKGFSDKL DFLEGDQKPL AQRKKAGAKG QQMRKGPSAK RRYKNQKFGF
260 270 280 290 300
GGKKKGSKWN TRESYDDVSS FRAKTAHGRG LKRPGKKGSN KRPGKRTREK

MKNRTH
Length:306
Mass (Da):34,852
Last modified:October 17, 2006 - v2
Checksum:i1212FC2E9442FA2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147M → V in AAB46731 (PubMed:11327720).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024437223R → H.Corresponds to variant rs7163dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86602 mRNA. Translation: AAB46731.1.
BC009175 mRNA. Translation: AAH09175.1.
CCDSiCCDS478.1.
PIRiJC7687.
RefSeqiNP_001153408.1. NM_001159936.1.
NP_006815.2. NM_006824.2.
UniGeneiHs.346868.

Genome annotation databases

EnsembliENST00000236051; ENSP00000236051; ENSG00000117395.
GeneIDi10969.
KEGGihsa:10969.
UCSCiuc001cin.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86602 mRNA. Translation: AAB46731.1.
BC009175 mRNA. Translation: AAH09175.1.
CCDSiCCDS478.1.
PIRiJC7687.
RefSeqiNP_001153408.1. NM_001159936.1.
NP_006815.2. NM_006824.2.
UniGeneiHs.346868.

3D structure databases

ProteinModelPortaliQ99848.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116166. 124 interactors.
IntActiQ99848. 32 interactors.
MINTiMINT-86910.
STRINGi9606.ENSP00000407323.

PTM databases

iPTMnetiQ99848.
PhosphoSitePlusiQ99848.
SwissPalmiQ99848.

Polymorphism and mutation databases

BioMutaiEBNA1BP2.
DMDMi116241344.

2D gel databases

SWISS-2DPAGEQ99848.

Proteomic databases

EPDiQ99848.
MaxQBiQ99848.
PaxDbiQ99848.
PeptideAtlasiQ99848.
PRIDEiQ99848.

Protocols and materials databases

DNASUi10969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236051; ENSP00000236051; ENSG00000117395.
GeneIDi10969.
KEGGihsa:10969.
UCSCiuc001cin.4. human.

Organism-specific databases

CTDi10969.
DisGeNETi10969.
GeneCardsiEBNA1BP2.
HGNCiHGNC:15531. EBNA1BP2.
HPAiHPA026512.
HPA028277.
MIMi614443. gene.
neXtProtiNX_Q99848.
OpenTargetsiENSG00000117395.
PharmGKBiPA27586.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3080. Eukaryota.
ENOG410YYHN. LUCA.
GeneTreeiENSGT00390000014984.
HOGENOMiHOG000231281.
HOVERGENiHBG031528.
InParanoidiQ99848.
KOiK14823.
PhylomeDBiQ99848.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117395-MONOMER.

Miscellaneous databases

ChiTaRSiEBNA1BP2. human.
GeneWikiiEBNA1BP2.
GenomeRNAii10969.
PROiQ99848.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117395.
CleanExiHS_EBNA1BP2.
ExpressionAtlasiQ99848. baseline and differential.
GenevisibleiQ99848. HS.

Family and domain databases

InterProiIPR008610. Ebp2.
[Graphical view]
PANTHERiPTHR13028. PTHR13028. 1 hit.
PfamiPF05890. Ebp2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEBP2_HUMAN
AccessioniPrimary (citable) accession number: Q99848
Secondary accession number(s): Q96A66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.