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Q99835

- SMO_HUMAN

UniProt

Q99835 - SMO_HUMAN

Protein

Smoothened homolog

Gene

SMO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.1 Publication

    GO - Molecular functioni

    1. drug binding Source: UniProtKB
    2. G-protein coupled receptor activity Source: UniProtKB-KW
    3. patched binding Source: BHF-UCL
    4. PDZ domain binding Source: RefGenome
    5. protein binding Source: UniProtKB
    6. Wnt-activated receptor activity Source: RefGenome
    7. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. adenohypophysis development Source: RefGenome
    2. atrial septum morphogenesis Source: Ensembl
    3. axon extension involved in axon guidance Source: RefGenome
    4. canonical Wnt signaling pathway Source: RefGenome
    5. cardioblast differentiation Source: RefGenome
    6. cell fate specification Source: Ensembl
    7. cellular response to cholesterol Source: BHF-UCL
    8. central nervous system neuron differentiation Source: RefGenome
    9. cerebellar cortex morphogenesis Source: RefGenome
    10. ciliary receptor clustering involved in smoothened signaling pathway Source: RefGenome
    11. detection of cell density by contact stimulus involved in contact inhibition Source: BHF-UCL
    12. determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
    13. determination of left/right symmetry Source: RefGenome
    14. dorsal/ventral neural tube patterning Source: RefGenome
    15. embryonic camera-type eye development Source: RefGenome
    16. embryonic digestive tract morphogenesis Source: RefGenome
    17. embryonic neurocranium morphogenesis Source: RefGenome
    18. embryonic viscerocranium morphogenesis Source: RefGenome
    19. epithelial-mesenchymal cell signaling Source: Ensembl
    20. exocrine pancreas development Source: RefGenome
    21. facial nerve development Source: RefGenome
    22. floor plate formation Source: RefGenome
    23. forebrain morphogenesis Source: BHF-UCL
    24. gonad development Source: RefGenome
    25. hair follicle morphogenesis Source: Ensembl
    26. heart looping Source: BHF-UCL
    27. heart morphogenesis Source: RefGenome
    28. in utero embryonic development Source: Ensembl
    29. mammary gland epithelial cell differentiation Source: Ensembl
    30. mesenchymal to epithelial transition involved in metanephric renal vesicle formation Source: UniProtKB
    31. midgut development Source: BHF-UCL
    32. multicellular organism growth Source: Ensembl
    33. muscle cell fate commitment Source: RefGenome
    34. negative regulation of apoptotic process Source: RefGenome
    35. negative regulation of DNA binding Source: UniProtKB
    36. negative regulation of epithelial cell differentiation Source: Ensembl
    37. negative regulation of gene expression Source: UniProtKB
    38. negative regulation of hair follicle development Source: Ensembl
    39. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    40. neural crest cell migration Source: RefGenome
    41. neuron fate commitment Source: RefGenome
    42. neuron projection regeneration Source: RefGenome
    43. odontogenesis of dentin-containing tooth Source: RefGenome
    44. osteoblast differentiation Source: RefGenome
    45. otolith morphogenesis Source: RefGenome
    46. pancreas morphogenesis Source: Ensembl
    47. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    48. positive regulation of epithelial cell proliferation Source: RefGenome
    49. positive regulation of gene expression Source: UniProtKB
    50. positive regulation of hh target transcription factor activity Source: BHF-UCL
    51. positive regulation of mesenchymal cell proliferation Source: RefGenome
    52. positive regulation of neuroblast proliferation Source: RefGenome
    53. positive regulation of protein import into nucleus Source: Ensembl
    54. positive regulation of smoothened signaling pathway Source: RefGenome
    55. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    56. protein localization to nucleus Source: Ensembl
    57. protein stabilization Source: Ensembl
    58. regulation of heart morphogenesis Source: BHF-UCL
    59. regulation of stem cell maintenance Source: Ensembl
    60. renal system development Source: UniProtKB
    61. semicircular canal morphogenesis Source: RefGenome
    62. smoothened signaling pathway Source: UniProtKB
    63. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RefGenome
    64. smoothened signaling pathway involved in ventral spinal cord patterning Source: RefGenome
    65. somite development Source: BHF-UCL
    66. spermatogenesis Source: RefGenome
    67. thalamus development Source: Ensembl
    68. type B pancreatic cell development Source: Ensembl
    69. vasculogenesis Source: RefGenome
    70. ventral midline determination Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
    SignaLinkiQ99835.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Smoothened homolog
    Short name:
    SMO
    Alternative name(s):
    Protein Gx
    Gene namesi
    Name:SMO
    Synonyms:SMOH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:11119. SMO.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell projectioncilium 1 Publication

    GO - Cellular componenti

    1. ciliary membrane Source: Ensembl
    2. cilium Source: RefGenome
    3. cytoplasm Source: RefGenome
    4. extracellular vesicular exosome Source: UniProt
    5. integral component of membrane Source: UniProtKB-KW
    6. intracellular membrane-bounded organelle Source: BHF-UCL
    7. neuronal cell body Source: RefGenome
    8. plasma membrane Source: UniProtKB
    9. primary cilium Source: BHF-UCL

    Keywords - Cellular componenti

    Cell projection, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35968.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 787760Smoothened homologPRO_0000013015Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi70 ↔ 134PROSITE-ProRule annotation
    Disulfide bondi78 ↔ 127PROSITE-ProRule annotation
    Disulfide bondi118 ↔ 154PROSITE-ProRule annotation
    Disulfide bondi147 ↔ 169PROSITE-ProRule annotation
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi193 ↔ 2131 PublicationPROSITE-ProRule annotation
    Disulfide bondi217 ↔ 2951 PublicationPROSITE-ProRule annotation
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi314 ↔ 3901 PublicationPROSITE-ProRule annotation
    Disulfide bondi490 ↔ 5071 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ99835.
    PRIDEiQ99835.

    PTM databases

    PhosphoSiteiQ99835.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99835.
    BgeeiQ99835.
    CleanExiHS_SMO.
    GenevestigatoriQ99835.

    Organism-specific databases

    HPAiCAB011446.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with ARRB2. Interacts with KIF7. Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO.3 Publications

    Protein-protein interaction databases

    BioGridi112492. 3 interactions.
    DIPiDIP-34574N.
    IntActiQ99835. 5 interactions.
    STRINGi9606.ENSP00000249373.

    Structurei

    Secondary structure

    1
    787
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi190 – 1923
    Beta strandi197 – 1993
    Helixi203 – 2053
    Beta strandi210 – 2189
    Helixi224 – 25431
    Helixi256 – 2594
    Turni262 – 2654
    Helixi266 – 28217
    Helixi283 – 2853
    Helixi289 – 2946
    Beta strandi299 – 3013
    Beta strandi304 – 3063
    Helixi313 – 34735
    Turni352 – 3565
    Helixi361 – 37818
    Beta strandi381 – 3844
    Turni385 – 3884
    Beta strandi389 – 3957
    Helixi397 – 4037
    Helixi405 – 43228
    Beta strandi436 – 4427
    Helixi443 – 49250
    Helixi515 – 53218
    Helixi533 – 5364
    Helixi539 – 54810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4JKVX-ray2.45A/B190-555[»]
    4N4WX-ray2.80A190-555[»]
    4O9RX-ray3.20A190-433[»]
    A441-555[»]
    ProteinModelPortaliQ99835.
    SMRiQ99835. Positions 55-175, 190-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 233206ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini255 – 2628CytoplasmicSequence Analysis
    Topological domaini284 – 31431ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini336 – 35823CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini380 – 40223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini424 – 45128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini473 – 52452ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini546 – 787242CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei234 – 25421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei525 – 54521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 181117FZPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni538 – 56932Interaction with BBS5 and BBS7Add
    BLAST

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG312505.
    HOGENOMiHOG000252964.
    HOVERGENiHBG000352.
    InParanoidiQ99835.
    KOiK06226.
    OMAiEVCPLAP.
    OrthoDBiEOG74J972.
    PhylomeDBiQ99835.
    TreeFamiTF106460.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99835-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR    50
    SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE 100
    EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT 150
    RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT 200
    DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA 250
    TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT 300
    MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY 350
    QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR 400
    AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML 450
    RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT 500
    KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC 550
    RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV 600
    AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE 650
    QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST 700
    IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP 750
    SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF 787
    Length:787
    Mass (Da):86,397
    Last modified:May 1, 1997 - v1
    Checksum:i8B4C459B34D13F83
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti473 – 4731D → H.
    Corresponds to variant rs17710891 [ dbSNP | Ensembl ].
    VAR_037891
    Natural varianti535 – 5351W → L in basal cell carcinoma samples; somatic mutation. 1 Publication
    VAR_007848
    Natural varianti562 – 5621R → Q in basal cell carcinoma samples; somatic mutation. 1 Publication
    VAR_007849

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84401 mRNA. Translation: AAB41788.1.
    AF114821, AF114819, AF114820 Genomic DNA. Translation: AAD17202.1.
    AF120103 mRNA. Translation: AAF31757.1.
    AF071494 mRNA. Translation: AAC24863.1.
    CH236950 Genomic DNA. Translation: EAL24102.1.
    CH471070 Genomic DNA. Translation: EAW83715.1.
    BC009989 mRNA. Translation: AAH09989.1.
    CCDSiCCDS5811.1.
    RefSeqiNP_005622.1. NM_005631.4.
    UniGeneiHs.437846.

    Genome annotation databases

    EnsembliENST00000249373; ENSP00000249373; ENSG00000128602.
    GeneIDi6608.
    KEGGihsa:6608.
    UCSCiuc003vor.3. human.

    Polymorphism databases

    DMDMi6226142.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84401 mRNA. Translation: AAB41788.1 .
    AF114821 , AF114819 , AF114820 Genomic DNA. Translation: AAD17202.1 .
    AF120103 mRNA. Translation: AAF31757.1 .
    AF071494 mRNA. Translation: AAC24863.1 .
    CH236950 Genomic DNA. Translation: EAL24102.1 .
    CH471070 Genomic DNA. Translation: EAW83715.1 .
    BC009989 mRNA. Translation: AAH09989.1 .
    CCDSi CCDS5811.1.
    RefSeqi NP_005622.1. NM_005631.4.
    UniGenei Hs.437846.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4JKV X-ray 2.45 A/B 190-555 [» ]
    4N4W X-ray 2.80 A 190-555 [» ]
    4O9R X-ray 3.20 A 190-433 [» ]
    A 441-555 [» ]
    ProteinModelPortali Q99835.
    SMRi Q99835. Positions 55-175, 190-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112492. 3 interactions.
    DIPi DIP-34574N.
    IntActi Q99835. 5 interactions.
    STRINGi 9606.ENSP00000249373.

    Chemistry

    BindingDBi Q99835.
    ChEMBLi CHEMBL5971.
    GuidetoPHARMACOLOGYi 239.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99835.

    Polymorphism databases

    DMDMi 6226142.

    Proteomic databases

    PaxDbi Q99835.
    PRIDEi Q99835.

    Protocols and materials databases

    DNASUi 6608.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249373 ; ENSP00000249373 ; ENSG00000128602 .
    GeneIDi 6608.
    KEGGi hsa:6608.
    UCSCi uc003vor.3. human.

    Organism-specific databases

    CTDi 6608.
    GeneCardsi GC07P128828.
    HGNCi HGNC:11119. SMO.
    HPAi CAB011446.
    MIMi 601500. gene.
    neXtProti NX_Q99835.
    PharmGKBi PA35968.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312505.
    HOGENOMi HOG000252964.
    HOVERGENi HBG000352.
    InParanoidi Q99835.
    KOi K06226.
    OMAi EVCPLAP.
    OrthoDBi EOG74J972.
    PhylomeDBi Q99835.
    TreeFami TF106460.

    Enzyme and pathway databases

    Reactomei REACT_18372. Class B/2 (Secretin family receptors).
    SignaLinki Q99835.

    Miscellaneous databases

    ChiTaRSi Smo. human.
    GeneWikii Smoothened.
    GenomeRNAii 6608.
    NextBioi 25725.
    PROi Q99835.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99835.
    Bgeei Q99835.
    CleanExi HS_SMO.
    Genevestigatori Q99835.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryonic lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-535 AND GLN-562.
    3. "Cloning and identification of Gx gene in NPC."
      Jiang N., Zeng Z.Y., Li G.Y.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."
      Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S.
      Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH KIF7.
    8. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."
      Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.
      PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH THE BBSOME COMPLEX, INTERACTION WITH BBS5 AND BBS7, SUBCELLULAR LOCATION.
    9. "Structure of the human smoothened receptor bound to an antitumour agent."
      Wang C., Wu H., Katritch V., Han G.W., Huang X.P., Liu W., Siu F.Y., Roth B.L., Cherezov V., Stevens R.C.
      Nature 497:338-343(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 190-555 IN COMPLEX WITH ANTAGONIST, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiSMO_HUMAN
    AccessioniPrimary (citable) accession number: Q99835
    Secondary accession number(s): A4D1K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 147 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3