Q99848 (EBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable rRNA-processing protein EBP2

Alternative name(s):
EBNA1-binding protein 2
Nucleolar protein p40

Gene names

Name:	EBNA1BP2
Synonyms:	EBP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the processing of the 27S pre-rRNA By similarity.
Subunit structure	Specifically interacts with EBV EBNA1. The EBNA1-EBP2 interaction is important for the stable segregation of EBV episomes during cell division. Ref.1
Subcellular location	Nucleus › nucleolus Ref.4.
Tissue specificity	Ubiquitous. Ref.2
Sequence similarities	Belongs to the EBP2 family.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane fraction Traceable author statement. Source: ProtInc nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Probable rRNA-processing protein EBP2		PRO_0000119993
Regions
	Coiled coil	138 – 169	32	Potential
Amino acid modifications
	Modified residue	270	1	Phosphoserine Ref.5
Natural variations
	Natural variant	223	1	R → H. Corresponds to variant rs7163 [ dbSNP | Ensembl ].		VAR_024437
Experimental info
	Sequence conflict	147	1	M → V in AAB46731. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q99848 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 1212FC2E9442FA2E	FASTA	306	34,852
	10 20 30 40 50 60 MDTPPLSDSE SESDESLVTD RELQDAFSRG LLKPGLNVVL EGPKKAVNDV NGLKQCLAEF 70 80 90 100 110 120 KRDLEWVERL DVTLGPVPEI GGSEAPAPQN KDQKAVDPED DFQREMSFYR QAQAAVLAVL 130 140 150 160 170 180 PRLHQLKVPT KRPTDYFAEM AKSDLQMQKI RQKLQTKQAA MERSEKAKQL RALRKYGKKV 190 200 210 220 230 240 QTEVLQKRQQ EKAHMMNAIK KYQKGFSDKL DFLEGDQKPL AQRKKAGAKG QQMRKGPSAK 250 260 270 280 290 300 RRYKNQKFGF GGKKKGSKWN TRESYDDVSS FRAKTAHGRG LKRPGKKGSN KRPGKRTREK MKNRTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance." Shire K., Ceccarelli D.F.J., Avolio-Hunter T.M., Frappier L. J. Virol. 73:2587-2595(1999) [PubMed: 10074103] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EBNA1.
[2]	"Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2." Henning D., Valdez B.C. Biochem. Biophys. Res. Commun. 283:430-436(2001) [PubMed: 11327720] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[4]	"Identification and partial characterization of a Mr 40,000 nucleolar antigen associated with cell proliferation." Chatterjee A., Freeman J.W., Busch H. Cancer Res. 47:1123-1129(1987) [PubMed: 2879624] [Abstract] Cited for: SUBCELLULAR LOCATION.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U86602 mRNA. Translation: AAB46731.1. BC009175 mRNA. Translation: AAH09175.1.
IPI	IPI00745955.
PIR	JC7687.
RefSeq	NP_001153408.1. NM_001159936.1. NP_006815.2. NM_006824.2.
UniGene	Hs.346868.
3D structure databases
ProteinModelPortal	Q99848.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99848. 5 interactions.
MINT	MINT-86910.
STRING	Q99848.
PTM databases
PhosphoSite	Q99848.
Polymorphism databases
DMDM	116241344.
2D gel databases
SWISS-2DPAGE	Q99848.
Proteomic databases
PRIDE	Q99848.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000236051; ENSP00000236051; ENSG00000117395.
GeneID	10969.
KEGG	hsa:10969.
Organism-specific databases
CTD	10969.
GeneCards	GC01M043572.
HGNC	HGNC:15531. EBNA1BP2.
HPA	HPA026512. HPA028277.
neXtProt	NX_Q99848.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000014984.
HOGENOM	HBG714721.
HOVERGEN	HBG031528.
InParanoid	Q99848.
OMA	NDFKREM.
OrthoDB	EOG4P2Q2V.
PhylomeDB	Q99848.
Gene expression databases
ArrayExpress	Q99848.
Bgee	Q99848.
CleanEx	HS_EBNA1BP2.
Genevestigator	Q99848.
GermOnline	ENSG00000117395. Homo sapiens.
Family and domain databases
InterPro	IPR008610. Ebp2. [Graphical view]
KO	K14823.
PANTHER	PTHR13028. Ebp2. 1 hit.
Pfam	PF05890. Ebp2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	41678.

Entry information

Entry name

EBP2_HUMAN

Accession

Primary (citable) accession number: Q99848
Secondary accession number(s): Q96A66

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.