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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: ProtInc

GO - Biological processi

  • binding of sperm to zona pellucida Source: Ensembl
  • positive regulation of establishment of protein localization to telomere Source: BHF-UCL
  • positive regulation of protein localization to Cajal body Source: BHF-UCL
  • positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
  • protein folding Source: Reactome
  • protein stabilization Source: BHF-UCL
  • toxin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135624-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.
R-HSA-389960. Formation of tubulin folding intermediates by CCT/TriC.
R-HSA-390450. Folding of actin by CCT/TriC.
R-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
HIV-1 Nef-interacting protein
Cleaved into the following chain:
Gene namesi
Name:CCT7
Synonyms:CCTH, NIP7-1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:1622. CCT7.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: Ensembl
  • chaperonin-containing T-complex Source: UniProtKB
  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB
  • mitochondrion Source: Ensembl
  • zona pellucida receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10574.
MalaCardsiCCT7.
OpenTargetsiENSG00000135624.
PharmGKBiPA26185.

Polymorphism and mutation databases

BioMutaiCCT7.
DMDMi3041738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283651 – 543T-complex protein 1 subunit etaAdd BLAST543
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004343912 – 543T-complex protein 1 subunit eta, N-terminally processedAdd BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei67N6-acetyllysineCombined sources1
Modified residuei250N6-acetyllysineBy similarity1
Modified residuei320N6-acetyllysineCombined sources1
Modified residuei535Omega-N-methylarginineCombined sources1
Isoform 3 (identifier: Q99832-3)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ99832.
MaxQBiQ99832.
PaxDbiQ99832.
PeptideAtlasiQ99832.
PRIDEiQ99832.

2D gel databases

REPRODUCTION-2DPAGEIPI00018465.

PTM databases

iPTMnetiQ99832.
PhosphoSitePlusiQ99832.
SwissPalmiQ99832.

Expressioni

Gene expression databases

BgeeiENSG00000135624.
CleanExiHS_CCT7.
ExpressionAtlasiQ99832. baseline and differential.
GenevisibleiQ99832. HS.

Organism-specific databases

HPAiHPA008425.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SSSCA1O602325EBI-357046,EBI-741415

GO - Molecular functioni

  • unfolded protein binding Source: ProtInc

Protein-protein interaction databases

BioGridi115825. 227 interactors.
DIPiDIP-51608N.
IntActiQ99832. 120 interactors.
MINTiMINT-1131353.
STRINGi9606.ENSP00000258091.

Structurei

3D structure databases

ProteinModelPortaliQ99832.
SMRiQ99832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074832.
HOGENOMiHOG000226730.
HOVERGENiHBG001052.
InParanoidiQ99832.
KOiK09499.
OMAiLCEHFEE.
OrthoDBiEOG091G05UO.
PhylomeDBiQ99832.
TreeFamiTF105641.

Family and domain databases

CDDicd03340. TCP1_eta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99832-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV
60 70 80 90 100
DGRGKATISN DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL
110 120 130 140 150
AAEFLKQVKP YVEEGLHPQI IIRAFRTATQ LAVNKIKEIA VTVKKADKVE
160 170 180 190 200
QRKLLEKCAM TALSSKLISQ QKAFFAKMVV DAVMMLDDLL QLKMIGIKKV
210 220 230 240 250
QGGALEDSQL VAGVAFKKTF SYAGFEMQPK KYHNPKIALL NVELELKAEK
260 270 280 290 300
DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT
310 320 330 340 350
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSAD VLGRCQVFEE
360 370 380 390 400
TQIGGERYNF FTGCPKAKTC TFILRGGAEQ FMEETERSLH DAIMIVRRAI
410 420 430 440 450
KNDSVVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC
460 470 480 490 500
DNAGFDATNI LNKLRARHAQ GGTWYGVDIN NEDIADNFEA FVWEPAMVRI
510 520 530 540
NALTAASEAA CLIVSVDETI KNPRSTVDAP TAAGRGRGRG RPH
Length:543
Mass (Da):59,367
Last modified:July 15, 1998 - v2
Checksum:i9F1E33FA80E6238E
GO
Isoform 2 (identifier: Q99832-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-89: Missing.
     90-206: Missing.

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):37,499
Checksum:iBA74E59CE7977306
GO
Isoform 3 (identifier: Q99832-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:499
Mass (Da):54,804
Checksum:i19F19C1820F6A80A
GO
Isoform 4 (identifier: Q99832-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-89: Missing.

Note: No experimental confirmation available.
Show »
Length:456
Mass (Da):50,352
Checksum:iAD52175094D0BD23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti282 – 283HH → RQ in AAB41437 (Ref. 8) Curated2
Sequence conflicti293L → P in AAB41437 (Ref. 8) Curated1
Sequence conflicti336A → P in AAB41437 (Ref. 8) Curated1
Sequence conflicti364C → L in AAB41437 (Ref. 8) Curated1
Sequence conflicti374 – 376LRG → SPC in AAB41437 (Ref. 8) Curated3
Sequence conflicti407A → P in AAB41437 (Ref. 8) Curated1
Sequence conflicti411A → P in AAB41437 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052269259T → A.Corresponds to variant rs2231427dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0435721 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0435733 – 89Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_04357490 – 206Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026292 mRNA. Translation: AAC96011.1.
CR536511 mRNA. Translation: CAG38749.1.
AK291961 mRNA. Translation: BAF84650.1.
AK293597 mRNA. Translation: BAH11543.1.
AK297846 mRNA. Translation: BAH12675.1.
AK298153 mRNA. Translation: BAH12733.1.
AC010913 Genomic DNA. Translation: AAX88902.1.
CH471053 Genomic DNA. Translation: EAW99739.1.
CH471053 Genomic DNA. Translation: EAW99740.1.
BC019296 mRNA. Translation: AAH19296.1.
BC088351 mRNA. Translation: AAH88351.1.
U83843 mRNA. Translation: AAB41437.1.
CCDSiCCDS42696.1. [Q99832-2]
CCDS46336.1. [Q99832-1]
CCDS54366.1. [Q99832-4]
CCDS54367.1. [Q99832-3]
RefSeqiNP_001009570.1. NM_001009570.2. [Q99832-2]
NP_001159756.1. NM_001166284.1. [Q99832-4]
NP_001159757.1. NM_001166285.1. [Q99832-3]
NP_006420.1. NM_006429.3. [Q99832-1]
XP_011530780.1. XM_011532478.2. [Q99832-3]
XP_011530781.1. XM_011532479.1. [Q99832-3]
UniGeneiHs.368149.

Genome annotation databases

EnsembliENST00000258091; ENSP00000258091; ENSG00000135624. [Q99832-1]
ENST00000398422; ENSP00000381456; ENSG00000135624. [Q99832-2]
ENST00000539919; ENSP00000437824; ENSG00000135624. [Q99832-3]
ENST00000540468; ENSP00000442058; ENSG00000135624. [Q99832-4]
GeneIDi10574.
KEGGihsa:10574.
UCSCiuc002siz.4. human. [Q99832-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026292 mRNA. Translation: AAC96011.1.
CR536511 mRNA. Translation: CAG38749.1.
AK291961 mRNA. Translation: BAF84650.1.
AK293597 mRNA. Translation: BAH11543.1.
AK297846 mRNA. Translation: BAH12675.1.
AK298153 mRNA. Translation: BAH12733.1.
AC010913 Genomic DNA. Translation: AAX88902.1.
CH471053 Genomic DNA. Translation: EAW99739.1.
CH471053 Genomic DNA. Translation: EAW99740.1.
BC019296 mRNA. Translation: AAH19296.1.
BC088351 mRNA. Translation: AAH88351.1.
U83843 mRNA. Translation: AAB41437.1.
CCDSiCCDS42696.1. [Q99832-2]
CCDS46336.1. [Q99832-1]
CCDS54366.1. [Q99832-4]
CCDS54367.1. [Q99832-3]
RefSeqiNP_001009570.1. NM_001009570.2. [Q99832-2]
NP_001159756.1. NM_001166284.1. [Q99832-4]
NP_001159757.1. NM_001166285.1. [Q99832-3]
NP_006420.1. NM_006429.3. [Q99832-1]
XP_011530780.1. XM_011532478.2. [Q99832-3]
XP_011530781.1. XM_011532479.1. [Q99832-3]
UniGeneiHs.368149.

3D structure databases

ProteinModelPortaliQ99832.
SMRiQ99832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115825. 227 interactors.
DIPiDIP-51608N.
IntActiQ99832. 120 interactors.
MINTiMINT-1131353.
STRINGi9606.ENSP00000258091.

PTM databases

iPTMnetiQ99832.
PhosphoSitePlusiQ99832.
SwissPalmiQ99832.

Polymorphism and mutation databases

BioMutaiCCT7.
DMDMi3041738.

2D gel databases

REPRODUCTION-2DPAGEIPI00018465.

Proteomic databases

EPDiQ99832.
MaxQBiQ99832.
PaxDbiQ99832.
PeptideAtlasiQ99832.
PRIDEiQ99832.

Protocols and materials databases

DNASUi10574.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258091; ENSP00000258091; ENSG00000135624. [Q99832-1]
ENST00000398422; ENSP00000381456; ENSG00000135624. [Q99832-2]
ENST00000539919; ENSP00000437824; ENSG00000135624. [Q99832-3]
ENST00000540468; ENSP00000442058; ENSG00000135624. [Q99832-4]
GeneIDi10574.
KEGGihsa:10574.
UCSCiuc002siz.4. human. [Q99832-1]

Organism-specific databases

CTDi10574.
DisGeNETi10574.
GeneCardsiCCT7.
HGNCiHGNC:1622. CCT7.
HPAiHPA008425.
MalaCardsiCCT7.
MIMi605140. gene.
neXtProtiNX_Q99832.
OpenTargetsiENSG00000135624.
PharmGKBiPA26185.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074832.
HOGENOMiHOG000226730.
HOVERGENiHBG001052.
InParanoidiQ99832.
KOiK09499.
OMAiLCEHFEE.
OrthoDBiEOG091G05UO.
PhylomeDBiQ99832.
TreeFamiTF105641.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135624-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.
R-HSA-389960. Formation of tubulin folding intermediates by CCT/TriC.
R-HSA-390450. Folding of actin by CCT/TriC.
R-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

ChiTaRSiCCT7. human.
GeneWikiiCCT7.
GenomeRNAii10574.
PROiQ99832.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135624.
CleanExiHS_CCT7.
ExpressionAtlasiQ99832. baseline and differential.
GenevisibleiQ99832. HS.

Family and domain databases

CDDicd03340. TCP1_eta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPH_HUMAN
AccessioniPrimary (citable) accession number: Q99832
Secondary accession number(s): A8K7E6
, A8MWI8, B7WNW9, B7Z4T9, B7Z4Z7, O14871, Q6FI26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.