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Q99835

- SMO_HUMAN

UniProt

Q99835 - SMO_HUMAN

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Protein

Smoothened homolog

Gene

SMO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.1 Publication

GO - Molecular functioni

  1. drug binding Source: UniProtKB
  2. G-protein coupled receptor activity Source: UniProtKB-KW
  3. patched binding Source: BHF-UCL
  4. PDZ domain binding Source: RefGenome
  5. Wnt-activated receptor activity Source: RefGenome
  6. Wnt-protein binding Source: RefGenome

GO - Biological processi

  1. adenohypophysis development Source: RefGenome
  2. anterior/posterior pattern specification Source: Ensembl
  3. atrial septum morphogenesis Source: Ensembl
  4. axon extension involved in axon guidance Source: RefGenome
  5. canonical Wnt signaling pathway Source: RefGenome
  6. cardioblast differentiation Source: RefGenome
  7. cell fate specification Source: Ensembl
  8. cellular response to cholesterol Source: BHF-UCL
  9. central nervous system neuron differentiation Source: RefGenome
  10. cerebellar cortex morphogenesis Source: RefGenome
  11. ciliary receptor clustering involved in smoothened signaling pathway Source: RefGenome
  12. detection of cell density by contact stimulus involved in contact inhibition Source: BHF-UCL
  13. determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
  14. determination of left/right symmetry Source: RefGenome
  15. dorsal/ventral neural tube patterning Source: RefGenome
  16. embryonic camera-type eye development Source: RefGenome
  17. embryonic digestive tract morphogenesis Source: RefGenome
  18. embryonic neurocranium morphogenesis Source: RefGenome
  19. embryonic viscerocranium morphogenesis Source: RefGenome
  20. epithelial-mesenchymal cell signaling Source: Ensembl
  21. exocrine pancreas development Source: RefGenome
  22. facial nerve development Source: RefGenome
  23. floor plate formation Source: RefGenome
  24. forebrain morphogenesis Source: BHF-UCL
  25. gonad development Source: RefGenome
  26. hair follicle morphogenesis Source: Ensembl
  27. heart looping Source: BHF-UCL
  28. heart morphogenesis Source: RefGenome
  29. in utero embryonic development Source: Ensembl
  30. mammary gland epithelial cell differentiation Source: Ensembl
  31. mesenchymal to epithelial transition involved in metanephric renal vesicle formation Source: UniProtKB
  32. midgut development Source: BHF-UCL
  33. multicellular organism growth Source: Ensembl
  34. muscle cell fate commitment Source: RefGenome
  35. myoblast migration Source: Ensembl
  36. negative regulation of apoptotic process Source: RefGenome
  37. negative regulation of DNA binding Source: UniProtKB
  38. negative regulation of epithelial cell differentiation Source: Ensembl
  39. negative regulation of gene expression Source: UniProtKB
  40. negative regulation of hair follicle development Source: Ensembl
  41. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  42. neural crest cell migration Source: RefGenome
  43. neuron fate commitment Source: RefGenome
  44. neuron projection regeneration Source: RefGenome
  45. odontogenesis of dentin-containing tooth Source: RefGenome
  46. osteoblast differentiation Source: RefGenome
  47. otolith morphogenesis Source: RefGenome
  48. pancreas morphogenesis Source: Ensembl
  49. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  50. positive regulation of epithelial cell proliferation Source: RefGenome
  51. positive regulation of gene expression Source: UniProtKB
  52. positive regulation of hh target transcription factor activity Source: BHF-UCL
  53. positive regulation of mesenchymal cell proliferation Source: RefGenome
  54. positive regulation of neuroblast proliferation Source: RefGenome
  55. positive regulation of protein import into nucleus Source: Ensembl
  56. positive regulation of smoothened signaling pathway Source: RefGenome
  57. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  58. protein localization to nucleus Source: Ensembl
  59. protein stabilization Source: Ensembl
  60. regulation of heart morphogenesis Source: BHF-UCL
  61. regulation of stem cell maintenance Source: Ensembl
  62. renal system development Source: UniProtKB
  63. semicircular canal morphogenesis Source: RefGenome
  64. skeletal muscle fiber development Source: Ensembl
  65. smoothened signaling pathway Source: UniProtKB
  66. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RefGenome
  67. smoothened signaling pathway involved in ventral spinal cord patterning Source: RefGenome
  68. somite development Source: BHF-UCL
  69. spermatogenesis Source: RefGenome
  70. thalamus development Source: Ensembl
  71. type B pancreatic cell development Source: Ensembl
  72. vasculogenesis Source: RefGenome
  73. ventral midline determination Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
SignaLinkiQ99835.

Names & Taxonomyi

Protein namesi
Recommended name:
Smoothened homolog
Short name:
SMO
Alternative name(s):
Protein Gx
Gene namesi
Name:SMO
Synonyms:SMOH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:11119. SMO.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell projectioncilium 1 Publication

GO - Cellular componenti

  1. ciliary membrane Source: Ensembl
  2. cilium Source: RefGenome
  3. cytoplasm Source: RefGenome
  4. extracellular vesicular exosome Source: UniProtKB
  5. integral component of membrane Source: UniProtKB-KW
  6. intracellular membrane-bounded organelle Source: BHF-UCL
  7. neuronal cell body Source: RefGenome
  8. plasma membrane Source: UniProtKB
  9. primary cilium Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35968.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 787760Smoothened homologPRO_0000013015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi70 ↔ 134PROSITE-ProRule annotation
Disulfide bondi78 ↔ 127PROSITE-ProRule annotation
Disulfide bondi118 ↔ 154PROSITE-ProRule annotation
Disulfide bondi147 ↔ 169PROSITE-ProRule annotation
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi193 ↔ 2131 PublicationPROSITE-ProRule annotation
Disulfide bondi217 ↔ 2951 PublicationPROSITE-ProRule annotation
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi314 ↔ 3901 PublicationPROSITE-ProRule annotation
Disulfide bondi490 ↔ 5071 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99835.
PRIDEiQ99835.

PTM databases

PhosphoSiteiQ99835.

Expressioni

Gene expression databases

BgeeiQ99835.
CleanExiHS_SMO.
ExpressionAtlasiQ99835. baseline and differential.
GenevestigatoriQ99835.

Organism-specific databases

HPAiCAB011446.

Interactioni

Subunit structurei

Homodimer. Interacts with ARRB2. Interacts with KIF7. Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO.3 Publications

Protein-protein interaction databases

BioGridi112492. 4 interactions.
DIPiDIP-34574N.
IntActiQ99835. 5 interactions.
STRINGi9606.ENSP00000249373.

Structurei

Secondary structure

1
787
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi190 – 1923
Beta strandi197 – 1993
Helixi203 – 2053
Beta strandi210 – 2189
Helixi224 – 25431
Helixi256 – 2594
Turni262 – 2654
Helixi266 – 28217
Helixi283 – 2853
Helixi289 – 2946
Beta strandi299 – 3013
Beta strandi304 – 3063
Helixi313 – 34735
Turni352 – 3565
Helixi361 – 37818
Beta strandi381 – 3844
Turni385 – 3884
Beta strandi389 – 3957
Helixi397 – 4037
Helixi405 – 43228
Beta strandi436 – 4427
Helixi443 – 49250
Helixi515 – 53218
Helixi533 – 5364
Helixi539 – 54810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JKVX-ray2.45A/B190-555[»]
4N4WX-ray2.80A190-555[»]
4O9RX-ray3.20A190-433[»]
A441-555[»]
4QIMX-ray2.61A190-433[»]
A441-555[»]
4QINX-ray2.60A190-433[»]
A441-555[»]
ProteinModelPortaliQ99835.
SMRiQ99835. Positions 55-175, 190-553.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 233206ExtracellularSequence AnalysisAdd
BLAST
Topological domaini255 – 2628CytoplasmicSequence Analysis
Topological domaini284 – 31431ExtracellularSequence AnalysisAdd
BLAST
Topological domaini336 – 35823CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini380 – 40223ExtracellularSequence AnalysisAdd
BLAST
Topological domaini424 – 45128CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini473 – 52452ExtracellularSequence AnalysisAdd
BLAST
Topological domaini546 – 787242CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei234 – 25421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei315 – 33521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei359 – 37921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei403 – 42321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei452 – 47221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei525 – 54521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 181117FZPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni538 – 56932Interaction with BBS5 and BBS7Add
BLAST

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312505.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000252964.
HOVERGENiHBG000352.
InParanoidiQ99835.
KOiK06226.
OMAiEVCPLAP.
OrthoDBiEOG74J972.
PhylomeDBiQ99835.
TreeFamiTF106460.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99835 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR
60 70 80 90 100
SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE
110 120 130 140 150
EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT
160 170 180 190 200
RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT
210 220 230 240 250
DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA
260 270 280 290 300
TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT
310 320 330 340 350
MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY
360 370 380 390 400
QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR
410 420 430 440 450
AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML
460 470 480 490 500
RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT
510 520 530 540 550
KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC
560 570 580 590 600
RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV
610 620 630 640 650
AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE
660 670 680 690 700
QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST
710 720 730 740 750
IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP
760 770 780
SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF
Length:787
Mass (Da):86,397
Last modified:May 1, 1997 - v1
Checksum:i8B4C459B34D13F83
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti473 – 4731D → H.
Corresponds to variant rs17710891 [ dbSNP | Ensembl ].
VAR_037891
Natural varianti535 – 5351W → L in basal cell carcinoma samples; somatic mutation. 1 Publication
VAR_007848
Natural varianti562 – 5621R → Q in basal cell carcinoma samples; somatic mutation. 1 Publication
VAR_007849

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U84401 mRNA. Translation: AAB41788.1.
AF114821, AF114819, AF114820 Genomic DNA. Translation: AAD17202.1.
AF120103 mRNA. Translation: AAF31757.1.
AF071494 mRNA. Translation: AAC24863.1.
CH236950 Genomic DNA. Translation: EAL24102.1.
CH471070 Genomic DNA. Translation: EAW83715.1.
BC009989 mRNA. Translation: AAH09989.1.
CCDSiCCDS5811.1.
RefSeqiNP_005622.1. NM_005631.4.
UniGeneiHs.437846.

Genome annotation databases

EnsembliENST00000249373; ENSP00000249373; ENSG00000128602.
GeneIDi6608.
KEGGihsa:6608.
UCSCiuc003vor.3. human.

Polymorphism databases

DMDMi6226142.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U84401 mRNA. Translation: AAB41788.1 .
AF114821 , AF114819 , AF114820 Genomic DNA. Translation: AAD17202.1 .
AF120103 mRNA. Translation: AAF31757.1 .
AF071494 mRNA. Translation: AAC24863.1 .
CH236950 Genomic DNA. Translation: EAL24102.1 .
CH471070 Genomic DNA. Translation: EAW83715.1 .
BC009989 mRNA. Translation: AAH09989.1 .
CCDSi CCDS5811.1.
RefSeqi NP_005622.1. NM_005631.4.
UniGenei Hs.437846.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JKV X-ray 2.45 A/B 190-555 [» ]
4N4W X-ray 2.80 A 190-555 [» ]
4O9R X-ray 3.20 A 190-433 [» ]
A 441-555 [» ]
4QIM X-ray 2.61 A 190-433 [» ]
A 441-555 [» ]
4QIN X-ray 2.60 A 190-433 [» ]
A 441-555 [» ]
ProteinModelPortali Q99835.
SMRi Q99835. Positions 55-175, 190-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112492. 4 interactions.
DIPi DIP-34574N.
IntActi Q99835. 5 interactions.
STRINGi 9606.ENSP00000249373.

Chemistry

BindingDBi Q99835.
ChEMBLi CHEMBL5971.
DrugBanki DB01047. Fluocinonide.
DB08828. Vismodegib.
GuidetoPHARMACOLOGYi 239.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q99835.

Polymorphism databases

DMDMi 6226142.

Proteomic databases

PaxDbi Q99835.
PRIDEi Q99835.

Protocols and materials databases

DNASUi 6608.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249373 ; ENSP00000249373 ; ENSG00000128602 .
GeneIDi 6608.
KEGGi hsa:6608.
UCSCi uc003vor.3. human.

Organism-specific databases

CTDi 6608.
GeneCardsi GC07P128828.
HGNCi HGNC:11119. SMO.
HPAi CAB011446.
MIMi 601500. gene.
neXtProti NX_Q99835.
PharmGKBi PA35968.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312505.
GeneTreei ENSGT00760000118864.
HOGENOMi HOG000252964.
HOVERGENi HBG000352.
InParanoidi Q99835.
KOi K06226.
OMAi EVCPLAP.
OrthoDBi EOG74J972.
PhylomeDBi Q99835.
TreeFami TF106460.

Enzyme and pathway databases

Reactomei REACT_18372. Class B/2 (Secretin family receptors).
SignaLinki Q99835.

Miscellaneous databases

ChiTaRSi Smo. human.
GeneWikii Smoothened.
GenomeRNAii 6608.
NextBioi 25725.
PROi Q99835.
SOURCEi Search...

Gene expression databases

Bgeei Q99835.
CleanExi HS_SMO.
ExpressionAtlasi Q99835. baseline and differential.
Genevestigatori Q99835.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-535 AND GLN-562.
  3. "Cloning and identification of Gx gene in NPC."
    Jiang N., Zeng Z.Y., Li G.Y.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."
    Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S.
    Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KIF7.
  8. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."
    Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.
    PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH THE BBSOME COMPLEX, INTERACTION WITH BBS5 AND BBS7, SUBCELLULAR LOCATION.
  9. "Structure of the human smoothened receptor bound to an antitumour agent."
    Wang C., Wu H., Katritch V., Han G.W., Huang X.P., Liu W., Siu F.Y., Roth B.L., Cherezov V., Stevens R.C.
    Nature 497:338-343(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 190-555 IN COMPLEX WITH ANTAGONIST, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiSMO_HUMAN
AccessioniPrimary (citable) accession number: Q99835
Secondary accession number(s): A4D1K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3